A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth

Chromosome translocations involving mixed lineage leukemia 1 (MLL1) cause acute leukemia in most infants and 5 –10% children/adults with dismal clinical outcomes. Most frequent MLL1-fusion partners AF4/AFF4, AF...

Source: Journal of Hematology and Oncology - April 8, 2022 Category: Hematology Authors: Xin Li, Yuan Yao, Fangrui Wu and Yongcheng Song Tags: Research Source Type: research