Reductive TCA cycle catalyzed by wild-type IDH2 promotes acute myeloid leukemia and is a metabolic vulnerability for potential targeted therapy
Isocitrate dehydrogenase-2 (IDH2) is a mitochondrial enzyme that catalyzes the metabolic conversion between isocitrate and alpha-ketoglutarate ( α-KG) in the TCA cycle. IDH2 mutation is an oncogenic event in ac... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 21, 2022 Category: Hematology Authors: Peiting Zeng, Wenhua Lu, Jingyu Tian, Shuang Qiao, Jiangjiang Li, Christophe Glorieux, Shijun Wen, Hui Zhang, Yiqing Li and Peng Huang Tags: Research Source Type: research
A four-stage model for murine natural killer cell development in vivo
Natural killer (NK) cells are the predominant innate lymphoid cells that mediate anti-viral and anti-tumor immunity. NK cells arise from hematopoietic stem cells in the bone marrow (BM) and undergo lineage spe... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 21, 2022 Category: Hematology Authors: Shoubao Ma, Michael A. Caligiuri and Jianhua Yu Tags: Letter to the Editor Source Type: research
Solamargine induces hepatocellular carcinoma cell apoptosis and autophagy via inhibiting LIF/miR-192-5p/CYR61/Akt signaling pathways and eliciting immunostimulatory tumor microenvironment
Hepatocellular carcinoma (HCC) is well-known to be a highly prevalent malignant tumor, but the treatment of this pathological state has been still challenging. Solamargine (SM), a traditional Chinese herb-deri... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 21, 2022 Category: Hematology Authors: Shuangshuang Yin, Wenke Jin, Yuling Qiu, Leilei Fu, Tao Wang and Haiyang Yu Tags: Letter to the Editor Source Type: research
Altered pathways and targeted therapy in double hit lymphoma
High-grade B-cell lymphoma with translocations involving MYC and BCL2 or BCL6, usually referred to as double hit lymphoma (DHL), is an aggressive hematological malignance with distinct genetic features and poor c... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 18, 2022 Category: Hematology Authors: Yuxin Zhuang, Jinxin Che, Meijuan Wu, Yu Guo, Yongjin Xu, Xiaowu Dong and Haiyan Yang Tags: Review Source Type: research
Determinants of SARS-CoV-2 waning immunity in allogeneic hematopoietic stem cell transplant recipients
Hematopoietic stem cell transplant (HSCT) recipients are at high-risk for severe COVID-19 and have altered immune responses to vaccination. We sought to evaluate the dynamics of immune response to BNT162b2 mRN... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 18, 2022 Category: Hematology Authors: Mathieu Leclerc, Rabah Redjoul, Anne Le Bouter, Florence Beckerich, Christine Robin, Vincent Parinet, C écile Pautas, Dehbia Menouche, Selwa Bouledroua, Lydia Roy, Ludovic Cabanne, Yakout Nait-Sidenas, Slim Fourati and Sébastien Maury Tags: Rapid communication Source Type: research
