Multi-gene custom panels for the characterisation of metastatic colorectal carcinoma in clinical practice: express the role of PIK3CA mutations

Conclusions
Our study demonstrates the feasibility and efficacy of lab-developed targeted multi-gene NGS panels in the clinical practice of CRC. Moreover, the data lead to hypothesise that PIK3CA mutations, together with those of RAS/BRAF, worth to be further investigated in clinical CRC specimens.

Source: Journal of Clinical Pathology - June 17, 2022 Category: Pathology Authors: de Biase, D., Malapelle, U., De Leo, A., Maloberti, T., Visani, M., Pisapia, P., Acquaviva, G., Pepe, F., Russo, G., Iaccarino, A., Pession, A., Tallini, G., Troncone, G. Tags: Original research Source Type: research