Dysfunctional States of Unconventional T cell Subsets in Cancer
J Leukoc Biol. 2023 Oct 14:qiad129. doi: 10.1093/jleuko/qiad129. Online ahead of print.ABSTRACTUnconventional T cells (UCTs) represent a promising therapeutic agent to overcome the current limitations of immunotherapies due to their universal T-cell receptors (TCRs), ability to respond directly to cytokine stimulation, and capacity to recruit and modulate conventional immune cells in the tumor microenvironment (TME). Like conventional T-cells, UCTs can enter a dysfunctional state and the functional differences associated with this state may provide insight into the discrepancies observed in their role in anti-tumor immunit...
Source: Journal of Leukocyte Biology - October 14, 2023 Category: Hematology Authors: Elizabeth N Katsnelson Andrea Spengler Joanne Domenico Kasey L Couts Liyen Loh Laurent Gapin Martin D McCarter Richard P Tobin Source Type: research
Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function
J Leukoc Biol. 2023 Oct 14:qiad125. doi: 10.1093/jleuko/qiad125. Online ahead of print.ABSTRACTPneumonia caused by Streptococcus pneumoniae is a leading cause of death worldwide. A growing body of evidence indicates that the successful treatment of bacterial infections results from synergy between antibiotic-mediated direct antibacterial activity and the host's immune defenses. However, the mechanisms underlying the protective immune responses induced by amoxicillin, a β-lactam antibiotic used as the first-line treatment of S. pneumoniae infections, have not been characterized. A better understanding of amoxicillin's effe...
Source: Journal of Leukocyte Biology - October 14, 2023 Category: Hematology Authors: M élanie Mondemé Yasmine Zeroual Daphn ée Soulard Benjamin Hennart Delphine Beury Jean-Michel Saliou Christophe Carnoy Jean-Claude Sirard Christelle Faveeuw Source Type: research
Dysfunctional States of Unconventional T cell Subsets in Cancer
J Leukoc Biol. 2023 Oct 14:qiad129. doi: 10.1093/jleuko/qiad129. Online ahead of print.ABSTRACTUnconventional T cells (UCTs) represent a promising therapeutic agent to overcome the current limitations of immunotherapies due to their universal T-cell receptors (TCRs), ability to respond directly to cytokine stimulation, and capacity to recruit and modulate conventional immune cells in the tumor microenvironment (TME). Like conventional T-cells, UCTs can enter a dysfunctional state and the functional differences associated with this state may provide insight into the discrepancies observed in their role in anti-tumor immunit...
Source: Journal of Leukocyte Biology - October 14, 2023 Category: Hematology Authors: Elizabeth N Katsnelson Andrea Spengler Joanne Domenico Kasey L Couts Liyen Loh Laurent Gapin Martin D McCarter Richard P Tobin Source Type: research
Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function
J Leukoc Biol. 2023 Oct 14:qiad125. doi: 10.1093/jleuko/qiad125. Online ahead of print.ABSTRACTPneumonia caused by Streptococcus pneumoniae is a leading cause of death worldwide. A growing body of evidence indicates that the successful treatment of bacterial infections results from synergy between antibiotic-mediated direct antibacterial activity and the host's immune defenses. However, the mechanisms underlying the protective immune responses induced by amoxicillin, a β-lactam antibiotic used as the first-line treatment of S. pneumoniae infections, have not been characterized. A better understanding of amoxicillin's effe...
Source: Journal of Leukocyte Biology - October 14, 2023 Category: Hematology Authors: M élanie Mondemé Yasmine Zeroual Daphn ée Soulard Benjamin Hennart Delphine Beury Jean-Michel Saliou Christophe Carnoy Jean-Claude Sirard Christelle Faveeuw Source Type: research
Dysfunctional States of Unconventional T cell Subsets in Cancer
J Leukoc Biol. 2023 Oct 14:qiad129. doi: 10.1093/jleuko/qiad129. Online ahead of print.ABSTRACTUnconventional T cells (UCTs) represent a promising therapeutic agent to overcome the current limitations of immunotherapies due to their universal T-cell receptors (TCRs), ability to respond directly to cytokine stimulation, and capacity to recruit and modulate conventional immune cells in the tumor microenvironment (TME). Like conventional T-cells, UCTs can enter a dysfunctional state and the functional differences associated with this state may provide insight into the discrepancies observed in their role in anti-tumor immunit...
Source: Journal of Leukocyte Biology - October 14, 2023 Category: Hematology Authors: Elizabeth N Katsnelson Andrea Spengler Joanne Domenico Kasey L Couts Liyen Loh Laurent Gapin Martin D McCarter Richard P Tobin Source Type: research
