A novel role of lysophosphatidic acid (LPA) in human myeloma resistance to proteasome inhibitors
Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that regulates cell proliferation, survival, and migration. However, its role on human multiple myeloma (MM) cells is largely unknown. In this ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 7, 2022 Category: Hematology Authors: Pan Su, Liuling Xiao, Lingqun Ye, Zhuo Wang, Wei Xiong, Qiang Wang, Xingzhe Ma, Miao Xian, Maojie Yang, Youli Zu, Sai Ravi Pingali, Jianfei Qian and Qing Yi Tags: Correspondence Source Type: research
Correction: The long and short non-coding RNAs modulating EZH2 signaling in cancer
(Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 6, 2022 Category: Hematology Authors: Sepideh Mirzaei, Mohammad Hossein Gholami, Kiavash Hushmandi, Farid Hashemi, Amirhossein Zabolian, Israel Canadas, Ali Zarrabi, Noushin Nabavi, Amir Reza Aref, Francesco Crea, Yuzhuo Wang, Milad Ashrafizadeh and Alan Prem Kumar Tags: Correction Source Type: research
3D chromatin architecture and transcription regulation in cancer
Chromatin has distinct three-dimensional (3D) architectures important in key biological processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn, aberrant 3D structure... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 4, 2022 Category: Hematology Authors: Siwei Deng, Yuliang Feng and Siim Pauklin Tags: Review Source Type: research
Prostate cancer multiparametric magnetic resonance imaging visibility is a tumor-intrinsic phenomena
Multiparametric magnetic resonance imaging (mpMRI) is an emerging standard for diagnosing and prognosing prostate cancer, but ~ 20% of clinically significant tumors are invisible to mpMRI, as defined by the Pr... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 3, 2022 Category: Hematology Authors: Amanda Khoo, Lydia Y. Liu, Taylor Y. Sadun, Amirali Salmasi, Aydin Pooli, Ely Felker, Kathleen E. Houlahan, Vladimir Ignatchenko, Steven S. Raman, Anthony E. Sisk Jr., Robert E. Reiter, Paul C. Boutros and Thomas Kislinger Tags: Letter to the Editor Source Type: research
Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses
Personalized immunotherapy utilizing cancer vaccines tailored to the tumors of individual patients holds promise for tumors with high genetic heterogeneity, potentially enabling eradication of the tumor in its... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 29, 2022 Category: Hematology Authors: Bingfeng Zuo, Yang Zhang, Kangjie Zhao, Li Wu, Han Qi, Rong Yang, Xianjun Gao, Mengyuan Geng, Yingjie Wu, Renwei Jing, Qibing Zhou, Yiqi Seow and HaiFang Yin Tags: Research Source Type: research
Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies
The gut microbiota have long been recognized to play a key role in human health and disease. Currently, several lines of evidence from preclinical to clinical research have gradually established that the gut m... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 29, 2022 Category: Hematology Authors: Yuting Lu, Xiangliang Yuan, Miao Wang, Zhihao He, Hongzhong Li, Ji Wang and Qin Li Tags: Review Source Type: research
Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy
Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but also exert serious side effects. With in-depth studies of nucleotide metabolism, our understanding of nucleotide metabo... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 27, 2022 Category: Hematology Authors: Huai-liang Wu, Yue Gong, Peng Ji, Yi-fan Xie, Yi-Zhou Jiang and Guang-yu Liu Tags: Review Source Type: research
Emerging role of RNA sensors in tumor microenvironment and immunotherapy
RNA sensors detect foreign and endogenous RNAs to protect the host by initiating innate and adaptive immune response. In tumor microenvironment (TME), activation of RNA sensors induces tumor-inhibitory cytotox... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 12, 2022 Category: Hematology Authors: Rui Yang, Sihui Yu, Tianhan Xu, Jiawen Zhang and Sufang Wu Tags: Review Source Type: research
Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies
Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell death (RCD), also known as ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 12, 2022 Category: Hematology Authors: Minru Liao, Rui Qin, Wei Huang, Hong-Ping Zhu, Fu Peng, Bo Han and Bo Liu Tags: Review Source Type: research
Targeting Fc γRIIB by antagonistic antibody BI-1206 improves the efficacy of rituximab-based therapies in aggressive mantle cell lymphoma
Inevitable relapses remain as the major therapeutic challenge in patients with mantle cell lymphoma (MCL) despite FDA approval of multiple targeted therapies and immunotherapies. Fc gamma receptors (Fc γRs) pla... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 11, 2022 Category: Hematology Authors: Vivian Changying Jiang, Yang Liu, Alexa Jordan, Angela Leeming, Joseph McIntosh, Shengjian Huang, Rongjia Zhang, Qingsong Cai, Zhihong Chen, Yijing Li, Yuxuan Che, Lei Nie, Ingrid Karlsson, Linda M årtensson, Mathilda Kovacek, Ingrid Teige & hellip; Tags: Letter to the Editor Source Type: research
A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth
Chromosome translocations involving mixed lineage leukemia 1 (MLL1) cause acute leukemia in most infants and 5 –10% children/adults with dismal clinical outcomes. Most frequent MLL1-fusion partners AF4/AFF4, AF... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 8, 2022 Category: Hematology Authors: Xin Li, Yuan Yao, Fangrui Wu and Yongcheng Song Tags: Research Source Type: research
A new risk-assessment tool for venous thromboembolism in advanced lung cancer: a prospective, observational study
Management of cancer-associated venous thromboembolism (VTE) is essential in treatment selection and cancer prognosis. However, to date, there is no method to assess the risk of VTE specifically associated wit... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 4, 2022 Category: Hematology Authors: Yukari Tsubata, Takamasa Hotta, Kosuke Hamai, Naoki Furuya, Toshihide Yokoyama, Ryota Saito, Atsushi Nakamura, Takeshi Masuda, Megumi Hamaguchi, Shoichi Kuyama, Ryoichi Honda, Tadashi Senoo, Masamoto Nakanishi, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazuno Tags: Letter to the Editor Source Type: research
Chimeric antigen receptors containing the OX40 signalling domain enhance the persistence of T cells even under repeated stimulation with multiple myeloma target cells
In this study, we designed and cons... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 1, 2022 Category: Hematology Authors: Jingwen Tan, Yujie Jia, Meixia Zhou, Chengcheng Fu, Israth Jahan Tuhin, Jing Ye, Masuma Akter Monty, Nan Xu, Liqing Kang, Minghao Li, Jiaqi Shao, Xiaoyan Fang, Hongjia Zhu, Lingzhi Yan, Changju Qu, Shengli Xue & hellip; Tags: Letter to the Editor Source Type: research
Immune cell atlas of cholangiocarcinomas reveals distinct tumor microenvironments and associated prognoses
Immunotherapy has demonstrated a limited clinical efficacy in approximately 5% of cholangiocarcinoma. The main challenges for an effective immunotherapy response in cholangiocarcinoma arise from the tumor micr... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 28, 2022 Category: Hematology Authors: Tao Xia, Keyu Li, Nan Niu, Yingkuan Shao, Ding Ding, Dwayne L. Thomas, Hao Jing, Kenji Fujiwara, Haijie Hu, Arsen Osipov, Chunhui Yuan, Christopher L. Wolfgang, Elizabeth D. Thompson, Robert A. Anders, Jin He, Yiping Mou & hellip; Tags: Research Source Type: research
Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells
Short persistence and early exhaustion of T cells are major limits to the efficacy and broad application of immunotherapy. Exhausted T and chimeric antigen receptor (CAR)-T cells upregulate expression of genes... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 28, 2022 Category: Hematology Authors: Yue Huang, Xiaohui Si, Mi Shao, Xinyi Teng, Gang Xiao and He Huang Tags: Review Source Type: research
