The Association of Agent Orange Exposure with the progression of monoclonal gammopathy of undetermined significance to multiple myeloma: a population-based study of Vietnam War Era Veterans
Herbicide and pesticide exposure [e.g., agent orange (AO)] is associated with an increased risk of multiple myeloma (MM) due to the contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, it is unclear ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 8, 2024 Category: Hematology Authors: Lawrence W. Liu, Mei Wang, Nikhil Grandhi, Mark A. Schroeder, Theodore Thomas, Kristin Vargo, Feng Gao, Kristen M. Sanfilippo and Su-Hsin Chang Tags: Correspondence Source Type: research
Vaccines: a promising therapy for myelodysplastic syndrome
Myelodysplastic neoplasms (MDS) define clonal hematopoietic malignancies characterized by heterogeneous mutational and clinical spectra typically seen in the elderly. Curative treatment entails allogeneic hema... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 8, 2024 Category: Hematology Authors: Kriti Gera, Anjali Chauhan, Paul Castillo, Maryam Rahman, Akash Mathavan, Akshay Mathavan, Elizabeth Oganda-Rivas, Leighton Elliott, John R. Wingard and Elias J. Sayour Tags: Review Source Type: research
Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry
The use of peripheral blood (PB) or bone marrow (BM) stem cells graft in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide (PTCy) for graft-versus-host disease (GVHD)... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 7, 2024 Category: Hematology Authors: Claire Lacan, J érôme Lambert, Edouard Forcade, Marie Robin, Patrice Chevallier, Sandrine Loron, Claude-Éric Bulabois, Corentin Orvain, Patrice Ceballos, Etienne Daguindau, Amandine Charbonnier, Yves Chalandon, Marc Bernard, Célestine Simand, Marie-Th Tags: Correspondence Source Type: research
The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors
Antibody-drug conjugates (ADCs) represent an important class of cancer therapies that have revolutionized the treatment paradigm of solid tumors. To date, many ongoing studies of ADC combinations with a variet... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 4, 2024 Category: Hematology Authors: Qing Wei, Peijing Li, Teng Yang, Jiayu Zhu, Lu Sun, Ziwen Zhang, Lu Wang, Xuefei Tian, Jiahui Chen, Can Hu, Junli Xue, Letao Ma, Takaya Shimura, Jianmin Fang, Jieer Ying, Peng Guo & hellip; Tags: Review Source Type: research
Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer
Liquid –liquid phase separation (LLPS) is a novel principle for interpreting precise spatiotemporal coordination in living cells through biomolecular condensate (BMC) formation via dynamic aggregation. LLPS cha... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 18, 2023 Category: Hematology Authors: Le-Wei Zheng, Cui-Cui Liu and Ke-Da Yu Tags: Review Source Type: research
Harnessing immunotherapy for brain metastases: insights into tumor –brain microenvironment interactions and emerging treatment modalities
Brain metastases signify a deleterious milestone in the progression of several advanced cancers, predominantly originating from lung, breast and melanoma malignancies, with a median survival timeframe nearing ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 16, 2023 Category: Hematology Authors: Dairan Zhou, Zhenyu Gong, Dejun Wu, Chao Ma, Lijun Hou, Xiaomin Niu and Tao Xu Tags: Review Source Type: research
Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle Cell Lymphoma Consortium
Patients with mantle cell lymphoma (MCL) exhibit a wide variation in clinical presentation and outcome. However, the commonly used prognostic models are outdated and inadequate to address the needs of the curr... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 16, 2023 Category: Hematology Authors: Julie M. Vose, Kai Fu, Lu Wang, Adnan Mansoor, Douglas Stewart, Hongxia Cheng, Lynette Smith, Ji Yuan, Hina Naushad Qureishi, Brian K. Link, Melissa H. Cessna, Paul M. Barr, Brad S. Kahl, Matthew S. Mckinney, Nadia Khan, Ranjana H. Advani & hellip; Tags: Research Source Type: research
Multiscale protein networks systematically identify aberrant protein interactions and oncogenic regulators in seven cancer types
Global proteomic data generated by advanced mass spectrometry (MS) technologies can help bridge the gap between genome/transcriptome and functions and hold great potential in elucidating unbiased functional mo... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 15, 2023 Category: Hematology Authors: Won-Min Song, Abdulkadir Elmas, Richard Farias, Peng Xu, Xianxiao Zhou, Benjamin Hopkins, Kuan-lin Huang and Bin Zhang Tags: Correspondence Source Type: research
Safety and antitumor activity of metformin plus lanreotide in patients with advanced gastro-intestinal or lung neuroendocrine tumors: the phase Ib trial MetNET2
In retrospective studies, metformin use has been associated with better clinical outcomes in diabetic patients with advanced, well-differentiated neuroendocrine tumors (WDNETs). However, prospective evidence o... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 14, 2023 Category: Hematology Authors: Sara Pusceddu, Francesca Corti, Natalie Prinzi, Federico Nichetti, Silva Ljevar, Adele Busico, Tommaso Cascella, Rita Leporati, Simone Oldani, Chiara Carlotta Pircher, Jorgelina Coppa, Veronica Resi, Massimo Milione, Marco Maccauro, Rosalba Miceli, Elena Tags: Correspondence Source Type: research
Development and characterization of NILK-2301, a novel CEACAM5xCD3 κλ bispecific antibody for immunotherapy of CEACAM5-expressing cancers
T-cell retargeting to eliminate CEACAM5-expressing cancer cells via CEACAM5xCD3 bispecific antibodies (BsAbs) showed limited clinical activity so far, mostly due to insufficient T-cell activation, dose-limitin... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 12, 2023 Category: Hematology Authors: Anja Seckinger, Sara Majocchi, Val éry Moine, Lise Nouveau, Hoang Ngoc, Bruno Daubeuf, Ulla Ravn, Nicolas Pleche, Sebastien Calloud, Lucile Broyer, Laura Cons, Adeline Lesnier, Laurence Chatel, Anne Papaioannou, Susana Salgado-Pires, Sebastian Krämer & Tags: Research Source Type: research
Considerations for the design of antibody drug conjugates (ADCs) for clinical development: lessons learned
Antibody –drug conjugates (ADCs) have emerged as a novel therapeutic strategy that has successfully reached patient treatment in different clinical scenarios. ADCs are formed by an antibody against a specific t... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 12, 2023 Category: Hematology Authors: Alfonso L ópez de Sá, Cristina Díaz-Tejeiro, Elisa Poyatos-Racionero, Cristina Nieto-Jiménez, Lucía Paniagua-Herranz, Adrián Sanvicente, Emiliano Calvo, Pedro Pérez-Segura, Víctor Moreno, Francisco Moris and Alberto Ocana Tags: Review Source Type: research
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy
Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses is associated with most human diseases. Reactive oxygen species (ROS) are a class of chemic... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 30, 2023 Category: Hematology Authors: Jiatong Liu, Xiaoyue Han, Tingyue Zhang, Keyue Tian, Zhaoping Li and Feng Luo Tags: Review Source Type: research
Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
T cell engagers (TCEs) have been established as an emerging modality for hematologic malignancies, but solid tumors remain refractory. However, the upregulation of programmed cell death 1 (PD-1) is correlated ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 29, 2023 Category: Hematology Authors: Ziqiang Ding, Shuyang Sun, Xuan Wang, Xiaomei Yang, Wei Shi, Xianing Huang, Shenxia Xie, Fengzhen Mo, Xiaoqiong Hou, Aiqun Liu, Xiaobing Jiang, Zhuoran Tang and Xiaoling Lu Tags: Research Source Type: research
Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment
Research into the potential benefits of artificial intelligence for comprehending the intricate biology of cancer has grown as a result of the widespread use of deep learning and machine learning in the health... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 27, 2023 Category: Hematology Authors: Chaoyi Zhang, Jin Xu, Rong Tang, Jianhui Yang, Wei Wang, Xianjun Yu and Si Shi Tags: Review Source Type: research
Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is a type of hematologic tumor with malignant proliferation of hematopoietic progenitor cells. However, traditional clinical treatment of T-ALL included chemotherapy... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 22, 2023 Category: Hematology Authors: Long Chen, Anqi Ren, Yuan Zhao, Hangyu Chen, Qifang Wu, Mengzhu Zheng, Zijian Zhang, Tongcun Zhang, Wu Zhong, Jian Lin and Haichuan Zhu Tags: Correspondence Source Type: research
