Novel strategies for cancer immunotherapy: counter-immunoediting therapy
The advent of immunotherapy has made an indelible mark on the field of cancer therapy, especially the application of immune checkpoint inhibitors in clinical practice. Although immunotherapy has proven its eff... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 13, 2023 Category: Hematology Authors: Shaochuan Liu, Qian Sun and Xiubao Ren Tags: Review Source Type: research
Cancer and COVID-19: unravelling the immunological interplay with a review of promising therapies against severe SARS-CoV-2 for cancer patients
Cancer patients, due to their immunocompromised status, are at an increased risk for severe SARS-CoV-2 infection. Since severe SARS-CoV-2 infection causes multiple organ damage through IL-6-mediated inflammati... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 13, 2023 Category: Hematology Authors: Yan Leyfman, Nancy Emmanuel, Gayathri P. Menon, Muskan Joshi, William B. Wilkerson, Jared Cappelli, Timothy K. Erick, Chandler H. Park and Pushpa Sharma Tags: Review Source Type: research
Whole-genome sequencing identifies novel predictors for hematopoietic cell transplant outcomes for patients with myelodysplastic syndrome: a CIBMTR study
Recurrent mutations in TP53, RAS pathway and JAK2 genes were shown to be highly prognostic of allogeneic hematopoietic cell transplant (alloHCT) outcomes in myelodysplastic syndromes (MDS). However, a signific... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 11, 2023 Category: Hematology Authors: Tao Zhang, Paul Auer, Jing Dong, Corey Cutler, Amy E. Dezern, Shahinaz M. Gadalla, H. Joachim Deeg, Aziz Nazha, Karen-Sue Carlson, Stephen Spellman, Yung-Tsi Bolon and Wael Saber Tags: Correspondence Source Type: research
The functional and clinical roles of liquid biopsy in patient-derived models
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) and extracellular vesicles... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 8, 2023 Category: Hematology Authors: Ziqing Zhu, Erya Hu, Hong Shen, Jun Tan and Shan Zeng Tags: Review Source Type: research
CAR-NK cell therapy for hematological malignancies: recent updates from ASH 2022
Chimeric antigen receptor (CAR)-NK cell therapy has the advantages of a low incidence of side effects and a low cost. However, the clinical outcomes are not satisfactory due to limited antitumor effects and a ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 7, 2023 Category: Hematology Authors: Ruihao Huang, Qin Wen and Xi Zhang Tags: Correspondence Source Type: research
Long-term follow-up of donor-derived CD7 CAR T-cell therapy in patients with T-cell acute lymphoblastic leukemia
Donor-derived CD7-directed chimeric antigen receptor (CAR) T cells showed feasibility and early efficacy in patients with refractory or relapsed T-cell acute lymphoblastic leukemia (r/r T-ALL), in a previous p... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 5, 2023 Category: Hematology Authors: Yue Tan, Lingling Shan, Liping Zhao, Biping Deng, Zhuojun Ling, Yanlei Zhang, Shuixiu Peng, Jinlong Xu, Jiajia Duan, Zelin Wang, Xinjian Yu, Qinlong Zheng, Xiuwen Xu, Zhenglong Tian, Yibing Zhang, Jiecheng Zhang & hellip; Tags: Research Source Type: research
PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation
In human cells BRAF oncogene is invariably expressed as a mix of two coding transcripts: BRAF-ref and BRAF-X1. These two mRNA isoforms, remarkably different in the sequence and length of their 3 ′UTRs, are potenti... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 3, 2023 Category: Hematology Authors: Andrea Marranci, Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi, Maurizio S. Podda, Serena Mero, Marianna Vitiello, Cinzia Franchin, Mariavittoria Laezza, Laura Comelli, Giorgio Arrigoni, Tiziana Cervelli, Giovanna Del Pozzo and Tags: Correspondence Source Type: research
Passive pre-exposure immunization by tixagevimab/cilgavimab in patients with hematological malignancy and COVID-19: matched-paired analysis in the EPICOVIDEHA registry
Only few studies have analyzed the efficacy of tixagevimab/cilgavimab to prevent severe Coronavirus disease 2019 (COVID-19) and related complications in hematologic malignancies (HM) patients. Here, we report ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 1, 2023 Category: Hematology Authors: Francesco Marchesi, Jon Salmanton-Garc ía, Caterina Buquicchio, Federico Itri, Caroline Besson, Julio Dávila-Valls, Sonia Martín-Pérez, Luana Fianchi, Laman Rahimli, Giuseppe Tarantini, Federica Irene Grifoni, Mariarita Sciume, Jorge Labrador, Raul Co Tags: Correspondence Source Type: research
APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine deaminases involved in innate and adaptive immunity. However, some APOBEC family members can also deaminate host genomes to g... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 28, 2023 Category: Hematology Authors: Kelly Butler and A. Rouf Banday Tags: Review Source Type: research
LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia
Cancer cachexia is a deadly wasting syndrome that accompanies various diseases (including ~ 50% of cancers). Clinical studies have established that cachexia is not a nutritional deficiency and is linked to exp... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 27, 2023 Category: Hematology Authors: Dong Wang, Xiaohui Li, Defeng Jiao, Ying Cai, Liting Qian, Yiqing Shen, Yichen Lu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Xiaohu Zheng and Haiming Wei Tags: Research Source Type: research
Recent advances in targeted therapies in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival for younger patients over the last several decades has improved nearly sixfold with the optimization of intensive induct... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 25, 2023 Category: Hematology Authors: Rahul S. Bhansali, Keith W. Pratz and Catherine Lai Tags: Review Source Type: research
Aging microenvironment and antitumor immunity for geriatric oncology: the landscape and future implications
The tumor microenvironment (TME) has been extensively investigated; however, it is complex and remains unclear, especially in elderly patients. Senescence is a cellular response to a variety of stress signals,... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 21, 2023 Category: Hematology Authors: Binghao Zhao, Bo Wu, Nan Feng, Xiang Zhang, Xin Zhang, Yiping Wei and Wenxiong Zhang Tags: Review Source Type: research
AMLnet, A deep-learning pipeline for the differential diagnosis of acute myeloid leukemia from bone marrow smears
Acute myeloid leukemia (AML) is a deadly hematological malignancy. Cellular morphology detection of bone marrow smears based on the French –American–British (FAB) classification system remains an essential crit... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 21, 2023 Category: Hematology Authors: Zebin Yu, Jianhu Li, Xiang Wen, Yingli Han, Penglei Jiang, Meng Zhu, Minmin Wang, Xiangli Gao, Dan Shen, Ting Zhang, Shuqi Zhao, Yijing Zhu, Jixiang Tong, Shuchong Yuan, HongHu Zhu, He Huang & hellip; Tags: Correspondence Source Type: research
Nab-paclitaxel and gemcitabine plus camrelizumab and radiotherapy versus nab-paclitaxel and gemcitabine alone for locally advanced pancreatic adenocarcinoma: a prospective cohort study
Treatment options specifically for patients with locally advanced pancreatic adenocarcinoma (LAPC) are scare and chemotherapy alone delivers limited efficacy. Immunotherapy and radiotherapy are potential effec... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 20, 2023 Category: Hematology Authors: Shuling Chen, Jiaxin Li, Aoran Dong, Zelong Liu, Meiyan Zhu, Meng Jin, Guangyan Wei, Shuang Wu, Yan Wang, Yong Chen and Zhenwei Peng Tags: Correspondence Source Type: research
Similar outcomes following non-first-degree and first-degree related donor haploidentical hematopoietic cell transplantation for acute leukemia patients in complete remission: a study from the Global Committee and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
There are situations where non-first-degree (NFD) related donors have to be considered as alternatives to first-degree (FD) related donors for haploidentical hematopoietic cell transplantation (HAPLO). However... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 18, 2023 Category: Hematology Authors: Yishan Ye, Myriam Labopin, Jia Chen, Zafer Gulbas, Xi Zhang, Yener Koc, Didier Blaise, Fabio Ciceri, Emmanuelle Polge, Mohamed Houhou, Lin Li, Yi Luo, Depei Wu, He Huang, Mohamad Mohty and Norbert-Claude Gorin Tags: Correspondence Source Type: research
