Cystic fibrosis in the era of CFTR modulators: did the neutrophil slip through the cracks?
J Leukoc Biol. 2024 Jan 9:qiad164. doi: 10.1093/jleuko/qiad164. Online ahead of print.NO ABSTRACTPMID:38193848 | DOI:10.1093/jleuko/qiad164 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - January 9, 2024 Category: Hematology Authors: V éronique Witko-Sarsat Pierre-R égis Burgel Source Type: research
Foxo1 Drives the TGF β1-Dependent Dichotomy of Th17 Cell Fates
In this study, we demonstrate that the transcription factor Foxo1 is upregulated in a TGFβ1 dose-dependent manner, serving as a critical regulator that specifically modulates the fate of pathogenic Th17 cells. Analyses in both uveitis patients and an Experimental Autoimmune Uveitis (EAU) mouse model reveal a strong correlation between disease severity and diminished Foxo1 expression levels. Ectopic expression of Foxo1 selectively attenuates IL-17A production under pathogenic Th17-inducing conditions. Moreover, enhanced Foxo1 expression, triggered by TGFβ1 signaling, is implicated in fatty acid metabolism pathways that fa...
Source: Journal of Leukocyte Biology - January 9, 2024 Category: Hematology Authors: Mengjuan Zhang Yude Guan Meijuan Han Fandi Kong Aoyu Xu Xiaohan Jin Xiao Hu Fang Dong Nianchao Zhang Xiuping Peng Dantong Liu Yongyan Chen Ruxin Zhao Xiulei Zhu Yanan Zhang Congcong Lu Wen Hou Lei Liu Dan Li Zhihui Zhang Xiaomin Zhang Song Zhang Source Type: research
Decreased percentages of plasmacytoid dendritic cells predict survival in critically ill patients
In conclusion, we observed low percentages of DCs in patients admitted to an ICU suffering from sepsis, respiratory failure, and cardiogenic shock, suggesting their depletion as a contributing mechanism for the development of immune paralysis. In our cohort, pDCs were identified as the most robust subset to predict 30-day mortality.PMID:38180532 | DOI:10.1093/jleuko/qiae003 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - January 5, 2024 Category: Hematology Authors: Eva Steinacher Max Lenz Konstantin A Krychtiuk Christian Hengstenberg Kurt Huber Johann Wojta Gottfried Heinz Alexander Niessner Walter S Speidl Lorenz Koller Source Type: research
Decreased percentages of plasmacytoid dendritic cells predict survival in critically ill patients
In conclusion, we observed low percentages of DCs in patients admitted to an ICU suffering from sepsis, respiratory failure, and cardiogenic shock, suggesting their depletion as a contributing mechanism for the development of immune paralysis. In our cohort, pDCs were identified as the most robust subset to predict 30-day mortality.PMID:38180532 | DOI:10.1093/jleuko/qiae003 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - January 5, 2024 Category: Hematology Authors: Eva Steinacher Max Lenz Konstantin A Krychtiuk Christian Hengstenberg Kurt Huber Johann Wojta Gottfried Heinz Alexander Niessner Walter S Speidl Lorenz Koller Source Type: research
Decreased percentages of plasmacytoid dendritic cells predict survival in critically ill patients
In conclusion, we observed low percentages of DCs in patients admitted to an ICU suffering from sepsis, respiratory failure, and cardiogenic shock, suggesting their depletion as a contributing mechanism for the development of immune paralysis. In our cohort, pDCs were identified as the most robust subset to predict 30-day mortality.PMID:38180532 | DOI:10.1093/jleuko/qiae003 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - January 5, 2024 Category: Hematology Authors: Eva Steinacher Max Lenz Konstantin A Krychtiuk Christian Hengstenberg Kurt Huber Johann Wojta Gottfried Heinz Alexander Niessner Walter S Speidl Lorenz Koller Source Type: research
Decreased percentages of plasmacytoid dendritic cells predict survival in critically ill patients
In conclusion, we observed low percentages of DCs in patients admitted to an ICU suffering from sepsis, respiratory failure, and cardiogenic shock, suggesting their depletion as a contributing mechanism for the development of immune paralysis. In our cohort, pDCs were identified as the most robust subset to predict 30-day mortality.PMID:38180532 | DOI:10.1093/jleuko/qiae003 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - January 5, 2024 Category: Hematology Authors: Eva Steinacher Max Lenz Konstantin A Krychtiuk Christian Hengstenberg Kurt Huber Johann Wojta Gottfried Heinz Alexander Niessner Walter S Speidl Lorenz Koller Source Type: research
Point-of-Care neutrophil and monocyte surface markers differentiate bacterial from viral infections at the emergency department within 30 minutes
J Leukoc Biol. 2024 Jan 3:qiad163. doi: 10.1093/jleuko/qiad163. Online ahead of print.ABSTRACTRapid discrimination between viral and bacterial infections in a Point-of-Care setting will improve clinical outcome. Expression of CD64 on neutrophils (neuCD64) increases during bacterial infections, whereas expression of CD169 on classical monocytes(cmCD169) increases during viral infections. The diagnostic value of automated Point-of-Care neuCD64 and cmCD169 analysis was assessed for detecting bacterial and viral infections at the Emergency Department (ED). Additionally, their value as input for machine learning models was stud...
Source: Journal of Leukocyte Biology - January 3, 2024 Category: Hematology Authors: Bernard N Jukema Titus A P de Hond Martijn Kroon Anna E Maranus Leo Koenderman Karin A H Kaasjager Source Type: research
Point-of-Care neutrophil and monocyte surface markers differentiate bacterial from viral infections at the emergency department within 30 minutes
J Leukoc Biol. 2024 Jan 3:qiad163. doi: 10.1093/jleuko/qiad163. Online ahead of print.ABSTRACTRapid discrimination between viral and bacterial infections in a Point-of-Care setting will improve clinical outcome. Expression of CD64 on neutrophils (neuCD64) increases during bacterial infections, whereas expression of CD169 on classical monocytes(cmCD169) increases during viral infections. The diagnostic value of automated Point-of-Care neuCD64 and cmCD169 analysis was assessed for detecting bacterial and viral infections at the Emergency Department (ED). Additionally, their value as input for machine learning models was stud...
Source: Journal of Leukocyte Biology - January 3, 2024 Category: Hematology Authors: Bernard N Jukema Titus A P de Hond Martijn Kroon Anna E Maranus Leo Koenderman Karin A H Kaasjager Source Type: research
Glucocorticoid-induced TNF receptor family-related protein functions as a co-stimulatory molecule for murine eosinophils
In conclusion, our results provide a new regulatory pathway of cytokine secretion from eosinophils where GITR functions as a co-stimulatory molecule.PMID:38159043 | DOI:10.1093/jleuko/qiad166 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - December 30, 2023 Category: Hematology Authors: Tomoya Narita Yusuke Murakami Takashi Isii Masashi Muroi Naomi Yamashita Source Type: research
Glucocorticoid-induced TNF receptor family-related protein functions as a co-stimulatory molecule for murine eosinophils
In conclusion, our results provide a new regulatory pathway of cytokine secretion from eosinophils where GITR functions as a co-stimulatory molecule.PMID:38159043 | DOI:10.1093/jleuko/qiad166 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - December 30, 2023 Category: Hematology Authors: Tomoya Narita Yusuke Murakami Takashi Isii Masashi Muroi Naomi Yamashita Source Type: research
Lipocalin-2 as a mediator of neuroimmune communication
J Leukoc Biol. 2023 Dec 27:qiad157. doi: 10.1093/jleuko/qiad157. Online ahead of print.ABSTRACTLipocalin-2 (LCN2), a neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa secreted protein implicated in a broad range of inflammatory diseases affecting the brain and periphery. It is a pleotropic protein expressed by various immune and non-immune cells throughout the body. Importantly, the surge in LCN2 levels in disease states has been associated with a myriad of undesirable effects, further exacerbating the ongoing pathological processes. In the brain, glial cells are the principal source of LCN2, which plays a def...
Source: Journal of Leukocyte Biology - December 27, 2023 Category: Hematology Authors: Ruqayya Afridi Jae-Hong Kim Anup Bhusal Won-Ha Lee Kyoungho Suk Source Type: research
Reprogramming of human γδ T cells by expression of an anti-CD19 TCR fusion construct (εTRuC) to enhance tumor killing
In conclusion, the generation and use of γδ εTRuC T cells might be a new approach for cancer immunotherapy.PMID:38149982 | DOI:10.1093/jleuko/qiad128 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - December 27, 2023 Category: Hematology Authors: Claudia Juraske Sonia M Krissmer Evelyn S Teuber Maria A Parigiani Juliane Strietz Daniela Wesch Dieter Kabelitz Susana Minguet Wolfgang W Schamel Source Type: research
Lipocalin-2 as a mediator of neuroimmune communication
J Leukoc Biol. 2023 Dec 27:qiad157. doi: 10.1093/jleuko/qiad157. Online ahead of print.ABSTRACTLipocalin-2 (LCN2), a neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa secreted protein implicated in a broad range of inflammatory diseases affecting the brain and periphery. It is a pleotropic protein expressed by various immune and non-immune cells throughout the body. Importantly, the surge in LCN2 levels in disease states has been associated with a myriad of undesirable effects, further exacerbating the ongoing pathological processes. In the brain, glial cells are the principal source of LCN2, which plays a def...
Source: Journal of Leukocyte Biology - December 27, 2023 Category: Hematology Authors: Ruqayya Afridi Jae-Hong Kim Anup Bhusal Won-Ha Lee Kyoungho Suk Source Type: research
Reprogramming of human γδ T cells by expression of an anti-CD19 TCR fusion construct (εTRuC) to enhance tumor killing
In conclusion, the generation and use of γδ εTRuC T cells might be a new approach for cancer immunotherapy.PMID:38149982 | DOI:10.1093/jleuko/qiad128 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - December 27, 2023 Category: Hematology Authors: Claudia Juraske Sonia M Krissmer Evelyn S Teuber Maria A Parigiani Juliane Strietz Daniela Wesch Dieter Kabelitz Susana Minguet Wolfgang W Schamel Source Type: research
Lipocalin-2 as a mediator of neuroimmune communication
J Leukoc Biol. 2023 Dec 27:qiad157. doi: 10.1093/jleuko/qiad157. Online ahead of print.ABSTRACTLipocalin-2 (LCN2), a neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa secreted protein implicated in a broad range of inflammatory diseases affecting the brain and periphery. It is a pleotropic protein expressed by various immune and non-immune cells throughout the body. Importantly, the surge in LCN2 levels in disease states has been associated with a myriad of undesirable effects, further exacerbating the ongoing pathological processes. In the brain, glial cells are the principal source of LCN2, which plays a def...
Source: Journal of Leukocyte Biology - December 27, 2023 Category: Hematology Authors: Ruqayya Afridi Jae-Hong Kim Anup Bhusal Won-Ha Lee Kyoungho Suk Source Type: research
