Construction of an Immune-Related Prognostic Signature and lncRNA ‒miRNA-mRNA ceRNA Network in Acute Myeloid Leukaemia
This study offers innovative insights for AML diagnosis and treatment through a novel immune-related signature and ceRNA axis. Identified novel biomarkers, including two mRNAs (CKLF, PNOC), one miRNA (hsa-miR-323a-3p), and ten lncRNAs (SNHG25, LINC01857, AL390728.6, AC127024.5, Z83843.1, AP002884.1, AC007038.1, AC112512, AC020659.1, AC005921.3) present promising candidates as potential targets for precision medicine, contributing to the ongoing advancements in the field.PMID:38393298 | DOI:10.1093/jleuko/qiae041 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - February 23, 2024 Category: Hematology Authors: Ling Qin Boya Li Shijie Wang Yulai Tang Aamir Fahira Yanqi Kou Tong Li Zhigang Hu Zunnan Huang Source Type: research
How murine neutrophils are hijacked within the microenvironment of pancreatic cancer
J Leukoc Biol. 2024 Feb 23:qiae042. doi: 10.1093/jleuko/qiae042. Online ahead of print.ABSTRACTDiscoveries made in the last decades have brought out that, in addition to their classical primary defensive functions against infections, polymorphonuclear neutrophils play key effector roles not only in chronic inflammatory and immune-mediated diseases but also in cancer. In addition, depending on their differentiation/activation status, and/or on the physiological or pathological microenvironment in which they reside, neutrophils have been shown to behave as highly plastic cells, able to acquire new phenotypes/functional state...
Source: Journal of Leukocyte Biology - February 23, 2024 Category: Hematology Authors: Marco Antonio Cassatella Patrizia Scapini Nicola Tamassia Source Type: research
Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line
J Leukoc Biol. 2024 Feb 20:qiae034. doi: 10.1093/jleuko/qiae034. Online ahead of print.ABSTRACTA well-documented Achilles heel of current cancer immunotherapy approaches is T cell exhaustion within solid tumor tissues. The pro-inflammatory cytokine interleukin-23 (IL-23) has been utilised to augment chimeric antigen receptor (CAR)-T cells survival and tumor immunity. However, in-depth interrogation of molecular events downstream of IL-23/IL23R signaling is hampered by a paucity of suitable cell models. The current study investigates the differential contribution of IL-2 and IL-23 to the maintenance and differentiation of t...
Source: Journal of Leukocyte Biology - February 20, 2024 Category: Hematology Authors: Momtazkari Sarah Dev Choudhury Anahita Wei Ern Yong Zachary Dong Le Thanh Nguyen Canh Hiep Harada Kenichi Toshiyuki Hori Osato Motomi Takahashi Chiaki Cai Ping Koh Chih-Cheng Voon Dominic Source Type: research
Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line
J Leukoc Biol. 2024 Feb 20:qiae034. doi: 10.1093/jleuko/qiae034. Online ahead of print.ABSTRACTA well-documented Achilles heel of current cancer immunotherapy approaches is T cell exhaustion within solid tumor tissues. The pro-inflammatory cytokine interleukin-23 (IL-23) has been utilised to augment chimeric antigen receptor (CAR)-T cells survival and tumor immunity. However, in-depth interrogation of molecular events downstream of IL-23/IL23R signaling is hampered by a paucity of suitable cell models. The current study investigates the differential contribution of IL-2 and IL-23 to the maintenance and differentiation of t...
Source: Journal of Leukocyte Biology - February 20, 2024 Category: Hematology Authors: Momtazkari Sarah Dev Choudhury Anahita Wei Ern Yong Zachary Dong Le Thanh Nguyen Canh Hiep Harada Kenichi Toshiyuki Hori Osato Motomi Takahashi Chiaki Cai Ping Koh Chih-Cheng Voon Dominic Source Type: research
Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line
J Leukoc Biol. 2024 Feb 20:qiae034. doi: 10.1093/jleuko/qiae034. Online ahead of print.ABSTRACTA well-documented Achilles heel of current cancer immunotherapy approaches is T cell exhaustion within solid tumor tissues. The pro-inflammatory cytokine interleukin-23 (IL-23) has been utilised to augment chimeric antigen receptor (CAR)-T cells survival and tumor immunity. However, in-depth interrogation of molecular events downstream of IL-23/IL23R signaling is hampered by a paucity of suitable cell models. The current study investigates the differential contribution of IL-2 and IL-23 to the maintenance and differentiation of t...
Source: Journal of Leukocyte Biology - February 20, 2024 Category: Hematology Authors: Momtazkari Sarah Dev Choudhury Anahita Wei Ern Yong Zachary Dong Le Thanh Nguyen Canh Hiep Harada Kenichi Toshiyuki Hori Osato Motomi Takahashi Chiaki Cai Ping Koh Chih-Cheng Voon Dominic Source Type: research
Accumulation of circulating myeloid-derived suppressor cell subsets: predicting poor clinical efficacy and prognosis through T cell suppression in non-Hodgkin's lymphoma
In conclusion, our study demonstrates that the increased circulating MDSC subsets predict poor clinical efficacy and prognosis in NHL, potentially involving T cell suppression through MDSC subsets expansion. These findings indicate the potential of MDSC subsets as comprehensive diagnostic, prognostic biomarkers, and therapeutic targets for NHL.PMID:38369808 | DOI:10.1093/jleuko/qiae032 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - February 19, 2024 Category: Hematology Authors: Lian-Fang Pu Man-Man Li Xiang-Jiang Feng Tun Zhang Lin-Hui Hu Hui-Min Zheng Alice Charwudzi Yang-Yang Ding Jun Liu Ze-Lin Liu Shu-Dao Xiong Source Type: research
Systemic Immune Response to a CD40-Agonist Antibody in Nonhuman Primates
J Leukoc Biol. 2024 Feb 19:qiae031. doi: 10.1093/jleuko/qiae031. Online ahead of print.ABSTRACTThe cell surface molecule CD40 is a member of the tumor necrosis factor receptor superfamily and is broadly expressed by immune cells including B cells, dendritic cells (DC), and monocytes, as well as other normal cells and some malignant cellsCD40 is constitutively expressed on antigen-presenting cells (APCs) and ligation promotes functional maturation leading to an increase in antigen presentation, cytokine production, and a subsequent increase in the activation of antigen specific T cells. It is postulated that CD40 agonists c...
Source: Journal of Leukocyte Biology - February 19, 2024 Category: Hematology Authors: David L Caudell Gregory O Dugan Galina Babitzki Christine Schubert Annamaria Braendli-Baiocco Ken Wasserman Gonzalo Acona Martin Stern Alexandre Passioukov J Mark Cline Jehad Charo Source Type: research
Anlotinib and anti-PD-1 mAbs perfected CIK cell therapy for lung adenocarcinoma in preclinical trials
J Leukoc Biol. 2024 Feb 19:qiae037. doi: 10.1093/jleuko/qiae037. Online ahead of print.ABSTRACTMurine cytokine-induced killer (CIK) cells are heterologous cells that kill various allogeneic and isogenic tumors and have functional and phenotypic characteristics of natural killer cells and T lymphocytes. However, the effect of CIK alone on solid tumor therapy is only limited. To enhance the therapeutic effect, it is vital to discover a mix of several therapy approaches. Immune cell function is inhibited by abnormal tumor vessels and the tumor microenvironment, which block lymphocyte entry into tumor tissue. To increase the e...
Source: Journal of Leukocyte Biology - February 19, 2024 Category: Hematology Authors: Yingge Lv Hua Zhao Shaochuan Liu Yuan Meng Wenwen Yu Ting Liu Qian Sun Meng Shen Xiubao Ren Liang Liu Source Type: research
Accumulation of circulating myeloid-derived suppressor cell subsets: predicting poor clinical efficacy and prognosis through T cell suppression in non-Hodgkin's lymphoma
In conclusion, our study demonstrates that the increased circulating MDSC subsets predict poor clinical efficacy and prognosis in NHL, potentially involving T cell suppression through MDSC subsets expansion. These findings indicate the potential of MDSC subsets as comprehensive diagnostic, prognostic biomarkers, and therapeutic targets for NHL.PMID:38369808 | DOI:10.1093/jleuko/qiae032 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - February 19, 2024 Category: Hematology Authors: Lian-Fang Pu Man-Man Li Xiang-Jiang Feng Tun Zhang Lin-Hui Hu Hui-Min Zheng Alice Charwudzi Yang-Yang Ding Jun Liu Ze-Lin Liu Shu-Dao Xiong Source Type: research
Systemic Immune Response to a CD40-Agonist Antibody in Nonhuman Primates
J Leukoc Biol. 2024 Feb 19:qiae031. doi: 10.1093/jleuko/qiae031. Online ahead of print.ABSTRACTThe cell surface molecule CD40 is a member of the tumor necrosis factor receptor superfamily and is broadly expressed by immune cells including B cells, dendritic cells (DC), and monocytes, as well as other normal cells and some malignant cellsCD40 is constitutively expressed on antigen-presenting cells (APCs) and ligation promotes functional maturation leading to an increase in antigen presentation, cytokine production, and a subsequent increase in the activation of antigen specific T cells. It is postulated that CD40 agonists c...
Source: Journal of Leukocyte Biology - February 19, 2024 Category: Hematology Authors: David L Caudell Gregory O Dugan Galina Babitzki Christine Schubert Annamaria Braendli-Baiocco Ken Wasserman Gonzalo Acona Martin Stern Alexandre Passioukov J Mark Cline Jehad Charo Source Type: research
Anlotinib and anti-PD-1 mAbs perfected CIK cell therapy for lung adenocarcinoma in preclinical trials
J Leukoc Biol. 2024 Feb 19:qiae037. doi: 10.1093/jleuko/qiae037. Online ahead of print.ABSTRACTMurine cytokine-induced killer (CIK) cells are heterologous cells that kill various allogeneic and isogenic tumors and have functional and phenotypic characteristics of natural killer cells and T lymphocytes. However, the effect of CIK alone on solid tumor therapy is only limited. To enhance the therapeutic effect, it is vital to discover a mix of several therapy approaches. Immune cell function is inhibited by abnormal tumor vessels and the tumor microenvironment, which block lymphocyte entry into tumor tissue. To increase the e...
Source: Journal of Leukocyte Biology - February 19, 2024 Category: Hematology Authors: Yingge Lv Hua Zhao Shaochuan Liu Yuan Meng Wenwen Yu Ting Liu Qian Sun Meng Shen Xiubao Ren Liang Liu Source Type: research
Along with PaO2/FiO2 ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in Emergency Departments
J Leukoc Biol. 2024 Feb 15:qiae022. doi: 10.1093/jleuko/qiae022. Online ahead of print.ABSTRACTSince 1/3 of patients deteriorate after their admission to the emergency department (ED), assessing the prognosis of COVID-19 patients is of great importance. But to date, only lymphopenia and PaO2/FiO2 (P/F) ratio have been reported as partly predictive of COVID-19 further deterioration and their association has not been evaluated. We asked whether other key biomarkers of SARS-CoV2 immunologic defects - increase in circulating immature granulocytes (IGs), loss of monocyte HLA-DR (mHLA-DR) expression and monocyte differentiation ...
Source: Journal of Leukocyte Biology - February 17, 2024 Category: Hematology Authors: Thomas Lafon Nicolas Chapuis Estelle Guerin Thomas Daix Marcela Otranto Ahmed Boumediene Robin Jeannet Michaela Fontenay Henri Hani Karam Philippe Vignon Guillaume Monneret Bruno Fran çois Jean-Philippe Jais Jean Feuillard Source Type: research
6-Formylindolo[3,2-b]carbazole, a potent ligand for the aryl hydrocarbon receptor, attenuates concanavalin-induced hepatitis by limiting T-cell activation and infiltration of proinflammatory CD11b+ Kupffer cells
In this study, we investigated the effect of aryl hydrocarbon receptor activation by FICZ in a murine model of autoimmune hepatitis induced by concanavalin A. High-throughput sequencing techniques such as single-cell RNA sequencing and assay for transposase accessible chromatin sequencing were used to explore the mechanisms through which FICZ induces its effects. FICZ treatment attenuated concanavalin A-induced hepatitis, evidenced by decreased T-cell infiltration, decreased circulating alanine transaminase levels, and suppression of proinflammatory cytokines. Concanavalin A revealed an increase in natural killer T cells, ...
Source: Journal of Leukocyte Biology - February 17, 2024 Category: Hematology Authors: Alkeiver S Cannon Bryan L Holloman Kiesha Wilson Kathryn Miranda Prakash S Nagarkatti Mitzi Nagarkatti Source Type: research
Along with PaO2/FiO2 ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in Emergency Departments
J Leukoc Biol. 2024 Feb 15:qiae022. doi: 10.1093/jleuko/qiae022. Online ahead of print.ABSTRACTSince 1/3 of patients deteriorate after their admission to the emergency department (ED), assessing the prognosis of COVID-19 patients is of great importance. But to date, only lymphopenia and PaO2/FiO2 (P/F) ratio have been reported as partly predictive of COVID-19 further deterioration and their association has not been evaluated. We asked whether other key biomarkers of SARS-CoV2 immunologic defects - increase in circulating immature granulocytes (IGs), loss of monocyte HLA-DR (mHLA-DR) expression and monocyte differentiation ...
Source: Journal of Leukocyte Biology - February 17, 2024 Category: Hematology Authors: Thomas Lafon Nicolas Chapuis Estelle Guerin Thomas Daix Marcela Otranto Ahmed Boumediene Robin Jeannet Michaela Fontenay Henri Hani Karam Philippe Vignon Guillaume Monneret Bruno Fran çois Jean-Philippe Jais Jean Feuillard Source Type: research
6-Formylindolo[3,2-b]carbazole, a potent ligand for the aryl hydrocarbon receptor, attenuates concanavalin-induced hepatitis by limiting T-cell activation and infiltration of proinflammatory CD11b+ Kupffer cells
In this study, we investigated the effect of aryl hydrocarbon receptor activation by FICZ in a murine model of autoimmune hepatitis induced by concanavalin A. High-throughput sequencing techniques such as single-cell RNA sequencing and assay for transposase accessible chromatin sequencing were used to explore the mechanisms through which FICZ induces its effects. FICZ treatment attenuated concanavalin A-induced hepatitis, evidenced by decreased T-cell infiltration, decreased circulating alanine transaminase levels, and suppression of proinflammatory cytokines. Concanavalin A revealed an increase in natural killer T cells, ...
Source: Journal of Leukocyte Biology - February 17, 2024 Category: Hematology Authors: Alkeiver S Cannon Bryan L Holloman Kiesha Wilson Kathryn Miranda Prakash S Nagarkatti Mitzi Nagarkatti Source Type: research
