The Framingham Score and the Systematic Coronary Risk Evaluation at Low Cutoff Values Are Useful Surrogate Markers of High-risk Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis.
CONCLUSION: The Framingham score and SCORE at markedly low cutoff values of 7.3% to 10.8% and 0.5% to 1.5%, respectively, can usefully estimate plaque presence in RA. Effective population-specific CVD risk assessment strategies are needed in black African patients with RA. PMID: 26773110 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Dessein PH, Corrales A, Lopez-Mejias R, Solomon A, Woodiwiss AJ, Llorca J, Norton GR, Genre F, Blanco R, Pina T, Gonzalez-Juanatey C, Tsang L, Gonzalez-Gay MA Tags: J Rheumatol Source Type: research

Incremental Costs for Psoriasis and Psoriatic Arthritis in a Population-based Cohort in Southern Sweden: Is It All Psoriasis-attributable Morbidity?
CONCLUSION: Annual mean incremental societal cost per patient was highest for PsA, mainly because of productivity losses and biological treatment. A minor fraction of the costs were identified as attributable to PsO/PsA specifically, indicating an increased morbidity in these patients that needs to be further investigated. PMID: 26773111 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Löfvendahl S, Petersson IF, Theander E, Svensson Å, Zhou C, Steen Carlsson K Tags: J Rheumatol Source Type: research

Physical and Mental Functioning in Patients with Established Rheumatoid Arthritis over an 11-year Followup Period: The Role of Specific Comorbidities.
Abstract OBJECTIVE: To investigate the longterm association of a wide range of comorbidities with physical and mental functioning in patients with rheumatoid arthritis (RA). METHODS: Longitudinal data over a period of 11 years were collected from 882 patients with RA. Somatic comorbidity and comorbid depression were measured at baseline, with a questionnaire including 20 chronic diseases and with the Center for Epidemiologic Depression Scale, respectively. Physical functioning was measured at 5 timepoints with a disease-specific measure [Health Assessment Questionnaire (HAQ)] and a generic measure [physical s...
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: van den Hoek J, Roorda LD, Boshuizen HC, Tijhuis GJ, van den Bos GA, Dekker J Tags: J Rheumatol Source Type: research

A Prospective Study Investigating Prediagnostic Leukocyte Telomere Length and Risk of Developing Rheumatoid Arthritis in Women.
CONCLUSION: Our results do not support an involvement for short LTL preceding RA development. PMID: 26773113 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Prescott J, Karlson EW, Orr EH, Zee RY, De Vivo I, Costenbader KH Tags: J Rheumatol Source Type: research

Path Analysis Identifies Receptor Activator of Nuclear Factor-κB Ligand, Osteoprotegerin, and Sclerostin as Potential Mediators of the Tophus-bone Erosion Relationship in Gout.
CONCLUSION: Tophus number is strongly associated with bone erosion in gout. Circulating RANKL, OPG, and sclerostin are potential mediators of tophus-related erosion. PMID: 26773114 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Chhana A, Aati O, Gamble GD, Callon KE, Doyle AJ, Roger M, McQueen FM, Horne A, Reid IR, Cornish J, Dalbeth N Tags: J Rheumatol Source Type: research

Predictors of Incident Seizure in Systemic Lupus Erythematosus.
We examined incident seizures in 3 ways: at the time of diagnosis, more than 45 days after the diagnosis of SLE, and after cohort entry. RESULTS: Of 2203 patients with no history of seizure prior to SLE diagnosis, 157 (7.13%) had the first seizure occurrence at the time of (37 patients, 1.68%) or after diagnosis (120 patients, 5.45%) of SLE. The risk of seizure occurring around the time of SLE diagnosis was higher in patients with a history of malar rash (p = 0.002), proteinuria (p = 0.004), and psychosis (p
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Huang X, Magder LS, Petri M Tags: J Rheumatol Source Type: research

Novel Composite Radiographic Score for Longitudinal Observational Studies of Psoriatic Arthritis: A Proof-of-concept Study.
CONCLUSION: We report a proof-of-concept radiographic score for observational studies derived though data reduction. PMID: 26773116 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Tillett W, Shaddick G, Jadon D, Robinson G, Korendowych E, McHugh N Tags: J Rheumatol Source Type: research

Longterm Efficacy of an Antipneumococcal Polysaccharide Vaccine among Patients with Autoimmune Inflammatory Rheumatic Diseases.
CONCLUSION: The longterm efficacy of the PPSV23 vaccination seems to be preserved among patients with RA, PsA, AS, and IBD-associated SpA for at least 10 years. Efficacy is slightly impaired by MTX, but it is not affected by biologics. These findings suggest that revaccination after 5 years might not be needed for all, and testing the antibody titers should be considered to identify those who may benefit from revaccination. PMID: 26773117 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Broyde A, Arad U, Madar-Balakirski N, Paran D, Kaufman I, Levartovsky D, Wigler I, Caspi D, Elkayam O Tags: J Rheumatol Source Type: research

Examining the Minimal Important Difference of Patient-reported Outcome Measures for Individuals with Knee Osteoarthritis: A Model Using the Knee Injury and Osteoarthritis Outcome Score.
CONCLUSION: MID vary with patient and clinical characteristics, KOOS subscale, and analytical approach. Provided the anchor question is relevant to the patient-reported outcome and baseline status is considered, the anchor does not appear to influence the MID for improvement or worsening when using some anchor-based methods. PMID: 26773118 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Mills KA, Naylor JM, Eyles JP, Roos EM, Hunter DJ Tags: J Rheumatol Source Type: research

Severe Intracranial Involvement in Giant Cell Arteritis: 5 Cases and Literature Review.
CONCLUSION: IC GCA appears to be associated with neurologic complications and mortality. In some cases corticosteroid alone was not sufficient to prevent neurologic complications. The role of additional immunosuppressive agents needs further investigation. PMID: 26773119 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Alsolaimani RS, Bhavsar SV, Khalidi NA, Pagnoux C, Mandzia JL, Tay K, Barra LJ Tags: J Rheumatol Source Type: research

High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study.
CONCLUSION: The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade. PMID: 26773120 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Edwards MH, Parsons C, Bruyère O, Petit Dop F, Chapurlat R, Roemer FW, Guermazi A, Zaim S, Genant H, Reginster JY, Dennison EM, Cooper C, and the SEKOIA Study Group Tags: J Rheumatol Source Type: research

Mycophenolate Mofetil in Nonrenal Manifestations of Systemic Lupus Erythematosus: An Observational Cohort Study.
Abstract OBJECTIVE: Mycophenolate mofetil (MMF), along with corticosteroids, is considered as the standard of care in lupus nephritis (LN); however, little is known regarding its efficacy in extrarenal manifestations of systemic lupus erythematosus (SLE). We aimed to determine its effectiveness in nonrenal SLE. METHODS: One hundred seventy-seven patients with SLE were enrolled; 105 for whom MMF was introduced for active LN (mean age 35.6 ± 10.7 yrs, mean disease duration 8.9 ± 7.8 yrs) and 72 for extrarenal manifestations (mean age 38.6 ± 11.7 yrs, mean disease duration 11.7 ± 9.2 ...
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Tselios K, Gladman DD, Su J, Urowitz MB Tags: J Rheumatol Source Type: research

Venous and Arterial Thrombotic Events in Systemic Lupus Erythematosus.
ero J Abstract OBJECTIVE: The incidence of thrombosis in patients with systemic lupus erythematosus (SLE) is 25 to 50-fold higher than in the general population; we aimed to define the characteristics of venous thrombotic events (VTE) and arterial thrombotic events (ATE) to identify the patients at highest risk. METHODS: The study included 219 patients with recent-onset SLE. At baseline, standardized medical history and laboratory tests were done. Followup visits occurred quarterly, and information about damage accrual, comorbidities, and cardiovascular risk factors was updated annually. Main outcome was deve...
Source: J Rheumatol - January 15, 2016 Category: Rheumatology Authors: Hinojosa-Azaola A, Romero-Diaz J, Vargas-Ruiz AG, Nuñez-Alvarez CA, Cicero-Casarrubias A, Ocampo-Torres MC, Sanchez-Guerrero J Tags: J Rheumatol Source Type: research

The Need for Biological Outcomes for Biological Drugs in Psoriatic Arthritis.
PMID: 26724315 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Tan AL, McGONAGLE D Tags: J Rheumatol Source Type: research

Compositional Magnetic Resonance Imaging Measures of Cartilage - Endpoints for Clinical Trials of Disease-modifying Osteoarthritis Drugs?
PMID: 26724316 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Guermazi A, Crema MD, Roemer FW Tags: J Rheumatol Source Type: research

Rare Cause of Nuchal Pain: Calcification of the Alar Ligament.
PMID: 26724317 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Takizawa N, Nomura A, Fujita Y Tags: J Rheumatol Source Type: research

A Case of ANCA-associated Large Vessel Vasculitis with Multiple Saccular Aneurysms.
PMID: 26724318 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Sasaki H, Yamazaki H, Kohsaka H Tags: J Rheumatol Source Type: research

Extensive Lipoatrophy on a Buttock Revealing Systemic Lupus Erythematosus Panniculitis.
PMID: 26724319 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Li YC, Yeh FC, Chen HC Tags: J Rheumatol Source Type: research

Recent Orthopedic Surgeries Aiming to Improve Quality of Life for Patients with Rheumatoid Arthritis.
PMID: 26724320 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Momohara S, Yano K, Sakuma YU, Ikari K Tags: J Rheumatol Source Type: research

Drs. Waljee and Chung reply.
PMID: 26724321 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Waljee JF, Chung KC Tags: J Rheumatol Source Type: research

Specific Antinuclear Antibody Level Changes after B Cell Depletion Therapy in Systemic Sclerosis Are Associated with Improvement of Skin Thickening.
PMID: 26724322 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Bonroy C, Smith V, Deschepper E, DE Keyser F, Devreese K Tags: J Rheumatol Source Type: research

Rapid and Sustained Response to Tocilizumab in Patients with Polymyalgia Rheumatica Resistant or Intolerant to Glucocorticoids: A Multicenter Open-label Study.
cute;gent A PMID: 26724323 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Toussirot É, Martin A, Soubrier M, Redeker S, Régent A Tags: J Rheumatol Source Type: research

Knowledgebase and Lifestyle Choices in Patients with Psoriatic Arthritis.
PMID: 26724324 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Timmis A, Lenman M, Castagno S, Mmesi J, Tennekone D, Abraham S Tags: J Rheumatol Source Type: research

Serine Proteases in Systemic Lupus Erythematosus: The Other Half of the Story.
PMID: 26724325 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2016 Category: Rheumatology Authors: Rothschild B Tags: J Rheumatol Source Type: research

Whole Body Magnetic Resonance Imaging Features in Diffuse Idiopathic Skeletal Hyperostosis in Conjunction with Clinical Variables to Whole Body MRI and Clinical Variables in Ankylosing Spondylitis.
CONCLUSION: WB-MRI features can contribute to the correct diagnosis after a thorough conventional workup of patients with DISH and AS. PMID: 26669910 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Weiss BG, Bachmann LM, Pfirrmann CW, Kissling RO, Zubler V Tags: J Rheumatol Source Type: research

Anti-carbamylated Protein Antibody Levels Correlate with Anti-Sa (Citrullinated Vimentin) Antibody Levels in Rheumatoid Arthritis.
by WF Abstract OBJECTIVE: The presence of anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) indicates a breach in immune tolerance. Recent studies indicate that this breach extends to homocitrullination of lysines with the formation of anti-carbamylated protein (anti-CarP) antibodies. We analyzed the clinical and serologic relationships of anti-CarP in 2 RA cohorts. METHODS: Circulating levels of immunoglobulin G anti-CarP antibodies were determined by ELISA in established (Dartmouth-Hitchcock Medical Center) and early (Sherbrooke University Hospital Center) cohorts and evaluated for an...
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Challener GJ, Jones JD, Pelzek AJ, Hamilton BJ, Boire G, de Brum-Fernandes AJ, Masetto A, Carrier N, Ménard HA, Silverman GJ, Rigby WF Tags: J Rheumatol Source Type: research

Safety and Efficacy of Subcutaneous Golimumab in Patients with Active Rheumatoid Arthritis despite Methotrexate Therapy: Final 5-year Results of the GO-FORWARD Trial.
CONCLUSION: Improvements in the signs and symptoms of RA were maintained through 5 years. AE through 5 years were consistent with earlier reports of the GO-FORWARD trial; no apparent increased risk was observed over time. PMID: 26669912 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Keystone EC, Genovese MC, Hall S, Bae SC, Han C, Gathany TA, Xu S, Zhou Y, Leu JH, Hsia EC Tags: J Rheumatol Source Type: research

Methotrexate Efficacy in the Tight Control in Psoriatic Arthritis Study.
CONCLUSION: Despite the open-label design of the data, improvements in multiple clinical outcomes were seen. The proportion of patients reaching ACR20 in the TICOPA study was higher than in the Methotrexate in Psoriatic Arthritis study (41% vs 34%), but no comparative data are available for other outcomes. There is a suggestion of a dose response, but this is hard to assess when patients doing well may be maintained on lower doses. PMID: 26669913 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Coates LC, Helliwell PS Tags: J Rheumatol Source Type: research

Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project.
CONCLUSION: Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA. PMID: 26669914 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Nelson AE, Golightly YM, Renner JB, Schwartz TA, Liu F, Lynch JA, Gregory JS, Aspden RM, Lane NE, Jordan JM Tags: J Rheumatol Source Type: research

Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: Prevalence and Predictors.
This study assessed PAH prevalence and predictors in an SLE cohort. METHODS: The Borg dyspnea scale, DLCO, N-terminal pro-brain natriuretic peptide (NT-proBNP), and Doppler echocardiographic (DE) were performed. An echocardiographic Doppler exercise test was conducted in selected patients. When DE systolic pulmonary arterial pressure was ≥ 45 mmHg or increased during exercise> 20 mmHg, a right heart catheterization was performed. Hemodynamic during exercise was measured if rest mean pulmonary arterial pressure was
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Pérez-Peñate GM, Rúa-Figueroa I, Juliá-Serdá G, León-Marrero F, García-Quintana A, Ortega-Trujillo JR, Erausquin-Arruabarrena C, Rodríguez-Lozano C, Cabrera-Navarro P, Ojeda-Betancor N, Gómez-Sánchez MÁ Tags: J Rheumatol Source Type: research

Does Concomitant Methotrexate with Adalimumab Influence Treatment Outcomes in Patients with Psoriatic Arthritis? Data from a Large Observational Study.
CONCLUSION: ADA is an effective treatment option for patients with PsA with or without axial involvement. Compared with ADA monotherapy, the use of concomitant MTX with ADA does not improve articular or skin outcomes in patients with PsA regardless of axial symptoms. TRIAL REGISTRATION: Clinicaltrials.gov NCT01111240. PMID: 26669916 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Behrens F, Koehm M, Arndt U, Wittig BM, Greger G, Thaçi D, Scharbatke E, Tony HP, Burkhardt H Tags: J Rheumatol Source Type: research

Effectiveness of an Integrated Multidisciplinary Osteoarthritis Outpatient Program versus Outpatient Clinic as Usual: A Randomized Controlled Trial.
The objective was to compare satisfaction with and effectiveness of a new integrated multidisciplinary outpatient program with usual care in an outpatient clinic for patients with OA. METHODS: Patients with clinical OA referred to a rheumatology outpatient clinic were randomized to a 3.5-h multidisciplinary group-based educational program followed by individual consultations, or to usual care. The primary outcome was satisfaction with the health service evaluated on a numerical rating scale (0 = extremely unsatisfied, 10 = extremely satisfied) after 4 months. Secondary outcomes included health-related quality of life ...
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Moe RH, Grotle M, Kjeken I, Olsen IC, Mowinckel P, Haavardsholm EA, Hagen KB, Kvien TK, Uhlig T Tags: J Rheumatol Source Type: research

Defining Low Disease Activity States in Psoriatic Arthritis using Novel Composite Disease Instruments.
CONCLUSION: An MDA score of 7/7 is proposed as very low disease activity in psoriatic arthritis. Using this definition, the equivalent cutoffs for PASDAS and CPDAI are 1.9 and 2, respectively. PMID: 26669918 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Coates LC, Helliwell PS Tags: J Rheumatol Source Type: research

Safety and Efficacy of Open-label Subcutaneous Ixekizumab Treatment for 48 Weeks in a Phase II Study in Biologic-naive and TNF-IR Patients with Rheumatoid Arthritis.
CONCLUSION: Ixekizumab was well tolerated, and safety findings in the OLE were consistent overall with those in the double-blind period of this study. Clinical improvements observed with ixekizumab through Week 16 were maintained or improved in patients participating in the OLE through Week 64. TRIAL REGISTRATION NUMBER: NCT00966875. PMID: 26669919 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Genovese MC, Braun DK, Erickson JS, Berclaz PY, Banerjee S, Heffernan MP, Carlier H Tags: J Rheumatol Source Type: research

Retrospective Comparison of Open versus Endovascular Procedures for Takayasu Arteritis.
CONCLUSION: In patients with TA, both open surgical and endovascular revascularization procedures are associated with high failure rates and frequent operative complications. Traditional cardiovascular risk factors, corticosteroid dose, and active disease are risk factors for restenosis after revascularization procedures. PMID: 26669920 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Labarca C, Makol A, Crowson CS, Kermani TA, Matteson EL, Warrington KJ Tags: J Rheumatol Source Type: research

Disability with Persistent Pain Following an Epidemic of Chikungunya in Rural South India.
CONCLUSION: Persistence of pain noted in post-CKG disease resulted in significantly deteriorated functional status of those affected. PMID: 26669921 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Rahim AA, Thekkekara RJ, Bina T, Paul BJ Tags: J Rheumatol Source Type: research

Comorbidities Associated with Psoriatic Arthritis Compared with Non-psoriatic Spondyloarthritis: A Cross-sectional Study.
Abstract OBJECTIVE: Psoriatic arthritis (PsA) is a chronic inflammatory skeletal disease associated with health concerns such as obesity, Type II diabetes, dyslipidemia, hypertension (HTN), and cardiovascular (CV) disease. The involvement of these metabolic factors in the pathogenesis, severity, and progression of PsA remains unclear. In our study, we compared comorbidities associated with PsA to those patients with related but non-PsA forms of spondyloarthritis (SpA). METHODS: The SpA database at the Rheumatology Department of University Hospitals Leuven was analyzed in a cross-sectional manner using the dem...
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Haque N, Lories RJ, de Vlam K Tags: J Rheumatol Source Type: research

SMAD3 Is Upregulated in Human Osteoarthritic Cartilage Independent of the Promoter DNA Methylation.
CONCLUSION: Our study demonstrates that SMAD3 is significantly overexpressed in OA. This overexpression cannot be explained by DNA methylation in the promoter region. The results suggest that the transforming growth factor-β/SMAD3 pathway may be overactivated in OA cartilage and has potential in developing targeted therapies for OA. PMID: 26669923 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Aref-Eshghi E, Liu M, Razavi-Lopez SB, Hirasawa K, Harper PE, Martin G, Furey A, Green R, Sun G, Rahman P, Zhai G Tags: J Rheumatol Source Type: research

Obesity Is Common in Axial Spondyloarthritis and Is Associated with Poor Clinical Outcome.
Abstract OBJECTIVE: To assess the prevalence of overweight and obesity in a large cohort of patients with axial spondyloarthritis (axSpA) in comparison with the general population. To explore the relationship of body mass index (BMI) with clinical outcome in axSpA. METHODS: Patients from the Groningen Leeuwarden Axial SpA cohort who visited the outpatient clinic in 2011/2012 were included in this cross-sectional analysis. Body weight, height, disease activity, physical function, and quality of life (QoL) were assessed. Patients were divided into normal weight (BMI
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Maas F, Arends S, van der Veer E, Wink F, Efde M, Bootsma H, Brouwer E, Spoorenberg A Tags: J Rheumatol Source Type: research

Minimal Disease Activity and Remission in Psoriatic Arthritis Patients Treated with Anti-TNF-α Drugs.
Minimal Disease Activity and Remission in Psoriatic Arthritis Patients Treated with Anti-TNF-α Drugs. J Rheumatol. 2015 Dec 15; Authors: Perrotta FM, Marchesoni A, Lubrano E Abstract OBJECTIVE: A state of remission is the target of therapy in chronic arthritis. The aim of the present study was to assess the rate of minimal disease activity (MDA) and remission in patients with psoriatic arthritis (PsA) treated with tumor necrosis factor (TNF-α) blockers. Disease characteristics and predictors of MDA were also evaluated. METHODS: Patients fulfilling the ClASsification for Psoriatic ARth...
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Perrotta FM, Marchesoni A, Lubrano E Tags: J Rheumatol Source Type: research

Radiologic Changes in the Symphysis Pubis of Male Patients with Ankylosing Spondylitis.
CONCLUSION: Among male patients with AS, 47.3% exhibited symphysis pubis involvement. Moreover, a correlation was observed between the radiographic symphysis pubis and spine changes. PMID: 26669926 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Koo BS, Song Y, Joo KB, Lee S, Kim TH Tags: J Rheumatol Source Type: research

A Multicenter Study of Invasive Fungal Infections in Patients with Childhood-onset Systemic Lupus Erythematosus.
S, Silva CA Abstract OBJECTIVE: To study the prevalence, risk factors, and mortality of invasive fungal infections (IFI) in patients with childhood-onset systemic lupus erythematosus (cSLE). METHODS: A retrospective multicenter cohort study was performed in 852 patients with cSLE from 10 pediatric rheumatology services. An investigator meeting was held and all participants received database training. IFI were diagnosed according to the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses St...
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: Silva MF, Ferriani MP, Terreri MT, Pereira RM, Magalhães CS, Bonfá E, Campos LM, Okuda EM, Appenzeller S, Ferriani VP, Barbosa CM, Ramos VC, Lotufo S, Silva CA Tags: J Rheumatol Source Type: research

Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry.
CONCLUSION: The Yalcinkaya-Ozen criteria yielded a better sensitivity than the other criteria in this international cohort of patients and thus can be used as a tool for FMF diagnosis in pediatric patients from either the European or eastern Mediterranean region. However, the specificity was lower than the previously suggested adult criteria. PMID: 26568587 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: Demirkaya E, Saglam C, Turker T, Koné-Paut I, Woo P, Doglio M, Amaryan G, Frenkel J, Uziel Y, Insalaco A, Cantarini L, Hofer M, Boiu S, Duzova A, Modesto C, Bryant A, Rigante D, Papadopoulou-Alataki E, Guillaume-Czitrom S, Kuemmerle-Deschner J, Neven B, Tags: J Rheumatol Source Type: research

Discriminant Capacity of Clinical Efficacy and Nonsteroidal Antiinflammatory Drug-sparing Endpoints, Alone or in Combination, in Axial Spondyloarthritis.
Abstract OBJECTIVE: Using data from a randomized, double-blind, placebo-controlled study, we assessed the capacity of clinical and nonsteroidal antiinflammatory drug (NSAID)-sparing endpoints, alone and in combination, to discriminate between treatment effects in axial spondyloarthritis (axSpA). METHODS: Patients with active NSAID-resistant axSpA received etanercept (ETN) 50 mg/week or placebo for 8 weeks and tapered/discontinued NSAID. In posthoc logistic regression analyses, OR were calculated that indicated the capacity of the following endpoints to discriminate between the effects of ETN and placebo at We...
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: Dougados M, Wood E, Gossec L, Dubanchet A, Logeart I, van der Heijde D Tags: J Rheumatol Source Type: research

Lack of Interferon and Proinflammatory Cyto/chemokines in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus.
CONCLUSION: The levels of proinflammatory factors in SACQ mirror those of SQCQ patients, indicating reduced production of these factors despite the presence of immune complexes. PMID: 26568589 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: Steiman AJ, Gladman DD, Ibañez D, Noamani B, Landolt-Marticorena C, Urowitz MB, Wither JE Tags: J Rheumatol Source Type: research

Barriers to Care in Gout: From Prescriber to Patient.
CONCLUSION: Patients and GP wished to know more about gout and its management. Greater success in establishing and maintaining ULT will require further and better education to substantially benefit patients. Also, given the prevalence, and personal and societal significance of gout, innovative approaches to transforming the management of this eminently treatable disease are needed. PMID: 26568590 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: Vaccher S, Kannangara DR, Baysari MT, Reath J, Zwar N, Williams KM, Day RO Tags: J Rheumatol Source Type: research

Optimal Monitoring For Coronary Heart Disease Risk in Patients with Systemic Lupus Erythematosus: A Systematic Review.
CONCLUSION: Premature CHD in SLE is multifactorial; modifiable variables should be monitored at frequent intervals to ensure prompt management. Disease-specific factors also affect the atherogenic process and should be evaluated regularly. Carotid ultrasonography may hold promise in predicting CVE in selected high-risk patients. PMID: 26568591 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: Tselios K, Sheane BJ, Gladman DD, Urowitz MB Tags: J Rheumatol Source Type: research

Clinical and Radiographic Outcomes in Patients Diagnosed with Early Rheumatoid Arthritis in the First Years of the Biologic Treatment Era: A 10-year Prospective Observational Study.
CONCLUSION: A large proportion of our patients with RA diagnosed and treated in the new biologic treatment era achieved a status of clinical remission or low disease activity and had only a minor increase in radiographic joint damage after the first years of followup. PMID: 26568592 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: Haugeberg G, Bøyesen P, Helgetveit K, Prøven A Tags: J Rheumatol Source Type: research

Tumor Necrosis Factor-α Inhibition in Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Treatment Response, Drug Survival, and Patient Outcome.
Tumor Necrosis Factor-α Inhibition in Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Treatment Response, Drug Survival, and Patient Outcome. J Rheumatol. 2015 Nov 15; Authors: Corli J, Flipo RM, Philippe P, Bera-Louville A, Béhal H, Wibaux C, Paccou J Abstract OBJECTIVE: The purpose of this study was to (1) evaluate baseline characteristics of nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) treated with tumor necrosis factor-α inhibitors (TNFi), (2) assess the response to first TNFi treatment, and (3) compare drug-survival dura...
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: Corli J, Flipo RM, Philippe P, Bera-Louville A, Béhal H, Wibaux C, Paccou J Tags: J Rheumatol Source Type: research

Proposal for a Candidate Core Set of Fitness and Strength Tests for Patients with Childhood or Adult Idiopathic Inflammatory Myopathies.
CONCLUSION: The core set of fitness- and strength-related outcome measures provided by this expert consensus process will assist practitioners and researchers in deciding which tests to use in patients with IIM. This will improve the uniformity of fitness and strength tests across studies, thereby facilitating the comparison of study results and therapeutic exercise program outcomes among patients with IIM. PMID: 26568594 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 15, 2015 Category: Rheumatology Authors: van der Stap DK, Rider LG, Alexanderson H, Huber AM, Gualano B, Gordon P, van der Net J, Mathiesen P, Johnson LG, Ernste FC, Feldman BM, Houghton KM, Singh-Grewal D, Kutzbach AG, Munters LA, Takken T Tags: J Rheumatol Source Type: research