Expanding the Dialogue: A Closer Look at AIH Management and HCC Risk
This study notably bridges a significant knowledge gap in our understanding of the progression from A utoimmune Hepatitis (AIH) to Hepatocellular Carcinoma (HCC), leveraging the largest multicentric AIH cohort to date. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 12, 2024 Category: Gastroenterology Authors: Dan Shan Tags: Letter to the Editor Source Type: research
Reply to: “irLI or Not irLI: That is the Question”
We thank Dr. Meunier et al. for their interest in our study and for pointing out the challenges to a correct and unified diagnosis and management of immunotherapy-related liver injury (irLI). (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 12, 2024 Category: Gastroenterology Authors: Ciro Celsa, Giuseppe Cabibbo, David James Pinato Tags: Letter to the Editor Source Type: research
One-year transplant-free survival following hospital discharge after ICU Admission for ACLF in the Netherlands
Patients with acute decompensated (AD) liver cirrhosis or acute-on-chronic liver failure (ACLF) often require intensive care unit (ICU) admission for organ support. Existing research, mostly from specialized liver transplant centers, largely addresses short-term outcomes. Our aim was to evaluate in-hospital mortality and 1-year transplant-free survival after hospital discharge in the Netherlands. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 11, 2024 Category: Gastroenterology Authors: Jubi de Haan, Fabian Termorshuizen, Nicolette de Keizer, Diederik Gommers, Caroline den Hoed Tags: Research Article Source Type: research
Validation of Baveno VII criteria and other non-invasive diagnostic algorithms for clinically significant portal hypertension in hepatitis delta
Non-invasive tests (NIT) for clinically significant portal hypertension (CSPH) in compensated advanced chronic liver disease (cACLD) lack validation in patients infected with hepatitis D virus (HDV). (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 11, 2024 Category: Gastroenterology Authors: Mathias JACHS, Lisa SANDMANN, Lukas HARTL, Tammo TERGAST, Michael SCHWARZ, David Josef Maria BAUER, Lorenz BALCAR, Alena EHRENBAUER, Benedikt Silvester HOFER, Markus CORNBERG, Henrike LENZEN, Katja DETERDING, Michael TRAUNER, Mattias MANDORFER, Heiner WED Tags: Research Article Source Type: research
Prospective validation of the EASL management algorithm for acute kidney injury in cirrhosis
The management of acute kidney injury (AKI) in cirrhosis is challenging. The EASL guidelines proposed an algorithm, but this has never been validated. We aimed to prospectively evaluate this algorithm in clinical practice. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 11, 2024 Category: Gastroenterology Authors: Ann Thu Ma, Cristina Sol é, Adrià Juanola, Laia Escudé, Laura Napoleone, Emma Avitabile, Martina Pérez-Guasch, Marta Carol, Enrico Pompili, Jordi Gratacós-Ginés, Anna Soria, Ana Belén Rubio, Marta Cervera, Maria José Moreta, Manuel Morales, Elsa S Tags: Research Article Source Type: research
Efficacy of Stereotactic Ablative Radiotherapy in Patients with Oligometastatic Hepatocellular Carcinoma: A Phase II Study
Stereotactic ablative radiotherapy (SABR) has demonstrated curative potential with survival benefits in patients with oligometastatic disease (OMD). However, limited evidence exists regarding its use in oligometastatic hepatocellular carcinoma (HCC). We aimed to prospectively investigate the efficacy and safety of SABR in patients with oligometastatic HCC. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 8, 2024 Category: Gastroenterology Authors: Seo Hee Choi, Byung min Lee, Jina Kim, Do Young Kim, Jinsil Seong Tags: Research Article Source Type: research
Ultrasensitive HBsAg Assays-Not Yet Ready for Primetime
This work was supported by the Intramural Program of the National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 8, 2024 Category: Gastroenterology Authors: Marc G. Ghany, Maria Buti, Pietro Lampertico, Hannah M. Lee Tags: Letter to the Editor Source Type: research
Democratising the scientific method
None to disclose. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 8, 2024 Category: Gastroenterology Authors: Shivaram Prasad Singh, Prajna Anirvan Tags: Letter to the Editor Source Type: research
Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree
In the developing liver, bipotent epithelial progenitor cells undergo lineage segregation to form hepatocytes, which constitute the bulk of the liver parenchyma, and biliary epithelial cells (cholangiocytes), which comprise the bile duct (a complex tubular network that is critical for normal liver function). Notch and TGF β signalling promote the formation of a sheet of biliary epithelial cells, the ductal plate, that organises into discontinuous tubular structures. How these structures elongate and connect to form a continuous duct remains undefined. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 7, 2024 Category: Gastroenterology Authors: Michaela Raab, Ersi Christodoulou, Roopesh Krishnankutty, Andreea Gradinaru, Alexander Daniel Walker, Paula Olaizola, Nicholas Thomas Younger, Anabel Martinez Lyons, Edward Joseph Jarman, Konstantinos Gournopanos, Alexander von Kriegsheim, Scott Hamilton Tags: Research Article Source Type: research
Pkd1l1-deficiency drives biliary atresia through ciliary dysfunction in biliary epithelial cells
Syndromic biliary atresia is a cholangiopathy characterized by fibro-obliterative changes in the extrahepatic bile duct (EHBD) and congenital malformations including laterality defects. The aetiology remains elusive and faithful animal models are lacking. Genetic syndromes provide important clues for underlying pathogenic mechanisms of disease. We investigated the role of the gene Pkd1l1 in syndromic biliary atresia pathophysiology. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 7, 2024 Category: Gastroenterology Authors: Yi Zou Lim, Min Zhu, Yunguan Wang, Tripti Sharma, Shannon Kelley, Estelle Oertling, Hao Zhu, Natasha Corbitt Tags: Research Article Source Type: research
Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree.
In the developing liver, bipotent epithelial progenitor cells known as hepatoblasts undergo lineage segregation to form the two major epithelial cell types, hepatocytes that constitute the bulk of the liver parenchyma and biliary epithelial cells (cholangiocytes) which comprise the bile duct, a complex tubular network which is critical for normal liver function. Notch and TGF β signalling promote the formation of a sheet of biliary epithelial cells, the ductal plate that organises into discontinuous tubular structures. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 7, 2024 Category: Gastroenterology Authors: Michaela Raab, Ersi Christodoulou, Roopesh Krishnankutty, Andreea Gradinaru, Alexander Daniel Walker, Paula Olaizola, Nicholas Thomas Younger, Anabel Martinez Lyons, Edward Joseph Jarman, Konstantinos Gournopanos, Alexander von Kriegsheim, Scott Hamilton Tags: Research Article Source Type: research
Cutting edges in the HBV genome: How RNA splicing is involved in modulating virus ultrastructure to promote infection
The DNA genome of HBV replicates via reverse transcription of a pregenomic RNA (pgRNA) template inside nucleocapsid particles within the cytosol of the infected cell. Apart from its function as a replication intermediate, pgRNA has been shown in numerous studies to be subject to splicing, leading to shortened viral RNA species (reviewed in1). So far, five splice donor (SD) and six acceptor (SA) sites have been experimentally validated. The combinatorial utilization of these “cutting edges” in the pgRNA leads to 20 variants of single or multiple spliced derivatives. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 6, 2024 Category: Gastroenterology Authors: Stefan Seitz, Ralf Bartenschlager Tags: Editorial Source Type: research
Cutting edges in the hepatitis B virus genome: How RNA splicing is involved in modulating virus ultrastructure to promote infection
The DNA genome of hepatitis B virus (HBV) replicates via reverse transcription of a pregenomic RNA (pgRNA) template inside nucleocapsid particles within the cytosol of the infected cell. Apart from its function as replication intermediate, pgRNA has been shown in numerous studies to be subject to splicing leading to shortened viral RNA species (reviewed in 1). So far, five splice donor (SD) and six acceptor (SA) sites have been experimentally validated. The combinatorial utilization of these “cutting edges” in the pgRNA leads to 20 variants of single or multiple spliced derivatives. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 6, 2024 Category: Gastroenterology Authors: Stefan Seitz, Ralf Bartenschlager Tags: Editorial Source Type: research
Endothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis
NOTCH signaling in liver sinusoidal endothelial cells (LSECs) regulates liver fibrosis, a pathological feature of chronic liver diseases. POFUT1 is an essential regulator of NOTCH signaling. Here, we investigated the role of LSECs-expressed POFUT1 in liver fibrosis. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 6, 2024 Category: Gastroenterology Authors: Shan He, Yuru Luo, Wangge Ma, Xiaoke Wang, Chengrong Yan, Wenyang Hao, Yuan Fang, Hongyu Su, Baochang Lai, Junhui Liu, Ying Xiong, Ting Bai, Xiaoyong Ren, Enqi Liu, Hua Han, Yue Wu, Zuyi Yuan, Yidong Wang Tags: Research Article Source Type: research
Syngeneic Murine Models with Distinct Immune Microenvironments Represent Subsets of Human Intrahepatic Cholangiocarcinoma
Cholangiocarcinoma (CCA) is a poorly immunogenic malignancy with limited survival. Syngeneic, immunocompetent mouse models of CCA are an essential tool to elucidate the tumor immune microenvironment (TIME), understand mechanisms of tumor immune evasion, and test novel immunotherapeutic strategies. The scope of this study was to develop and characterize immunocompetent CCA models with distinct genetic drivers, and correlate tumor genomics, immunobiology, and therapeutic response. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 6, 2024 Category: Gastroenterology Authors: Jennifer L. Tomlinson, Binbin Li, Jingchun Yang, Emilien Loeuillard, Hannah E. Stumpf, Hendrien Kuipers, Ryan Watkins, Danielle M. Carlson, Jessica Willhite, Daniel R. O ’Brien, Rondell P. Graham, Xin Chen, Rory L. Smoot, Haidong Dong, Gregory J. Gores, Tags: Research Article Source Type: research
