Correction: Large-scale real-life analysis of survival and usage of therapies in multiple myeloma
(Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 25, 2023 Category: Hematology Authors: N. Lopez-Mu ñoz, G. Hernández-Ibarburu, R. Alonso, J. M. Sanchez-Pina, R. Ayala, M. Calbacho, C. Cuellar, M. T. Cedena, A. Jiménez-Ubieto, R. Iñiguez, M. Pedrera, J. Cruz, L. Meloni, D. Pérez-Rey, P. Serrano, J. de la Cruz & hellip; Tags: Correction Source Type: research
Metabolism, metabolites, and macrophages in cancer
Tumour-associated macrophages (TAMs) are crucial components of the tumour microenvironment and play a significant role in tumour development and drug resistance by creating an immunosuppressive microenvironmen... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 25, 2023 Category: Hematology Authors: Mengyuan Li, Yuhan Yang, Liting Xiong, Ping Jiang, Junjie Wang and Chunxiao Li Tags: Review Source Type: research
Novel target and treatment agents for natural killer/T-cell lymphoma
The rapidly increasing use of high-throughput screening had produced a plethora of expanding knowledge on the molecular basis of natural killer/T-cell lymphoma (NKTCL), which in turn has revolutionized the tre... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 22, 2023 Category: Hematology Authors: Xiao-Peng Tian, Yi Cao, Jun Cai, Yu-Chen Zhang, Qi-Hua Zou, Jin-Ni Wang, Yu Fang, Jia-Hui Wang, Song-Bin Guo and Qing-Qing Cai Tags: Review Source Type: research
Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial
Third-generation chimeric antigen receptor (CAR)-engineered T cells (CARTs) might improve clinical outcome of patients with B cell malignancies. This is the first report on a third-generation CART dose-escalat... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 22, 2023 Category: Hematology Authors: Maria-Luisa Schubert, Anita Schmitt, Angela H ückelhoven-Krauss, Brigitte Neuber, Alexander Kunz, Philip Waldhoff, Dominik Vonficht, Schayan Yousefian, Lea Jopp-Saile, Lei Wang, Felix Korell, Anna Keib, Birgit Michels, Dominik Haas, Tim Sauer, Patrick De Tags: Research Source Type: research
GAS6-based CAR-T cells exhibit potent antitumor activity against pancreatic cancer
The receptor tyrosine kinases TAM family (TYRO3, AXL, and MERTK) are highly expressed in multiple forms of cancer cells and tumor-associated macrophages and promote the development of cancers including pancrea... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 20, 2023 Category: Hematology Authors: Jiawei Fan, Ye Yu, Lanzhen Yan, Yuncang Yuan, Bin Sun, Dong Yang, Nan Liu, Jing Guo, Jie Zhang and Xudong Zhao Tags: Research Source Type: research
Large-scale real-life analysis of survival and usage of therapies in multiple myeloma
Survival in multiple myeloma has improved significantly in recent years, especially in young patients. We reviewed the evolution of the survival of patients with MM in three groups based on age at MM diagnosis... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 19, 2023 Category: Hematology Authors: N. Lopez-Mu ñoz, G. Hernández-Ibarburu, R. Alonso, J. M. Sanchez-Pina, R. Ayala, M. Calbacho, C. Cuellar, M. T. Cedena, A. Jimenez, R. Iñiguez, M. Pedrera, J. Cruz, L. Meloni, D. Pérez-Rey, P. Serrano, J. de la Cruz & hellip; Tags: Correspondence Source Type: research
Clinical development of mRNA therapies against solid tumors
The mRNA-based therapeutics have become the hot spot of biopharmaceutical industries in recent years. The landscape of this area is expanding from infectious disease to cancer, which needs to be summarized to ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 18, 2023 Category: Hematology Authors: Dawei Wu, Lingfeng Hu, Xin Wang, Yue Yu, Shuo-Peng Jia, Hui-Yao Huang, Zi-Wei Li, Jin-Feng Ma, Hai-Bo Zhu, Yu Tang and Ning Li Tags: Correspondence Source Type: research
Advances of medical nanorobots for future cancer treatments
Early detection and diagnosis of many cancers is very challenging. Late stage detection of a cancer always leads to high mortality rates. It is imperative to develop novel and more sensitive and effective diag... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 14, 2023 Category: Hematology Authors: Xiangyi Kong, Peng Gao, Jing Wang, Yi Fang and Kuo Chu Hwang Tags: Review Source Type: research
Unresolved questions in selection of therapies for treatment-na ïve chronic lymphocytic leukemia
The treatment landscape for chronic lymphocytic leukemia (CLL) continues to undergo considerable evolution. Optimal selection of initial therapy from multiple effective options provides a major challenge for c... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 8, 2023 Category: Hematology Authors: Rory Bennett, Mary Ann Anderson and John F. Seymour Tags: Review Source Type: research
A phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents
Pevonedistat is a first-in-class, small molecular inhibitor of NEDD8-activating enzyme that has clinical activity in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Preclinical data suggest s... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 8, 2023 Category: Hematology Authors: Nicholas J. Short, Muharrem Muftuoglu, Faustine Ong, Lewis Nasr, Walid Macaron, Guillermo Montalban-Bravo, Yesid Alvarado, Mahesh Basyal, Naval Daver, Courtney D. Dinardo, Gautam Borthakur, Nitin Jain, Maro Ohanian, Elias Jabbour, Ghayas C. Issa, Wei Qiao Tags: Research Source Type: research
Tumor-associated myeloid cells in cancer immunotherapy
Tumor-associated myeloid cells (TAMCs) are among the most important immune cell populations in the tumor microenvironment, and play a significant role on the efficacy of immune checkpoint blockade. Understandi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 6, 2023 Category: Hematology Authors: Xinyu Cheng, Huilan Wang, Zhongyu Wang, Bo Zhu and Haixia Long Tags: Review Source Type: research
A gene signature can predict risk of MGUS progressing to multiple myeloma
Multiple myeloma is preceded by monoclonal gammopathy of undetermined significance (MGUS). Serum markers are currently used to stratify MGUS patients into clinical risk groups. A molecular signature predicting... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 29, 2023 Category: Hematology Authors: Fumou Sun, Yan Cheng, Jun Ying, David Mery, Samer Al Hadidi, Visanu Wanchai, Eric R. Siegel, Hongwei Xu, Dongzheng Gai, Timothy Cody Ashby, Clyde Bailey, Jin-Ran Chen, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Siegfried Janz & hellip; Tags: Correspondence Source Type: research
Mosunetuzumab and lymphoma: latest updates from 2022 ASH annual meeting
Bispecific antibodies are emerging as a promising new immunotherapy modality and are actively being evaluated in clinical trials for patients with lymphoma. As the first BsAb to receive regulatory approval for... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 28, 2023 Category: Hematology Authors: Yang Cao, Emanuela C. Marcucci and Lihua E. Budde Tags: Review Source Type: research
Exosomal circRNA: emerging insights into cancer progression and clinical application potential
Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and other components, thereby regul... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 26, 2023 Category: Hematology Authors: Fan Zhang, Jiajia Jiang, Hui Qian, Yongmin Yan and Wenrong Xu Tags: Review Source Type: research
Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study
We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated miR-221, demonstrated anti-tumor activity agai... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 26, 2023 Category: Hematology Authors: Pierfrancesco Tassone, Maria Teresa Di Martino, Mariamena Arbitrio, Lucia Fiorillo, Nicoletta Staropoli, Domenico Ciliberto, Alessia Cordua, Francesca Scionti, Bernardo Bertucci, Angela Salvino, Mariangela Lopreiato, Fredrik Thunarf, Onofrio Cuomo, Maria Tags: Research Source Type: research
