Laboratory interpretative comments and guidance: clinical and operative outcomes on moderate to severe hyponatraemia patient management
Conclusions We have demonstrated the reduction in the time for diagnosing and management by physicians, the higher uniformity in the time required to solve hyponatraemia episodes following our laboratory procedure and the clinicians’ satisfaction. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - January 19, 2023 Category: Pathology Authors: Montero-San-Martin, B., Oliver, P., Fernandez-Calle, P., Sanchez-Pascuala Callau, J. J., Diaz Almiron, M., Alcaide Martin, M. J., Fernandez-Puntero, B., Duque Alcorta, M., Valero Recio, J. M., Martin Quiros, A., de Ceano-Vivas la Calle, M., Martin Sanchez Tags: Original research Source Type: research

Prognostic value of proliferation, PD-L1 and nuclear size in patients with superior sulcus tumours treated with chemoradiotherapy and surgery
Conclusions Low proliferative activity determined by MIB-1 as well as a negative PD-L1 expression are significantly associated with better overall survival in patients with residual tumour after CRT for superior sulcus tumour. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - January 19, 2023 Category: Pathology Authors: Blaauwgeers, H., Lissenberg-Witte, B. I., Dickhoff, C., Duin, S., Thunnissen, E. Tags: Original research Source Type: research

Evaluation of the Oncomine Comprehensive Assay v3 panel for the detection of 1p/19q codeletion in oligodendroglial tumours
Conclusions This commercial NGS panel, along with the standard Ion Torrent algorithm, accurately detected 1p/19q losses in ODG samples, obviating the need for specialised custom-made informatic analyses. This can easily be incorporated into routine glioma workflow as an alternative to FISH. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - January 19, 2023 Category: Pathology Authors: Ali, R. H., Alateeqi, M., Jama, H., Alrumaidhi, N., Alqallaf, A., Mohammed, E. M., Almurshed, M., Bahzad, S. Tags: Original research Source Type: research

Adipophilin: roles in physiology and pathology
Adipophilin (ADRP/ADPH/PLIN2), an adipocyte differentiation-related protein, is highly expressed at a very early time during the differentiation of adipocytes. It assists in the formation and maintenance of intracellular lipid droplets and plays a role in regulating the physiological functions of the body. More and more studies indicate that it is involved in the occurrence and development of a variety of glycolipid metabolic diseases and tumours. In this review, we comprehensively stated the expression and functions of adipophilin and introduced its roles in physiology and pathology. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - January 19, 2023 Category: Pathology Authors: Li, F.-Z., Fang, S. Tags: Molecules in pathogenesis Source Type: research

Investigation and monitoring of heavy metal poisoning
Historically, heavy metal measurement and interpretation has been a highly specialised area performed only in a handful of centres within the UK. However, recent years have seen a move to more local testing due to the repatriation of referred work into pathology networks and the increased availability of inductively coupled plasma mass spectrometry technology. While management of significant poisoning is still overseen by tertiary care poisoning specialists, management of milder cases may be undertaken locally. Non-specialist clinical scientists and clinicians need to know when heavy metal testing is appropriate, which sam...
Source: Journal of Clinical Pathology - January 19, 2023 Category: Pathology Authors: Barlow, N. L., Bradberry, S. M. Tags: Best practice Source Type: research

Decline of case reports in pathology and their renewal in the digital age: an analysis of publication trends over four decades
Conclusions CRs publication decreased during the last decade, especially for journals which are older or have higher IF. Social media CRs may represent a valid alternative and by using standardised templates to enter all relevant data may be organised in digital databases and/or transformed in traditional CRs. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - January 19, 2023 Category: Pathology Authors: Cima, L., Pagliuca, F., Torresani, E., Polonia, A., Eloy, C., Dhanasekeran, V., Mannan, R., Gamba Torrez, S., Mirabassi, N., Cassisa, A., Palicelli, A., Barbareschi, M. Tags: Editor's choice Review Source Type: research

Gene of the month: PALB2
The partner and localiser of BRCA2 (PALB2) gene, located on chromosome 16, functions as a tumour suppressor that plays a critical role in homologous recombination repair after DNA double-strand breaks. It encodes proteins involved in the BRCA2 and BRCA1, and RAD51 pathways. Heterozygous germline mutations in PALB2 have been implicated in the development of breast, pancreatic and ovarian cancers. Whereas biallelic mutations of PALB2 have been associated with Fanconi anaaemia. Currently, 604 distinct PALB2 variants have been discovered. However, only 140 variants are thought to be pathogenic and approximately 400 are variant...
Source: Journal of Clinical Pathology - January 19, 2023 Category: Pathology Authors: Hamdan, O., Nowak, K. M. Tags: Gene of the month Source Type: research

Variability of top medicare laboratory prices among 'shoppable service price estimators in the USA
We examined the utility of this executive order by analysing and comparing estimated prices of Medicare’s seven... (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 24, 2022 Category: Pathology Authors: Ghatnekar, S., Faletsky, A., Nambudiri, V. E. Tags: PostScript Source Type: research

Real-world digital pathology: considerations and ruminations of four young pathologists
Digital pathology offers the opportunity to improve all aspects of pathology by introducing recent technical advancements in daily diagnostic practice.1 Its introduction in routine work, especially as part of a fully digitised workflow, allows for the creation of a smoother, traceable and interconnected environment where primary diagnoses can be rendered directly on digital slides.2 Besides its main use as a diagnostic tool, however, digital pathology has a role in enhancing education of trainees and in research activities.3 In this letter, we present the impressions of two pathology residents and two young pathologists af...
Source: Journal of Clinical Pathology - December 24, 2022 Category: Pathology Authors: Caputo, A., Gibilisco, F., Belmonte, B., Mondello, A., L'Imperio, V., Fraggetta, F. Tags: PostScript Source Type: research

Characterising the use of surgical pathology rush requests: a descriptive analysis and survey
This study aimed to characterise priority or ‘rush’ surgical pathology requests and identify potentially targetable factors. We performed a retrospective descriptive analysis of rush requests at our institution from 2016 to 2019 and conducted a survey asking pathologists about their perspectives on rush cases. There were 3677 rush cases, with case characteristics generally stable over the study period. Two categories of requests were identified based on hospital status; outpatient requests more frequently provided a specific date for diagnosis, while inpatient rush requests generally required a diagnosis as soo...
Source: Journal of Clinical Pathology - December 24, 2022 Category: Pathology Authors: Tran, C., Virine, B., Gershon, A., Kwan, K. F., Ettler, H. C. Tags: Short report Source Type: research

Potential pitfalls in multiplex PCR-based next-generation sequencing: a case-based report
In this report, we illustrate three different potential pitfalls related to amplicon-based NGS assays based on our institutional experience and highlight how the risk of such events can be minimised. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 24, 2022 Category: Pathology Authors: Tung, J. K., Devereaux, K. A., Erdmann, A. L., Schrijver, I., Zehnder, J., Suarez, C. J. Tags: Short report Source Type: research

IgG4-related disease: an analysis of the clinicopathological spectrum: UK centre experience
Conclusion Histological diagnosis of IgG4RD remains challenging, as not all characteristic features are always present especially in small biopsies. Due to the novelty of its experience, fear of over diagnosis in the context of malignancy and features overlapping with diseases of similar clinical scenario, diagnosis of IgG4RD has become more puzzling. Further multicentre clinical trials/studies are advisable. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 24, 2022 Category: Pathology Authors: Dassanayaka, W., Liyanaarachchi, K. S., Ala, A., Bagwan, I. N. Tags: Original research Source Type: research

Reference standards for gene fusion molecular assays on cytological samples: an international validation study
Conclusions Reference standards in cytological format yield better results when Pap staining and processed by amplicon-based assays. Further investigation is required to optimise these standards for MGG stained cells and for hybridisation-based approaches. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 24, 2022 Category: Pathology Authors: Malapelle, U., Pepe, F., Pisapia, P., Altimari, A., Bellevicine, C., Brunnström, H., Bruno, R., Büttner, R., Cirnes, L., De Andrea, C. E., de Biase, D., Dumur, C. I., Ericson Lindquist, K., Fontanini, G., Gautiero, E., Gentien, D., Hofman, Tags: Original research Source Type: research

High-risk human papillomavirus (HPV) detection in formalin-fixed paraffin-embedded cervical tissues: performances of Aptima HPV assay and Beckton Dickinson (BD) Onclarity assay
Conclusion Both assays are reliable methods for high-risk HPV detection and genotype determination in FFPE specimens, with high PPV and specificity. The Aptima HPV assay has the advantage of higher sensitivity. As far as we are aware, this is the first study comparing the Aptima HPV assay and the BD Onclarity assay in FFPE tissues. Our study results should be tested and confirmed in larger cohorts. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 24, 2022 Category: Pathology Authors: Kir, G., Gunel, H., Olgun, Z. C., McCluggage, W. G. Tags: Original research Source Type: research

Clinicopathological significance of neutrophil-rich colorectal carcinoma
Conclusions Our findings reveal that high TIN confers poorer patient prognosis in both MMR-proficient and MMR-deficient CRCs. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 24, 2022 Category: Pathology Authors: Rottmann, B. G., Patel, N., Ahmed, M., Deng, Y., Ciarleglio, M., Vyas, M., Jain, D., Zhang, X. Tags: Original research Source Type: research