The Role of Leukocytes in Myeloproliferative Neoplasms Thromboinflammation
J Leukoc Biol. 2024 Mar 25:qiae071. doi: 10.1093/jleuko/qiae071. Online ahead of print.ABSTRACTClassic myeloproliferative neoplasms lacking the Philadelphia chromosome are stem cell disorders characterized by the proliferation of myeloid cells in the bone marrow and increased counts of peripheral blood cells. The occurrence of thrombotic events is a common complication in myeloproliferative neoplasms. The heightened levels of cytokines play a substantial role in the morbidity and mortality of these patients, establishing a persistent proinflammatory condition that culminates in thrombosis. The etiology of thrombosis remain...
Source: Journal of Leukocyte Biology - March 25, 2024 Category: Hematology Authors: Yu Liu Yingying Wang Gang Huang Sanyun Wu Xiaoyan Liu Shuo Chen Ping Luo Chang Liu Xuelan Zuo Source Type: research
Extracellular Sombrero Vesicles are Hallmarks of Eosinophilic Cytolytic Degranulation in Tissue Sites of Human Diseases
J Leukoc Biol. 2024 Mar 25:qiae079. doi: 10.1093/jleuko/qiae079. Online ahead of print.ABSTRACTEosinophil sombrero vesicles (EoSVs) are large tubular carriers resident in the cytoplasm of human eosinophils, identifiable by transmission electron microscopy (TEM), and important for immune mediator transport. Increased EoSV formation occurs in activated eosinophils in vitro and in vivo. In tissue sites of eosinophilic cytolytic inflammation, extracellular EoSVs are noted, but their frequency and significance in eosinophil-associated diseases (EADs) remain unclear. Here, we performed comprehensive quantitative TEM analyses and...
Source: Journal of Leukocyte Biology - March 25, 2024 Category: Hematology Authors: Vitor H Neves Cinthia Palazzi K ássia K Malta Kennedy Bonjour Felipe Kneip Felipe F Dias Josiane S Neves Peter F Weller Rossana C N Melo Source Type: research
A Physiologic Roll for Cell Surface GlycoRNAs
J Leukoc Biol. 2024 Mar 25:qiae073. doi: 10.1093/jleuko/qiae073. Online ahead of print.ABSTRACTGlycosylated RNA molecules (glycoRNAs) that can be bound by lectins have been demonstrated on the surfaces of leukocytes, but their physiologic function(s) was not known. A recent paper (PMID 38262409) demonstrates that at least one function is to promote capture and rolling of neutrophils in the vasculature. Of interest, the neutrophil glycoRNAs bind to P-selectin, but not E-selectin.PMID:38527802 | DOI:10.1093/jleuko/qiae073 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - March 25, 2024 Category: Hematology Authors: William A Muller Source Type: research
Buena VISTA: A Promising Outlook on Targeting Immune Checkpoint Regulators to Combat Sepsis
J Leukoc Biol. 2024 Mar 25:qiae080. doi: 10.1093/jleuko/qiae080. Online ahead of print.NO ABSTRACTPMID:38526166 | DOI:10.1093/jleuko/qiae080 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - March 25, 2024 Category: Hematology Authors: Madeline D Mott Briana Trusiano Irving Coy Allen Source Type: research
Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer
J Leukoc Biol. 2024 Mar 25:qiae077. doi: 10.1093/jleuko/qiae077. Online ahead of print.ABSTRACTMacrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor-1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of osteoclasts and deficiency in bone resorption. Here we demonstrate that homozygous Csf1r mutation in rat leads to delayed postnatal skeletal ossification associated with substantial loss of osteal macrophages (osteomacs) in addition to osteoclasts. Osteosclerosis and site-specific skeletal abnormaliti...
Source: Journal of Leukocyte Biology - March 25, 2024 Category: Hematology Authors: Lena Batoon Sahar Keshvari Katharine M Irvine Eileen Ho Melanie Caruso Omkar L Patkar Anuj Sehgal Susan M Millard David A Hume Allison R Pettit Source Type: research
The Role of Leukocytes in Myeloproliferative Neoplasms Thromboinflammation
J Leukoc Biol. 2024 Mar 25:qiae071. doi: 10.1093/jleuko/qiae071. Online ahead of print.ABSTRACTClassic myeloproliferative neoplasms lacking the Philadelphia chromosome are stem cell disorders characterized by the proliferation of myeloid cells in the bone marrow and increased counts of peripheral blood cells. The occurrence of thrombotic events is a common complication in myeloproliferative neoplasms. The heightened levels of cytokines play a substantial role in the morbidity and mortality of these patients, establishing a persistent proinflammatory condition that culminates in thrombosis. The etiology of thrombosis remain...
Source: Journal of Leukocyte Biology - March 25, 2024 Category: Hematology Authors: Yu Liu Yingying Wang Gang Huang Sanyun Wu Xiaoyan Liu Shuo Chen Ping Luo Chang Liu Xuelan Zuo Source Type: research
Extracellular Sombrero Vesicles are Hallmarks of Eosinophilic Cytolytic Degranulation in Tissue Sites of Human Diseases
J Leukoc Biol. 2024 Mar 25:qiae079. doi: 10.1093/jleuko/qiae079. Online ahead of print.ABSTRACTEosinophil sombrero vesicles (EoSVs) are large tubular carriers resident in the cytoplasm of human eosinophils, identifiable by transmission electron microscopy (TEM), and important for immune mediator transport. Increased EoSV formation occurs in activated eosinophils in vitro and in vivo. In tissue sites of eosinophilic cytolytic inflammation, extracellular EoSVs are noted, but their frequency and significance in eosinophil-associated diseases (EADs) remain unclear. Here, we performed comprehensive quantitative TEM analyses and...
Source: Journal of Leukocyte Biology - March 25, 2024 Category: Hematology Authors: Vitor H Neves Cinthia Palazzi K ássia K Malta Kennedy Bonjour Felipe Kneip Felipe F Dias Josiane S Neves Peter F Weller Rossana C N Melo Source Type: research
A Physiologic Roll for Cell Surface GlycoRNAs
J Leukoc Biol. 2024 Mar 25:qiae073. doi: 10.1093/jleuko/qiae073. Online ahead of print.ABSTRACTGlycosylated RNA molecules (glycoRNAs) that can be bound by lectins have been demonstrated on the surfaces of leukocytes, but their physiologic function(s) was not known. A recent paper (PMID 38262409) demonstrates that at least one function is to promote capture and rolling of neutrophils in the vasculature. Of interest, the neutrophil glycoRNAs bind to P-selectin, but not E-selectin.PMID:38527802 | DOI:10.1093/jleuko/qiae073 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - March 25, 2024 Category: Hematology Authors: William A Muller Source Type: research
Endoplasmic reticulum stress drives macrophages to produce IL-33 to favor Th2 polarization in the airways
In conclusion, asthma airway macrophages express high levels of IL-33 and at high ER stress status. Inhibition of IL-33 or ER stress in macrophages can effectively alleviate experimental asthma.PMID:38517856 | DOI:10.1093/jleuko/qiad109 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - March 22, 2024 Category: Hematology Authors: Yuan Xiao Huangping Zhang Yu Liu Lihua Mo Yun Liao Qinmiao Huang Liteng Yang Caijie Zhou Jiangqi Liu Xizhuo Sun Haiqiong Yu Pingchang Yang Source Type: research
Platycodin D facilitates antiviral immunity through inhibiting cytokine storm via targeting K63-linked TRAF6 ubiquitination
J Leukoc Biol. 2024 Mar 22:qiae075. doi: 10.1093/jleuko/qiae075. Online ahead of print.ABSTRACTInfluenza virus infection is a worldwide challenge that causes heavy burdens on public health. The mortality rate of severe influenza patients is often associated with hyperactive immunological abnormalities characterized by hypercytokinemia. Due to the continuous mutations and the occurrence of drug-resistant influenza virus strains, the development of host-directed immunoregulatory drugs is urgently required. Platycodon grandiflorum is among the top 10 herbs of traditional Chinese medicine used to treat pulmonary diseases. As o...
Source: Journal of Leukocyte Biology - March 22, 2024 Category: Hematology Authors: Hui Liu Lirong Xu Enhao Lu Chenchen Tang Hanxiao Zhang Yanwu Xu Yuanyuan Yu Naomi Ong Xiao-Dong Yang Qilong Chen Yuejuan Zheng Source Type: research
Endoplasmic reticulum stress drives macrophages to produce IL-33 to favor Th2 polarization in the airways
In conclusion, asthma airway macrophages express high levels of IL-33 and at high ER stress status. Inhibition of IL-33 or ER stress in macrophages can effectively alleviate experimental asthma.PMID:38517856 | DOI:10.1093/jleuko/qiad109 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - March 22, 2024 Category: Hematology Authors: Yuan Xiao Huangping Zhang Yu Liu Lihua Mo Yun Liao Qinmiao Huang Liteng Yang Caijie Zhou Jiangqi Liu Xizhuo Sun Haiqiong Yu Pingchang Yang Source Type: research
Platycodin D facilitates antiviral immunity through inhibiting cytokine storm via targeting K63-linked TRAF6 ubiquitination
J Leukoc Biol. 2024 Mar 22:qiae075. doi: 10.1093/jleuko/qiae075. Online ahead of print.ABSTRACTInfluenza virus infection is a worldwide challenge that causes heavy burdens on public health. The mortality rate of severe influenza patients is often associated with hyperactive immunological abnormalities characterized by hypercytokinemia. Due to the continuous mutations and the occurrence of drug-resistant influenza virus strains, the development of host-directed immunoregulatory drugs is urgently required. Platycodon grandiflorum is among the top 10 herbs of traditional Chinese medicine used to treat pulmonary diseases. As o...
Source: Journal of Leukocyte Biology - March 22, 2024 Category: Hematology Authors: Hui Liu Lirong Xu Enhao Lu Chenchen Tang Hanxiao Zhang Yanwu Xu Yuanyuan Yu Naomi Ong Xiao-Dong Yang Qilong Chen Yuejuan Zheng Source Type: research
Endoplasmic reticulum stress drives macrophages to produce IL-33 to favor Th2 polarization in the airways
In conclusion, asthma airway macrophages express high levels of IL-33 and at high ER stress status. Inhibition of IL-33 or ER stress in macrophages can effectively alleviate experimental asthma.PMID:38517856 | DOI:10.1093/jleuko/qiad109 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - March 22, 2024 Category: Hematology Authors: Yuan Xiao Huangping Zhang Yu Liu Lihua Mo Yun Liao Qinmiao Huang Liteng Yang Caijie Zhou Jiangqi Liu Xizhuo Sun Haiqiong Yu Pingchang Yang Source Type: research
Platycodin D facilitates antiviral immunity through inhibiting cytokine storm via targeting K63-linked TRAF6 ubiquitination
J Leukoc Biol. 2024 Mar 22:qiae075. doi: 10.1093/jleuko/qiae075. Online ahead of print.ABSTRACTInfluenza virus infection is a worldwide challenge that causes heavy burdens on public health. The mortality rate of severe influenza patients is often associated with hyperactive immunological abnormalities characterized by hypercytokinemia. Due to the continuous mutations and the occurrence of drug-resistant influenza virus strains, the development of host-directed immunoregulatory drugs is urgently required. Platycodon grandiflorum is among the top 10 herbs of traditional Chinese medicine used to treat pulmonary diseases. As o...
Source: Journal of Leukocyte Biology - March 22, 2024 Category: Hematology Authors: Hui Liu Lirong Xu Enhao Lu Chenchen Tang Hanxiao Zhang Yanwu Xu Yuanyuan Yu Naomi Ong Xiao-Dong Yang Qilong Chen Yuejuan Zheng Source Type: research
Titanium induces pro-inflammatory and tissue-destructive responses in primary human macrophages
In this study, for the first time, we have performed a systematic analysis of the response of differentially activated human macrophages (M(Control), M(IFNγ) and M(IL-4)) to the polished and porous titanium surfaces in order to identify the detrimental effect of titanium leading to the tissue destruction and chronic inflammation. Transcriptome analysis revealed that the highest number of differences between titanium and control settings are found in M(IL-4) that model healing type of macrophages. RT-qPCR analysis confirmed that both polished and porous titanium affected expression of cytokines, chitinases/chitinase-like p...
Source: Journal of Leukocyte Biology - March 21, 2024 Category: Hematology Authors: Alexandru Gudima David Hesselbarth Guanhao Li Vladimir Riabov Julia Michel Quan Liu Christina Schmuttermaier Zhen Jiao Carsten Sticht Ahmed Jawhar Udo Obertacke Harald Kl üter Nihal Engin Vrana Julia Kzhyshkowska Source Type: research
