Perfusate immune cell profiling during machine perfusion – A new tool to link risk and immune response after liver transplantation?
AP and AS conceptualized and designed the article; AP and AS wrote the manuscript; CJ and AS designed the Figure; all authors contributed and approved the manuscript. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Alessandro Parente, Chunbao Jiao, Janina Eden, Philipp Dutkowski, Robert L. Fairchild, Andrea Schlegel Tags: Letter to the Editor Source Type: research
Enhancing HCC Recurrence Prediction after Liver Transplantation: from DCP plus AFP-L3 model to GALAD Score
MH, FvB, and TB were responsible for the conceptualization and drafting of the manuscript. FvB has initiated the study. All authors, including AH and DS, critically reviewed and provided significant input to the manuscript. AH and DS also contributed to the data collection process. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Magdalena Hahn, Adam Herber, Thomas Berg, Daniel Seehofer, Florian van B ömmel Tags: Letter to the Editor Source Type: research
Changing from NAFLD to MASLD: Similar Prognosis of Unresectable Extrahepatic Gastrointestinal Cancer Under Chemotherapy between NAFLD and MASLD
The multisociety consensus group has redefined the nomenclature of nonalcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated steatotic liver disease (MASLD) in 2023.1 This revision enabled us to better capture the underlying etiologic pathways of the disease and eliminate stigmatization potential.1,2 As definitional modifications often yield considerable confusion from numerous perspectives, it is likely that we will encounter obstacles for some time. In particular, in order to avoid wasting valuable research resources, it is most important to extend previous research on NAFLD to MASLD, and several repor...
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Hiroyuki Suzuki, Toshimitsu Tanaka, Shotaro Yamaguchi, Keisuke Miwa, Takumi Kawaguchi Tags: Letter to the Editor Source Type: research
A new clinical and prognostic characterization of the patterns of decompensation of cirrhosis
The bad prognosis of Acute Decompensation (AD), i.e. the development of complications that require hospitalization, has recently been assessed. However, complications of cirrhosis do not necessarily require hospitalization and can develop progressively, as in the recently defined Non-Acute Decompensation (NAD). Nevertheless, there is no data regarding the incidence and prognostic impact of NAD. The aim of the study was to evaluate the incidence and the prognostic impact of NAD and AD in outpatients with cirrhosis. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Marta Tonon, Roberta D ’Ambrosio, Valeria Calvino, Giulia Tosetti, Anna Barone, Simone Incicco, Carmine Gambino, Roberta Gagliardi, Marta Borghi, Nicola Zeni, Salvatore Piano, Pietro Lampertico, Paolo Angeli Tags: Research Article Source Type: research
Unmet need in screening for hepatitis D virus: time to take action
None declared. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Jimmy Che-To Lai, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Terry Cheuk-Fung Yip Tags: Letter to the Editor Source Type: research
Uric acid may serve as the sixth cardiometabolic criterion for defining MASLD
The definition of MASLD (metabolic dysfunction-associated steatotic liver disease) incorporates five cardiometabolic criteria that emphasize the impact of metabolic disorders 1. These criteria revolve around hypertension, hyperglycemia, and hyperlipidemia. However, we realize that hyperuricemia (HUA), known as the "fourth hyper" 2, is not currently included. In today's society, the incidence of hyperuricemia is rapidly increasing due to high-purine diets and sugary beverages 3, and the correlation between HUA and fatty liver has been reported 4. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Linfeng He, Kangli Qiu, Wenbin Zheng, Wen Kong, Tianshu Zeng Tags: Letter to the Editor Source Type: research
machine perfusion, randomized controlled trials, liver transplantation, immune cellsPerfusate immune cell profiling during machine perfusion – A new tool to link risk and immune response after liver transplantation?
AP and AS conceptualized and designed the article; AP and AS wrote the manuscript; CJ and AS designed the Figure; all authors contributed and approved the manuscript. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Alessandro Parente, Chunbao Jiao, Janina Eden, Philipp Dutkowski, Robert L. Fairchild, Andrea Schlegel Tags: Letter to the Editor Source Type: research
Response to: A comment on “A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B.”
Florian van B ömmel and Thomas Berg: conceptualization and manuscript draft. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Florian van B ömmel, Thomas Berg Tags: Letter to the Editor Source Type: research
SARS-CoV-2 anti-spike IgG antibodies are present in all liver transplant recipients after fifth vaccine dose
JS: patient inclusion, data collection and analysis, writing; HvM: patient inclusion, critical revision manuscript; SvdM: patient inclusion, critical revision manuscript; FN: patient inclusion, critical revision manuscript; JV: conceptualisation, patient inclusion, supervision, writing. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 16, 2023 Category: Gastroenterology Authors: Jenny J.H. Smeets, Hannah van Malenstein, Schalk van der Merwe, Frederik Nevens, Jef Verbeek Tags: Letter to the Editor Source Type: research
Battle of the Biopsies: Role of tissue and liquid biopsy in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) diagnosis and management have undergone significant improvements in recent years. With the introduction of immunotherapy-based combination therapy, there has been a notable expansion in treatment options for patients with unresectable HCC. Simultaneously, innovative molecular tests for early detection and management of HCC are emerging. This progress prompts a key question: as liquid biopsy techniques rise in prominence, will they replace traditional tissue biopsies, or will both techniques remain relevant? Given the ongoing challenges of early HCC detection, including issues with ultrasound ...
Source: Journal of Hepatology - December 14, 2023 Category: Gastroenterology Authors: Brandon M. Lehrich, Josephine Zhang, Satdarshan P. Monga, Renumathy Dhanasekaran Tags: Review Source Type: research
In memoriam Gustav Paumgartner
“Three virtues of the physician the academic teacher wishes to instill in his students: Love for mankind, humility in the execution and evaluation of the experiment, and indefatigable diligence in the study of outcomes of scientific and empirical medicine.” S.J. Thannhauser (1885-1962) (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 13, 2023 Category: Gastroenterology Authors: Ulrich Beuers, Tilman Sauerbruch, Michael Trauner Tags: Obituary Source Type: research
An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis
Patients with autoimmune hepatitis (AIH) almost inevitably require lifelong immunosuppressive treatment. There is genuine concern about the efficacy and tolerability of the current standard combination therapy of prednisolone and azathioprine. Mycophenolate mofetil (MMF) has emerged as an alternative option. The aim of this study was to compare MMF to azathioprine as induction therapy. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 13, 2023 Category: Gastroenterology Authors: Rom ée JALM. Snijders, Anna EC. Stoelinga, Tom JG. Gevers, Simon Pape, Maaike Biewenga, Maarten E. Tushuizen, Robert C. Verdonk, Hendrik JM. de Jonge, Jan Maarten Vrolijk, Sjoerd F. Bakker, Thomas Vanwolleghem, Ynto S. de Boer, Martine AMC. Baven Pronk, Tags: Research Article Source Type: research
Long-term use of tenofovir disoproxil fumarate increases fracture risk in elderly patients with chronic hepatitis B
The use of tenofovir disoproxil fumarate (TDF) is associated with a reduction in bone mineral density and an increase in bone metabolism biomarkers. However, data on clinical bone fractures remain limited. We evaluated the impact of TDF compared to entecavir on the risk of fracture in elderly patients with chronic hepatitis B (CHB). (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 13, 2023 Category: Gastroenterology Authors: Terry Cheuk-Fung Yip, Jimmy Che-To Lai, Tsz-Fai Yam, Yee-Kit Tse, Vicki Wing-Ki Hui, Mandy Sze-Man Lai, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Grace Lai-Hung Wong Tags: Research Article Source Type: research
Reply to: “5-MTHF enhances the portal pressure reduction achieved with propranolol in patients with cirrhosis: A randomized placebo-controlled trial. Was an accurate statistical analysis performed?”
We thank Dr Fernandez-Garza for his interest in our work and for his comments on the statistical analysis. He underlines that our intention-to-treat analysis (ITT) did not include all planned randomized patients (30 per group) and that we do not explain why.1 We would like to clarify this point. (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 12, 2023 Category: Gastroenterology Authors: Ranka Vukotic, Roberto Di Donato, Jaime Bosch, Pietro Andreone Tags: Letter to the Editor Source Type: research
Normal weight and central obesity as predictors of increased all-cause mortality in metabolic dysfunction associated steatotic liver disease
The authors declare that they do not have any conflict of interest to disclose in terms of funding for this manuscript (Source: Journal of Hepatology)
Source: Journal of Hepatology - December 12, 2023 Category: Gastroenterology Authors: Junhong Chen, Hao Zhou, Kai Liu Tags: Letter to the Editor Source Type: research
