Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis.
Abstract OBJECTIVE: To date, "healed/non-healed" and clinical judgment are the only available assessment tools for digital ulcers (DU) in patients with systemic sclerosis (SSc). The aim of our study is to examine a preliminary composite DU clinical assessment score (DUCAS) for SSc for face, content, and construct validity. METHODS: Patients with SSc presenting at least 1 finger DU were enrolled and assessed with the Health Assessment Questionnaire-Disability Index, Cochin scale, visual analog scale (VAS) for DU-related pain, patient global DU status, and global assessment as patient-reported outcome...
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Bruni C, Ngcozana T, Braschi F, Pucci T, Piemonte G, Benelli L, Poli M, Suliman YA, Guiducci S, Bellando-Randone S, Balduzzi S, Grotts J, Denton CP, Rasero L, Montecucco C, Furst DE, Matucci-Cerinic M Tags: J Rheumatol Source Type: research

Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes.
CONCLUSION: With both high and low HCQ levels associated with preterm birth and disease activity in SLE, further study is necessary to understand HCQ disposition throughout pregnancy and to clarify the relationship between drug levels and outcomes. PMID: 30275257 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Balevic SJ, Cohen-Wolkowiez M, Eudy AM, Green TP, Schanberg LE, Clowse MEB Tags: J Rheumatol Source Type: research

Performance of the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis Is Not Superior to the ACC/AHA Risk Calculator.
CONCLUSION: ERS-RA underestimated the risk of a CV event in our cohort of patients, especially when risk estimations were based on patient or physician reports of HTN and hyperlipidemia instead of assessment of BP and blood lipids. The performance of ERS-RA was no better than that of ACC/AHA × 1.5, and neither performed well in high-inflammatory patients. PMID: 30275258 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Wahlin B, Innala L, Magnusson S, Möller B, Smedby T, Rantapää-Dahlqvist S, Wållberg-Jonsson S Tags: J Rheumatol Source Type: research

Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus.
CONCLUSION: An international consensus was reached to identify different proposed homogeneous chronic disorders that fall under the historical term JIA. These preliminary criteria will be formally validated with a dedicated project. PMID: 30275259 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Martini A, Ravelli A, Avcin T, Beresford MW, Burgos-Vargas R, Cuttica R, Ilowite NT, Khubchandani R, Laxer RM, Lovell DJ, Petty RE, Wallace CA, Wulffraat NM, Pistorio A, Ruperto N, Pediatric Rheumatology International Trials Organization (PRINTO) Tags: J Rheumatol Source Type: research

Risk Factors for Mortality and Cardiopulmonary Hospitalization in Systemic Sclerosis Patients At Risk for Pulmonary Hypertension, in the PHAROS Registry.
teen VD Abstract OBJECTIVE: We sought to identify predictors of mortality and cardiopulmonary hospitalizations in patients at risk for pulmonary hypertension (PH) and enrolled in PHAROS, a prospective cohort study to investigate the natural history of PH in systemic sclerosis (SSc). METHODS: The at-risk population for PH was defined by the following entry criteria: echocardiogram systolic pulmonary arterial pressure> 40 mmHg, or DLCO 1.6, measured by pulmonary function testing. Baseline clinical measures were evaluated as predictors of hospitalization and death between 2005 and 2014. Cox proportional hazar...
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Hsu VM, Chung L, Hummers LK, Shah A, Simms R, Bolster M, Hant FN, Silver RM, Fischer A, Hinchcliff ME, Varga J, Goldberg AZ, Derk CT, Schiopu E, Khanna D, Shapiro LS, Domsic RT, Medsger T, Mayes MD, Furst D, Csuka ME, Molitor JA, Saketkoo LA, Salazar CR, Tags: J Rheumatol Source Type: research

Relationship Between Insulin Sensitivity and β-Cell Secretion in Nondiabetic Subjects with Rheumatoid Arthritis.
Relationship Between Insulin Sensitivity and β-Cell Secretion in Nondiabetic Subjects with Rheumatoid Arthritis. J Rheumatol. 2018 Oct 01;: Authors: Tejera-Segura B, López-Mejías R, Vera-González AM, Jiménez-Sosa A, Olmos JM, Hernández JL, Llorca J, González-Gay MA, Ferraz-Amaro I Abstract OBJECTIVE: In nondiabetic healthy individuals, insulin secretion and sensitivity are linked by a negative feedback loop characterized by a hyperbolic function. We aimed to study the association of traditional insulin resistance (IR) factors with insulin secretion and se...
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Tejera-Segura B, López-Mejías R, Vera-González AM, Jiménez-Sosa A, Olmos JM, Hernández JL, Llorca J, González-Gay MA, Ferraz-Amaro I Tags: J Rheumatol Source Type: research

Biologic and Glucocorticoid Use after Methotrexate Initiation in Patients with Rheumatoid Arthritis.
Abstract OBJECTIVE: Biologic therapies can improve disease control for patients with rheumatoid arthritis (RA) but may be both overused and underused. We aimed to identify predictors of greater use of biologic therapies and to identify factors associated with persistent glucocorticoid use. METHODS: Using national US Veteran's Affairs databases 2005-2016, we identified patients with RA receiving a first-ever prescription of methotrexate (MTX), requiring ≥ 6 months of baseline data. We evaluated predictors of biologic therapy initiation within 2 years of starting MTX and factors associated with baseline and ...
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: George MD, Sauer BC, Teng CC, Cannon GW, England BR, Kerr GS, Mikuls TR, Baker JF Tags: J Rheumatol Source Type: research

Quadriceps Weakness and the Risk of Knee Cartilage Loss Seen on Magnetic Resonance Imaging in a Population-based Cohort with Knee Pain.
CONCLUSION: In this symptomatic, population-based cohort, quadriceps weakness predicted whole knee and medial TF cartilage loss after 3 years. To our knowledge, this is the first study to show that a simple clinical examination of quadriceps strength can predict the risk of knee cartilage loss. PMID: 30275263 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Chin C, Sayre EC, Guermazi A, Nicolaou S, Esdaile JM, Kopec J, Thorne A, Singer J, Wong H, Cibere J Tags: J Rheumatol Source Type: research

Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis.
CONCLUSION: The preliminary evidence suggests that sirolimus may serve as an alternative treatment for patients with LN who do not tolerate standard treatment or who had a history of malignancy, and it has an acceptable longterm safety profile. PMID: 30275264 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Yap DYH, Tang C, Chan GCW, Kwan LPY, Ma MKM, Mok MMY, Chan TM Tags: J Rheumatol Source Type: research

Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis.
Abstract OBJECTIVE: Forced vital capacity (FVC) and DLCO are used for screening of systemic sclerosis-associated interstitial lung disease (SSc-ILD). The study purpose was to determine the sensitivity, specificity, and negative predictive value (NPV) (proportion of true negative screening tests) of FVC and DLCO thresholds for SSc-ILD on chest high-resolution computed tomography (HRCT) scans. METHODS: Patients fulfilling American College of Rheumatology 2013 SSc criteria with a chest HRCT scan and pulmonary function tests (PFT) were studied. A thoracic radiologist quantified radiographic ILD. Optimal FVC and D...
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Showalter K, Hoffmann A, Rouleau G, Aaby D, Lee J, Richardson C, Dematte J, Agrawal R, Chang RW, Hinchcliff M Tags: J Rheumatol Source Type: research

What Is Most Important in Rheumatoid Arthritis Treatment - Where You Are, Who You Are, or Where You Are Going?
PMID: 30275339 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: England BR Tags: J Rheumatol Source Type: research

Crowned Dens Syndrome: Calcium Pyrophosphate Deposition Disease Masquerading as Osteomyelitis.
PMID: 30275340 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Heck A, Nolan N, Rojas-Moreno C Tags: J Rheumatol Source Type: research

Retro-odontoid Pseudotumor Associated with Sj ögren Syndrome and Systemic Lupus Erythematosus Serology.
Retro-odontoid Pseudotumor Associated with Sjögren Syndrome and Systemic Lupus Erythematosus Serology. J Rheumatol. 2018 Oct;45(10):1424-1425 Authors: Yamada S, Nagafuchi Y, Fujio K PMID: 30275341 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Yamada S, Nagafuchi Y, Fujio K Tags: J Rheumatol Source Type: research

Chikungunya in Brazil: Rheumatologists on the Front Line.
PMID: 30275342 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - October 1, 2018 Category: Rheumatology Authors: Amaral JK, Schoen RT Tags: J Rheumatol Source Type: research

Acute Unilateral Sacroiliitis Mimicking Infection on Magnetic Resonance Imaging with Response to Nonsteroidal Antiinflammatory Drugs: A Distinct Presentation of Spondyloarthritis?
Abstract Sacroiliitis is associated with the spondyloarthropathies (SpA) including ankylosing spondylitis, psoriatic arthritis, and reactive arthritis (ReA), and may be visualized using magnetic resonance imaging (MRI). Here, we describe 4 cases of acute unilateral sacroiliitis with florid MRI appearances that mimicked infection but demonstrated a prompt and complete response to nonsteroidal antiinflammatory drugs (NSAID). PMID: 30111637 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 15, 2018 Category: Rheumatology Authors: Dubash S, Pease C, Aslam A, Coady D, McGonagle D, Marzo-Ortega H Tags: J Rheumatol Source Type: research

Measuring Disease Activity and Damage with Validated Metrics: A Systematic Review on Mortality and Damage in Systemic Lupus Erythematosus.
CONCLUSION: Active SLE disease and damage are associated with and predict greater mortality and damage. The use of validated disease activity and damage metrics is important in the assessment of disease activity and damage and will inform upcoming Canadian recommendations for the assessment of SLE. PMID: 30111638 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 15, 2018 Category: Rheumatology Authors: Keeling SO, Vandermeer B, Medina J, Chatterley T, Nevskaya T, Pope J, Alaburubalnabi Z, Bissonauth A, Touma Z Tags: J Rheumatol Source Type: research

Effect of the Inclusion of the Metacarpophalangeal Joints on the Wrist Magnetic Resonance Imaging Scoring System in Juvenile Idiopathic Arthritis.
CONCLUSION: The extended score showed better reliability, construct validity, and sensitivity to change than the original. Inclusion of the MCP joints should be considered for a more accurate assessment of disease activity and treatment efficacy in JIA. PMID: 30111639 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 15, 2018 Category: Rheumatology Authors: van Dijkhuizen EHP, Vanoni F, Magnano GM, Magnaguagno F, Rosendahl K, van Rossum MA, Martini A, Malattia C, the OMERACT Working Group MRI in JIA Tags: J Rheumatol Source Type: research

Rheumatological Assessment Is Important for Interstitial Lung Disease Diagnosis.
CONCLUSION: Adding routine rheumatology assessments could significantly increase diagnostic accuracy and reduce invasive procedures. PMID: 30111640 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 15, 2018 Category: Rheumatology Authors: Levi Y, Israeli-Shani L, Kuchuk M, Epstein Shochet G, Koslow M, Shitrit D Tags: J Rheumatol Source Type: research

Cardiac Disease in Rheumatoid Arthritis - Can Cardiovascular Magnetic Resonance Imaging Depict the Janus Duality?
PMID: 30068756 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Mavrogeni SI, Markousis-Mavrogenis G, Kolovou GD Tags: J Rheumatol Source Type: research

Work Disability and the Cost-effectiveness of Drugs to Treat Rheumatic Diseases - Time for a New Dialogue?
PMID: 30068757 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Tillett W, Bojke L Tags: J Rheumatol Source Type: research

Rheumatoid Nodule at the Scrotum: A Rare Manifestation of Rheumatoid Arthritis.
PMID: 30068758 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Choi T, Kim HK, Lee DG Tags: J Rheumatol Source Type: research

Endocarditis in Adult-onset Still Disease: A Case Report and Literature Review.
PMID: 30068759 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Dang X, Han Y, Zhang X Tags: J Rheumatol Source Type: research

Unusual Presentation of Giant Cell Arteritis in 2 Patients: Uterine Involvement.
PMID: 30068760 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Butendieck RR, Abril A, Cortese C Tags: J Rheumatol Source Type: research

Methodological Issues in Studying Sex-specific Relationships of Serum Uric Acid with All-cause Mortality in Adults with Normal Kidney Function.
PMID: 30068761 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Ayubi E, Safiri S Tags: J Rheumatol Source Type: research

Practice Variations in the Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus in Canada.
CONCLUSION: Considerable practice variation in SLE management was noted. This may help inform future recommendations for the diagnosis, monitoring, and treatment of SLE in Canada. PMID: 30068762 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Keeling SO, Bissonauth A, Bernatsky S, Vandermeer B, Fortin PR, Gladman DD, Peschken C, Urowitz MB Tags: J Rheumatol Source Type: research

Is SAPHO Syndrome Linked to PASH Syndrome and Hidradenitis Suppurativa by Nicastrin Mutation? A Case Report.
Abstract The SAPHO syndrome is a group of disorders that manifest as synovitis, acne, pustulosis, hyperostosis, and osteitis. Of these, acne damage can present as acne conglobata, acne fulminans, or hidradenitis suppurativa (HS). PMID: 30068763 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Li C, Xu H, Wang B Tags: J Rheumatol Source Type: research

Abnormal Cardiac Biomarkers in Patients with Systemic Lupus Erythematosus and No Prior Heart Disease: A Consequence of Antimalarials?
CONCLUSION: About 10% of patients with SLE had elevated myocardial biomarkers, in the absence of prior cardiac disease or PAH. One-third of them were diagnosed with AMIC. Prolonged AM therapy and persistent CPK elevation conferred an increased risk for abnormal BNP and cTnI, which might predict AMIC. PMID: 30068764 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Tselios K, Gladman DD, Harvey P, Akhtari S, Su J, Urowitz MB Tags: J Rheumatol Source Type: research

In-stent Restenosis after Drug-eluting Stent Implantation in Rheumatoid Arthritis: Possible Protective Effect of Methotrexate.
Abstract Patients with rheumatoid arthritis (RA) are at higher risk of cardiovascular events compared with the general population. Therefore, these patients with RA have a greater chance of undergoing percutaneous coronary intervention (PCI). PMID: 30068765 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Kwon OC, Oh JS, Kim YG Tags: J Rheumatol Source Type: research

Increased Soluble Cytoplasmic Bcl-2 Protein Serum Levels and Expression and Decreased Fas Expression in Lymphocytes and Monocytes in Juvenile Dermatomyositis.
CONCLUSION: Patients with JDM presented a unique apoptosis-related proteins profile, which may contribute to disease development. PMID: 30068766 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Liphaus BL, Sallum AEM, Aikawa NE, Kiss MHB, Carrasco S, Palmeira P, Lima L, Silva CA, Goldenstein-Schainberg C, Carneiro-Sampaio M Tags: J Rheumatol Source Type: research

Pulmonary Manifestations and Progression of Lung Disease in Juvenile-onset Mixed Connective Tissue Disease.
, Lilleby V Abstract OBJECTIVE: To assess the occurrence and extent of interstitial lung disease (ILD) in patients with juvenile mixed connective tissue disease (JMCTD), compare pulmonary function in patients and matched controls, study associations between ILD and disease-related variables, and examine progression of pulmonary manifestations over time. METHODS: A cohort of 52 patients with JMCTD were examined in a cross-sectional study after a mean 16.2 (SD 10.3) years of disease duration with high-resolution computed tomography (HRCT) and pulmonary function tests (PFT) comprising spirometry, DLCO, and total...
Source: J Rheumatol - August 1, 2018 Category: Rheumatology Authors: Hetlevik SO, Flatø B, Aaløkken TM, Lund MB, Reiseter S, Mynarek GK, Nordal E, Rygg M, Lilleby V Tags: J Rheumatol Source Type: research

Epidemiology and Survival of Systemic Sclerosis-Systemic Lupus Erythematosus Overlap Syndrome.
Abstract OBJECTIVE: Systemic sclerosis (SSc) may overlap with systemic lupus erythematous (SLE). Little is known about the epidemiology, clinical characteristics, and survival of SSc-SLE overlap. We evaluated the prevalence of SSc-SLE overlap and differences in SSc characteristics, and compared survival with SSc without SLE. METHODS: A cohort study was conducted including subjects who fulfilled the American College of Rheumatology (ACR)/European League Against Rheumatism classification criteria for SSc and/or the ACR criteria for SLE. The primary outcome was time from diagnosis to all-cause mortality. Surviva...
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Alharbi S, Ahmad Z, Bookman AA, Touma Z, Sanchez-Guerrero J, Mitsakakis N, Johnson SR Tags: J Rheumatol Source Type: research

Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus.
CONCLUSION: Poor/intermediate preconception CV health affects pregnancy outcomes of preterm birth and SGA infants among women with SLE. Efforts to maintain BMI, total cholesterol, and BP within the recommended ideal range prior to pregnancy is important to improve pregnancy outcomes in women with SLE. PMID: 30008449 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Eudy AM, Siega-Riz AM, Engel SM, Franceschini N, Howard AG, Clowse MEB, Petri M Tags: J Rheumatol Source Type: research

Monitoring of Systemic Lupus Erythematosus Pregnancies: A Systematic Literature Review.
CONCLUSION: Few existing studies address monitoring for optimal care during SLE pregnancies. The available data imply roles for aPL antibodies measurement (prior to pregnancy and/or during the first trimester), uterine and umbilical artery Doppler studies in the second trimester, and following disease activity. Optimal frequency of monitoring is not addressed in the existing literature. PMID: 30008450 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: McDonald EG, Bissonette L, Ensworth S, Dayan N, Clarke AE, Keeling S, Bernatsky S, Vinet E Tags: J Rheumatol Source Type: research

Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus.
CONCLUSION: Five patients had homozygous alterations in genes coding early complement proteins. This may lead to decreased clearance of apoptotic bodies. One patient had DNASE1L3 variant, which functions in the clearance of self-antigens. In 1 patient, we determined a novel gene that may be important in SLE pathogenesis. We suggest that monogenic causes/associations should be sought in early-onset and/or familial SLE. PMID: 30008451 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Batu ED, Koşukcu C, Taşkıran E, Sahin S, Akman S, Sözeri B, Ünsal E, Bilginer Y, Kasapcopur O, Alikaşifoğlu M, Ozen S Tags: J Rheumatol Source Type: research

Antiphosphatidylserine/prothrombin Antibodies in Antiphospholipid Syndrome with Intrauterine Growth Restriction and Preeclampsia.
ini P Abstract OBJECTIVE: Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/ prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association with pregnancy complications in the antiphospholipid syndrome (APS). METHODS: We enrolled 55 patients with APS who were seeking pregnancy in 2 Italian hospitals. Antiphospholipid antibodies (aPL), including anticardiolipin antibodies, anti-β2-glycoprotein I antibodies, lupus-like anticoagulant, and aPS/PT antibodies were assessed, a...
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Canti V, Del Rosso S, Tonello M, Lucianò R, Hoxha A, Coletto LA, Vaglio Tessitore I, Rosa S, Manfredi AA, Castiglioni MT, Ruffatti A, Rovere-Querini P Tags: J Rheumatol Source Type: research

Gout and the Risk of Incident Erectile Dysfunction: A Body Mass Index-matched Population-based Study.
CONCLUSION: This population-based study suggests that gout is associated with an increased risk of developing ED, supporting a possible role for hyperuricemia and inflammation as independent risk factors for ED. PMID: 30008453 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Schlesinger N, Lu N, Choi HK Tags: J Rheumatol Source Type: research

Tongue Atrophy in Sj ögren Syndrome Patients with Mucosa-associated Lymphoid Tissue Lymphoma: Autoimmune Epithelitis beyond the Epithelial Cells of Salivary Glands?
Tongue Atrophy in Sjögren Syndrome Patients with Mucosa-associated Lymphoid Tissue Lymphoma: Autoimmune Epithelitis beyond the Epithelial Cells of Salivary Glands? J Rheumatol. 2018 Jul 15;: Authors: Zampeli E, Kalogirou EM, Piperi E, Mavragani CP, Moutsopoulos HM Abstract OBJECTIVE: Primary Sjögren syndrome (pSS), an autoimmune epithelitis, bears the risk of evolving to non-Hodgkin lymphoma and most frequently to the mucosa-associated lymphoid tissue (MALT) subtype. Based on the observation that pSS patients with MALT present a more atrophic and more intensely fissured tongue, we aimed to s...
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Zampeli E, Kalogirou EM, Piperi E, Mavragani CP, Moutsopoulos HM Tags: J Rheumatol Source Type: research

Clinical and Laboratory Characteristics and Mortality in Korean Patients with Systemic Sclerosis: A Nationwide Multicenter Retrospective Cohort Study.
CONCLUSION: Clinical manifestations and survival rates in Korean SSc patients are similar to those of other populations. However, the prevalence of anti-Scl-70 antibody is higher in Korean SSc patients compared with whites, while the prevalence of anticentromere antibody is lower. PMID: 30008455 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Moon KW, Lee SS, Lee YJ, Jun JB, Yoo SJ, Ju JH, Chang SH, Choi IA, Kang TY, Lee EB, Lee SG Tags: J Rheumatol Source Type: research

Risk Factors for Future Scleroderma Renal Crisis at Systemic Sclerosis Diagnosis.
Abstract OBJECTIVE: Systemic sclerosis (SSc) is a disease of autoimmunity, fibrosis, and vasculopathy. Scleroderma renal crisis (SRC) is one of the most severe complications. Corticosteroid exposure, presence of anti-RNA polymerase III antibodies (ARA), skin thickness, and significant tendon friction rubs are among the known risk factors at SSc diagnosis for developing future SRC. Identification of additional clinical characteristics and laboratory findings could expand and improve the risk profile for future SRC at SSc diagnosis. METHODS: In this retrospective cohort study of the entire military electronic m...
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Gordon SM, Stitt RS, Nee R, Bailey WT, Little DJ, Knight KR, Hughes JB, Edison JD, Olson SW Tags: J Rheumatol Source Type: research

Cardiovascular Disease Prevention in Rheumatoid Arthritis: Compliance with Diabetes Screening Guidelines.
lle D Abstract OBJECTIVE: To evaluate compliance with diabetes screening guidelines for cardiovascular disease (CVD) prevention in rheumatoid arthritis (RA) compared to the general population. METHODS: We conducted the first longitudinal study of a population-based RA cohort including all prevalent RA cases in British Columbia between 1996 and 2006 and followed until 2010, with matched general population comparators. Using administrative data, we measured compliance with general population guidelines [i.e., testing plasma glucose (PG) at least once every 3 years after age 45] after excluding individuals with ...
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Schmidt TJ, Aviña-Zubieta JA, Sayre EC, Abrahamowicz M, Esdaile JM, Lacaille D Tags: J Rheumatol Source Type: research

Psoriatic Arthritis Sonographic Enthesitis Instruments: A Systematic Review of the Literature.
CONCLUSION: Although sonographic enthesitis scoring instruments have been developed for SpA, only a few have been validated in PsA. None of them passed the OMERACT filter in patients with PsA. Additional research is required before endorsing a specific instrument for the assessment of enthesitis in patients with PsA. PMID: 30008458 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Elalouf O, Bakirci Ureyen S, Touma Z, Anderson M, Kaeley GS, Aydin SZ, Eder L Tags: J Rheumatol Source Type: research

Primary and Secondary Fibromyalgia Are The Same: The Universality of Polysymptomatic Distress.
CONCLUSION: PFM and SFM are equivalent regarding symptom burden. PSD scores are more informative about severity and severity within diagnosis than dichotomization into FM/non-FM. Studies of FM versus "healthy individuals," or FM versus other diseases, are inherently defective, while studies of FM and PSD in RA offer the opportunity to have meaningful comparison groups, because there are no readily available unbiased appropriate controls for PFM. PMID: 30008459 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Wolfe F, Walitt B, Rasker JJ, Häuser W Tags: J Rheumatol Source Type: research

Characteristics and Outcomes of Patients with Systemic Lupus Erythematosus-associated Thrombotic Microangiopathy, and Their Acquired ADAMTS13 Inhibitor Profiles.
Abstract OBJECTIVE: To investigate the characteristics and outcomes of patients with systemic lupus erythematosus (SLE)-associated thrombotic microangiopathy (TMA) based on their ADAMTS13 inhibitor profiles. METHODS: The medical data of 31 SLE patients with clinically diagnosed TMA were analyzed. ADAMTS13 activity and ADAMTS13 inhibitor were measured in all patients. RESULTS: TMA was attributable to active SLE in 19 patients. ADAMTS13 inhibitor and severe ADAMTS13 deficiency were detected in 6 of them. Patients with ADAMTS13 inhibitor (n = 6) exhibited a lower platelet count (7.3 ± 5.1 vs 25.0 &pl...
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Yue C, Su J, Gao R, Wen Y, Li C, Chen G, Zhang X, Li X Tags: J Rheumatol Source Type: research

Zoster after Cyclophosphamide for Systemic Lupus Erythematosus or Vasculitis: Incidence, Risk Factors, and Effect of Antiviral Prophylaxis.
Abstract OBJECTIVE: To assess the incidence and the risk factors for zoster in patients exposed to intravenous cyclophosphamide (CYC) for systemic vasculitis or systemic lupus erythematosus (SLE), as well as the protective effect of prophylaxis by valacyclovir (VCV). METHODS: This retrospective study included all adults treated by intravenous CYC for SLE or systemic vasculitis between 2011 and 2015 at Toulouse University Hospital, France. Zoster occurrence was recorded using medical chart review, laboratory data, and patient interviews. Univariate Cox models were computed to assess the risk factors for zoster...
Source: J Rheumatol - July 15, 2018 Category: Rheumatology Authors: Garnier C, Ribes D, Chauveau D, Huart A, Pugnet G, Adoue D, Prevot G, Alric L, Delobel P, Derumeaux H, Mengelle C, Sailler L, Moulis G Tags: J Rheumatol Source Type: research

Chasing the Ghost of Imaging Remission in Rheumatoid Arthritis.
PMID: 29961675 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2018 Category: Rheumatology Authors: Kaeley GS, Ranganath VK Tags: J Rheumatol Source Type: research

Fat Metaplasia in Inflammatory Sacroiliitis and in Nonrheumatic Conditions: A Step Toward Better Characterization.
PMID: 29961676 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2018 Category: Rheumatology Authors: Eshed I, Lidar M Tags: J Rheumatol Source Type: research

Isolated Cervical Cord Involvement in Primary Central Nervous System Vasculitis.
PMID: 29961677 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2018 Category: Rheumatology Authors: Wang CR, Peng SL, Huang HW Tags: J Rheumatol Source Type: research

Impairment of Motivational Efforts: Another Complication of Opioid Compromise of Sleep Quality?
PMID: 29961678 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2018 Category: Rheumatology Authors: Rothschild BM Tags: J Rheumatol Source Type: research

Dr. Rossides, et al reply.
PMID: 29961679 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2018 Category: Rheumatology Authors: Rossides M, Simard JF, Svenungsson E, VON Euler M, Arkema EV Tags: J Rheumatol Source Type: research

At What Age Was Systemic Lupus Erythematosus Diagnosed in This Cohort?
PMID: 29961680 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - July 1, 2018 Category: Rheumatology Authors: Băicuş C Tags: J Rheumatol Source Type: research