Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1
circRNA has been established to play a pivotal role in tumorigenesis development in a variety of cancers; nevertheless, the biological functions and molecular mechanisms of hypoxia-induced exosomal circRNAs in... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 6, 2022 Category: Hematology Authors: Jiewei Lin, Xinjing Wang, Shuyu Zhai, Minmin Shi, Chenghong Peng, Xiaxing Deng, Da Fu, Jiancheng Wang and Baiyong Shen Tags: Research Source Type: research
ASXL1/2 mutations and myeloid malignancies
Myeloid malignancies develop through the accumulation of genetic and epigenetic alterations that dysregulate hematopoietic stem cell (HSC) self-renewal, stimulate HSC proliferation and result in differentiatio... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 6, 2022 Category: Hematology Authors: Edward A. Medina, Caroline R. Delma and Feng-Chun Yang Tags: Review Source Type: research
Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation
The role of allogeneic hematopoietic cell transplantation (alloHCT) in acute myeloid leukemia (AML) with mutated IDH1/2 has not been defined. Therefore, we analyzed a large cohort of 3234 AML patients in first co... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 5, 2022 Category: Hematology Authors: Desiree Kunadt, Sebastian Stasik, Klaus H. Metzeler, Christoph R öllig, Christoph Schliemann, Philipp A. Greif, Karsten Spiekermann, Maja Rothenberg-Thurley, Utz Krug, Jan Braess, Alwin Krämer, Andreas Hochhaus, Sebastian Scholl, Inken Hilgendorf, Tim H Tags: Research Source Type: research
Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients
Analysis of circulating free DNA (cfDNA) is a promising tool for personalized management of colorectal cancer (CRC) patients. Untargeted cfDNA analysis using whole-genome sequencing (WGS) does not need a prior... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 2, 2022 Category: Hematology Authors: Ariane Hallermayr, Tobias Wohlfrom, Verena Steinke-Lange, Anna Benet-Pag ès, Florentine Scharf, Ellen Heitzer, Ulrich Mansmann, Christopher Haberl, Maike de Wit, Holger Vogelsang, Markus Rentsch, Elke Holinski-Feder and Julia M. A. Pickl Tags: Research Source Type: research
Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)
The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged from studies using external beam radiation therapy (EBRT). Yet, less is known about the... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 31, 2022 Category: Hematology Authors: Michal Grzmil, Paul Boersema, Ashish Sharma, Alain Blanc, Stefan Imobersteg, Martin Pruschy, Paola Picotti, Roger Schibli and Martin Behe Tags: Correspondence Source Type: research
Treatment of myelodysplastic syndromes in the era of precision medicine and immunomodulatory drugs: a focus on higher-risk disease
Myelodysplastic syndromes (MDS) are a heterogeneous clonal disease of myeloid neoplasms characterized by ineffective hematopoiesis, variable degree of cytopenias, and an increased risk of progression to acute ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 31, 2022 Category: Hematology Authors: Razan Mohty, Rama Al Hamed, Ali Bazarbachi, Eolia Brissot, Arnon Nagler, Amer Zeidan and Mohamad Mohty Tags: Review Source Type: research
CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR
Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. CircRNAs are expected to be potential diagnostic biomarkers and therapeutic targ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 29, 2022 Category: Hematology Authors: Xiaolong Wang, Tong Chen, Chen Li, Wenhao Li, Xianyong Zhou, Yaming Li, Dan Luo, Ning Zhang, Bing Chen, Lijuan Wang, Wenjing Zhao, Shanji Fu and Qifeng Yang Tags: Research Source Type: research
Posttranslational control of lipogenesis in the tumor microenvironment
Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of t... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 29, 2022 Category: Hematology Authors: Yahui Zhu, Xingrong Lin, Xiaojun Zhou, Edward V. Prochownik, Fubing Wang and Youjun Li Tags: Review Source Type: research
Recent advances in therapeutic strategies for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current treatment options are limited to surgery, adjuvant chemotherapy and radiotherapy; however... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 29, 2022 Category: Hematology Authors: Yun Li, Huajun Zhang, Yulia Merkher, Lin Chen, Na Liu, Sergey Leonov and Yongheng Chen Tags: Review Source Type: research
Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable treatment responses which have revolu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 28, 2022 Category: Hematology Authors: Yi Wang, Kai Conrad Cecil Johnson, Margaret E. Gatti-Mays and Zihai Li Tags: Review Source Type: research
Osteosarcoma with cell-cycle and fibroblast growth factor genomic alterations: case report of Molecular Tumor Board combination strategy resulting in long-term exceptional response
We report a 31-year-old woman with chemotherapy –refractory metastatic osteosarcoma who was successfully treated with the com... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 28, 2022 Category: Hematology Authors: Hanna E. Persha, Shumei Kato, Pradip De, Jacob J. Adashek, Jason K. Sicklick, Vivek Subbiah and Razelle Kurzrock Tags: Correspondence Source Type: research
Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells
A cardinal feature that distinguishes clinically high-risk neuroblastoma from low-risk tumors is telomere maintenance. Specifically, neuroblastoma tumors with either active telomerase or alternative lengthenin... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 27, 2022 Category: Hematology Authors: Eun Young Yu, Nai-Kong V. Cheung and Neal F. Lue Tags: Review Source Type: research
Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disea... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 26, 2022 Category: Hematology Authors: Darko Antic, Natasa Milic, Thomas Chatzikonstantinou, Lydia Scarf ò, Vladimir Otasevic, Nina Rajovic, David Allsup, Alejandro Alonso Cabrero, Martin Andres, Monica Baile Gonzales, Antonella Capasso, Rosa Collado, Raul Cordoba, Carolina Cuéllar-García, Tags: Research Source Type: research
Revealing the evolution of the tumor immune microenvironment in follicular lymphoma patients progressing within 24 months using single-cell imaging mass cytometry
Patients with follicular lymphoma (FL) who experience disease progression within 24 months (POD24) have inferior outcomes. The tumor immune microenvironment (TIME) plays a crucial role in pathogenesis and prog... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 22, 2022 Category: Hematology Authors: Long Liu, Xingxing Yu, Zhifeng Li, Xiaohua He, Jie Zha, Zhijuan Lin, Yan Hong, Huijian Zheng, Qian Lai, Kaiyang Ding, Xian Jia, Guo Fu, Haifeng Yu, Haiyan Yang, Zhiming Li, Ken H. Young & hellip; Tags: Correspondence Source Type: research
Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial
BCR-ABL1T315I mutations confer resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML). Olverembatinib is a new potent BCR-ABL1 TKI with preclinical activity against T315I-mutated CML. I... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 18, 2022 Category: Hematology Authors: Qian Jiang, Zongru Li, Yazhen Qin, Weiming Li, Na Xu, Bingcheng Liu, Yanli Zhang, Li Meng, Huanling Zhu, Xin Du, Suning Chen, Yang Liang, Yu Hu, Xiaoli Liu, Yongping Song, Lichuang Men & hellip; Tags: Research Source Type: research
