Reply to: “Familial clustering of MASLD: Rethinking strategies for population screening”
Familial coaggregation of MASLD and liver-related outcomes (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 5, 2024 Category: Gastroenterology Authors: Fahim Ebrahimi, Jonas F. Ludvigsson Tags: Letter to the Editor Source Type: research
The Synergism of Public Health Policies and Social Work May Reduce Mortality from Cancer, Liver Disease and Cardiovascular Disease
This study not only sheds light on the critical role of stringent alcohol-related public health policies in reducing mortality rates associated with alcohol-related disorders but also emphasize the potential of such policies to significantly impact the social determinants of health. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 5, 2024 Category: Gastroenterology Authors: Shijie GUO, Jingqiang ZENG Tags: Letter to the Editor Source Type: research
Autoimmune Hepatitis: Mycophenolate mofetil versus azathioprine as first line therapy
A recent open label, multicenter, randomized, controlled trial by Snijders et al.1 compared the efficacy and safety of mycophenolate mofetil (MMF) and azathioprine (AZA) as first-line induction therapy in treatment naive autoimmune hepatitis (AIH). The main findings were that MMF showed better tolerability and higher rate of biochemical response at 24 weeks. The study is a welcome addition to the limited number of randomized controlled trials in AIH. The authors present clear data but we think that several issues need further clarification. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 5, 2024 Category: Gastroenterology Authors: Cem Şimşek, Staffan Wahlin, Cumali Efe Tags: Letter to the Editor Source Type: research
Rare monogenic causes of steatotic liver disease masquerading as MASLD
With interest we read the Delphi consensus statement on the new fatty liver disease nomenclature.1 The strong link between non-alcoholic fatty liver disease and metabolic dysfunction/insulin resistance has resulted in the inclusion of cardiometabolic risk factors as diagnostic criteria of metabolic dysfunction associated steatotic liver disease (MASLD). When these risk factors are absent, other specific aetiologies of steatotic liver disease, such as monogenic diseases, should be considered.1 (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 5, 2024 Category: Gastroenterology Authors: Martijn CGJ. Brouwers, David Cassiman Tags: Letter to the Editor Source Type: research
Uric acid in pediatric MASLD definition: is it time to implement diagnostic criteria?
Authors have nothing to disclose. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 5, 2024 Category: Gastroenterology Authors: Anna Di Sessa, Stefano Guarino, Giuseppina Rosaria Umano, Emanuele Miraglia del Giudice, Pierluigi Marzuillo Tags: Letter to the Editor Source Type: research
Familial Coaggregation of MASLD and Liver-related Outcomes
Dr. Ebrahimi has served as an advisory board member for Boehringer Ingelheim. Dr Ludvigsson has coordinated an unrelated study on behalf of the Swedish IBD quality register (SWIBREG). That study received funding from Janssen Corporation. Dr Ludvigsson has also received financial support from MSD to develop a paper reviewing national healthcare registers in China and is currently discussing potential research collaboration on celiac disease with Takeda. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 5, 2024 Category: Gastroenterology Authors: Fahim Ebrahimi, Jonas F. Ludvigsson Tags: Letter to the Editor Source Type: research
Multi-omics characterization of healthy and PSC human liver – what we knew and what we have learned
To date, we have not fully understood the pathogenesis of primary sclerosing cholangitis (PSC), a dreadful progressive cholestatic disease associated with an increased risk of bacterial cholangitis and malignancies, such as cholangiocarcinoma and colorectal carcinoma, for which effective treatment options are lacking.1,2 Several reports and genetic association studies have pointed toward a dysregulation of the adaptive immune response in PSC,3 –5 but deeper functional insights into the immune pathogenesis have been hampered by the availability of sufficient amounts of human liver tissue, especially from early-disease sta...
Source: Journal of Hepatology - February 27, 2024 Category: Gastroenterology Authors: Jenny Krause, Christoph Schramm Tags: Editorial Source Type: research
Multidrug-resistant bacterial infections after liver transplantation: prevalence, impact, and risk factors
This study analyzes the incidence, burden, and risk factors associated with MDR infections after liver transplantation (LT). (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 27, 2024 Category: Gastroenterology Authors: Rosa Martin-Mateos, Laura Mart ínez-Arenas, Ángela Carvalho-Gomes, Laia Aceituno, Valle Cadahía, María Magdalena Salcedo, Ana Arias, Sara Lorente Pérez, Aitor Odriozola, Javier Zamora, Marino Blanes, Óscar Len, Laura Benítez, Isabel Campos-Varela, Tags: Research Article Source Type: research
PTEN Deficiency Induces an Extrahepatic Cholangitis-Cholangiocarcinoma Continuum via Aurora kinase A in Mice
The PTEN-AKT pathway is frequently altered in extrahepatic cholangiocarcinoma (eCCA). We aim to evaluate the role of PTEN in the pathogenesis of eCCA and find novel therapies for this disease. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 27, 2024 Category: Gastroenterology Authors: Yan Yang, Jiale Wang, Jianhua Wan, Qianqian Cheng, Zenong Cheng, Xueli Zhou, Oliver Wang, Kelvin Shi, Lingxiang Wang, Bin Wang, Xiaohui Zhu, Jiaxiang Chen, Dongfeng Feng, Yang Liu, Yasmin Jahan-mihan, Ashley N. Haddock, Brandy H. Edenfield, Guang Peng, Je Tags: Research Article Source Type: research
Using liver stiffness to predict and monitor the risk of decompensation and mortality in patients with alcohol-related liver disease
Liver stiffness measurements (LSM) are recommended for disease prognostication and monitoring. We evaluated if LSM, using transient elastography, and LSM changes predict decompensation and mortality in patients with alcohol-related liver disease (ALD). (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 27, 2024 Category: Gastroenterology Authors: Katrine Holtz Thorhauge, Georg Semmler, Stine Johansen, Katrine Prier Lindvig, Maria Kj ærgaard, Johanne Kragh Hansen, Nikolaj Torp, Camilla Dalby Hansen, Peter Andersen, Benedikt Silvester Hofer, Wenyi Gu, Mads Israelsen, Mattias Mandorfer, Thomas Reibe Tags: Research Article Source Type: research
Multi-omics characterization of healthy and PSC human liver – what we know and what we learn
JK: Deutsche Forschungsgemeinschaft DFG: CRU306, No 42658125. CS: Deutsche Forschungsgemeinschaft DFG: CRU306, No 290522633 and RU5068, No 429191104 and Helmut and Hannelore Greve Foundation, YAEL Foundation. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 27, 2024 Category: Gastroenterology Authors: Jenny Krause, Christoph Schramm Tags: Editorial Source Type: research
Single cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity
In this study we comprehensively interrogate disease-associated cell states (DACS) identified within intra-hepatic tissue and matched PBMCs from either CHB or FC patients, at the resolution of single cells, to provide novel insights into putative mechanisms underlying FC. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 27, 2024 Category: Gastroenterology Authors: Balakrishnan Chakrapani Narmada, Atefeh Khakpoor, Niranjan Shirgaonkar, Sriram Narayanan, Pauline Poh Kim Aw, Malay Singh, Kok Haur Ong, Collins Oduor Owino, Jane Wei Ting Ng, Hui Chuing Yew, Nu Soibah Binte Mohamed Nasir, Veonice Bijin Au, Reina Sng, Niv Tags: Research Article Source Type: research
The Transition from NAFLD to MASLD and Its Impact on Clinical Practice and Outcomes
We read the study by Younossi et al1 with great interest and would like to congratulate the authors for their superb study. Over the last decade, due to changes in lifestyle, there's been a worldwide uptick in metabolic disorders such as obesity and type 2 diabetes, which have directly or indirectly impacted around 37% of the global adult population with non-alcoholic fatty liver disease (NAFLD).2 This condition is also recognized as a leading cause of hepatocellular carcinoma (HCC).3 However, given the insufficient understanding of NAFLD and the potential misconceptions its name may cause, a Delphi conference conducted by...
Source: Journal of Hepatology - February 27, 2024 Category: Gastroenterology Authors: Zhenhua Lu, Weiwei Shao, Jinghai Song Tags: Letter to the Editor Source Type: research
Autoimmune hepatitis: Azathioprine or mycophenolate mofetil for inducing remission?
We read with interest the first randomized-controlled trial evaluating the safety and efficacy of mycophenolate mofetil (MMF) as the first-line over azathioprine (AZA) for induction of adult-onset autoimmune hepatitis (AIH)1 and would like to raise the following points. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 23, 2024 Category: Gastroenterology Authors: Avinash Tiwari, Duncan Khanikar, Santosh Govind Rathod Tags: Letter to the Editor Source Type: research
An in-depth exploration of difference and similarity between NAFLD and MASLD
None. (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 23, 2024 Category: Gastroenterology Authors: Yubo Liu, Liao Tan Tags: Letter to the Editor Source Type: research
