Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations.
CONCLUSION: Definition of 7 operational standardized terms provides an optimal platform for communication across healthcare providers involved in JIA-TMJ arthritis management. PMID: 30647179 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Stoustrup P, Resnick CM, Pedersen TK, Abramowicz S, Michelotti A, Küseler A, Verna C, Kellenberger CJ, Berit Nordal E, Caserta G, Jankovska I, Halbig JM, Kristensen KD, Arvidsson LZ, Spiegel L, Stoll ML, Lerman M, Glerup M, Defabianis P, Frid P, Alstergr Tags: J Rheumatol Source Type: research

Predictors of Effectiveness of Anakinra in Systemic Juvenile Idiopathic Arthritis.
CONCLUSION: Our findings help to delineate the clinical profile of patients with sJIA who are more likely to benefit from IL-1 blockade. They also underscore the need for studies aimed at examining the therapeutic role of early IL-1 inhibition and to identify biomarkers predicting response to either IL-1 or IL-6 antagonists. PMID: 30647180 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Saccomanno B, Tibaldi J, Minoia F, Bagnasco F, Pistorio A, Guariento A, Caorsi R, Consolaro A, Gattorno M, Ravelli A Tags: J Rheumatol Source Type: research

Variable Clinical Phenotypes and Relation of Interferon Signature with Disease Activity in ADA2 Deficiency.
CONCLUSION: Our data confirm the high variability of DADA2 and suggest type I IS as a biomarker of disease activity. PMID: 30647181 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Insalaco A, Moneta GM, Pardeo M, Caiello I, Messia V, Bracaglia C, Passarelli C, De Benedetti F Tags: J Rheumatol Source Type: research

Predictors of Achieving Remission among Patients with Psoriatic Arthritis Initiating a Tumor Necrosis Factor Inhibitor.
Abstract OBJECTIVE: To examine predictors of remission among patients with psoriatic arthritis (PsA) initiating a tumor necrosis factor (TNF) inhibitor. METHODS: Patients with PsA enrolled in the Corrona Registry between 2005 and 2013 were followed from initiation of a TNF inhibitor (TNFi; etanercept, adalimumab, infliximab, certolizumab, or golimumab) to the visit closest to 12 months. Additional inclusion criteria included 3 tender or 3 swollen joints. Outcomes of interest were Clinical Disease Activity Index (CDAI) ≤ 2.8 (remission), low disease activity (LDA; CDAI ≤ 10), change in the modified Healt...
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Ogdie A, Palmer JL, Greenberg J, Curtis JR, Harrold LR, Solomon DH, Kavanaugh A, Kremer JM, Mease PJ Tags: J Rheumatol Source Type: research

Position Statement: A Pragmatic Approach for Medical Cannabis and Patients with Rheumatic Diseases.
CONCLUSION: Despite lack of evidence for use of medical cannabis in rheumatology patients, we acknowledge the need to provide empathetic and pragmatic guidance for patient care. This position statement aims to facilitate the dialogue between patients and healthcare professionals in a mutually respectful manner to ensure harm reduction for patients and society. PMID: 30647183 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Fitzcharles MA, Zahedi Niaki O, Hauser W, Hazlewood G, the Canadian Rheumatology Association Tags: J Rheumatol Source Type: research

Epidemiologic Profile of Erectile Dysfunction in Patients with Systemic Lupus Erythematosus: The Latin American Landscape.
CONCLUSION: Regardless of comorbidities, treatment (excluding steroids), and type of disease activity, patients with SLE have a high prevalence of ED, especially considering that most patients are young. Recent corticosteroid use and persistent lymphopenia, which could be related to endothelial dysfunction, are risk factors for this complication in men with SLE. PMID: 30647184 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Merayo-Chalico J, Barrera-Vargas A, Morales-Padilla S, Reyna-De la Garza R, Vázquez-Rodríguez R, Campos-Guzmán J, Alcocer-Varela J, Sotomayor M, Abud-Mendoza C, Martínez-Martínez M, Colunga-Pedraza I, Uriarte-Hernández C, Acosta-Hernández R, Fajard Tags: J Rheumatol Source Type: research

The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis.
CONCLUSION: The updated core domain set for hip and/or knee OA has been agreed upon. Work will commence to determine which outcome measurement instrument should be recommended to cover each core domain. PMID: 30647185 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Smith TO, Hawker GA, Hunter DJ, March LM, Boers M, Shea BJ, Christensen R, Guillemin F, Terwee CB, Williamson PR, Dodd S, Roos EM, Loeser RF, Schnitzer TJ, Kloppenburg M, Neogi T, Ladel CH, Kalsi G, Kaiser U, Buttel TW, Ashford AE, Mobasheri A, Arden NK, Tags: J Rheumatol Source Type: research

Association Between Psoriasis with Arthritis and Hearing Impairment in US Adults: Data from the National Health and Nutrition Examination Survey.
CONCLUSION: PsA is independently associated with a significantly increased risk of HI, which partially mediates an association with worsened psychiatric outcomes. PMID: 30647186 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Semenov YR, Hsiang EY, Huang A, Herbosa CM, Hui X, Kwatra SG, Cohen B, Anadkat MJ Tags: J Rheumatol Source Type: research

The Third Biennial 2018 OMERACT First-time Participant Program: A Qualitative and Quantitative Study.
CONCLUSION: The expanded new participant training program is valued by attendees. PMID: 30647187 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Sloan VS, Grosskleg S, Wells G, Singh JA Tags: J Rheumatol Source Type: research

Association of Smoking and Obesity on the Risk of Developing Primary Sj ögren Syndrome: A Population-based Cohort Study.
CONCLUSION: In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association. PMID: 30647188 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Servioli L, Maciel G, Nannini C, Crowson CS, Matteson EL, Cornec D, Berti A Tags: J Rheumatol Source Type: research

Opioid Use in Patients with Ankylosing Spondylitis is Common in the United States: Outcomes of a Retrospective Cohort Study.
CONCLUSION: AS patients receive opioids with concerning frequency. The infrequent prescription of recommended therapies to these patients reflects a need to optimize treatment further through education of patients and healthcare professionals alike. PMID: 30647189 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Sloan VS, Sheahan A, Stark JL, Suruki RY Tags: J Rheumatol Source Type: research

Use of Magnetic Resonance Imaging to Support Dose Selection in a Phase II Trial of Baricitinib Combined with Conventional Synthetic Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis.
CONCLUSION: Using MRI findings in this subgroup of patients suggest suppression of synovitis, osteitis, and combined inflammation by baricitinib 4- and 8-mg, which corroborate previously demonstrated clinical efficacy of baricitinib and increase confidence that baricitinib 4-mg could positively effect reduction of the radiographic progression in Phase III studies. PMID: 30647190 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Peterfy C, DiCarlo J, Emery P, Genovese MC, Keystone EC, Taylor PC, Schlichting DE, Beattie SD, Luchi M, Macias W Tags: J Rheumatol Source Type: research

The OMERACT Emerging Leaders program: The good, the bad and the future.
CONCLUSION: The ELP has the potential to provide targeted training for early career researchers to develop relevant skills for future leadership roles within OMERACT. PMID: 30647191 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Flurey CA, Tugwell PS, Black RJ, Halls S, Page MJ, Robson JC, Sahbudin I, Siddle HJ, Sinnathurai P, Stok KS, Richards B Tags: J Rheumatol Source Type: research

Use of Anakinra in Hospitalized Patients with Crystal-associated Arthritis.
CONCLUSION: This is the largest observational study of anakinra use in the inpatient setting for the acute treatment of crystal-associated arthritis. We observed a rapid response to anakinra, with 75% of episodes significantly improving or completely resolving within four days of the first dose. Our data also support the use of this biologic agent in individuals with infections, as well as perioperative individuals and immunosuppressed transplant recipients. PMID: 30647192 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Liew JW, Gardner GC Tags: J Rheumatol Source Type: research

Too Little of a Good Thing: Hydroxychloroquine in Pregnancy.
PMID: 30600233 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Bermas BL Tags: J Rheumatol Source Type: research

Scleroderma Renal Crisis: Still a Lot To Do.
PMID: 30600234 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Codullo V, Montecucco C Tags: J Rheumatol Source Type: research

The Importance of Patient Input into Development of Outcomes in Idiopathic Inflammatory Myopathy.
PMID: 30600235 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Huber AM Tags: J Rheumatol Source Type: research

Infrapatellar Ganglion Cyst of the Knee Fat Pad in a Child with Juvenile Idiopathic Arthritis.
PMID: 30600236 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Shimizu M, Nakase J, Yachie A Tags: J Rheumatol Source Type: research

Predictive Value of Musculoskeletal Ultrasound for Flares in Juvenile Idiopathic Arthritis.
PMID: 30600237 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Roth J Tags: J Rheumatol Source Type: research

Dr. Zhao, et al, reply.
PMID: 30600238 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Zhao Y, Rascoff NE, Iyer RS, Thapa M, Wallace CA Tags: J Rheumatol Source Type: research

Should aPS/PT Be Incorporated into the Routine Serological Tests in the Diagnosis of Antiphospholipid Syndrome?
PMID: 30600239 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Zhang S, Zhang F, Li Y Tags: J Rheumatol Source Type: research

N. Zohoury replies.
PMID: 30600240 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Zohoury N Tags: J Rheumatol Source Type: research

Do Comorbidities Play a Role in Hand Osteoarthritis Disease Burden? Data from the Hand Osteoarthritis in Secondary Care Cohort.
Authors: PMID: 30600241 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Gamma Delta T Cell Subset V Gamma 2+ Expansion Associated with Longterm Infliximab Treatment in a Patient with Ankylosing Spondylitis [letter].
Authors: PMID: 30600242 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Effect of the Presence of Fibromyalgia on Common Clinical Disease Activity Indices in Patients with Psoriatic Arthritis: A Cross-sectional Study.
Authors: PMID: 30600243 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Relationship Between Increased Fecal Calprotectin Levels and Interstitial Lung Disease in Systemic Sclerosis.
Abstract OBJECTIVE: To evaluate the relationship between fecal calprotectin (FC) and interstitial lung disease (ILD) in systemic sclerosis (SSc). METHODS: The study enrolled 129 outpatients with SSc. Data about disease characteristics, in particular lung involvement, were collected and FC was measured. RESULTS: Patients with ILD (35, 27.1%) had higher values of FC (p
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Caimmi C, Bertoldo E, Venturini A, Caramaschi P, Frulloni L, Ciccocioppo R, Brunelli S, Idolazzi L, Gatti D, Rossini M, Viapiana O Tags: J Rheumatol Source Type: research

Associations of Multiple NOTCH4 Exonic Variants with Systemic Sclerosis.
CONCLUSION: Multiple NOTCH4 exonic variants were associated with SSc and/or SSc subtypes. Several of these variants encode nonsynonymous sequence changes occurring in the NECD, which implicates a potentially functional effect of NOTCH4. PMID: 30442821 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Zhou X, Li H, Guo S, Wang J, Shi C, Espitia M, Guo X, Wang Q, Liu M, Assassi S, Reveille JD, Mayes MD Tags: J Rheumatol Source Type: research

Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with a Veterans Affairs Medical Center.
CONCLUSION: Anakinra is an effective and safe treatment for acute gout and pseudogout in hospitalized patients, particularly in those with comorbidities. PMID: 30442822 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Desmarais J, Chu CQ Tags: J Rheumatol Source Type: research

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study.
Emmi G, Iuliano A, Bauhammer J, Miehle N, Parisi S, Cavagna L, Codullo V, Montecucco C, Lopez-Longo FJ, Martínez-Barrio J, Nieto-González JC, Vichi S, Confalonieri M, Tomietto P, Bergner R, Sulli A, Bonella F, Furini F, Scirè CA, Bortoluzzi A, Specker C, Barsotti S, Neri R, Mosca M, Caproni M, Weinmann-Menke J, Schwarting A, Smith V, Cutolo M, American and European Network of Antisynthetase Syndrome Collaborative Group Abstract OBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical...
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Sebastiani M, Triantafyllias K, Manfredi A, González-Gay MA, Palmou-Fontana N, Cassone G, Drott U, Delbrück C, Rojas-Serrano J, Bertolazzi C, Nuño L, Giannini M, Iannone F, Vicente EF, Castañeda S, Selva-O'Callaghan A, Araguas ET, Emmi G, Iuliano A, B Tags: J Rheumatol Source Type: research

Factors Influencing the Uptake of Canadian Research Findings into the Care of Children with Arthritis: A Healthcare Provider Perspective.
CONCLUSION: We have described a comprehensive overview of the barriers and facilitators perceived by healthcare providers in the translation of knowledge from JIA research into use in clinical practice. These findings provide a foundation for the development of knowledge translation strategies in the care of children with JIA and other rheumatic diseases. PMID: 30442824 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Rose-Davis B, Curran J, Wright J, Cellucci T, Duffy CM, Tucker LB, Batthish M, Huber AM, Lang B, Levy DM, Rumsey DG, Watanabe Duffy KN, Stringer E Tags: J Rheumatol Source Type: research

Hepatic Safety of Febuxostat Compared with Allopurinol in Gout Patients with Fatty Liver Disease.
Abstract OBJECTIVE: Febuxostat has superior renal safety to allopurinol, but data on its hepatic safety are limited. Thus we compared the hepatotoxicity of febuxostat and allopurinol, and the clinical factors associated with hepatotoxicity, in patients with gout and fatty liver disease (FLD). METHODS: We included gout patients treated with allopurinol or febuxostat who were diagnosed with fatty liver based on ultrasonography or computed tomography. Hepatotoxicity was defined as follows: (1) elevation of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) at least 3× the upper limit of normal...
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Lee JS, Won J, Kwon OC, Lee SS, Oh JS, Kim YG, Lee CK, Yoo B, Hong S Tags: J Rheumatol Source Type: research

Fertility and Ovarian Reserve among Women with Rheumatoid Arthritis.
CONCLUSION: AMH was lower in women with RA, but reasons for infertility among women with RA remain unknown. PMID: 30442826 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Eudy AM, McDaniel G, Hurd WW, Clowse MEB Tags: J Rheumatol Source Type: research

Longitudinal Assessment of Patient-reported Outcome Measures in Systemic Sclerosis Patients with Gastroesophageal Reflux Disease - Scleroderma Clinical Trials Consortium.
Abstract OBJECTIVE: Validated gastrointestinal (GI) symptoms scales are used in clinical practice to assess patient-reported GI involvement. We sought to determine whether University of California, Los Angeles (UCLA) GI Tract Questionnaire (GIT) 2.0 Reflux scale, Patient-Reported Outcomes Measurement Information System (PROMIS) Reflux scale, and the Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD) are sensitive to identifying changes in GI symptoms following therapeutic intervention in participants with systemic sclerosis (SSc) and gastroesophageal reflux disease (GERD). METHODS: Participants wi...
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: McMahan ZH, Frech T, Berrocal V, Lim D, Bruni C, Matucci-Cerinic M, Smith V, Melsens K, Proudman S, Zhang J, Mendoza F, Woods M, Khanna D Tags: J Rheumatol Source Type: research

A Comparison of Radiographic Joint Space Width Measurements Versus Ultrasonographic Assessment of Cartilage Thickness in Children with Juvenile Idiopathic Arthritis.
C, Herlin T Abstract OBJECTIVE: Joint space narrowing (JSN) is a measurable outcome of tissue degeneration in arthritis. JSN is usually assessed by conventional radiography. Ultrasonographic (US) measurement of joint cartilage thickness has been validated in healthy children, and US measurement of the distal femoral cartilage has been validated in a group of patients with juvenile idiopathic arthritis (JIA). Our aim was to compare the measures of cartilage thickness of the proximal cartilage site in the second metacarpophalangeal (MCP), second proximal interphalangeal (PIP), and knee joints as assessed by US to jo...
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Pradsgaard DØ, Hørlyck A, Spannow AH, Heuck C, Herlin T Tags: J Rheumatol Source Type: research

An Adult Fatal Case with a STAT1 Gain-of-function Mutation Associated with Multiple Autoimmune Diseases.
Abstract Primary immunodeficiency diseases (PID) are a heterogeneous group of diseases with variable genetic etiologies. Although immunodeficiency is a hallmark of susceptibility to infection, autoimmunity is clearly a prevalent feature. PMID: 30442829 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Maeshima K, Ishii K, Shibata H Tags: J Rheumatol Source Type: research

Uptake and Clinical Utility of Multibiomarker Disease Activity Testing in the United States.
Abstract OBJECTIVE: The clinical utility of the multibiomarker disease activity (MBDA) test for rheumatoid arthritis (RA) management in routine care in the United States has not been thoroughly studied. METHODS: Using 2011-2015 Medicare data, we linked each patient with RA to their MBDA test result. Initiation of a biologic or Janus kinase (JAK) inhibitor in the 6 months following MBDA testing was described. Multivariable adjustment evaluated the likelihood of adding or switching biologic/JAK inhibitor, controlling for potential confounders. For patients with high MBDA scores who added a new RA therapy and we...
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Curtis JR, Xie F, Yang S, Danila MI, Owensby JK, Chen L Tags: J Rheumatol Source Type: research

Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality.
CONCLUSION: Prevalence of RA-ILD increased over time. For patients who could be followed over a 5-year period, healthcare use and costs were somewhat stable over time, but were substantial. RA-ILD is associated with decreased survival. PMID: 30442831 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Raimundo K, Solomon JJ, Olson AL, Kong AM, Cole AL, Fischer A, Swigris JJ Tags: J Rheumatol Source Type: research

JAK2 Specificity and Thrombosis Risk: Potential Role of Antiphospholipid Antibodies.
Abstract Janus kinase (JAK) inhibitors are a relatively new addition to our tools for treatment of rheumatoid arthritis (RA)1 They are responsible for transduction of more than 38 cytokinases2, with diffuse metabolic/immunologic implications. PMID: 30442832 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Rothschild BM Tags: J Rheumatol Source Type: research

Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis.
Abstract OBJECTIVE: To date, "healed/non-healed" and clinical judgment are the only available assessment tools for digital ulcers (DU) in patients with systemic sclerosis (SSc). The aim of our study is to examine a preliminary composite DU clinical assessment score (DUCAS) for SSc for face, content, and construct validity. METHODS: Patients with SSc presenting at least 1 finger DU were enrolled and assessed with the Health Assessment Questionnaire-Disability Index, Cochin scale, visual analog scale (VAS) for DU-related pain, patient global DU status, and global assessment as patient-reported outcome...
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Bruni C, Ngcozana T, Braschi F, Pucci T, Piemonte G, Benelli L, Poli M, Suliman YA, Guiducci S, Bellando-Randone S, Balduzzi S, Grotts J, Denton CP, Rasero L, Montecucco C, Furst DE, Matucci-Cerinic M Tags: J Rheumatol Source Type: research

Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes.
CONCLUSION: With both high and low HCQ levels associated with preterm birth and disease activity in SLE, further study is necessary to understand HCQ disposition throughout pregnancy and to clarify the relationship between drug levels and outcomes. PMID: 30275257 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Balevic SJ, Cohen-Wolkowiez M, Eudy AM, Green TP, Schanberg LE, Clowse MEB Tags: J Rheumatol Source Type: research

Performance of the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis Is Not Superior to the ACC/AHA Risk Calculator.
CONCLUSION: ERS-RA underestimated the risk of a CV event in our cohort of patients, especially when risk estimations were based on patient or physician reports of HTN and hyperlipidemia instead of assessment of BP and blood lipids. The performance of ERS-RA was no better than that of ACC/AHA × 1.5, and neither performed well in high-inflammatory patients. PMID: 30275258 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Wahlin B, Innala L, Magnusson S, Möller B, Smedby T, Rantapää-Dahlqvist S, Wållberg-Jonsson S Tags: J Rheumatol Source Type: research

Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus.
CONCLUSION: An international consensus was reached to identify different proposed homogeneous chronic disorders that fall under the historical term JIA. These preliminary criteria will be formally validated with a dedicated project. PMID: 30275259 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Martini A, Ravelli A, Avcin T, Beresford MW, Burgos-Vargas R, Cuttica R, Ilowite NT, Khubchandani R, Laxer RM, Lovell DJ, Petty RE, Wallace CA, Wulffraat NM, Pistorio A, Ruperto N, Pediatric Rheumatology International Trials Organization (PRINTO) Tags: J Rheumatol Source Type: research

Risk Factors for Mortality and Cardiopulmonary Hospitalization in Systemic Sclerosis Patients At Risk for Pulmonary Hypertension, in the PHAROS Registry.
teen VD Abstract OBJECTIVE: We sought to identify predictors of mortality and cardiopulmonary hospitalizations in patients at risk for pulmonary hypertension (PH) and enrolled in PHAROS, a prospective cohort study to investigate the natural history of PH in systemic sclerosis (SSc). METHODS: The at-risk population for PH was defined by the following entry criteria: echocardiogram systolic pulmonary arterial pressure> 40 mmHg, or DLCO 1.6, measured by pulmonary function testing. Baseline clinical measures were evaluated as predictors of hospitalization and death between 2005 and 2014. Cox proportional hazar...
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Hsu VM, Chung L, Hummers LK, Shah A, Simms R, Bolster M, Hant FN, Silver RM, Fischer A, Hinchcliff ME, Varga J, Goldberg AZ, Derk CT, Schiopu E, Khanna D, Shapiro LS, Domsic RT, Medsger T, Mayes MD, Furst D, Csuka ME, Molitor JA, Saketkoo LA, Salazar CR, Tags: J Rheumatol Source Type: research

Relationship Between Insulin Sensitivity and β-Cell Secretion in Nondiabetic Subjects with Rheumatoid Arthritis.
Relationship Between Insulin Sensitivity and β-Cell Secretion in Nondiabetic Subjects with Rheumatoid Arthritis. J Rheumatol. 2018 Oct 01;: Authors: Tejera-Segura B, López-Mejías R, Vera-González AM, Jiménez-Sosa A, Olmos JM, Hernández JL, Llorca J, González-Gay MA, Ferraz-Amaro I Abstract OBJECTIVE: In nondiabetic healthy individuals, insulin secretion and sensitivity are linked by a negative feedback loop characterized by a hyperbolic function. We aimed to study the association of traditional insulin resistance (IR) factors with insulin secretion and se...
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Tejera-Segura B, López-Mejías R, Vera-González AM, Jiménez-Sosa A, Olmos JM, Hernández JL, Llorca J, González-Gay MA, Ferraz-Amaro I Tags: J Rheumatol Source Type: research

Biologic and Glucocorticoid Use after Methotrexate Initiation in Patients with Rheumatoid Arthritis.
Abstract OBJECTIVE: Biologic therapies can improve disease control for patients with rheumatoid arthritis (RA) but may be both overused and underused. We aimed to identify predictors of greater use of biologic therapies and to identify factors associated with persistent glucocorticoid use. METHODS: Using national US Veteran's Affairs databases 2005-2016, we identified patients with RA receiving a first-ever prescription of methotrexate (MTX), requiring ≥ 6 months of baseline data. We evaluated predictors of biologic therapy initiation within 2 years of starting MTX and factors associated with baseline and ...
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: George MD, Sauer BC, Teng CC, Cannon GW, England BR, Kerr GS, Mikuls TR, Baker JF Tags: J Rheumatol Source Type: research

Quadriceps Weakness and the Risk of Knee Cartilage Loss Seen on Magnetic Resonance Imaging in a Population-based Cohort with Knee Pain.
CONCLUSION: In this symptomatic, population-based cohort, quadriceps weakness predicted whole knee and medial TF cartilage loss after 3 years. To our knowledge, this is the first study to show that a simple clinical examination of quadriceps strength can predict the risk of knee cartilage loss. PMID: 30275263 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Chin C, Sayre EC, Guermazi A, Nicolaou S, Esdaile JM, Kopec J, Thorne A, Singer J, Wong H, Cibere J Tags: J Rheumatol Source Type: research

Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis.
CONCLUSION: The preliminary evidence suggests that sirolimus may serve as an alternative treatment for patients with LN who do not tolerate standard treatment or who had a history of malignancy, and it has an acceptable longterm safety profile. PMID: 30275264 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Yap DYH, Tang C, Chan GCW, Kwan LPY, Ma MKM, Mok MMY, Chan TM Tags: J Rheumatol Source Type: research

Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis.
Abstract OBJECTIVE: Forced vital capacity (FVC) and DLCO are used for screening of systemic sclerosis-associated interstitial lung disease (SSc-ILD). The study purpose was to determine the sensitivity, specificity, and negative predictive value (NPV) (proportion of true negative screening tests) of FVC and DLCO thresholds for SSc-ILD on chest high-resolution computed tomography (HRCT) scans. METHODS: Patients fulfilling American College of Rheumatology 2013 SSc criteria with a chest HRCT scan and pulmonary function tests (PFT) were studied. A thoracic radiologist quantified radiographic ILD. Optimal FVC and D...
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Showalter K, Hoffmann A, Rouleau G, Aaby D, Lee J, Richardson C, Dematte J, Agrawal R, Chang RW, Hinchcliff M Tags: J Rheumatol Source Type: research

What Is Most Important in Rheumatoid Arthritis Treatment - Where You Are, Who You Are, or Where You Are Going?
PMID: 30275339 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: England BR Tags: J Rheumatol Source Type: research

Crowned Dens Syndrome: Calcium Pyrophosphate Deposition Disease Masquerading as Osteomyelitis.
PMID: 30275340 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Heck A, Nolan N, Rojas-Moreno C Tags: J Rheumatol Source Type: research