Dual resolution deep learning network with self-attention mechanism for classification and localisation of colorectal cancer in histopathological images
Conclusions
We compared DRSANet with benchmark networks which only use the patches from high magnification level. Experimental results reveal that the performance of DRSANet is better than the benchmark networks. Both context and details should be considered in deep learning method. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - July 19, 2023 Category: Pathology Authors: Xu, Y., Jiang, L., Huang, S., Liu, Z., Zhang, J. Tags: Original research Source Type: research
Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene
The MYCN gene belongs to the MYC family of transcription factors. Amplification of MYCN, first discovered in neuroblastoma cells, ushered in the era of cancer genomics. The MYCN gene and MYCN protein are extensively studied in the context of neuroblastoma. As demonstrated in transgenic mouse models, MYCN gene shows a restricted spatiotemporal expression predominantly in the neural crest cells which explains the associated neoplasms including neuroblastoma and central nervous system tumours. In neuroblastoma, MYCN amplification is a marker of aggressive tumours with poor prognosis and survival and forms the basis of risk st...
Source: Journal of Clinical Pathology - July 19, 2023 Category: Pathology Authors: Bhardwaj, N., Das, G., Srinivasan, R. Tags: Molecules in pathogenesis Source Type: research
Factors predicting BRCA1/2 pathogenic variants in patients with ovarian cancer: a systematic review with meta-analysis
Conclusion
The results of this meta-analysis provide data on features increasing the prior probability of finding BRCA1/2 pathogenic variants that may prove helpful in counselling patients and prioritising testing.
PROSPERO registration number
CRD42021271815. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - July 19, 2023 Category: Pathology Authors: Innella, G., Godino, L., Erini, G., De Leo, A., Santini, D., Perrone, A. M., De Iaco, P., Zamagni, C., Turchetti, D. Tags: Systematic review Source Type: research
Drug-induced hyperammonaemia
Hyperammonaemia (HA) as a consequence of numerous primary or secondary causes, gives rise to clinical manifestations due to its toxic effects on the brain. The neurological consequences broadly reflect the ammonia level, duration and age, with paediatric patients being more susceptible. Drug-induced HA may arise due to either decreased ammonia elimination or increased production. This is associated most frequently with use of valproate and presents a dilemma between ongoing therapeutic need, toxicity and the possibility of an alternative cause. As there is no specific test for drug-induced HA, prompt discussion with a meta...
Source: Journal of Clinical Pathology - July 19, 2023 Category: Pathology Authors: Shakerdi, L., Ryan, A. Tags: Editor's choice, Best practice Source Type: research
Mortality Rates and autopsy findings in fat embolism syndrome complicating sickle cell disease
Fat embolism syndrome is a rare but underdiagnosed complication of sickle cell disease associated with high morbidity and mortality. It affects predominantly patients with a previously mild course of their illness and those of non-SS genotypes while there is possibly an association with infection with human parvovirus B19 (HPV B19). Here, we present the mortality rates and autopsy findings of all reported cases to date. A systematic review has revealed 99 published cases in the world literature with a mortality rate of 46%. Mortality varied greatly according to the time of reported cases with no survivors in the 1940s, 195...
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Samaee, S., Samaee, S., Mihalca, D., Fitzgerald, L., Ahmed, A., Hall, J., Tsitsikas, D. A. Tags: Short report Source Type: research
MMR profile and microsatellite instability status in colorectal mucinous adenocarcinoma with synchronous metastasis: a new clue for the clinical practice
Conclusions
Several methodologies are frequently adopted in routine practice to successfully perform MMR/MSI status analysis. The most relevant issues related to MMR/MSI status analysis in MAs concern with low percentage of neoplastic cell and abundant mucine that may affect the molecular analysis. Thus, it might be useful to acquire both primary and metastatic sample to evaluate the MMR/MSI status by integrating IHC evaluation and molecular methodologies to successfully perform molecular profiling for MA patients. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Parente, P., Malapelle, U., Angerilli, V., Balistreri, M., Lonardi, S., Pucciarelli, S., De Luca, C., Pepe, F., Russo, G., Vigliar, E., Danza, A., Scaramuzzi, F., Troncone, G., Graziano, P., Fassan, M. Tags: Original research Source Type: research
Preference of grade and lymphovascular invasion over invasive size measurement in stage I lung adenocarcinoma
Conclusions
In any invasive size or total tumour size of p-Stage I lung adenocarcinoma, G, L and V are more powerful prognostic factors than the size criteria of p-Stage. Therefore, pathologists should focus on these pathological findings. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Itami, H., Kawaguchi, T., Yoshikawa, D., Watanabe, T., Terada, C., Okada, F., Uchiyama, T., Takeda, M., Ishida, E., Nishimoto, Y., Okada, H., Kushibe, K., Sawabata, N., Ohbayashi, C. Tags: Original research Source Type: research
Compound computer vision workflow for efficient and automated immunohistochemical analysis of whole slide images
Conclusions
We show how innovations in computer vision can be serially compounded to automate and improve implementation in clinical workflows. Generalisation of this approach to other ancillary studies has significant implications for computational pathology. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Lee, M. K. I., Rabindranath, M., Faust, K., Yao, J., Gershon, A., Alsafwani, N., Diamandis, P. Tags: Original research Source Type: research
GATA3 positivity is associated with poor prognosis in patients with oesophageal squamous cell carcinoma
Conclusion
To the best of our knowledge, this is the first study to investigate the incidence of GATA3 positivity in oesophageal SCC and showed GATA3 positivity is associated with poor prognosis in oesophageal SCC. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Chi, Z., Balani, J., Gopal, P., Hammer, S., Xu, J., Peng, L. Tags: Original research Source Type: research
Agreement between L1 and E6/E7-based assays for detection of high-risk HPV in cervical, oropharyngeal and penile cancers
Conclusions
Analysis of the valid results from our data indicates that L1 and E6/E7 targeting assays show similar performance for detection of hrHPV in high grade cervical lesions and cancers of cervix, penis and oropharynx. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Alcaniz Boada, E., Cuschieri, K., Graham, C., Moncur, S., Bhatia, R. Tags: Original research Source Type: research
Unique correlation between GTF2I mutation and spindle cell morphology in thymomas (type A and AB thymomas)
Conclusions
GTF2I mutation appears unique in type A and AB thymomas, including those with atypical features and micronodular type, all of which share spindle cell morphology, indicating they represent a group biologically distinct from type B thymomas. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Wells, K., Lamrca, A., Papaxoinis, G., Wallace, A., Quinn, A. M., Summers, Y., Nonaka, D. Tags: Original research Source Type: research
Coronial postmortem reports and indirect COVID-19 pandemic-related mortality
Conclusions
Postmortem reports have considerable utility in evaluating excess mortality due to healthcare and wider societal disruption during a pandemic. They provide information at an individual case level that is not available from assessment of death certification data. Detailed evaluation of coroners’ autopsy reports, supported by appropriate regulatory oversight, is recommended to mitigate disruption and indirect causes of mortality in future pandemics. Maintaining access to healthcare, including substance misuse and mental health services, is an important consideration. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Pell, R., Suvarna, S. K., Cooper, N., Rutty, G., Green, A., Osborn, M., Johnson, P., Hayward, A., Durno, J., Estrin-Serlui, T., Mafham, M., Roberts, I. S. D. Tags: COVID-19 Original research Source Type: research
Effect of CD274 (PD-L1) overexpression on survival outcomes in 10 specific cancers: a systematic review and meta-analysis
Conclusions
This large meta-analysis suggests that CD274 (PD-L1) overexpression is a potential biomarker for multiple types of cancers. However, further studies are needed to reduce high heterogeneity.
PROSPERO registration number
CRD42022296801. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Park, J. H., Luchini, C., Nottegar, A., Tizaoui, K., Koyanagi, A., Ogino, S., Shin, J. I., Lim, B. J., Smith, L. Tags: Systematic review Source Type: research
Performance and pitfalls of the tools for measuring glomerular filtration rate to guide chronic kidney disease diagnosis and assessment
In conclusion, early identification, risk stratification of kidney disease and timely intervention are important to impact kidney disease progression. However, clinician awareness of the limitations and variability of creatinine, cystatin C and the eGFR equations, is key to appropriate interpretation of results. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Gama, R. M., Griffiths, K., Vincent, R. P., Peters, A. M., Bramham, K. Tags: Best practice Source Type: research
Wilsons disease: best practice
Wilson’s disease is an autosomal recessive disorder arising from pathogenic variants in the Atp7b gene on chromosome 13. The defective translated ATPase copper (Cu) transport protein produced leads to Cu accumulation, initially affecting the liver but eventually affecting other cells. It is just over 20 years since the last Best Practice on this topic in this journal. This review is an update on this, covering new disease biomarkers, pathogenesis, assumptions around clinical features and developments in therapy. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 19, 2023 Category: Pathology Authors: Ryan, A., Twomey, P. J., Cook, P. Tags: Best practice Source Type: research
