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Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2023 Dec 22:kuad047. doi: 10.1093/jimb/kuad047. Online ahead of print.ABSTRACTMonoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands of structurally unique bioactive compounds with significant therapeutic values. Due to difficulties associated with isolation from native plant species and organic synthesis of these structurally complex molecules, microbial production of MIAs using engineered hosts are highly desired. In this work, we report the engineering of fully integrated Saccharomyces cerevisiae strains that allow de novo access to strictosidine, the unive...
Source: Journal of Industrial Microbiology and Biotechnology - December 23, 2023 Category: Microbiology Authors: Moriel J Dror Joshua Misa Danielle A Yee Angela M Chu Rachel K Yu Bradley B Chan Lauren S Aoyama Anjali P Chaparala Sarah E O'Connor Yi Tang Source Type: research

Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2023 Dec 22:kuad047. doi: 10.1093/jimb/kuad047. Online ahead of print.ABSTRACTMonoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands of structurally unique bioactive compounds with significant therapeutic values. Due to difficulties associated with isolation from native plant species and organic synthesis of these structurally complex molecules, microbial production of MIAs using engineered hosts are highly desired. In this work, we report the engineering of fully integrated Saccharomyces cerevisiae strains that allow de novo access to strictosidine, the unive...
Source: Journal of Industrial Microbiology and Biotechnology - December 23, 2023 Category: Microbiology Authors: Moriel J Dror Joshua Misa Danielle A Yee Angela M Chu Rachel K Yu Bradley B Chan Lauren S Aoyama Anjali P Chaparala Sarah E O'Connor Yi Tang Source Type: research

Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2023 Dec 22:kuad047. doi: 10.1093/jimb/kuad047. Online ahead of print.ABSTRACTMonoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands of structurally unique bioactive compounds with significant therapeutic values. Due to difficulties associated with isolation from native plant species and organic synthesis of these structurally complex molecules, microbial production of MIAs using engineered hosts are highly desired. In this work, we report the engineering of fully integrated Saccharomyces cerevisiae strains that allow de novo access to strictosidine, the unive...
Source: Journal of Industrial Microbiology and Biotechnology - December 23, 2023 Category: Microbiology Authors: Moriel J Dror Joshua Misa Danielle A Yee Angela M Chu Rachel K Yu Bradley B Chan Lauren S Aoyama Anjali P Chaparala Sarah E O'Connor Yi Tang Source Type: research

Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2023 Dec 22:kuad047. doi: 10.1093/jimb/kuad047. Online ahead of print.ABSTRACTMonoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands of structurally unique bioactive compounds with significant therapeutic values. Due to difficulties associated with isolation from native plant species and organic synthesis of these structurally complex molecules, microbial production of MIAs using engineered hosts are highly desired. In this work, we report the engineering of fully integrated Saccharomyces cerevisiae strains that allow de novo access to strictosidine, the unive...
Source: Journal of Industrial Microbiology and Biotechnology - December 23, 2023 Category: Microbiology Authors: Moriel J Dror Joshua Misa Danielle A Yee Angela M Chu Rachel K Yu Bradley B Chan Lauren S Aoyama Anjali P Chaparala Sarah E O'Connor Yi Tang Source Type: research

Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2023 Dec 22:kuad047. doi: 10.1093/jimb/kuad047. Online ahead of print.ABSTRACTMonoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands of structurally unique bioactive compounds with significant therapeutic values. Due to difficulties associated with isolation from native plant species and organic synthesis of these structurally complex molecules, microbial production of MIAs using engineered hosts are highly desired. In this work, we report the engineering of fully integrated Saccharomyces cerevisiae strains that allow de novo access to strictosidine, the unive...
Source: Journal of Industrial Microbiology and Biotechnology - December 23, 2023 Category: Microbiology Authors: Moriel J Dror Joshua Misa Danielle A Yee Angela M Chu Rachel K Yu Bradley B Chan Lauren S Aoyama Anjali P Chaparala Sarah E O'Connor Yi Tang Source Type: research

Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2023 Dec 22:kuad047. doi: 10.1093/jimb/kuad047. Online ahead of print.ABSTRACTMonoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands of structurally unique bioactive compounds with significant therapeutic values. Due to difficulties associated with isolation from native plant species and organic synthesis of these structurally complex molecules, microbial production of MIAs using engineered hosts are highly desired. In this work, we report the engineering of fully integrated Saccharomyces cerevisiae strains that allow de novo access to strictosidine, the unive...
Source: Journal of Industrial Microbiology and Biotechnology - December 23, 2023 Category: Microbiology Authors: Moriel J Dror Joshua Misa Danielle A Yee Angela M Chu Rachel K Yu Bradley B Chan Lauren S Aoyama Anjali P Chaparala Sarah E O'Connor Yi Tang Source Type: research

Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2023 Dec 22:kuad047. doi: 10.1093/jimb/kuad047. Online ahead of print.ABSTRACTMonoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands of structurally unique bioactive compounds with significant therapeutic values. Due to difficulties associated with isolation from native plant species and organic synthesis of these structurally complex molecules, microbial production of MIAs using engineered hosts are highly desired. In this work, we report the engineering of fully integrated Saccharomyces cerevisiae strains that allow de novo access to strictosidine, the unive...
Source: Journal of Industrial Microbiology and Biotechnology - December 23, 2023 Category: Microbiology Authors: Moriel J Dror Joshua Misa Danielle A Yee Angela M Chu Rachel K Yu Bradley B Chan Lauren S Aoyama Anjali P Chaparala Sarah E O'Connor Yi Tang Source Type: research

Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2023 Dec 22:kuad047. doi: 10.1093/jimb/kuad047. Online ahead of print.ABSTRACTMonoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands of structurally unique bioactive compounds with significant therapeutic values. Due to difficulties associated with isolation from native plant species and organic synthesis of these structurally complex molecules, microbial production of MIAs using engineered hosts are highly desired. In this work, we report the engineering of fully integrated Saccharomyces cerevisiae strains that allow de novo access to strictosidine, the unive...
Source: Journal of Industrial Microbiology and Biotechnology - December 23, 2023 Category: Microbiology Authors: Moriel J Dror Joshua Misa Danielle A Yee Angela M Chu Rachel K Yu Bradley B Chan Lauren S Aoyama Anjali P Chaparala Sarah E O'Connor Yi Tang Source Type: research

Discovery and Structure Elucidation of Glycosyl and 5-Hydroxy Migrastatins from Dung Beetle Gut Kitasatospora sp
J Ind Microbiol Biotechnol. 2023 Dec 13:kuad046. doi: 10.1093/jimb/kuad046. Online ahead of print.ABSTRACTTwo new macrocyclic secondary metabolites, glycosyl-migrastatin (1) and 5-hydroxy-migrastatin (2), were isolated from a gut bacterium Kitasatospora sp. JL24 in dung beetle Onthophagus lenzii. Based on a comprehensive analysis of the NMR, MS, and UV spectroscopic data, the planar structures of 1 and 2 were successfully identified as new candidates for migrastatin. Compound 1 was the first glycosylated member of the migrastatin family. The absolute configuration of the sugar moiety was determined to be d-glucose through ...
Source: Journal of Industrial Microbiology and Biotechnology - December 14, 2023 Category: Microbiology Authors: Ji Hyeon Im Seoyoung Oh Eun Seo Bae Soohyun Um Sang Kook Lee Yeon Hee Ban Dong-Chan Oh Source Type: research

Discovery and Structure Elucidation of Glycosyl and 5-Hydroxy Migrastatins from Dung Beetle Gut Kitasatospora sp
J Ind Microbiol Biotechnol. 2023 Dec 13:kuad046. doi: 10.1093/jimb/kuad046. Online ahead of print.ABSTRACTTwo new macrocyclic secondary metabolites, glycosyl-migrastatin (1) and 5-hydroxy-migrastatin (2), were isolated from a gut bacterium Kitasatospora sp. JL24 in dung beetle Onthophagus lenzii. Based on a comprehensive analysis of the NMR, MS, and UV spectroscopic data, the planar structures of 1 and 2 were successfully identified as new candidates for migrastatin. Compound 1 was the first glycosylated member of the migrastatin family. The absolute configuration of the sugar moiety was determined to be d-glucose through ...
Source: Journal of Industrial Microbiology and Biotechnology - December 14, 2023 Category: Microbiology Authors: Ji Hyeon Im Seoyoung Oh Eun Seo Bae Soohyun Um Sang Kook Lee Yeon Hee Ban Dong-Chan Oh Source Type: research

Discovery and Structure Elucidation of Glycosyl and 5-Hydroxy Migrastatins from Dung Beetle Gut Kitasatospora sp
J Ind Microbiol Biotechnol. 2023 Dec 13:kuad046. doi: 10.1093/jimb/kuad046. Online ahead of print.ABSTRACTTwo new macrocyclic secondary metabolites, glycosyl-migrastatin (1) and 5-hydroxy-migrastatin (2), were isolated from a gut bacterium Kitasatospora sp. JL24 in dung beetle Onthophagus lenzii. Based on a comprehensive analysis of the NMR, MS, and UV spectroscopic data, the planar structures of 1 and 2 were successfully identified as new candidates for migrastatin. Compound 1 was the first glycosylated member of the migrastatin family. The absolute configuration of the sugar moiety was determined to be d-glucose through ...
Source: Journal of Industrial Microbiology and Biotechnology - December 14, 2023 Category: Microbiology Authors: Ji Hyeon Im Seoyoung Oh Eun Seo Bae Soohyun Um Sang Kook Lee Yeon Hee Ban Dong-Chan Oh Source Type: research

Discovery and Structure Elucidation of Glycosyl and 5-Hydroxy Migrastatins from Dung Beetle Gut Kitasatospora sp
J Ind Microbiol Biotechnol. 2023 Dec 13:kuad046. doi: 10.1093/jimb/kuad046. Online ahead of print.ABSTRACTTwo new macrocyclic secondary metabolites, glycosyl-migrastatin (1) and 5-hydroxy-migrastatin (2), were isolated from a gut bacterium Kitasatospora sp. JL24 in dung beetle Onthophagus lenzii. Based on a comprehensive analysis of the NMR, MS, and UV spectroscopic data, the planar structures of 1 and 2 were successfully identified as new candidates for migrastatin. Compound 1 was the first glycosylated member of the migrastatin family. The absolute configuration of the sugar moiety was determined to be d-glucose through ...
Source: Journal of Industrial Microbiology and Biotechnology - December 14, 2023 Category: Microbiology Authors: Ji Hyeon Im Seoyoung Oh Eun Seo Bae Soohyun Um Sang Kook Lee Yeon Hee Ban Dong-Chan Oh Source Type: research

Discovery and Structure Elucidation of Glycosyl and 5-Hydroxy Migrastatins from Dung Beetle Gut Kitasatospora sp
J Ind Microbiol Biotechnol. 2023 Dec 13:kuad046. doi: 10.1093/jimb/kuad046. Online ahead of print.ABSTRACTTwo new macrocyclic secondary metabolites, glycosyl-migrastatin (1) and 5-hydroxy-migrastatin (2), were isolated from a gut bacterium Kitasatospora sp. JL24 in dung beetle Onthophagus lenzii. Based on a comprehensive analysis of the NMR, MS, and UV spectroscopic data, the planar structures of 1 and 2 were successfully identified as new candidates for migrastatin. Compound 1 was the first glycosylated member of the migrastatin family. The absolute configuration of the sugar moiety was determined to be d-glucose through ...
Source: Journal of Industrial Microbiology and Biotechnology - December 14, 2023 Category: Microbiology Authors: Ji Hyeon Im Seoyoung Oh Eun Seo Bae Soohyun Um Sang Kook Lee Yeon Hee Ban Dong-Chan Oh Source Type: research

Discovery and Structure Elucidation of Glycosyl and 5-Hydroxy Migrastatins from Dung Beetle Gut Kitasatospora sp
J Ind Microbiol Biotechnol. 2023 Dec 13:kuad046. doi: 10.1093/jimb/kuad046. Online ahead of print.ABSTRACTTwo new macrocyclic secondary metabolites, glycosyl-migrastatin (1) and 5-hydroxy-migrastatin (2), were isolated from a gut bacterium Kitasatospora sp. JL24 in dung beetle Onthophagus lenzii. Based on a comprehensive analysis of the NMR, MS, and UV spectroscopic data, the planar structures of 1 and 2 were successfully identified as new candidates for migrastatin. Compound 1 was the first glycosylated member of the migrastatin family. The absolute configuration of the sugar moiety was determined to be d-glucose through ...
Source: Journal of Industrial Microbiology and Biotechnology - December 14, 2023 Category: Microbiology Authors: Ji Hyeon Im Seoyoung Oh Eun Seo Bae Soohyun Um Sang Kook Lee Yeon Hee Ban Dong-Chan Oh Source Type: research

Discovery and Structure Elucidation of Glycosyl and 5-Hydroxy Migrastatins from Dung Beetle Gut Kitasatospora sp
J Ind Microbiol Biotechnol. 2023 Dec 13:kuad046. doi: 10.1093/jimb/kuad046. Online ahead of print.ABSTRACTTwo new macrocyclic secondary metabolites, glycosyl-migrastatin (1) and 5-hydroxy-migrastatin (2), were isolated from a gut bacterium Kitasatospora sp. JL24 in dung beetle Onthophagus lenzii. Based on a comprehensive analysis of the NMR, MS, and UV spectroscopic data, the planar structures of 1 and 2 were successfully identified as new candidates for migrastatin. Compound 1 was the first glycosylated member of the migrastatin family. The absolute configuration of the sugar moiety was determined to be d-glucose through ...
Source: Journal of Industrial Microbiology and Biotechnology - December 14, 2023 Category: Microbiology Authors: Ji Hyeon Im Seoyoung Oh Eun Seo Bae Soohyun Um Sang Kook Lee Yeon Hee Ban Dong-Chan Oh Source Type: research