Journal of Industrial Microbiology and Biotechnology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Diverse Mechanisms of Bioproduction Heterogeneity in Fermentation and Their Control Strategies
J Ind Microbiol Biotechnol. 2023 Oct 3:kuad033. doi: 10.1093/jimb/kuad033. Online ahead of print.ABSTRACTMicrobial bioproduction often faces challenges related to populational heterogeneity, where cells exhibit varying biosynthesis capabilities. Bioproduction heterogeneity can stem from genetic and non-genetic factors, resulting in decreased titer, yield, stability, and reproducibility. Consequently, understanding and controlling bioproduction heterogeneity are crucial for enhancing the economic competitiveness of large-scale biomanufacturing. In this review, we provide a comprehensive overview of current understandings of...
Source: Journal of Industrial Microbiology and Biotechnology - October 4, 2023 Category: Microbiology Authors: Xinyue Mu Fuzhong Zhang Source Type: research

Abolishing storage lipids induces protein misfolding and stress responses in Yarrowia lipolytica
J Ind Microbiol Biotechnol. 2023 Sep 23:kuad031. doi: 10.1093/jimb/kuad031. Online ahead of print.ABSTRACTYarrowia lipolytica naturally saves carbon excess as storage lipids. Engineering efforts allow redirecting the high precursor flux required for lipid synthesis towards added-value chemicals such as polyketides, flavonoids, and terpenoids. To redirect precursor flux from storage lipids to other products, four genes involved in triacylglycerol and sterol ester synthesis (DGA1, DGA2, LRO1, ARE1) can be deleted. To elucidate the effect of the deletions on cell physiology and regulation, we performed chemostat cultivations ...
Source: Journal of Industrial Microbiology and Biotechnology - September 24, 2023 Category: Microbiology Authors: Simone Zaghen Oliver Konzock Jing Fu Eduard J Kerkhoven Source Type: research

Metabolic engineering and optimization of Escherichia coli co-culture for the de novo synthesis of genkwanin
J Ind Microbiol Biotechnol. 2023 Sep 20:kuad030. doi: 10.1093/jimb/kuad030. Online ahead of print.ABSTRACTGenkwanin has various significant roles in nutrition, biomedicine, and pharmaceutical biology. Previously, this compound has been chiefly produced by plant-originated extraction or chemical synthesis. However, due to increasing concern and demand for safe food and environmental issues, the biotechnological production of genkwanin and other bioactive compounds based on safe, cheap, and renewable substrates has gained much interest. This paper described recombinant Escherichia coli-based co-culture engineering that was r...
Source: Journal of Industrial Microbiology and Biotechnology - September 22, 2023 Category: Microbiology Authors: Thuan Huy Nguyen Vinay Bharadwaj Tatipamula Nguyen Thanh Trung Nguyen Van Giang Source Type: research

Reducing the virulence of Pseudomonas aeruginosa by using multiple quorum quenching enzymes
J Ind Microbiol Biotechnol. 2023 Sep 20:kuad028. doi: 10.1093/jimb/kuad028. Online ahead of print.ABSTRACTThe emergence of multidrug-resistant Pseudomonas aeruginosa in healthcare settings poses a tremendous challenge to traditional antibiotic therapy. P. aeruginosa utilizes quorum sensing (QS) to coordinate the production of virulence factors and the formation of drug-resistant biofilms. QS is mediated by signal compounds produced by P. aeruginosa as well as signal molecules produced by other non-pseudomonad bacteria. A potential strategy to prevent bacterial pathogenicity is utilizing enzymes to interfere with QS. Here, ...
Source: Journal of Industrial Microbiology and Biotechnology - September 22, 2023 Category: Microbiology Authors: Mst Afroza Khatun Md Anarul Hoque Mattheos Koffas Yan Feng Source Type: research