Jaundice with severe leucocytosis
A 36-year-old Hispanic woman was admitted to the emergency department with jaundice, abdominal pain and fatigue. The patient reported daily alcohol consumption (70 units per week). Physical examination revealed jaundice, hepatosplenomegaly, high BMI (30 kg/m2) and significant bilateral oedema of the lower limbs. Complete blood count showed a severe leucocytosis with neutrophilia (white blood cell count at 48,000/ μl including 85% neutrophils) associated with bicytopenia (haemoglobin at 4.3 g/dl and platelet count at 87,000/μl). (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Authors: Sarah Haxhe, Pamela Baldin, Pierre Trefois, Violaine Havelange, Nicolas Lanthier Tags: What Is Your Diagnosis? Source Type: research
From the Editor ’s Desk...
The detrimental health consequences of alcohol use disorders are undisputed, but the impact of political actions to address this on a societal level has been unclear. D íaz, Fuentes-López and coworkers analysed alcohol-related public health policies (PHPs) in 169 countries, from which they developed an alcohol preparedness index (API). The API quantified differences in alcohol-related PHPs, and countries with a higher API had reduced prevalence of alcohol use dis orders, as well as reduced mortality due to alcohol-related liver diseases, cancers and cardiovascular disease. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Authors: Patrizia Burra, Frank Tacke, Vlad Ratziu, Stefan Zeuzem, Bruno Sangro, Paolo Angeli Tags: From the Editor's Desk Source Type: research
Editorial Board
(Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Source Type: research
Submit your late-breaker abstract for the EASL Congress 2024 between 27 March - 10 April
(Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Source Type: research
Register now for the EASL Liver Cancer Summit 2024!
(Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Source Type: research
Let ’s unite Hepatology! Become an EASL member today and discover your benefits
(Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Source Type: research
Sign up to EASL Campus: your open-access eLearning Hub
(Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Source Type: research
Contents
(Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Source Type: research
JHEP at a glance (March 2024)
(Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Source Type: research
Use of stem cell-derived hepatocytes to model liver disease
Liver disease is a leading cause of global mortality and a multibillion-dollar per year economic burden that presents an urgent target for research.1 Established model systems have proven useful in advancing the field. However, constraints exist which have impeded the translatability of scientific findings derived from these systems. Human stem cell-derived hepatocytes have emerged as a highly relevant technology that can be used to model liver disease with increased availability, lower cost, and more faithful replication of hepatic physiology than traditional model systems. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 15, 2024 Category: Gastroenterology Authors: Josef Blaszkiewicz, Stephen A. Duncan Tags: Hepatology Snapshot Source Type: research
Reply to: “Hepatic encephalopathy and survival after transjugular intra-hepatic portosystemic shunt: Do spontaneous portosystemic shunts matter?”
Overt hepatic encephalopathy (OHE) may negatively impact the quality of life of patients and their caregivers, and our study aimed to investigate whether episodic OHE following a transjugular intrahepatic portosystemic shunt (TIPS) procedure adversely affects survival rates. Our findings suggest that episodic post-derivative OHE does not affect patient survival. On the contrary, we found that the development of persistent OHE leads to worse survival rates, particularly in patients with more advanced liver disease. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 14, 2024 Category: Gastroenterology Authors: Silvia Nardelli, Filippo Schepis, Francesco Vizzutti Tags: Letter to the Editor Source Type: research
Democracy in Science
It is not standard practice for the Editor-in-Chief to reply to a Letter to the Editor with a dedicated Editorial, but such a response is warranted in the case of the letter from Lonardo A. et al.,1 given its nature and the relevance of its content, which call into question the editorial strategy of the Journal of Hepatology regarding the new nomenclature of “metabolic fatty liver syndromes” endorsed by ALEH, AASLD and EASL after a long and difficult consensus process.2 (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 14, 2024 Category: Gastroenterology Authors: Paolo Angeli Tags: Editorial Source Type: research
Exploring the impact of the PNPLA3 I148M variant on primary human hepatic stellate cells using 3D extracellular matrix models
The PNPLA3 rs738409 C>G (encoding for I148M) variant is a risk locus for the fibrogenic progression of chronic liver diseases, a process driven by hepatic stellate cells (HSCs). We investigated how the PNPLA3 I148M variant affects HSCs biology using transcriptomic data and validated findings in 3D-culture models. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 14, 2024 Category: Gastroenterology Authors: Elisabetta Caon, Maria Martins, Harry Hodgetts, Lieke Blanken, Maria Giovanna Vilia, Ana Levi, Kessarin Thanapirom, Walid Al-Akkad, Jeries Abu-Hanna, Guido Baselli, Andrew R. Hall, Tu Vinh Luong, Jan-Willem Taanman, Michele Vacca, Luca Valenti, Stefano Ro Tags: Research Article Source Type: research
Response to “Hepatic encephalopathy and survival after transjugular intra-hepatic portosystemic shunt: do spontaneous portosystemic shunts matter?”
Overt hepatic encephalopathy (OHE) may negatively impact the quality of life of patients and their caregivers, and our study our study aimed to investigate whether episodic overt hepatic encephalopathy (OHE) following a transjugular intrahepatic portosystemic shunt (TIPS) procedure adversely affects survival rates. Our findings suggest that episodic post-derivative OHE does not affect patient survival. On the contrary, we found that the development of persistent OHE leads to worse survival rates, particularly in patients with more advanced liver disease1. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 14, 2024 Category: Gastroenterology Authors: S. Nardelli, O. Riggio, F. Marra, S. Gioia, D. Saltini, D. Bellafante, V. Adotti, T. Guasconi, L. Ridola, M. Rosi, C. Caporali, F. Fanelli, D. Roccarina, M. Bianchini, F. Indulti, A. Spagnoli, M. Merli, F. Schepis, F. Vizzutti Tags: Letter to the Editor Source Type: research
Tailoring allocation policies and improving access to pediatric liver transplantation in Italy: outframing and concluding
No conflict of interest – academic opinion work. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 12, 2024 Category: Gastroenterology Authors: Jean de Ville de Goyet Tags: Letter to the Editor Source Type: research
