Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells

Short persistence and early exhaustion of T cells are major limits to the efficacy and broad application of immunotherapy. Exhausted T and chimeric antigen receptor (CAR)-T cells upregulate expression of genes...

Source: Journal of Hematology and Oncology - March 28, 2022 Category: Hematology Authors: Yue Huang, Xiaohui Si, Mi Shao, Xinyi Teng, Gang Xiao and He Huang Tags: Review Source Type: research