Assessing Elementary Lesions in Gout by Ultrasound: Results of an OMERACT Patient-based Agreement and Reliability Exercise.
Authors: PMID: 28042133 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor- β1 toward Fibroblast-like Synovial Cells.
Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells. J Rheumatol. 2017 Jan;44(1):131 Authors: PMID: 28042134 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Developing a Risk-scoring Model for Ankylosing Spondylitis Based on a Combination of HLA-B27, Single-nucleotide Polymorphism, and Copy Number Variant Markers.
Authors: PMID: 28042135 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Five-year Efficacy and Safety of Tocilizumab Monotherapy in Patients with Rheumatoid Arthritis Who Were Methotrexate- and Biologic-naive or Free of Methotrexate for 6 Months: the AMBITION Study.
CONCLUSION: Longterm monotherapy with TCZ demonstrated continuing efficacy and safety. PMID: 27909081 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Jones G, Wallace T, McIntosh MJ, Brockwell L, Gómez-Reino JJ, Sebba A Tags: J Rheumatol Source Type: research

Proteomic Investigation of Dermal Fibroblasts Isolated from Affected and Unaffected Skin Samples from Patients with Limited Cutaneous Systemic Sclerosis: 2 Distinct Entities?
CONCLUSION: Consistent with previous studies, these findings are important for 2 reasons: first, because they reveal the opposite behavior of dermal fibroblasts in the unaffected and affected skin areas of the same patient with lcSSc; second, because they demonstrate the histological/histochemical similarities between unaffected skin from patients with lcSSc and healthy control skin. PMID: 27909082 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Corallo C, Santucci A, Bernardini G, Figura N, Leoncini R, Riolo G, Montella A, Chirico C, Nuti R, Giordano N Tags: J Rheumatol Source Type: research

Continual Maintenance of Remission Defined by the ACR/EULAR Criteria in Daily Practice Leads to Better Functional Outcomes in Patients with Rheumatoid Arthritis.
CONCLUSION: Continual fulfillment of any remission criteria was strongly effective in preventing patients from progression of functional disability; however, the ACR/EULAR criteria appear to be preferable. PMID: 27909083 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Shidara K, Nakajima A, Inoue E, Hoshi D, Sugimoto N, Seto Y, Tanaka E, Momohara S, Taniguchi A, Yamanaka H Tags: J Rheumatol Source Type: research

Sustained Benefits of Exercise-based Motivational Interviewing, but Only among Nonusers of Opioids in Patients with Fibromyalgia.
CONCLUSION: Exercise-based MI was associated with sustained clinical benefits 6 months after completion of therapy, but only for those who were not taking opioids. PMID: 27909084 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Kim S, Slaven JE, Ang DC Tags: J Rheumatol Source Type: research

A Negative Antinuclear Antibody Does Not Indicate Autoantibody Negativity in Myositis: Role of Anticytoplasmic Antibody as a Screening Test for Antisynthetase Syndrome.
Abstract OBJECTIVE: To evaluate the utility of anticytoplasmic autoantibody (anti-CytAb) in antisynthetase antibody-positive (anti-SynAb+) patients. METHODS: Anti-SynAb+ patients were evaluated for antinuclear antibody (ANA) and anti-CytAb [cytoplasmic staining on indirect immunofluorescence (IIF)] positivity. Anti-SynAb+ patients included those possessing anti-Jo1 and other antisynthetase autoantibodies. Control groups included scleroderma, systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis, and healthy subjects. Sensitivity, specificity, positive predictive value (PPV), negative predi...
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Aggarwal R, Dhillon N, Fertig N, Koontz D, Qi Z, Oddis CV Tags: J Rheumatol Source Type: research

The 12-item Psoriatic Arthritis Impact of Disease Questionnaire: Construct Validity, Reliability, and Interpretability in a Clinical Setting.
Abstract OBJECTIVE: To study, in a real-life setting, the construct validity, the reliability, and the interpretability of the 12-item Psoriatic Arthritis Impact of Disease (PsAID-12) questionnaire in patients with psoriatic arthritis (PsA). METHODS: In 144 consecutive patients with PsA (81 men and 63 women, mean age of 51.4 ± 12.8 yrs, and 77 receiving biologic treatment), the PsAID-12 and other patient-reported outcomes (PRO) were collected, such as the Dermatology Life Quality Index. Each patient underwent articular and skin assessment. RESULTS: Construct validity: Factor analysis revealed a 2-...
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Di Carlo M, Becciolini A, Lato V, Crotti C, Favalli EG, Salaffi F Tags: J Rheumatol Source Type: research

Construct Validity of Radiographs of the Feet to Assess Joint Damage in Patients with Gout.
CONCLUSION: Our results support construct validity for radiographs of the feet when assessing joint damage in gout. PMID: 27909088 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Spaetgens B, van Durme C, Webers C, Tran-Duy A, Schoonbrood T, Boonen A Tags: J Rheumatol Source Type: research

Willie Sutton Was Right: It's Time to Turn to the Synovium to Drive Rheumatoid Arthritis Therapy.
PMID: 27909137 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Ruderman EM, Mandelin AM, Perlman HR Tags: J Rheumatol Source Type: research

Causes of Cardiovascular Ischemic Events in Giant Cell Arteritis.
PMID: 27909138 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Richter JG, Sander O, Schneider M Tags: J Rheumatol Source Type: research

Safety and Efficacy of SBI-087, a Subcutaneous Agent for B Cell Depletion, in Patients with Active Rheumatoid Arthritis: Results from a Phase II Randomized, Double-blind, Placebo-controlled Study.
CONCLUSION: SBI-087 effectively depleted peripheral CD20 B cells and was well tolerated. Improvements were consistently observed in the SBI/SBI/SBI group for the majority of efficacy and quality-of-life outcomes. PMID: 27909139 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Damjanov N, Tlustochowicz M, Aelion J, Greenwald M, Diehl A, Bhattacharya I, Peeva E, Menon S, Gourley I Tags: J Rheumatol Source Type: research

Longterm Work Productivity Costs Due to Absenteeism and Permanent Work Disability in Patients with Early Rheumatoid Arthritis: A Nationwide Register Study of 7831 Patients.
CONCLUSION: The longterm PC increased significantly in parallel with years elapsing after RA diagnosis. Further, the majority of these PC are incurred by a small proportion of patients. PMID: 27909140 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Martikainen JA, Kautiainen H, Rantalaiho V, Puolakka KT Tags: J Rheumatol Source Type: research

Developing a Risk-scoring Model for Ankylosing Spondylitis Based on a Combination of HLA-B27, Single-nucleotide Polymorphism, and Copy Number Variant Markers.
CONCLUSION: Our AS-GRS could be used to identify individuals at high risk for AS before major symptoms appear, which may improve the prognosis for them through early treatment. PMID: 27909141 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Jung SH, Cho SM, Yim SH, Kim SH, Park HC, Cho ML, Shim SC, Kim TH, Park SH, Chung YJ Tags: J Rheumatol Source Type: research

Disease Activity and Increased Risk of Cardiovascular Death among Patients with Psoriatic Arthritis.
nius GM Abstract OBJECTIVE: Recent studies indicate increased cardiovascular (CV) morbidity and mortality in patients with psoriatic arthritis (PsA), but results are inconsistent. This prompted our investigation of the mortality rate, cause of death, and incidence of acute CV events in patients from northern Sweden with PsA. METHODS: Patients with established PsA (464) were included. To calculate standardized mortality ratio (SMR) and standardized incidence ratio (SIR) for CV events, data were extracted from the National Causes of Death Register and the National Inpatient Care Register in Sweden, and compared...
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Juneblad K, Rantapää-Dahlqvist S, Alenius GM Tags: J Rheumatol Source Type: research

Interobserver and Intraobserver Reliability of Clinical Assessments in Knee Osteoarthritis.
CONCLUSION: Among individuals with symptomatic knee OA, the reliability of clinical examination of the knee was at least good for the majority of clinical signs of knee OA. PMID: 27909143 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Maricar N, Callaghan MJ, Parkes MJ, Felson DT, O'Neill TW Tags: J Rheumatol Source Type: research

Bone Area Provides a Responsive Outcome Measure for Bone Changes in Short-term Knee Osteoarthritis Studies.
CONCLUSION: In this small cohort at high risk of OA progression, bone area changed at 3 and 6 months when cartilage morphometric measures did not. PMID: 27909144 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Bowes MA, Maciewicz RA, Waterton JC, Hunter DJ, Conaghan PG Tags: J Rheumatol Source Type: research

Perianal Crohn Disease after Treatment with Rituximab for Active Granulomatosis with Polyangiitis.
PMID: 27909145 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Fraser D, Boyle S, Amft N Tags: J Rheumatol Source Type: research

Dr. Elsaman, et al reply.
PMID: 27909146 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Elsaman A, Radwan A, Mohammed W, Ohrndorf S Tags: J Rheumatol Source Type: research

Reduction of Knee Pain by Effusion Reduction.
PMID: 27909147 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Authors: Rothschild B Tags: J Rheumatol Source Type: research

Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High-resolution Peripheral Quantitative Computed Tomography.
Authors: PMID: 27909148 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Tags: J Rheumatol Source Type: research

Reviewer Index.
Authors: PMID: 27909149 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - December 1, 2016 Category: Rheumatology Tags: J Rheumatol Source Type: research

Developing an OMERACT Core Outcome Set for Assessing Safety Components in Rheumatology Trials: The OMERACT Safety Working Group.
CONCLUSION: The OMERACT Safety Working Group will advance the work previously done within OMERACT using a new patient-driven approach. PMID: 27744393 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2016 Category: Rheumatology Authors: Klokker L, Tugwell P, Furst DE, Devoe D, Williamson P, Terwee CB, Suarez-Almazor ME, Strand V, Woodworth T, Leong AL, Goel N, Boers M, Brooks PM, Simon LS, Christensen R Tags: J Rheumatol Source Type: research

Risk of Diabetes Mellitus among Patients Diagnosed with Giant Cell Arteritis or Granulomatosis with Polyangiitis: Comparison with the General Population.
CONCLUSION: Patients diagnosed with GCA or GPA have a markedly increased risk of new-onset DM during early treatment phases. PMID: 27744394 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2016 Category: Rheumatology Authors: Faurschou M, Ahlström MG, Lindhardsen J, Obel N, Baslund B Tags: J Rheumatol Source Type: research

Rheumatoid Arthritis and Coronary Artery Disease: Genetic Analyses Do Not Support a Causal Relation.
um Abstract OBJECTIVE: Inflammatory diseases, specifically rheumatoid arthritis (RA), are assumed to increase the risk of coronary artery disease (CAD). More recently, multiple single-nucleotide polymorphisms (SNP) associated with RA risk were identified. If causal mechanisms affecting risks of RA and CAD are overlapping, risk alleles for RA might also increase the risk of CAD. METHODS: Sixty-one SNP associating with RA in genome-wide significant analyses were tested for association with CAD in CARDIoGRAM (Coronary ARtery DIsease Genome wide Replication and Meta-analysis), a metaanalysis including genome-wid...
Source: J Rheumatol - October 15, 2016 Category: Rheumatology Authors: Jansen H, Willenborg C, Lieb W, Zeng L, Ferrario PG, Loley C, König IR, Erdmann J, Samani NJ, Schunkert H, the CARDIoGRAM Consortium Tags: J Rheumatol Source Type: research

Quantification of Bone Marrow Edema by Magnetic Resonance Imaging Only Marginally Reflects Clinical Neck Pain Evaluation in Rheumatoid Arthritis and Ankylosing Spondylitis.
CONCLUSION: In this small study of patients with RA and AS complaining about neck pain, BME was found in many different cervical sites, including the facet joints and the spinous processes. However, the occurrence and severity of BME did not correlate with the severity of neck pain. PMID: 27744396 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2016 Category: Rheumatology Authors: Baraliakos X, Heldmann F, Callhoff J, Suppiah R, McQueen FM, Krause D, Klink C, Schmitz-Bortz E, Igelmann M, Kalthoff L, Kiltz U, Schmuedderich A, Braun J Tags: J Rheumatol Source Type: research

Limited Reliability of Radiographic Assessment of Sacroiliac Joints in Patients with Suspected Early Spondyloarthritis.
CONCLUSION: Reproducibility of radiographic SIJ classification in an SpA inception cohort was only fair to at best moderate among 7 readers with varying levels of experience, questioning the applicability of mNY in early SpA. PMID: 27744397 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2016 Category: Rheumatology Authors: Christiansen AA, Hendricks O, Kuettel D, Hørslev-Petersen K, Jurik AG, Nielsen S, Rufibach K, Loft AG, Pedersen SJ, Hermansen LT, Østergaard M, Arnbak B, Manniche C, Weber U Tags: J Rheumatol Source Type: research

Prevalence of Systemic Sclerosis in Primary Biliary Cholangitis Using the New ACR/EULAR Classification Criteria.
CONCLUSION: Our data show a high prevalence of SSc in patients with PBC with probable underestimation by previous studies using the original ACR criteria. Comorbid SSc should be actively searched for based on newly described criteria to improve detection and increase benefits of earlier treatment. PMID: 27744398 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2016 Category: Rheumatology Authors: Zheng B, Vincent C, Fritzler MJ, Senécal JL, Koenig M, Joyal F Tags: J Rheumatol Source Type: research

Success Rate and Utility of Ultrasound-guided Synovial Biopsies in Clinical Practice.
CONCLUSION: US-guided synovial biopsies in clinical practice can be performed safely on patients with undifferentiated arthritis and with heterogeneous presentations. The rate of success in acquiring synovial tissue is high. The procedure usually retrieves quality tissue and leads to a definite diagnosis in a significant minority of patients. PMID: 27744399 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 15, 2016 Category: Rheumatology Authors: Najm A, Orr C, Heymann MF, Bart G, Veale DJ, Le Goff B Tags: J Rheumatol Source Type: research

Effects of Longterm Treatment with Bosentan and Iloprost on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion, and Clinical Status in Systemic Sclerosis.
CONCLUSION: The study shows in patients with SSc with up to 4 years of combined therapy a progressive significant recovery in structure and function of microvasculature linked to improved clinical outcomes, independent of disease severity. PMID: 27744392 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2016 Category: Rheumatology Authors: Trombetta AC, Pizzorni C, Ruaro B, Paolino S, Sulli A, Smith V, Cutolo M Tags: J Rheumatol Source Type: research

Fibromyalgia in Spondyloarthritis: Effect on Disease Activity Assessment in Clinical Practice.
CONCLUSION: FM is a frequent comorbidity in patients with SpA, especially in peripheral forms. In patients with SpA-FM, disease activity may be overestimated when measured by BASDAI and to a lesser extent by ASDAS-CRP, and this overestimation could lead to inappropriate treatment escalation. PMID: 27633820 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - September 15, 2016 Category: Rheumatology Authors: Wach J, Letroublon MC, Coury F, Tebib JG Tags: J Rheumatol Source Type: research

Evidence for Tocilizumab as a Treatment Option in Refractory Uveitis Associated with Juvenile Idiopathic Arthritis.
CONCLUSION: TCZ appears to represent a therapeutic option for severe JIA-associated uveitis that has been refractory to MTX and TNF-α inhibitors in selected patients. The present data indicate that inflammatory macular edema responds well to TCZ in patients with JIA-associated uveitis. PMID: 27633821 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - September 15, 2016 Category: Rheumatology Authors: Tappeiner C, Mesquida M, Adán A, Anton J, Ramanan AV, Carreno E, Mackensen F, Kotaniemi K, de Boer JH, Bou R, de Vicuña CG, Heiligenhaus A Tags: J Rheumatol Source Type: research

Intratracheal Dilation-injection Technique in the Treatment of Granulomatosis with Polyangiitis Patients with Subglottic Stenosis.
CONCLUSION: SGS often occurs independently of other features of active GPA. IDIT is a safe and effective technique in the treatment of GPA-related SGS. It should be performed in all patients with GPA who develop significant SGS and in those with multiorgan disease concomitantly with IST. In patients with isolated SGS, IDIT also makes IST and tracheostomy unnecessary. PMID: 27633822 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - September 15, 2016 Category: Rheumatology Authors: Fijolek J, Wiatr E, Gawryluk D, Martusewicz-Boros MM, Orlowski TM, Dziedzic D, Polubiec-Kownacka M, Oniszh K, Langfort R, Roszkowski-Sliz K Tags: J Rheumatol Source Type: research

Toward Electronic Health Recording: Evaluation of Electronic Patient-reported Outcome Measures System for Remote Monitoring of Early Rheumatoid Arthritis.
Abstract OBJECTIVE: To assess the use of electronic patient-reported outcome measures (ePROM) in standard clinical practice for early rheumatoid arthritis (RA) management, the ePROM ability to enhance clinical care, and how computing technology can improve the patients' adherence to therapy. METHODS: In a double-blinded randomized-controlled study, 211 patients with early RA diagnosed according to American College of Rheumatology/European League Against Rheumatism criteria completed a PROM in paper format at their first clinic visit. Patients were then randomized to Group 1, which completed an ePROM questionn...
Source: J Rheumatol - September 15, 2016 Category: Rheumatology Authors: El Miedany Y, El Gaafary M, Youssef S, Bahlas S, Almedany S, Ahmed I, Palmer D Tags: J Rheumatol Source Type: research

Beta2-glycoprotein I Expression in Lupus Nephritis Patients with Antiphospholipid-associated Nephropathy.
The objectives of this study were to investigate whether β2GPI expression was involved in patients with LN with aPLN and to determine its specificity. METHODS: We retrospectively investigated β2GPI expression in 231 renal biopsy specimens of patients with LN. Data from biopsy reports and clinical information were collected. Immunohistochemical staining for β2GPI expression was performed. RESULTS: Histological aPLN was detected in 88 patients with LN (38.1%). The LN with aPLN consisted of 43 patients (18.6%). Expression of β2GPI was detected in endothelial cells in 14 (32.6%) in renal arteries ...
Source: J Rheumatol - September 15, 2016 Category: Rheumatology Authors: Gao R, Yu W, Wen Y, Li H Tags: J Rheumatol Source Type: research

Incidence of Malignancies in a Cohort of Psoriatic Arthritis Patients Taking Traditional Disease Modifying Antirheumatic Drug and Tumor Necrosis Factor Inhibitor Therapy: An Observational Study.
CONCLUSION: Data from this study confirm that biological therapies do not lead to any increased risk for cancer development, when adequately administered and with proper followup. PMID: 27633825 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - September 15, 2016 Category: Rheumatology Authors: Costa L, Caso F, Del Puente A, Di Minno MN, Peluso R, Scarpa R Tags: J Rheumatol Source Type: research

Comparable Efficacy of Abatacept Used as First-line or Second-line Biological Agent for Severe Juvenile Idiopathic Arthritis-related Uveitis.
CONCLUSION: ABA, used as first-line biological treatment or after 1 or more anti-TNF agents, induces a comparable improvement in severe refractory JIA-related uveitis. PMID: 27633826 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - September 15, 2016 Category: Rheumatology Authors: Birolo C, Zannin ME, Arsenyeva S, Cimaz R, Miserocchi E, Dubko M, Deslandre CJ, Falcini F, Alessio M, La Torre F, Denisova E, Martini G, Nikishina I, Zulian F Tags: J Rheumatol Source Type: research

Health State Utilities and Disease Duration in Systemic Sclerosis: Is There an Association?
The objective of this study was to examine the association between disease duration and direct HSUV scores in patients with systemic sclerosis (SSc). METHODS: Our study included patients with SSc from a US SSc center. An interviewer administered direct HSUV techniques including the visual analog scale (VAS), time tradeoff (TTO), and standard gamble (SG). We calculated the Short Form 6D HSUV from the Medical Outcomes Study Short Form-36. Additional clinical and demographic variables were collected. RESULTS: The mean age of the SSc sample (n = 223) was 51 years (SD 16) with the majority being women (84%). Median di...
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Raymakers AJ, Tsao NW, Marra CA, Clements PJ, Khanna D Tags: J Rheumatol Source Type: research

Usefulness of IgA Anti- α-fodrin Antibodies in Combination with Rheumatoid Factor and/or Antinuclear Antibodies as Substitute Immunological Criterion in Sjögren Syndrome with Negative Anti-SSA/SSB Antibodies.
CONCLUSION: The combination AFA + RF, AFA + ANA> 1:320, or at least 2 out of 3, performed well as a proxy immunological test for patients with SS and negative Ro/La serology. PMID: 27481899 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Hernández-Molina G, Nuñez-Alvarez C, Avila-Casado C, Llorente L, Hernández-Hernández C, Calderillo ML, Marroquín V, Recillas-Gispert C, Romero-Díaz J, Sánchez-Guerrero J Tags: J Rheumatol Source Type: research

Effectiveness of Tumor Necrosis Factor Inhibitors in Combination with Various csDMARD in the Treatment of Rheumatoid Arthritis: Data from the DREAM Registry.
Abstract OBJECTIVE: To analyze and compare the effectiveness and drug survival in patients with rheumatoid arthritis, as measured by 28-joint Disease Activity Score (DAS28) and Health Assessment Questionnaire-Disability Index (HAQ-DI), of tumor necrosis factor inhibitor (TNFi) monotherapy, TNFi + leflunomide (LEF), TNFi + sulfasalazine (SSZ), TNFi + other conventional synthetic disease-modifying antirheumatic drugs (csDMARD), and TNFi + methotrexate (MTX) therapy, in daily practice. METHODS: Data were collected from the DREAM registry. Patients beginning their first TNFi treatment were included in the study: ...
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Manders SH, Kievit W, Jansen TL, Stolk JN, Visser H, Schilder AM, Vonkeman HE, Adang E, van de Laar MA, van Riel PL Tags: J Rheumatol Source Type: research

Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium.
CONCLUSION: Predominantly mediated by M1-like macrophages, the alarmin S100A9 stimulates the production of proinflammatory and catabolic mediators and activates canonical Wnt signaling in OA synovium. PMID: 27481901 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: van den Bosch MH, Blom AB, Schelbergen RF, Koenders MI, van de Loo FA, van den Berg WB, Vogl T, Roth J, van der Kraan PM, van Lent PL Tags: J Rheumatol Source Type: research

Ethnic Differences in Autoantibody Diversity and Hierarchy: More Clues from a US Cohort of Patients with Systemic Sclerosis.
Abstract OBJECTIVE: To determine the autoantibody repertoire and clinical associations in a multiethnic cohort of American patients with systemic sclerosis (SSc). METHODS: There were 1000 patients with SSc (196 Hispanic, 228 African American, 555 white, and 21 other) who were screened for antinuclear antibodies (ANA), including anticentromere antibodies (ACA) by indirect immunofluorescence assay, antitopoisomerase-1 (topo-1/Scl-70) by immunodiffusion, and anti-RNA polymerase III (RNAP III) by ELISA. Sera from 160 patients with mainly nucleolar and/or speckled ANA pattern, but negative for ACA, Scl-70, and RNA...
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Nandiwada SL, Peterson LK, Mayes MD, Jaskowski TD, Malmberg E, Assassi S, Satoh M, Tebo AE Tags: J Rheumatol Source Type: research

Association Between Dietary Intake of Antioxidants and Prevalence of Femoral Head Cartilage Defects and Bone Marrow Lesions in Community-based Adults.
CONCLUSION: Higher carotenoids intake and vegetable consumption were associated with reduced risk of hip cartilage defects and BML, and higher Vitamin E intake was associated with reduced risk of hip cartilage defects. These findings suggest a beneficial effect of dietary antioxidants on hip joint health. Although our findings need to be confirmed in other longitudinal studies, they suggest that the modification of dietary antioxidant intake may be a strategy for the prevention of hip OA. PMID: 27481903 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Wang Y, Smith S, Teichtahl AJ, Hodge AM, Wluka AE, Giles GG, Cicuttini FM Tags: J Rheumatol Source Type: research

Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden.
d J Abstract OBJECTIVE: To compare clinical characteristics and treatment between simultaneously investigated Sudanese and Swedish outpatients with rheumatoid arthritis (RA). METHODS: Outpatients with RA from Sudan (n = 281) and Sweden (n = 542) diagnosed according to the 1987 American College of Rheumatology criteria were recruited between December 2008 and September 2010 and compared concerning clinical presentation, treatment, and laboratory findings, including immunoglobulin M with rheumatoid factor (IgM-RF). RESULTS: Sudanese patients had lower inclusion age (median 49 vs 68 yrs), disease duration (...
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Elshafie AI, Elkhalifa AD, Elbagir S, Aledrissy MI, Elagib EM, Nur MA, Weitoft T, Rönnelid J Tags: J Rheumatol Source Type: research

Ability of a Urine Assay of Type II Collagen Cleavage by Collagenases to Detect Early Onset and Progression of Articular Cartilage Degeneration: Results from a Population-based Cohort Study.
Abstract OBJECTIVE: To evaluate the association of a sandwich assay for cartilage collagenase-mediated degradation, the C2C human urine sandwich assay (IB-C2C-HUSA), with early and late knee cartilage pathology and with progression of cartilage damage. METHODS: A population-based cohort with knee pain, age 40-79 years, was evaluated at baseline (n = 253) and after mean 3.3 years (n = 161). We evaluated the IB-C2C-HUSA and a related competitive inhibition assay (C2C). The C2C assay was applied to serum (sC2C) and urine (uC2C). Based on knee radiographs and magnetic resonance imaging (MRI), 3 subgroups [no cart...
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Poole AR, Ha N, Bourdon S, Sayre EC, Guermazi A, Cibere J Tags: J Rheumatol Source Type: research

The Responsiveness of the Modified Childhood Health Assessment Questionnaire.
CONCLUSION: The VASCHAQ was moderately more responsive than the CHAQ-30 and CHAQ-38 in both parent and patient groups and should be considered for use in studies evaluating change in function over time. PMID: 27481906 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Peters S, Ota S, Bolous E, Reich E, Chait S, Feldman BM Tags: J Rheumatol Source Type: research

Elevated Serum Krebs von den Lungen-6 in Early Disease Predicts Subsequent Deterioration of Pulmonary Function in Patients with Systemic Sclerosis and Interstitial Lung Disease.
Abstract OBJECTIVE: To identify predictors of poor prognosis in patients with systemic sclerosis (SSc) associated with interstitial lung disease (ILD). METHODS: Fifty patients with early-stage SSc-ILD who had never received disease-modifying drugs and were either observed for ≥ 10 years or died from ILD-related causes were enrolled. The baseline variables of patients who developed endstage lung disease (ESLD) were compared with those of patients who remained ESLD-free, and the Cox proportional hazard model was used to identify initial factors that correlated with ESLD development. RESULTS: Sixteen pat...
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Kuwana M, Shirai Y, Takeuchi T Tags: J Rheumatol Source Type: research

Gaps in Addressing Cardiovascular Risk in Rheumatoid Arthritis: Assessing Performance using Cardiovascular Quality Indicators.
This study sought to determine the performance of 11 recently developed CVD quality indicators (QI) for RA in clinical practice. METHODS: Medical charts for patients with RA (early disease or biologic-treated) followed at 1 center were retrospectively reviewed. A systematic assessment of adherence to 11 QI over a 2-year period was completed. Performance on the QI was reported as a percentage pass rate. RESULTS: There were 170 charts reviewed (107 early disease and 63 biologic-treated). The most frequent CVD risk factors present at diagnosis (early disease) and biologic start (biologic-treated) included hypertensi...
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Barber CE, Esdaile JM, Martin LO, Faris P, Barnabe C, Guo S, Lopatina E, Marshall DA Tags: J Rheumatol Source Type: research

The Use of Neck Support Pillows and Postural Exercises in the Management of Chronic Neck Pain.
CONCLUSION: These interventions could be beneficial in reducing neck pain symptoms. PMID: 27481909 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2016 Category: Rheumatology Authors: Jamal AN, Feldman BM, Pullenayegum E Tags: J Rheumatol Source Type: research