Correlation between circulating blood and microenvironment T lymphocytes in diffuse large B-cell lymphomas
Conclusions
Overall, these data suggest that DLBCL with high TME T cells display a pre-existing antitumour immune response. In the rituximab-containing regimen, TME T cells are stimulated further to participate in the immune response against lymphoma cells. In contrast, DLBCL lymphomas with low T-cell infiltration reflect the absence of a pre-existing antitumour immunity and have a lower likelihood of obtaining an optimal response to therapy. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 17, 2022 Category: Pathology Authors: Laddaga, F. E., Ingravallo, G., Mestice, A., Tamma, R., Perrone, T., Maiorano, E., Ribatti, D., Specchia, G., Gaudio, F. Tags: Original research Source Type: research
Multi-gene custom panels for the characterisation of metastatic colorectal carcinoma in clinical practice: express the role of PIK3CA mutations
Conclusions
Our study demonstrates the feasibility and efficacy of lab-developed targeted multi-gene NGS panels in the clinical practice of CRC. Moreover, the data lead to hypothesise that PIK3CA mutations, together with those of RAS/BRAF, worth to be further investigated in clinical CRC specimens. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 17, 2022 Category: Pathology Authors: de Biase, D., Malapelle, U., De Leo, A., Maloberti, T., Visani, M., Pisapia, P., Acquaviva, G., Pepe, F., Russo, G., Iaccarino, A., Pession, A., Tallini, G., Troncone, G. Tags: Original research Source Type: research
Cribriform colon cancer: a morphological growth pattern associated with extramural venous invasion, nodal metastases and microsatellite stability
Conclusion
Identifying CC may be useful due to its association with worse stage at presentation and EMVI, but given that cribriform-like appearance may be found in many colon cancer cases and that we did not find a survival difference for CC, CC may not necessitate its own subtype classification. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 17, 2022 Category: Pathology Authors: Taylor, A. S., Liu, N., Fang, J. M., Panarelli, N., Zhao, L., Cheng, J., Gopal, P., Hammer, S., Sun, J., Appelman, H., Westerhoff, M. Tags: Original research Source Type: research
High frequency of PIK3CA and TERT promoter mutations in fibromatosis-like spindle cell carcinomas
Conclusions
Our study showed that PIK3CA and TERT promoter mutations were common genetic features of FLSCCs. These findings contribute to our understanding of FLSCCs biology. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 17, 2022 Category: Pathology Authors: Zhong, S., Zhou, S., Li, A., Lv, H., Li, M., Tang, S., Xu, X., Shui, R., Yang, W. Tags: Original research Source Type: research
Pathologists assistants, an essential healthcare workforce: the experience of a surgical pathology department in Italy
Conclusion
In our experience, PA has represented a fundamental time-saving resource for the pathologists, who can devote time almost exclusively to diagnostic reporting. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 17, 2022 Category: Pathology Authors: Bortesi, M., Marchetti, M., Arpaia, I., Marchi, L., Ganassi, M., Zanetti, E., Fontanesi, C., Costantini, M., Piana, S. Tags: Original research Source Type: research
