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Utilizing a divalent metal ion transporter to control biogenic nanoparticle synthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad020. doi: 10.1093/jimb/kuad020. Online ahead of print.ABSTRACTBiogenic synthesis of inorganic nanomaterials has been demonstrated for both wild and engineered bacterial strains. In many systems the nucleation and growth of nanomaterials is poorly controlled and requires concentrations of heavy metals toxic to living cells. Here we utilized the tools of synthetic biology to engineer a strain of Escherichia coli capable of synthesizing cadmium sulfide nanoparticles from low concentrations of reactants with control over the location of synthesis. Informed by simulations of bacterial...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Manasi Subhash Gangan Kyle L Naughton James Q Boedicker Source Type: research

Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad019. doi: 10.1093/jimb/kuad019. Online ahead of print.ABSTRACTActinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can incr...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Amir Y Alwali Elizabeth I Parkinson Source Type: research

Utilizing a divalent metal ion transporter to control biogenic nanoparticle synthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad020. doi: 10.1093/jimb/kuad020. Online ahead of print.ABSTRACTBiogenic synthesis of inorganic nanomaterials has been demonstrated for both wild and engineered bacterial strains. In many systems the nucleation and growth of nanomaterials is poorly controlled and requires concentrations of heavy metals toxic to living cells. Here we utilized the tools of synthetic biology to engineer a strain of Escherichia coli capable of synthesizing cadmium sulfide nanoparticles from low concentrations of reactants with control over the location of synthesis. Informed by simulations of bacterial...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Manasi Subhash Gangan Kyle L Naughton James Q Boedicker Source Type: research

Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad019. doi: 10.1093/jimb/kuad019. Online ahead of print.ABSTRACTActinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can incr...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Amir Y Alwali Elizabeth I Parkinson Source Type: research

Utilizing a divalent metal ion transporter to control biogenic nanoparticle synthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad020. doi: 10.1093/jimb/kuad020. Online ahead of print.ABSTRACTBiogenic synthesis of inorganic nanomaterials has been demonstrated for both wild and engineered bacterial strains. In many systems the nucleation and growth of nanomaterials is poorly controlled and requires concentrations of heavy metals toxic to living cells. Here we utilized the tools of synthetic biology to engineer a strain of Escherichia coli capable of synthesizing cadmium sulfide nanoparticles from low concentrations of reactants with control over the location of synthesis. Informed by simulations of bacterial...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Manasi Subhash Gangan Kyle L Naughton James Q Boedicker Source Type: research

Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad019. doi: 10.1093/jimb/kuad019. Online ahead of print.ABSTRACTActinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can incr...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Amir Y Alwali Elizabeth I Parkinson Source Type: research

Utilizing a divalent metal ion transporter to control biogenic nanoparticle synthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad020. doi: 10.1093/jimb/kuad020. Online ahead of print.ABSTRACTBiogenic synthesis of inorganic nanomaterials has been demonstrated for both wild and engineered bacterial strains. In many systems the nucleation and growth of nanomaterials is poorly controlled and requires concentrations of heavy metals toxic to living cells. Here we utilized the tools of synthetic biology to engineer a strain of Escherichia coli capable of synthesizing cadmium sulfide nanoparticles from low concentrations of reactants with control over the location of synthesis. Informed by simulations of bacterial...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Manasi Subhash Gangan Kyle L Naughton James Q Boedicker Source Type: research

Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad019. doi: 10.1093/jimb/kuad019. Online ahead of print.ABSTRACTActinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can incr...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Amir Y Alwali Elizabeth I Parkinson Source Type: research

Utilizing a divalent metal ion transporter to control biogenic nanoparticle synthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad020. doi: 10.1093/jimb/kuad020. Online ahead of print.ABSTRACTBiogenic synthesis of inorganic nanomaterials has been demonstrated for both wild and engineered bacterial strains. In many systems the nucleation and growth of nanomaterials is poorly controlled and requires concentrations of heavy metals toxic to living cells. Here we utilized the tools of synthetic biology to engineer a strain of Escherichia coli capable of synthesizing cadmium sulfide nanoparticles from low concentrations of reactants with control over the location of synthesis. Informed by simulations of bacterial...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Manasi Subhash Gangan Kyle L Naughton James Q Boedicker Source Type: research

Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad019. doi: 10.1093/jimb/kuad019. Online ahead of print.ABSTRACTActinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can incr...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Amir Y Alwali Elizabeth I Parkinson Source Type: research

Utilizing a divalent metal ion transporter to control biogenic nanoparticle synthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad020. doi: 10.1093/jimb/kuad020. Online ahead of print.ABSTRACTBiogenic synthesis of inorganic nanomaterials has been demonstrated for both wild and engineered bacterial strains. In many systems the nucleation and growth of nanomaterials is poorly controlled and requires concentrations of heavy metals toxic to living cells. Here we utilized the tools of synthetic biology to engineer a strain of Escherichia coli capable of synthesizing cadmium sulfide nanoparticles from low concentrations of reactants with control over the location of synthesis. Informed by simulations of bacterial...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Manasi Subhash Gangan Kyle L Naughton James Q Boedicker Source Type: research

Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad019. doi: 10.1093/jimb/kuad019. Online ahead of print.ABSTRACTActinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can incr...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Amir Y Alwali Elizabeth I Parkinson Source Type: research

Utilizing a divalent metal ion transporter to control biogenic nanoparticle synthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad020. doi: 10.1093/jimb/kuad020. Online ahead of print.ABSTRACTBiogenic synthesis of inorganic nanomaterials has been demonstrated for both wild and engineered bacterial strains. In many systems the nucleation and growth of nanomaterials is poorly controlled and requires concentrations of heavy metals toxic to living cells. Here we utilized the tools of synthetic biology to engineer a strain of Escherichia coli capable of synthesizing cadmium sulfide nanoparticles from low concentrations of reactants with control over the location of synthesis. Informed by simulations of bacterial...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Manasi Subhash Gangan Kyle L Naughton James Q Boedicker Source Type: research

Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad019. doi: 10.1093/jimb/kuad019. Online ahead of print.ABSTRACTActinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can incr...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Amir Y Alwali Elizabeth I Parkinson Source Type: research

Utilizing a divalent metal ion transporter to control biogenic nanoparticle synthesis
J Ind Microbiol Biotechnol. 2023 Aug 16:kuad020. doi: 10.1093/jimb/kuad020. Online ahead of print.ABSTRACTBiogenic synthesis of inorganic nanomaterials has been demonstrated for both wild and engineered bacterial strains. In many systems the nucleation and growth of nanomaterials is poorly controlled and requires concentrations of heavy metals toxic to living cells. Here we utilized the tools of synthetic biology to engineer a strain of Escherichia coli capable of synthesizing cadmium sulfide nanoparticles from low concentrations of reactants with control over the location of synthesis. Informed by simulations of bacterial...
Source: Journal of Industrial Microbiology and Biotechnology - August 16, 2023 Category: Microbiology Authors: Manasi Subhash Gangan Kyle L Naughton James Q Boedicker Source Type: research