Ankylosing Spondylitis Is Associated with Increased Prevalence of Left Ventricular Hypertrophy.
mb AG Abstract OBJECTIVE: Ankylosing spondylitis (AS) is associated with increased risk for cardiovascular disease (CVD). Left ventricular (LV) hypertrophy is a strong precursor for clinical CVD. The aim of our study was to assess whether having AS was associated with increased prevalence of LV hypertrophy. METHODS: Clinical and echocardiographic data from 139 AS patients and 126 age- and sex-matched controls was used. LV mass was calculated according to guidelines and indexed to height2.7. LV hypertrophy was considered present if LV mass index was> 49.2 g/m2.7 in men and> 46.7 g/m2.7 in women. RES...
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Midtbø H, Gerdts E, Berg IJ, Rollefstad S, Jonsson R, Semb AG Tags: J Rheumatol Source Type: research

Effectiveness, Complications, and Costs of Rheumatoid Arthritis Treatment with Biologics in Alberta: Experience of Indigenous and Non-indigenous Patients.
Abstract OBJECTIVE: To examine clinical effectiveness, treatment complications, and healthcare costs for indigenous and non-indigenous Albertans with rheumatoid arthritis (RA) participating in the Alberta Biologics Pharmacosurveillance program. METHODS: Patients initiating biologic therapy in Alberta (2004-2012) were characterized for disease severity and treatment response. Provincial hospitalization separations, physician claims, outpatient department data, and emergency department data were used to estimate treatment complication event rates and healthcare costs. RESULTS: Indigenous patients (n = 90) ...
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Barnabe C, Zheng Y, Ohinmaa A, Crane L, White T, Hemmelgarn B, Kaplan GG, Martin L, Maksymowych WP Tags: J Rheumatol Source Type: research

Association of Physical Activity with Late-life Mobility Limitation among Women with Total Joint Replacement for Knee or Hip Osteoarthritis.
CONCLUSION: Women with lower PA levels before TJR were more likely to experience mobility limitation in late life following TJR for hip or knee OA. PMID: 29858237 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Shadyab AH, Eaton CB, Li W, LaCroix AZ Tags: J Rheumatol Source Type: research

Lack of Association among Peptidyl Arginine Deiminase Type 4 Autoantibodies, PADI4 Polymorphisms, and Clinical Characteristics in Rheumatoid Arthritis.
CONCLUSION: Taken together, the results from these combined serological, genetic, and clinical analyses suggest that anti-PAD4 appears to be a bystander autoantibody with no current clinical utility in RA. PMID: 29858238 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Guderud K, Mæhlen MT, Nordang GBN, Viken MK, Andreassen BK, Molberg Ø, Flåm ST, Lie BA Tags: J Rheumatol Source Type: research

Rheumatoid Arthritis and Risk of Sexual Dysfunction: A Systematic Review and Metaanalysis.
Abstract OBJECTIVE: It has been reported that there is an association between rheumatoid arthritis (RA) and increased susceptibility to sexual dysfunction (SD). This systematic review and metaanalysis aimed to investigate whether RA was a risk factor for SD. METHODS: MEDLINE (PubMed), EMBASE, and the Cochrane Library were systematically searched for all studies assessing sexual function in patients with RA. The association between RA and risk of SD was summarized using relative risk (RR) with 95% CI. RESULTS: Overall, 44,745 participants (mean age 43.2 yrs) were included from 7 studies (4 cross-sectional...
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Zhao S, Li E, Wang J, Luo L, Luo J, Zhao Z Tags: J Rheumatol Source Type: research

Monophasic Disease Course in Systemic Lupus Erythematosus.
CONCLUSION: A monophasic disease course was observed in 7.5% in this inception cohort. Patients sustained remission for 18 years on average, eventually without medications. Further study of such patients may provide unique pathophysiologic insights for SLE. PMID: 29858240 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Tselios K, Gladman DD, Touma Z, Su J, Anderson N, Urowitz MB Tags: J Rheumatol Source Type: research

Diffusion-weighted Imaging in Axial Spondyloarthritis: A Measure of Effusion or Does It Elicit Confusion?
PMID: 29858453 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Lambert RG, Maksymowych WP Tags: J Rheumatol Source Type: research

Cancer-associated Dermatomyositis: Does the PD-1 Checkpoint Pathway Play a Role?
PMID: 29858454 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Labrador-Horrillo M, Selva-O'Callaghan A Tags: J Rheumatol Source Type: research

Tongue and Scalp Necrosis: Simultaneous Initial Complications Revealing Giant Cell Arteritis.
PMID: 29858455 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Fongaufier C, Guffroy A, Lutz JC Tags: J Rheumatol Source Type: research

Reconsideration of Disappearing and Fusing Wrists.
PMID: 29858456 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Rothschild BM Tags: J Rheumatol Source Type: research

Dr. Wegner, et al, reply.
FMP PMID: 29858457 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Wegner F, Müller-Ladner U, Meier FMP Tags: J Rheumatol Source Type: research

Excessive Pricing Causes Poor Access to Biologics.
PMID: 29858458 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Boers M Tags: J Rheumatol Source Type: research

Dr. Johnson and Dr. Bah çe-Altuntaş reply.
Dr. Johnson and Dr. Bahçe-Altuntaş reply. J Rheumatol. 2018 Jun;45(6):876 Authors: Johnson BK, Bahçe-Altuntaş A PMID: 29858459 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Johnson BK, Bahçe-Altuntaş A Tags: J Rheumatol Source Type: research

Polyserositis in a Patient with Active Systemic Lupus Erythematosus: A Case of Pseudo-pseudo Meigs Syndrome.
PMID: 29858460 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Zampeli E, Skopouli FN, Moutsopoulos HM Tags: J Rheumatol Source Type: research

Flare of a Cryopyrin-associated Periodic Syndrome Following Vaccination with Neisseria Meningitidis Polysaccharides.
PMID: 29858461 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2018 Category: Rheumatology Authors: Walker UA, Luetke Volksbeck S, Kuemmerle-Deschner J Tags: J Rheumatol Source Type: research

Canadian Rheumatology Association Meeting, February 21-24, 2018. Introduction, Abstracts, Author Index.
Authors: Abstract The 73rd Annual Meeting of The Canadian Rheumatology Association (CRA) was held at the JW Marriott Parq Vancouver, Vancouver, British Columbia, Canada, February 21-24, 2018. The program consisted of presentations covering original research, symposia, awards, and lectures. PMID: 29764962 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 15, 2018 Category: Rheumatology Tags: J Rheumatol Source Type: research

Reducing Missed Opportunities for Influenza Vaccination in Patients with Rheumatoid Arthritis: Evaluation of a Multisystem Intervention.
Abstract OBJECTIVE: To assess a multimodal intervention for reducing missed opportunities for outpatient influenza vaccination in individuals with rheumatoid arthritis (RA). METHODS: Patients with RA were enrolled from a single center and each rheumatology outpatient visit was tracked for missed opportunities for influenza vaccination, defined as a visit in which an unvaccinated patient without contraindications remained unvaccinated or lacked documentation of vaccine recommendation in the electronic medical record (EMR). Providers then received a multimodal intervention consisting of an education session, EM...
Source: J Rheumatol - May 15, 2018 Category: Rheumatology Authors: Broderick R, Ventura I, Soroosh S, Franco L, Giles JT Tags: J Rheumatol Source Type: research

Cardiovascular (CV) Risk after Initiation of Abatacept versus TNF Inhibitors in Rheumatoid Arthritis Patients with and without Baseline CV Disease.
CONCLUSION: In this large cohort of publicly or privately insured patients with RA in the United States, ABA was associated with a 20% reduced risk of CVD versus TNFi. While this observational study is subject to potential residual confounding, our results were consistent in patients with baseline CVD. PMID: 29764964 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 15, 2018 Category: Rheumatology Authors: Jin Y, Kang EH, Brill G, Desai RJ, Kim SC Tags: J Rheumatol Source Type: research

Effect of Treat-to-target Strategies Aiming at Remission of Arterial Stiffness in Early Rheumatoid Arthritis: A Randomized Controlled Study.
Abstract OBJECTIVE: To determine the efficacy of 2 tight control treatment strategies aiming at Simplified Disease Activity Score (SDAI) remission (SDAI ≤ 3.3) compared to 28-joint count Disease Activity Score (DAS28) remission (DAS28
Source: J Rheumatol - May 15, 2018 Category: Rheumatology Authors: Tam LH, Shang Q, Li EK, Wong PC, Kwok KY, Kun EW, Yim IC, Lee VK, Yip RM, Pang SH, Lao VW, Mak QW, Cheng IT, Lau XS, Li TK, Zhu TY, Lee AP, Tam LS Tags: J Rheumatol Source Type: research

Risk Factors for Intraarticular Heterotopic Bone Formation in the Temporomandibular Joint in Juvenile Idiopathic Arthritis.
CONCLUSION: HBF within the TMJ is relatively common in patients with JIA receiving IAC injections for TMJ arthritis. Future prospective studies are required to delineate the risks posed by the injections themselves as opposed to the underlying disease activity, as well as to evaluate alternative forms of local therapy to the TMJ. PMID: 29764966 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 15, 2018 Category: Rheumatology Authors: Stoll ML, Amin D, Powell KK, Poholek CH, Strait RH, Aban I, Beukelman T, Young DW, Cron RQ, Waite PD Tags: J Rheumatol Source Type: research

High Disease Activity Is Associated with Self-reported Depression and Predicts Persistent Depression in Early Rheumatoid Arthritis: Results from the Ontario Best Practices Research Initiative.
CONCLUSION: Depression in ERA is common and initial high disease activity is associated with the probability of depression and its persistence. This risk seems particularly modified in women with active disease and represents an area for targeted focus and screening. Future studies in ERA are needed to determine if intervening during the "window of opportunity" to control disease activity has the potential to mitigate the development and maintenance of adverse mental health outcomes, including depression. PMID: 29764967 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - May 15, 2018 Category: Rheumatology Authors: Kuriya B, Joshi R, Movahedi M, Rampakakis E, Sampalis JS, Bombardier C, Ontario Best Practices Research Initiative Investigators Tags: J Rheumatol Source Type: research

Power Doppler Ultrasound Evaluation of Peripheral Joint, Entheses, Tendon, and Bursa Abnormalities in Psoriatic Patients: A Clinical Study.
Abstract OBJECTIVE: To evaluate the prevalence rates of peripheral joint, enthesis, tendon, and bursa abnormalities by power Doppler (PD) ultrasonic examination in patients with psoriatic arthritis (PsA), psoriatic patients without clinical signs of arthritis (non-PsA psoriasis group), and healthy individuals, to detect subclinical PsA. METHODS: A total of 253 healthy volunteers, 242 non-PsA psoriatic patients, and 86 patients with PsA were assessed by 2-dimensional and power Doppler (PD) ultrasound. Peripheral joint, enthesis, tendon, and bursa abnormalities were observed, characterizing abnormal PD. The aff...
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Tang Y, Yang Y, Xiang X, Wang L, Zhang L, Qiu L Tags: J Rheumatol Source Type: research

Longterm Safety and Efficacy of Adalimumab and Infliximab for Uveitis Associated with Juvenile Idiopathic Arthritis.
ini G, Vittadello F, Zulian F Abstract OBJECTIVE: Anti-TNF-α agents have significantly changed the management of juvenile idiopathic arthritis (JIA). We evaluated the safety and efficacy of adalimumab (ADA) and infliximab (IFX) for the treatment of JIA-associated uveitis in patients treated for ≥ 2 years. METHODS: Patients with JIA-associated uveitis treated with IFX and ADA were managed by a standardized protocol and data were entered in the ORCHIDEA registry. At baseline, all patients were refractory to standard immunosuppressive treatment or were corticosteroid-dependent. Data recorded every 3 mon...
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Cecchin V, Zannin ME, Ferrari D, Pontikaki I, Miserocchi E, Paroli MP, Bracaglia C, Marafon DP, Pastore S, Parentin F, Simonini G, De Libero C, Falcini F, Petaccia A, Filocamo G, De Marco R, La Torre F, Guerriero S, Martino S, Comacchio F, Muratore V, Mar Tags: J Rheumatol Source Type: research

Association of Serum Soluble CD163 with Polymyositis and Dermatomyositis, Especially in Anti-MDA5 Antibody-positive Cases.
Abstract OBJECTIVE: We elucidated the association of serum soluble CD163 (sCD163) with rapidly progressive interstitial lung disease (RP-ILD), autoantibody profiles, and serum ferritin in patients with polymyositis (PM), classic dermatomyositis (DM), and clinical amyopathic dermatomyositis (CADM). METHODS: Serum sCD163 levels were retrospectively measured by ELISA in patients with PM, classic DM, and CADM, as well as in healthy controls (HC). Repeat sera samples were obtained posttreatment from available patients. The associations between serum sCD163 levels and clinical information were analyzed. RESULT...
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Kawasumi H, Katsumata Y, Nishino A, Hirahara S, Kawaguchi Y, Kuwana M, Yamanaka H Tags: J Rheumatol Source Type: research

Age- and Sex-dependent Frequency of Fat Metaplasia and Other Structural Changes of the Sacroiliac Joints in Patients without Axial Spondyloarthritis: A Retrospective, Cross-sectional MRI Study.
Abstract OBJECTIVE: To determine the prevalence of fat metaplasia and other structural lesions of the sacroiliac joints associated with axial spondyloarthritis in a nonrheumatological patient population. METHODS: Magnetic resonance imaging examinations that included the pelvis and were performed in patients without known rheumatological disease were used for this retrospective cross-sectional study. These images were evaluated for sacroiliac fat metaplasia, sclerosis, osteophytes, and joint space alterations such as erosions or ankylosis. Patients were divided into 7 age groups (15-24 to ≥ 75 yrs). Prevale...
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Ziegeler K, Eshkal H, Schorr C, Sieper J, Diekhoff T, Makowski MR, Hamm B, Hermann KA Tags: J Rheumatol Source Type: research

Clinical and Serological Associations with the Development of Incident Proteinuria in Danish Patients with Systemic Lupus Erythematosus.
CONCLUSION: The risk of incident proteinuria after onset of SLE was increased by the presence of lymphopenia, anti-dsDNA antibodies, psychosis, younger age, and a high number of autoantibodies at onset. PMID: 29657143 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Tanha N, Hansen RB, Nielsen CT, Faurschou M, Jacobsen S Tags: J Rheumatol Source Type: research

Macrophage Activation Syndrome in Patients Affected by Adult-onset Still Disease: Analysis of Survival Rates and Predictive Factors in the Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale Cohort.
Abstract OBJECTIVE: Macrophage activation syndrome (MAS) is a reactive form of hemophagocytic lymphohistiocytosis, which can complicate adult-onset Still disease (AOSD). We investigated AOSD clinical features at the time of diagnosis, to assess predictors of MAS occurrence. Further, we analyzed the outcomes of patients with AOSD who experience MAS. METHODS: Patients with AOSD admitted to any Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale center were retrospectively analyzed for features typical of AOSD, MAS occurrence, and their survival rate. RESULTS: Of 119 patients with AOSD, 17 exp...
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Ruscitti P, Iacono D, Ciccia F, Emmi G, Cipriani P, Grembiale RD, Perosa F, Emmi L, Triolo G, Giacomelli R, Valentini G Tags: J Rheumatol Source Type: research

HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis.
CONCLUSION: SE alleles and disease activity were negatively correlated with the TCR repertoire diversity of CD4+ T cells in RA. Considering the pivotal role of CD4+ T cells in RA, restoring the altered TCR repertoire diversity will provide a potential RA therapeutic target. PMID: 29657145 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Sakurai K, Ishigaki K, Shoda H, Nagafuchi Y, Tsuchida Y, Sumitomo S, Kanda H, Suzuki A, Kochi Y, Yamamoto K, Fujio K Tags: J Rheumatol Source Type: research

Absence of Fibrosis and Inflammation by Cardiac Magnetic Resonance Imaging in Rheumatoid Arthritis Patients with Low to Moderate Disease Activity.
CONCLUSION: cMRI measures of cardiac structure and function were not significantly altered, and measures of fibrosis were similar or lower in RA patients with low to moderate disease activity compared to a matched control group. PMID: 29657146 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Bradham W, Ormseth MJ, Elumogo C, Palanisamy S, Liu CY, Lawson MA, Soslow JH, Kawel-Boehm N, Bluemke DA, Stein CM Tags: J Rheumatol Source Type: research

Longterm Safety and Efficacy of Subcutaneous Abatacept in Patients with Rheumatoid Arthritis: 5-year Results from a Phase IIIb Trial.
CONCLUSION: These 5-year data establish that SC ABA (125 mg/wk) has a consistent safety profile and durable efficacy for longterm treatment of patients with RA who had an inadequate response to MTX. PMID: 29657147 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Genovese MC, Pacheco-Tena C, Covarrubias A, Leon G, Mysler E, Keiserman M, Valente RM, Nash P, Simon-Campos JA, Box J, Legerton CW, Nasonov E, Durez P, Elegbe A, Wong R, Li X, Banerjee S, Alten R Tags: J Rheumatol Source Type: research

The Prevalence of Renal Impairment in Patients with Spondyloarthritis: Results from the International ASAS-COMOSPA Study.
Abstract OBJECTIVE: To assess the prevalence and association of renal dysfunction in patients with spondyloarthritis (SpA). METHODS: The ASAS-COMOSPA (Assessment of Spondyloarthritis international Society-COMOrbidities in SPondyloArthritis) was an international study (22 participating countries from 4 continents) investigating comorbidities in SpA. Renal function was assessed based on estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease equation. SpA characteristics and risk factors for renal impairment were collected. Nonsteroidal antiinflammatory drug (NSAID...
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Couderc M, Pereira B, Molto A, Tiple A, Soubrier M, Dougados M Tags: J Rheumatol Source Type: research

The Natural Course of Diffuse Idiopathic Skeletal Hyperostosis in the Thoracic Spine of Adult Males.
an JJ Abstract OBJECTIVE: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by flowing bony bridges on the right side of the spine. Knowledge of the development of these spinal bridges is limited. The current longitudinal computed tomography (CT) study was designed to bridge this gap. METHODS: Chest CT scans from elderly males with 2 scans (interval ≥ 2.5 yrs) were retrospectively included. Using the Resnick criteria, a pre-DISH group and a definite DISH group were identified. A scoring system based on the completeness of a bone bridge (score 0-3), extent of fluency, and location of the new ...
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Kuperus JS, Buckens CF, Šprem J, Oner FC, de Jong PA, Verlaan JJ Tags: J Rheumatol Source Type: research

Causes and Predictors of Early Hospital Readmission in Systemic Lupus Erythematosus.
CONCLUSION: One-third of hospitalized patients with SLE were readmitted within 30 days at our institution. We identified characteristics of this at-risk population at time of discharge with high specificity, in hopes of reducing this costly outcome. PMID: 29657150 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Nangit A, Lin C, Ishimori ML, Spiegel BMR, Weisman MH Tags: J Rheumatol Source Type: research

Crystal-proven Gout and Characteristic Gout Severity Factors are Associated with Cardiovascular Disease.
Abstract OBJECTIVE: Our aim was to examine the prevalence of cardiovascular disease (CVD) in patients with crystal-proven gout compared to arthritis controls. Further, we analyzed the association between characteristic gout severity factors and CVD to provide further support for a pathogenetic relationship between gout and CVD. METHODS: Patients with arthritis referred for diagnosis were consecutively included in the Gout Arnhem-Liemers cohort. Joint fluid analysis was performed in all referred patients; controls were negative for crystals. Patients' characteristics and different manifestations of CVD and gou...
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Disveld IJM, Fransen J, Rongen GA, Kienhorst LBE, Zoakman S, Janssens HJEM, Janssen M Tags: J Rheumatol Source Type: research

Venous Thromboembolism in Systemic Sclerosis: Prevalence, Risk Factors, and Effect on Survival.
CONCLUSION: The risk of VTE in SSc is comparable to the general population. The presence of PAH, peripheral arterial disease, Scl-70, and anticardiolipin antibodies are risk factors for VTE. VTE does not independently predict SSc survival. PMID: 29657152 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Johnson SR, Hakami N, Ahmad Z, Wijeysundera DN Tags: J Rheumatol Source Type: research

Repeat Testing of Antibodies and Complements in Systemic Lupus Erythematosus: When Is It Enough?
CONCLUSION: Anti-ENA results change infrequently, especially following 1 or more negative tests. The high cost and lack of evidence that changes affect management suggest that repeating anti-ENA tests routinely is unnecessary. Anti-dsDNA and complements change more frequently after an abnormal result, but less after a normal value. PMID: 29657153 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2018 Category: Rheumatology Authors: Raissi TC, Hewson C, Pope JE Tags: J Rheumatol Source Type: research

Evaluation of Self-reported Patient Experiences: Insights from Digital Patient Communities in Psoriatic Arthritis.
CONCLUSION: Patients often discussed physical and emotional implications of PsA in online platforms; some commonly used PRO instruments in PsA may not identify cognitive issues or parenting/family burden. Nearly one-third of patients with PsA reported access barriers to treatment. PMID: 29449495 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Sunkureddi P, Doogan S, Heid J, Benosman S, Ogdie A, Martin L, Palmer JB Tags: J Rheumatol Source Type: research

Patient-reported Outcomes, Resource Use, and Social Participation of Patients with Rheumatoid Arthritis Treated with Biologics in Alberta: Experience of Indigenous and Non-indigenous Patients.
Abstract OBJECTIVE: To characterize patient-reported outcomes, resource use, and social participation during the course of biologic therapy for indigenous and non-indigenous patients with rheumatoid arthritis (RA). METHODS: Patients initiating biologic therapy (2004 to 2012) were characterized longitudinally for patient-reported outcomes including physical function measured by the Health Assessment Questionnaire, EQ-5D, well-being [Medical Outcomes Study Short Form-36 (SF-36)], and visual analog scales for pain, fatigue, sleep, stiffness, and patient's global assessment. Resource use, participation in activit...
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Barnabe C, Crane L, White T, Hemmelgarn B, Kaplan GG, Martin L, Maksymowych WP Tags: J Rheumatol Source Type: research

Rheumatologists' Views and Experiences in Managing Rheumatoid Arthritis in Elderly Patients: A Qualitative Study.
CONCLUSION: The treat-to-target model is not automatically adopted in the elderly patient population. Future evidence-based RA management recommendations for elderly patients with RA are needed and should account for factors such as comorbidity and frailty. PMID: 29449497 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Nawrot J, Boonen A, Peeters R, Starmans M, van Onna M Tags: J Rheumatol Source Type: research

Early Psoriatic Arthritis Versus Early Seronegative Rheumatoid Arthritis: Role of Dermoscopy Combined with Ultrasonography for Differential Diagnosis.
CONCLUSION: Integrated rheumatological-dermatological clinical evaluation may be helpful in identifying patients with EPsA misclassified as seronegative ERA. Additionally, US and dermoscopy may be used as supportive tools in identifying subclinical psoriatic features, which may come in handy in distinguishing EPsA from ERA. PMID: 29449498 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Zabotti A, Errichetti E, Zuliani F, Quartuccio L, Sacco S, Stinco G, De Vita S Tags: J Rheumatol Source Type: research

Clinical Correlates, Outcomes, and Predictors of Inflammatory Ocular Disease Associated with Rheumatoid Arthritis in the Biologic Era.
CONCLUSION: This large single-center study highlights the variable presentation and outcomes of IOD in RA. Although ocular complications are associated with significant morbidity, it is reassuring that survival among those with IOD is now similar to those without ocular disease. PMID: 29449499 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Caimmi C, Crowson CS, Smith WM, Matteson EL, Makol A Tags: J Rheumatol Source Type: research

The Cost-effectiveness of Biannual Serum Urate (SU) Monitoring after Reaching Target in Gout: A Health Economic Analysis Comparing SU Monitoring.
CONCLUSION: The results suggest that biannual SU monitoring after attaining target SU is the most cost-effective, compared with no testing and annual testing. PMID: 29449500 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Robinson PC, Dalbeth N, Donovan P Tags: J Rheumatol Source Type: research

Diffusion-weighted Imaging Is a Sensitive and Specific Magnetic Resonance Sequence in the Diagnosis of Ankylosing Spondylitis.
CONCLUSION: DWI is informative for diagnosis of AS and nr-axSpA, and has moderate utility in assessment of disease activity or treatment response, with performance similar to that of the SPARCC MRI score. PMID: 29449501 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Bradbury LA, Hollis KA, Gautier B, Shankaranarayana S, Robinson PC, Saad N, Lê Cao KA, Brown MA Tags: J Rheumatol Source Type: research

The Crescentic Implication of Renal Outcomes in Proliferative Lupus Nephritis.
Abstract OBJECTIVE: To determine the association between crescents and renal outcomes, and the implications on therapeutic choices. METHODS: There were 231 patients with biopsy-proven proliferative lupus nephritis (PLN) who were divided into 4 groups: 59 patients were in the noncrescent group (NC); 59 patients exclusively with segmental crescents were in the segmental crescent group (SC); patients with circumferential crescents were categorized into 2 groups according to the crescentic ratio (C1 had 64 patients with ≤ 25%, and C2 had 49 patients with> 25%). Their baseline laboratory tests, histopatholog...
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Cai F, Han F, Wang H, Han H, Le J, Lan L, Xu Y, Chen J Tags: J Rheumatol Source Type: research

Early Renin-angiotensin System Blockade Improved Short-term and Longterm Renal Outcomes in Systemic Lupus Erythematosus Patients with Antiphospholipid-associated Nephropathy.
CONCLUSION: Early RAAS blockade improved the short-term and longterm renal outcomes in SLE patients with aPLN. The renal protective effect of RASI was independent of its antihypertensive and antiproteinuric effects. PMID: 29449503 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Yue C, Li G, Wen Y, Li X, Gao R Tags: J Rheumatol Source Type: research

Response to Tumor Necrosis Factor Inhibition in Male and Female Patients with Ankylosing Spondylitis: Data from a Swiss Cohort.
he Swiss Clinical Quality Management Program Abstract OBJECTIVE: To investigate sex differences in connection with the effectiveness of tumor necrosis factor inhibitors (TNFi) in patients with ankylosing spondylitis (AS). METHODS: A total of 440 patients with AS (294 men; 146 women) initiating a first TNFi in the prospective Swiss Clinical Quality Management Cohort were included. We evaluated the proportion of patients achieving the 20% and 40% improvement in the Assessment of Spondyloarthritis international Society criteria (ASAS20 and ASAS40) as well as Ankylosing Spondylitis Disease Activity Score (ASDAS) ...
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Hebeisen M, Neuenschwander R, Scherer A, Exer P, Weber U, Tamborrini G, Micheroli R, Wildi LM, Zufferey P, Nissen MJ, Villiger PM, Bernhard J, Finckh A, van der Horst-Bruinsma IE, Sieper J, Landewé R, van der Heijde D, Ciurea A, rheumatologists of the Sw Tags: J Rheumatol Source Type: research

Detection of Crohn Disease in Patients with Spondyloarthropathy: The SpACE Capsule Study.
CONCLUSION: CE uncovered SBI consistent with CD in 42.2% of patients with SpA, with a significant incremental yield over colonoscopy of 31%. FCP levels were significantly correlated with CE results, while GI symptoms and SGI results were poor predictors of SBI. PMID: 29449505 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Kopylov U, Starr M, Watts C, Dionne S, Girardin M, Seidman EG Tags: J Rheumatol Source Type: research

Whole-body Magnetic Resonance Imaging in Axial Spondyloarthritis: Reduction of Sacroiliac, Spinal, and Entheseal Inflammation in a Placebo-controlled Trial of Adalimumab.
CONCLUSION: ADA provided significant reductions in WBMRI indices of peripheral, axial, and whole-body inflammation in patients with axSpA. WBMRI is promising for objective assessment and monitoring of peripheral and axial disease activity in future clinical trials. PMID: 29449506 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 15, 2018 Category: Rheumatology Authors: Krabbe S, Østergaard M, Eshed I, Sørensen IJ, Jensen B, Møller JM, Balding L, Madsen OR, Asmussen K, Eng G, Jørgensen NR, Pedersen SJ Tags: J Rheumatol Source Type: research

Do Recent Trends in RA Surgery Reflect Success in Disease Management?
PMID: 29419445 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2018 Category: Rheumatology Authors: Goodman SM Tags: J Rheumatol Source Type: research

Underestimation of Risk of Carotid Subclinical Atherosclerosis by Cardiovascular Risk Scores in Patients with Psoriatic Arthritis: How Far Are We from the Truth?
PMID: 29419446 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2018 Category: Rheumatology Authors: Belur AD, Mehta NN Tags: J Rheumatol Source Type: research