Obesity-related glomerulopathy: recent advances in inflammatory mechanisms and related treatments
J Leukoc Biol. 2024 Mar 1:qiae035. doi: 10.1093/jleuko/qiae035. Online ahead of print.ABSTRACTObesity-related glomerulopathy (ORG), which is an obesity-triggered kidney damage, has become a significant threat to human health. Several studies have recently highlighted the critical role of inflammation in ORG development. Additionally, excess adipose tissue and adipocytes in patients with obesity produce various inflammatory factors that cause systemic low-grade inflammation with consequent damage to vascular endothelial cells, exacerbating glomerular injury. Therefore, we conducted a comprehensive review of ORG and addresse...
Source: Journal of Leukocyte Biology - March 1, 2024 Category: Hematology Authors: Yucan Guan Xianping Wei Jicui Li Yuexin Zhu Ping Luo Manyu Luo Source Type: research
Stability and plasticity of Regulatory T cells in health and disease
J Leukoc Biol. 2024 Mar 1:qiae049. doi: 10.1093/jleuko/qiae049. Online ahead of print.ABSTRACTThe mechanisms that negatively regulate inflammation upon a pathogenic stimulus are crucial for the maintenance of tissue integrity and organ function. T regulatory cells are one of the main drivers in controlling inflammation. The ability of Treg cells to adapt to different inflammatory cues and suppress inflammation is one of the relevant features of Tregs. During this process, Tregs express different transcription factors associated with the counterparts Th helper cells, including Tbx21, GATA-3, Bcl6 and Rorc. The acquisition o...
Source: Journal of Leukocyte Biology - March 1, 2024 Category: Hematology Authors: Eugenio Contreras-Castillo Ver ónica Yutsil García-Rasilla Mar ía Guadalupe García-Patiño Paula Licona-Lim ón Source Type: research
Hyperglycaemia amplifies TLR-mediated inflammatory response of M(IL4) macrophages to dyslipidemic ligands
J Leukoc Biol. 2024 Mar 1:qiae050. doi: 10.1093/jleuko/qiae050. Online ahead of print.ABSTRACTHyperglycaemia is critical for initiation of diabetic vascular complications. We systemically addressed the role of hyperglycaemia in the regulation of TLRs in primary human macrophages. Expression of TLRs (1-9) was examined in monocyte-derived M(NC), M(IFNγ) and M(IL4) differentiated in normoglycemic and hyperglycaemic conditions. Hyperglycaemia increased expression of TLR1 and TLR8 in M(NC), TLR 2 and 6 in M(IFNγ), and TLR4 and TLR5 in M(IL4). The strongest effect of hyperglycaemia in M(IL4) was the upregulation of TLR4 gene a...
Source: Journal of Leukocyte Biology - March 1, 2024 Category: Hematology Authors: Luis Ernesto Badillo-Garcia Quan Liu Kim Ziebner Michael Balduff Tatyana Sevastyanova Christina Schmuttermaier Harald Kl üter Martin Harmsen Julia Kzhyshkowska Source Type: research
Obesity-related glomerulopathy: recent advances in inflammatory mechanisms and related treatments
J Leukoc Biol. 2024 Mar 1:qiae035. doi: 10.1093/jleuko/qiae035. Online ahead of print.ABSTRACTObesity-related glomerulopathy (ORG), which is an obesity-triggered kidney damage, has become a significant threat to human health. Several studies have recently highlighted the critical role of inflammation in ORG development. Additionally, excess adipose tissue and adipocytes in patients with obesity produce various inflammatory factors that cause systemic low-grade inflammation with consequent damage to vascular endothelial cells, exacerbating glomerular injury. Therefore, we conducted a comprehensive review of ORG and addresse...
Source: Journal of Leukocyte Biology - March 1, 2024 Category: Hematology Authors: Yucan Guan Xianping Wei Jicui Li Yuexin Zhu Ping Luo Manyu Luo Source Type: research
Stability and plasticity of Regulatory T cells in health and disease
J Leukoc Biol. 2024 Mar 1:qiae049. doi: 10.1093/jleuko/qiae049. Online ahead of print.ABSTRACTThe mechanisms that negatively regulate inflammation upon a pathogenic stimulus are crucial for the maintenance of tissue integrity and organ function. T regulatory cells are one of the main drivers in controlling inflammation. The ability of Treg cells to adapt to different inflammatory cues and suppress inflammation is one of the relevant features of Tregs. During this process, Tregs express different transcription factors associated with the counterparts Th helper cells, including Tbx21, GATA-3, Bcl6 and Rorc. The acquisition o...
Source: Journal of Leukocyte Biology - March 1, 2024 Category: Hematology Authors: Eugenio Contreras-Castillo Ver ónica Yutsil García-Rasilla Mar ía Guadalupe García-Patiño Paula Licona-Lim ón Source Type: research
Hyperglycaemia amplifies TLR-mediated inflammatory response of M(IL4) macrophages to dyslipidemic ligands
J Leukoc Biol. 2024 Mar 1:qiae050. doi: 10.1093/jleuko/qiae050. Online ahead of print.ABSTRACTHyperglycaemia is critical for initiation of diabetic vascular complications. We systemically addressed the role of hyperglycaemia in the regulation of TLRs in primary human macrophages. Expression of TLRs (1-9) was examined in monocyte-derived M(NC), M(IFNγ) and M(IL4) differentiated in normoglycemic and hyperglycaemic conditions. Hyperglycaemia increased expression of TLR1 and TLR8 in M(NC), TLR 2 and 6 in M(IFNγ), and TLR4 and TLR5 in M(IL4). The strongest effect of hyperglycaemia in M(IL4) was the upregulation of TLR4 gene a...
Source: Journal of Leukocyte Biology - March 1, 2024 Category: Hematology Authors: Luis Ernesto Badillo-Garcia Quan Liu Kim Ziebner Michael Balduff Tatyana Sevastyanova Christina Schmuttermaier Harald Kl üter Martin Harmsen Julia Kzhyshkowska Source Type: research
Obesity-related glomerulopathy: recent advances in inflammatory mechanisms and related treatments
J Leukoc Biol. 2024 Mar 1:qiae035. doi: 10.1093/jleuko/qiae035. Online ahead of print.ABSTRACTObesity-related glomerulopathy (ORG), which is an obesity-triggered kidney damage, has become a significant threat to human health. Several studies have recently highlighted the critical role of inflammation in ORG development. Additionally, excess adipose tissue and adipocytes in patients with obesity produce various inflammatory factors that cause systemic low-grade inflammation with consequent damage to vascular endothelial cells, exacerbating glomerular injury. Therefore, we conducted a comprehensive review of ORG and addresse...
Source: Journal of Leukocyte Biology - March 1, 2024 Category: Hematology Authors: Yucan Guan Xianping Wei Jicui Li Yuexin Zhu Ping Luo Manyu Luo Source Type: research
Lymph node stromal cells vary in susceptibility to infection but can support the intracellular growth of Listeria monocytogenes
J Leukoc Biol. 2024 Feb 28:qiae040. doi: 10.1093/jleuko/qiae040. Online ahead of print.ABSTRACTLymph node stromal cells (LNSC) are an often overlooked component of the immune system, but play a crucial role in maintaining tissue homeostasis and orchestrating immune responses. Our understanding of the functions these cells serve in the context of bacterial infections remains limited. We previously showed that Listeria monocytogenes, a facultative intracellular foodborne bacterial pathogen, must replicate within an as-yet-unidentified cell type in the mesenteric lymph node (MLN) to spread systemically. Here, we show that L. ...
Source: Journal of Leukocyte Biology - February 28, 2024 Category: Hematology Authors: Jamila S Tucker Hiba Khan Sarah E F D'Orazio Source Type: research
PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function
J Leukoc Biol. 2024 Feb 28:qiae039. doi: 10.1093/jleuko/qiae039. Online ahead of print.ABSTRACTNeutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance. Therapeutic use of primary neutrophils has been limited as they have a short lifespan and are not amenable to genetic manipulation. Human induced pluripotent stem cells (iPSCs) can provide a robust source of neutrophils for infusion and are genetically tractable. However, current work has indicated that dampened intracellular signaling limits iPSC-derived neutrophil (iNeutrophil) cellular activation and antimicrobial response. Here, w...
Source: Journal of Leukocyte Biology - February 28, 2024 Category: Hematology Authors: Morgan A Giese David A Bennin Taylor J Schoen Ashley N Peterson Jonathan H Schrope Josh Brand Ho Sun Jung Nancy P Keller David J Beebe Huy Q Dinh Igor I Slukvin Anna Huttenlocher Source Type: research
Lymph node stromal cells vary in susceptibility to infection but can support the intracellular growth of Listeria monocytogenes
J Leukoc Biol. 2024 Feb 28:qiae040. doi: 10.1093/jleuko/qiae040. Online ahead of print.ABSTRACTLymph node stromal cells (LNSC) are an often overlooked component of the immune system, but play a crucial role in maintaining tissue homeostasis and orchestrating immune responses. Our understanding of the functions these cells serve in the context of bacterial infections remains limited. We previously showed that Listeria monocytogenes, a facultative intracellular foodborne bacterial pathogen, must replicate within an as-yet-unidentified cell type in the mesenteric lymph node (MLN) to spread systemically. Here, we show that L. ...
Source: Journal of Leukocyte Biology - February 28, 2024 Category: Hematology Authors: Jamila S Tucker Hiba Khan Sarah E F D'Orazio Source Type: research
PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function
J Leukoc Biol. 2024 Feb 28:qiae039. doi: 10.1093/jleuko/qiae039. Online ahead of print.ABSTRACTNeutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance. Therapeutic use of primary neutrophils has been limited as they have a short lifespan and are not amenable to genetic manipulation. Human induced pluripotent stem cells (iPSCs) can provide a robust source of neutrophils for infusion and are genetically tractable. However, current work has indicated that dampened intracellular signaling limits iPSC-derived neutrophil (iNeutrophil) cellular activation and antimicrobial response. Here, w...
Source: Journal of Leukocyte Biology - February 28, 2024 Category: Hematology Authors: Morgan A Giese David A Bennin Taylor J Schoen Ashley N Peterson Jonathan H Schrope Josh Brand Ho Sun Jung Nancy P Keller David J Beebe Huy Q Dinh Igor I Slukvin Anna Huttenlocher Source Type: research
Broad-Spectrum Defenders: γδ T Cells Take on a Multitude of Immune Challenges
J Leukoc Biol. 2024 Feb 27:qiae044. doi: 10.1093/jleuko/qiae044. Online ahead of print.ABSTRACTIn a recent PNAS article, Guo et al. investigate γδ T cell antigen specificity in mice and humans, in which they show that γδ T cell antigen specificity is not constrained to one epitope. Rather, γδ T cells recognize a broad range of diverse antigens containing similar chemical structures or properties. In this News and Views, the importance of γδ T cell antigen polyspecificity during immune responses is highlighted.PMID:38411623 | DOI:10.1093/jleuko/qiae044 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - February 27, 2024 Category: Hematology Authors: Julian J Freen-van Heeren Source Type: research
Controversies associated with the identification of the true origins of human neutrophils
J Leukoc Biol. 2024 Feb 27:qiae036. doi: 10.1093/jleuko/qiae036. Online ahead of print.NO ABSTRACTPMID:38412285 | DOI:10.1093/jleuko/qiae036 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - February 27, 2024 Category: Hematology Authors: Carlos Silvestre-Roig Sven Brandau Source Type: research
Broad-Spectrum Defenders: γδ T Cells Take on a Multitude of Immune Challenges
J Leukoc Biol. 2024 Feb 27:qiae044. doi: 10.1093/jleuko/qiae044. Online ahead of print.ABSTRACTIn a recent PNAS article, Guo et al. investigate γδ T cell antigen specificity in mice and humans, in which they show that γδ T cell antigen specificity is not constrained to one epitope. Rather, γδ T cells recognize a broad range of diverse antigens containing similar chemical structures or properties. In this News and Views, the importance of γδ T cell antigen polyspecificity during immune responses is highlighted.PMID:38411623 | DOI:10.1093/jleuko/qiae044 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - February 27, 2024 Category: Hematology Authors: Julian J Freen-van Heeren Source Type: research
Controversies associated with the identification of the true origins of human neutrophils
J Leukoc Biol. 2024 Feb 27:qiae036. doi: 10.1093/jleuko/qiae036. Online ahead of print.NO ABSTRACTPMID:38412285 | DOI:10.1093/jleuko/qiae036 (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - February 27, 2024 Category: Hematology Authors: Carlos Silvestre-Roig Sven Brandau Source Type: research
