Exploring the impact of the PNPLA3 I148M variant on primary human hepatic stellate cells using 3D extracellular matrix models

The PNPLA3 rs738409 C>G (encoding for I148M) variant is a risk locus for the fibrogenic progression of chronic liver diseases, a process driven by hepatic stellate cells (HSCs). We investigated how the PNPLA3 I148M variant affects HSCs biology using transcriptomic data and validated findings in 3D-culture models.

Source: Journal of Hepatology - February 14, 2024 Category: Gastroenterology Authors: Elisabetta Caon, Maria Martins, Harry Hodgetts, Lieke Blanken, Maria Giovanna Vilia, Ana Levi, Kessarin Thanapirom, Walid Al-Akkad, Jeries Abu-Hanna, Guido Baselli, Andrew R. Hall, Tu Vinh Luong, Jan-Willem Taanman, Michele Vacca, Luca Valenti, Stefano Ro Tags: Research Article Source Type: research