Patient selection for CAR T or BiTE therapy in multiple myeloma: Which treatment for each patient?
Multiple myeloma (MM) is a plasma cell malignancy that affects an increasing number of patients worldwide. Despite all the efforts to understand its pathogenesis and develop new treatment modalities, MM remain... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 7, 2022 Category: Hematology Authors: David Kegyes, Catalin Constantinescu, Louise Vrancken, Leo Rasche, Celine Gregoire, Bogdan Tigu, Diana Gulei, Delia Dima, Alina Tanase, Hermann Einsele, Stefan Ciurea, Ciprian Tomuleasa and Jo Caers Tags: Review Source Type: research
Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis
Ferroptosis, a novel non-apoptotic form of cell death, can induce tumor cell death and treatment resistance. Lipid metabolism is closely related to ferroptosis; however, the effect of mammary adipocytes on bre... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 3, 2022 Category: Hematology Authors: Yizhao Xie, Biyun Wang, Yannan Zhao, Zhonghua Tao, Ye Wang, Guangliang Chen and Xichun Hu Tags: Correspondence Source Type: research
DTX-P7, a peptide –drug conjugate, is highly effective for non-small cell lung cancer
Despite tremendous success of molecular targeted therapy together with immunotherapy, only a small subset of patients can benefit from them. Chemotherapy remains the mainstay treatment for most of tumors inclu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 3, 2022 Category: Hematology Authors: Yao Jiang, Wei Huang, Xiaojiao Sun, Xiaozhou Yang, Youming Wu, Jiaojiao Shi, Ji Zheng, Shujie Fan, Junya Liu, Jun Wang, Zhen Liang, Nan Yang, Zhenming Liu and Yanyong Liu Tags: Correspondence Source Type: research
How we treat NK/T-cell lymphomas
Natural killer (NK)/T-cell lymphomas are aggressive malignancies with a predilection for Asian and South American populations. Epstein –Barr virus (EBV) infection in lymphoma cells is universal. Predominantly e... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 3, 2022 Category: Hematology Authors: Eric Tse, Wei-Li Zhao, Jie Xiong and Yok-Lam Kwong Tags: Review Source Type: research
Clinical experiences with venetoclax and other pro-apoptotic agents in lymphoid malignancies: lessons from monotherapy and chemotherapy combination
BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. The only currently approved BH3-mimetic, the selective BCL2 inhibitor veneto... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 3, 2022 Category: Hematology Authors: Thomas E. Lew and John F. Seymour Tags: Review Source Type: research
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Stu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 3, 2022 Category: Hematology Authors: Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca and Vojtech Adam Tags: Review Source Type: research
Correction to: COVID-19 in pediatric cancer patients is associated with treatment interruptions but not with short-term mortality: a Polish national study
(Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 31, 2022 Category: Hematology Authors: Jadwiga W ęcławek-Tompol, Zuzanna Zakrzewska, Olga Gryniewicz-Kwiatkowska, Filip Pierlejewski, Ewa Bień, Agnieszka Zaucha-Prażmo, Olga Zając-Spychała, Anna Szmydki-Baran, Agnieszka Mizia-Malarz, Wioletta Bal, Małgorzata Sawicka-Żukowska, Agnieszka Tags: Correction Source Type: research
Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer
Advanced pancreatic ductal adenocarcinoma (PDAC) is usually an incurable malignancy that needs newer therapeutic targets. Interleukin-1 receptor accessory protein (IL1RAP) is an innate immune mediator that reg... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 23, 2022 Category: Hematology Authors: Yang Zhang, Xiaoyi Chen, Huamin Wang, Shanisha Gordon-Mitchell, Srabani Sahu, Tushar D. Bhagat, Gaurav Choudhary, Srinivas Aluri, Kith Pradhan, Plabani Sahu, Milagros Carbajal, Hui Zhang, Beamon Agarwal, Aditi Shastri, Robert Martell, Daniel Starczynowski Tags: Letter to the Editor Source Type: research
C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction
Although chimeric antigen receptor (CAR)-modified adoptive T cell therapy is a promising immunotherapy for hematological malignancies, the efficacy improvement in relapsed/refractory acute lymphoblastic leukem... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 21, 2022 Category: Hematology Authors: Peilong Lai, Xiaomei Chen, Yulian Wang, Jinghua Wang, Yuchen Zhang, Suxia Geng, Peng Li, Xin Du, Jianyu Weng and Duanqing Pei Tags: Correspondence Source Type: research
Direct oral anticoagulant versus low molecular weight heparin for the treatment of cancer-associated venous thromboembolism: 2022 updated systematic review and meta-analysis of randomized controlled trials
International clinical practice guidelines have progressively endorsed direct oral anticoagulants (DOACs) as an alternative to low-molecular-weight heparins (LMWHs) monotherapy for the initial and long-term tr... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 21, 2022 Category: Hematology Authors: Corinne Frere, Dominique Farge, Deborah Schrag, Pedro H. Prata and Jean M. Connors Tags: Correspondence Source Type: research
Risk of SARS-CoV-2 Breakthrough Infection in Vaccinated Cancer Patients: A Retrospective Cohort Study
Although messenger RNA (mRNA) vaccines have established efficacy for prevention of severe SARS-CoV2 infection in the general population, their effectiveness in patients with malignancy, especially those on ant... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 21, 2022 Category: Hematology Authors: Anthony Rooney, Cory Bivona, Ben Liu, David Streeter, Han Gong and Qamar Khan Tags: Letter to the Editor Source Type: research
The potential role of N7-methylguanosine (m7G) in cancer
N7-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecti.... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 19, 2022 Category: Hematology Authors: Yuejun Luo, Yuxin Yao, Peng Wu, Xiaohui Zi, Nan Sun and Jie He Tags: Review Source Type: research
Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant
Despite the increased usage of post-transplant cyclophosphamide (PTCy) in allogeneic hematopoietic stem cell transplantation (allo-HSCT), our knowledge of immune reconstitution post-allo-HSCT in the setting of... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 19, 2022 Category: Hematology Authors: Chenchen Zhao, Matthew Bartock, Bei Jia, Neal Shah, David F. Claxton, Baldeep Wirk, Kevin L. Rakszawski, Myles S. Nickolich, Seema G. Naik, Witold B. Rybka, W Christopher C. Ehmann, Raymond J. Hohl, Jessica Valentin, Michelle Bernas-Peterson, Emily M. Ger Tags: Correspondence Source Type: research
Worked to the bone: antibody-based conditioning as the future of transplant biology
Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding transplant rejection via ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 19, 2022 Category: Hematology Authors: James M. Griffin, Fiona M. Healy, Lekh N. Dahal, Yngvar Floisand and John F. Woolley Tags: Review Source Type: research
Safety of two-dose COVID-19 vaccination (BNT162b2 and CoronaVac) in adults with cancer: a territory-wide cohort study
The World Health Organization has defined a list of adverse events of special interest (AESI) for safety surveillance of vaccines. AESI have not been adequately assessed following COVID-19 vaccination in patie... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 19, 2022 Category: Hematology Authors: Wei Kang, Jessica J. P. Shami, Vincent K. C. Yan, Xuxiao Ye, Joseph E. Blais, Xue Li, Victor H. F. Lee, Celine S. L. Chui, Francisco T. T. Lai, Eric Y. F. Wan, Carlos K. H. Wong, Ian C. K. Wong and Esther W. Chan Tags: Brief Report Source Type: research
