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CRISPR-aided genome engineering for secondary metabolite biosynthesis in Streptomyces
J Ind Microbiol Biotechnol. 2024 Mar 4:kuae009. doi: 10.1093/jimb/kuae009. Online ahead of print.ABSTRACTThe demand for discovering novel microbial secondary metabolites is growing to address the limitations in bioactivities such as antibacterial, antifungal, anticancer, anthelmintic, and immunosuppressive functions. Among microbes, the genus Streptomyces holds particular significance for secondary metabolite discovery. Each Streptomyces species typically encodes approximately 30 secondary metabolite biosynthetic gene clusters within its genome, which are mostly uncharacterized in terms of their products and bioactivities....
Source: Journal of Industrial Microbiology and Biotechnology - March 5, 2024 Category: Microbiology Authors: Yongjae Lee Soonkyu Hwang Woori Kim Ji Hun Kim Bernhard O Palsson Byung-Kwan Cho Source Type: research

CRISPR-aided genome engineering for secondary metabolite biosynthesis in Streptomyces
J Ind Microbiol Biotechnol. 2024 Mar 4:kuae009. doi: 10.1093/jimb/kuae009. Online ahead of print.ABSTRACTThe demand for discovering novel microbial secondary metabolites is growing to address the limitations in bioactivities such as antibacterial, antifungal, anticancer, anthelmintic, and immunosuppressive functions. Among microbes, the genus Streptomyces holds particular significance for secondary metabolite discovery. Each Streptomyces species typically encodes approximately 30 secondary metabolite biosynthetic gene clusters within its genome, which are mostly uncharacterized in terms of their products and bioactivities....
Source: Journal of Industrial Microbiology and Biotechnology - March 5, 2024 Category: Microbiology Authors: Yongjae Lee Soonkyu Hwang Woori Kim Ji Hun Kim Bernhard O Palsson Byung-Kwan Cho Source Type: research

CRISPR-aided genome engineering for secondary metabolite biosynthesis in Streptomyces
J Ind Microbiol Biotechnol. 2024 Mar 4:kuae009. doi: 10.1093/jimb/kuae009. Online ahead of print.ABSTRACTThe demand for discovering novel microbial secondary metabolites is growing to address the limitations in bioactivities such as antibacterial, antifungal, anticancer, anthelmintic, and immunosuppressive functions. Among microbes, the genus Streptomyces holds particular significance for secondary metabolite discovery. Each Streptomyces species typically encodes approximately 30 secondary metabolite biosynthetic gene clusters within its genome, which are mostly uncharacterized in terms of their products and bioactivities....
Source: Journal of Industrial Microbiology and Biotechnology - March 5, 2024 Category: Microbiology Authors: Yongjae Lee Soonkyu Hwang Woori Kim Ji Hun Kim Bernhard O Palsson Byung-Kwan Cho Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research

Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production
J Ind Microbiol Biotechnol. 2024 Feb 16:kuae008. doi: 10.1093/jimb/kuae008. Online ahead of print.ABSTRACTThe Gram-negative beta-proteobacterium Cupriavidus necator is a chemolithotroph that can convert CO2 into biomass. C. necator has been engineered to produce a variety of high-value chemicals in the past. However, there is still a lack of a well-characterized toolbox for gene expression and genome engineering. Development and optimization of biosynthetic pathways in metabolically engineered microorganisms necessitates control of gene expression via functional genetic elements such as promoters, ribosome binding sites (R...
Source: Journal of Industrial Microbiology and Biotechnology - February 17, 2024 Category: Microbiology Authors: Shivangi Mishra Paul M Perkovich Wayne P Mitchell Maya Venkataraman Brian Pfleger Source Type: research