Fatigue Measurements in Systemic Lupus Erythematosus.
CONCLUSION: VAS, FSS and FACIT Fatigue scale were the most frequently used instruments in adult SLE studies from 2008-2017. Many studies detected clinically important changes in fatigue. Fatigue remains a key measure in both clinical trials and observational SLE studies. PMID: 30709953 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Barbacki A, Petri M, Aviña-Zubieta A, Alarcón GS, Bernatsky S Tags: J Rheumatol Source Type: research

Peripheral Lymphocyte Multidrug Resistance Activity as a Predictive Tool of Biological Therapeutic Response in Rheumatoid Arthritis.
CONCLUSION: Our results indicate that the determination of MAFC values in CD3 cells of RA patients may be of predictive value prior to the initiation of biological therapy to establish whether the patient will demonstrate sufficient therapeutic response. PMID: 30709954 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Toldi G, Batel P, Baráth S, Szerémy P, Apjok A, Filkor K, Szántó S, Szűcs G, Szamosi S, Häupl T, Grützkau A, Szekanecz Z Tags: J Rheumatol Source Type: research

Utility of Magnetic Resonance Imaging in Diagnosis and Monitoring Enthesitis in Patients with Spondyloarthritis: an OMERACT Systematic Literature Review.
CONCLUSION: Lack of a comprehensive, validated score warrants additional research to develop an MRI enthesitis scoring system. PMID: 30709955 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Mathew AJ, Krabbe S, Kirubakaran R, Barr AJ, Conaghan PG, Bird P, Østergaard M Tags: J Rheumatol Source Type: research

Spondyloarthritis Research Consortium of Canada Scoring System for Sacroiliitis in Juvenile Spondyloarthritis/Enthesitis-related Arthritis: A Reliability, Validity, and Responsiveness Study.
Abstract OBJECTIVE: Intra- and interreader reliability, construct validity, and responsiveness of the Spondyloarthritis Research Consortium of Canada (SPARCC) magnetic resonance imaging (MRI) scoring system were investigated for scoring sacroiliitis in patients with juvenile spondyloarthritis (JSpA)/enthesitis-related arthritis (ERA) who have received biologic and/or nonbiologic treatment. METHODS: Ninety whole-body MRI examinations with dedicated oblique coronal planes of the sacroiliac joints in 46 patients were independently reviewed and scored by 2 pediatric musculoskeletal radiologists, blinded to clinic...
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Panwar J, Tse SML, Lim L, Tolend MA, Radhakrishnan S, Salman M, Moineddin R, Doria AS, Stimec J Tags: J Rheumatol Source Type: research

Very Low Disease Activity, DAPSA Remission, and Impact of Disease in a Spanish Population with Psoriatic Arthritis.
MAAPS Study Group Abstract OBJECTIVE: To examine the grade of agreement between very low disease activity (VLDA) and Disease Activity Index for Psoriatic Arthritis (DAPSA) remission, as well as their association with the effect of the disease as assessed by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire in patients with psoriatic arthritis in routine clinical practice. METHODS: Posthoc analysis of data from a cross-sectional multicenter study. Patients were included who fulfilled the Classification for Psoriatic Arthritis (CASPAR) criteria with at least 1 year of disease duration and were tre...
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Queiro R, Cañete JD, Montilla C, Abad MA, Montoro M, Gómez S, Cábez A, MAAPS Study Group Tags: J Rheumatol Source Type: research

Serum Biomarkers for Prediction of Response to Methotrexate Monotherapy in Early Rheumatoid Arthritis: Results from the SWEFOT Trial.
CONCLUSION: Low baseline levels of CRP and leptin, and high baseline levels of TNF-RI and VCAM-1 were associated with LDA after 3 months of MTX therapy in patients with eRA. Combination of these 4 biomarkers increased accuracy of prediction. [Trial registration number: NCT00764725]. PMID: 30709958 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Hambardzumyan K, Bolce RJ, Wallman JK, van Vollenhoven RF, Saevarsdottir S Tags: J Rheumatol Source Type: research

Predictors of Hand Contracture in Early SSc and the Effect on Hand Function: A Prospective Study of the GENISOS Cohort.
CONCLUSION: ATA was predictive of contracture development in both early disease (≤ 2 years) and in the overall cohort. Hand extension declined linearly over time and was inversely associated with MHAQ and SF36 scores. ATA positivity and higher baseline mRSS were predictive of faster decline in hand extension. PMID: 30709959 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Buni M, Joseph J, Pedroza C, Theodore S, Nair D, McNearney TA, Draeger HT, Reveille JD, Assassi S, Mayes MD Tags: J Rheumatol Source Type: research

Towards a Core Outcome Measurement Set for Polymyalgia Rheumatica: Report from the OMERACT 2018 Special Interest Group.
CONCLUSION: Further assessment of candidate instruments is required prior to recommending a PMR core outcome measurement set. PMID: 30709960 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Owen CE, Yates M, Twohig H, Muller S, Neill LM, Harrison E, Shea B, Simon LS, Hill CL, Mackie SL Tags: J Rheumatol Source Type: research

The OMERACT MRI in Enthesitis Initiative: Definitions of Key Pathologies, Suggested MRI Sequences and Novel Heel Enthesitis Scoring System (HEMRIS).
CONCLUSION: The proposed definitions and heel enthesitis scoring system (HEMRIS) are reliable among trained readers and promising for clinical trials. PMID: 30709961 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Mathew AJ, Krabbe S, Eshed I, Gandjbakhch F, Bird P, Pedersen SJ, Stoenoiu MS, Foltz V, Glinatsi D, Lambert RG, Hermann KGA, Maksymowych WP, Haugen IK, Jaremko JL, Poggenborg RP, Paschke J, Laredo JD, Carron P, Conaghan PG, Østergaard M Tags: J Rheumatol Source Type: research

Peritenon extensor tendon inflammation in Psoriatic Arthritis is an enthesitis-related lesion.
CONCLUSION: In PsA, PTI is associated to enthesitis, on contrary to synovitis. PMID: 30709962 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Villa CM, Falcao S, Gutierrez M, Medina J, Hammer HB, De Miguel E Tags: J Rheumatol Source Type: research

Development of a Core Domain Set of Outcomes for Shared Decision Making Interventions: An Omeract White Paper and Stakeholder Interviews.
CONCLUSION: A revised core domain set will undergo further consensus-building. PMID: 30709963 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: April KT, Barton JL, Fraenkel L, Meara A, Li LC, Brooks P, de Wit M, Stacey D, Légaré F, Shea B, Lyddiatt A, Hofstetter C, Christensen R, Voshaar MS, Suarez-Almazor ME, Boonen A, Meade T, March L, Jull JE, Campbell W, Alten R, Karuranga S, Morgan EM, Ke Tags: J Rheumatol Source Type: research

On Needles and Haystacks: The Perils of Cardiovascular Risk Screening in Rheumatoid Arthritis.
PMID: 30709999 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Giles JT Tags: J Rheumatol Source Type: research

Juvenile Idiopathic Arthritis: An Idea Whose Time Has Gone?
PMID: 30710000 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Beukelman T, Nigrovic PA Tags: J Rheumatol Source Type: research

Secondary Fibromyalgia.
PMID: 30710001 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Bennett RM, Friend R Tags: J Rheumatol Source Type: research

Pseudochylothorax in a Patient with Rheumatoid Arthritis.
PMID: 30710002 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Kampolis CF, Vlachoyiannopoulos PG Tags: J Rheumatol Source Type: research

Added Value of Fecal Calprotectin to Support the Diagnosis of Spondyloarthropathies.
PMID: 30710003 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: VAN Hoovels L, VAN DEN Bremt S, Schiemsky T, Cauchie M, Vander Cruyssen B, Bossuyt X, VAN DER Steen K, Stubbe M Tags: J Rheumatol Source Type: research

Dr. Seidman replies.
PMID: 30710004 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Authors: Seidman E Tags: J Rheumatol Source Type: research

Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality.
Authors: PMID: 30710005 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Addressing Challenges in Developing a Core Domain Set in Adherence Interventions in Rheumatology: A Report from the OMERACT-Adherence Group.
CONCLUSION: Despite the challenges, the meeting clarified an approach to developing an Adherence-CDS that complements existing OMERACT work and methodology. PMID: 30647162 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Kelly A, Bartlett SJ, de Wit MP, Beaton DE, Dawson T, Evans V, Gill M, Hassett G, March L, Scholte-Voshaar M, Singh JA, Tong A, Tugwell P, Wong P, Tymms K Tags: J Rheumatol Source Type: research

Clinical Utility of Antipeptidyl Arginine Deiminase Type 4 Antibodies.
Abstract Rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are important biomarkers in the diagnosis of rheumatoid arthritis (RA) but leave a gap of> 50% seronegative in early RA1 In addition, there is marked clinical heterogeneity in the seropositive group, precluding the use of RF and ACPA alone as prognostic biomarkers. These characteristics drive the demand for novel diagnostic and prognostic markers in RA1. PMID: 30647163 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Darrah E, Martinez-Prat L, Mahler M Tags: J Rheumatol Source Type: research

Efficacy of Glucocorticoids and Calcineurin Inhibitors for Anti-aminoacyl-tRNA Synthetase Antibody-positive Polymyositis/dermatomyositis-associated Interstitial Lung Disease: A Propensity Score-matched Analysis.
CONCLUSION: Propensity score-matched analysis demonstrated that first-line PSL + CNI therapy for patients with ARS-PM/DM-ILD significantly improved the PFS compared with PSL monotherapy, although there was no significant difference regarding longterm survival. PMID: 30647164 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Hozumi H, Fujisawa T, Nakashima R, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Inui N, Nakamura Y, Mimori T, Suda T Tags: J Rheumatol Source Type: research

Toward a Core Domain Set for Glucocorticoid Impact in Inflammatory Rheumatic Diseases: The OMERACT 2018 Glucocorticoid Impact Working Group.
CONCLUSION: It was agreed that a patient-reported outcome to measure GC effect was required and a research agenda was developed for this goal. PMID: 30647165 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Cheah JTL, Black RJ, Robson JC, Navarro-Millán IY, Young SR, Richards P, Beard S, Simon LS, Goodman SM, Mackie SL, Hill CL Tags: J Rheumatol Source Type: research

Gene Expression Pathways across Multiple Tissues in Antineutrophil Cytoplasmic Antibody-associated Vasculitis Reveal Core Pathways of Disease Pathology.
CONCLUSION: This analysis identified individual genes and pathways of disease common to all AAV tissues thus far characterized. The use of a network pathway analysis allowed us to identify pathologic mechanisms that were not readily apparent in the commonly expressed genes alone. Many of these pathways are consistent with current theories about infectious drivers and the crossroads of innate and adaptive immune mechanisms. In addition, this analysis highlights novel pathways, such as vessel wall interactions and platelet activation, which require further investigation. PMID: 30647166 [PubMed - as supplied by publisher...
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Friedman MA, Choi D, Planck SR, Rosenbaum JT, Sibley CH Tags: J Rheumatol Source Type: research

Detection of Sacroiliitis by Short-tau Inversion Recovery and T2-weighted Turbo Spin Echo Sequences: Results from the SIMACT Study.
CONCLUSION: T2-FS sequences improve image quality and hence the detection of osteitis compared to the PD-STIR sequence. More patients were classified as axSpA based on a positive MRI by T2-FS. PMID: 30647167 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Greese J, Diekhoff T, Sieper J, Schwenke C, Makowski MR, Poddubnyy D, Hamm B, Hermann KGA Tags: J Rheumatol Source Type: research

Increased Incidence of Giant Cell Arteritis in Urban Areas?
Abstract Giant cell arteritis (GCA) is the most common systemic vasculitis in adults. The pathogenesis and the etiology of the disease are not fully understood, and environmental factors, which may influence the incidence and prevalence, are poorly investigated. Only a few small studies have previously addressed the potential influence of rural or urban residence on the occurrence of GCA1,2,3. PMID: 30647168 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Brekke LK, Fevang BT, Myklebust G Tags: J Rheumatol Source Type: research

Increased Risk of Hypertension Associated with Spondyloarthritis Disease Duration: Results from the ASAS-COMOSPA Study.
We examined the association of SpA disease duration and delay in diagnosis with CV-related conditions. METHODS: Using data from the COMOSPA study, the associations between SpA disease duration and CV-related conditions were evaluated in univariable and multivariable logistic regression models. Each model examined 1 CV-related factor as dependent and "SpA disease duration" as a predictor, adjusted for relevant confounders. RESULTS: Data from 3923 subjects (median SpA disease duration 5.1 yrs, interquartile range 1.3-11.8 yrs) were available for analysis. The main CV-related conditions were hypertension (...
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Derakhshan MH, Goodson NJ, Packham JC, Sengupta R, Molto A, Marzo-Ortega H, Siebert S, BRITSpA and COMOSPA Investigators Tags: J Rheumatol Source Type: research

Comorbidities in Patients with Rheumatoid Arthritis and Their Association with Patient-reported Outcomes: Results of Claims Data Linked to Questionnaire Survey.
CONCLUSION: Compared to a matched population, persons with RA present with increased prevalence of numerous comorbidities. Patients with RA and multimorbidity are at risk of insufficient rheumatological care and poorer patient-reported outcomes. PMID: 30647170 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Luque Ramos A, Redeker I, Hoffmann F, Callhoff J, Zink A, Albrecht K Tags: J Rheumatol Source Type: research

Efficacy of Methotrexate in Real-world Management of Giant Cell Arteritis: A Case-control Study.
CONCLUSION: In this large single-institution cohort, the addition of MTX to GC decreased the rate of subsequent relapse by nearly 2-fold compared to patients taking GC alone. MTX may be considered as adjunct therapy in patients with GCA to decrease the risk of further relapse events. PMID: 30647171 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Koster MJ, Yeruva K, Crowson CS, Muratore F, Labarca C, Warrington KJ Tags: J Rheumatol Source Type: research

The SPECTRA Collaboration OMERACT Working Group: Criterion Validity of Joint Space Outcomes with High Resolution Peripheral Quantitative Computed Tomography.
Abstract OBJECTIVE: We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis. METHODS: In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints. RESULTS: Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Manske SL, Brunet SC, Finzel S, Stok KS, Conaghan PG, Boyd SK, Barnabe C Tags: J Rheumatol Source Type: research

The 2018 OMERACT Synovial Tissue Biopsy Special Interest Group Report on Standardization of Synovial Biopsy Analysis.
CONCLUSION: Six markers were identified for examination in a multicenter study designed to define an OMERACT-endorsed set of STB markers to predict responses to treatment. PMID: 30647173 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Wechalekar MD, Najm A, Veale DJ, Strand V Tags: J Rheumatol Source Type: research

Identifying Provisional Generic Contextual Factor Domains for Clinical Trials in Rheumatology: Results from an OMERACT Initiative.
CONCLUSION: The identified important contextual factor domains may be considered a provisional list pending further research. PMID: 30647174 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Nielsen SM, Tugwell P, de Wit MPT, Boers M, Beaton DE, Woodworth TG, Escorpizo R, Shea B, Toupin-April K, Guillemin F, Strand V, Singh JA, Kloppenburg M, Furst DE, Wells GA, Smolen JS, Veselý R, Boonen A, Storgaard H, Voshaar M, March L, Christensen R, C Tags: J Rheumatol Source Type: research

Disease Damage Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Systemic Lupus Erythematosus.
CONCLUSION: Reclassification into a very high-risk category is frequent after carotid US assessments in patients with SLE. This is independently influenced by disease damage. PMID: 30647175 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Quevedo-Abeledo JC, Rúa-Figueroa Í, Sánchez-Pérez H, Tejera-Segura B, de Vera-González A, González-Delgado A, Llorca J, González-Gay MÁ, Ferraz-Amaro I Tags: J Rheumatol Source Type: research

Report from the Hand Osteoarthritis Working Group at OMERACT 2018: Update on Core Instrument Set Development.
CONCLUSION: The development of the core instrument set is progressing, and a research agenda was also developed. PMID: 30647176 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Wittoek R, Kroon FPB, Kundakci B, Abhishek A, Haugen IK, Berenbaum F, Conaghan PG, Ishimori ML, Smeets W, van der Heijde D, Kloppenburg M Tags: J Rheumatol Source Type: research

Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort.
Chatham WW, Petri M, Khamashta M, Aranow C, Mackay M, Dooley MA, Manzi S, Ramsey-Goldman R, Nived O, Steinsson K, Zoma A, Ruiz-Irastorza G, Lim S, Kalunian K, Inanc M, Vollenhoven RV, Ramos-Casals M, Kamen DL, Jacobsen S, Peschken C, Askanase A, Stoll T, Bruce IN, Wetterö J, Sjöwall C Abstract OBJECTIVE: In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede ...
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Wirestam L, Enocsson H, Skogh T, Padyukov L, Jönsen A, Urowitz MB, Gladman DD, Romero-Diaz J, Bae SC, Fortin PR, Sanchez-Guerrero J, Clarke AE, Bernatsky S, Gordon C, Hanly JG, Wallace D, Isenberg DA, Rahman A, Merrill J, Ginzler E, Alarcón GS, Chatham Tags: J Rheumatol Source Type: research

Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort.
, Tucker LB, ReACCh-Out Investigators Abstract OBJECTIVE: To estimate the probability of early remission with conventional treatment for each child with juvenile idiopathic arthritis (JIA). Children with a low chance of remission may be candidates for initial treatment with biologics or triple disease-modifying antirheumatic drugs (DMARD). METHODS: We used data from 1074 subjects in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcome was clinically inactive disease for ≥ 6 months starting within 1 year of JIA diagnosis in patients who did not recei...
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Guzman J, Henrey A, Loughin T, Berard RA, Shiff NJ, Jurencak R, Huber AM, Oen K, Gerhold K, Feldman BM, Scuccimarri R, Houghton K, Chédeville G, Morishita K, Lang B, Dancey P, Rosenberg AM, Barsalou J, Bruns A, Watanabe Duffy K, Benseler S, Duffy CM, Tuc Tags: J Rheumatol Source Type: research

Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations.
CONCLUSION: Definition of 7 operational standardized terms provides an optimal platform for communication across healthcare providers involved in JIA-TMJ arthritis management. PMID: 30647179 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Stoustrup P, Resnick CM, Pedersen TK, Abramowicz S, Michelotti A, Küseler A, Verna C, Kellenberger CJ, Berit Nordal E, Caserta G, Jankovska I, Halbig JM, Kristensen KD, Arvidsson LZ, Spiegel L, Stoll ML, Lerman M, Glerup M, Defabianis P, Frid P, Alstergr Tags: J Rheumatol Source Type: research

Predictors of Effectiveness of Anakinra in Systemic Juvenile Idiopathic Arthritis.
CONCLUSION: Our findings help to delineate the clinical profile of patients with sJIA who are more likely to benefit from IL-1 blockade. They also underscore the need for studies aimed at examining the therapeutic role of early IL-1 inhibition and to identify biomarkers predicting response to either IL-1 or IL-6 antagonists. PMID: 30647180 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Saccomanno B, Tibaldi J, Minoia F, Bagnasco F, Pistorio A, Guariento A, Caorsi R, Consolaro A, Gattorno M, Ravelli A Tags: J Rheumatol Source Type: research

Variable Clinical Phenotypes and Relation of Interferon Signature with Disease Activity in ADA2 Deficiency.
CONCLUSION: Our data confirm the high variability of DADA2 and suggest type I IS as a biomarker of disease activity. PMID: 30647181 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Insalaco A, Moneta GM, Pardeo M, Caiello I, Messia V, Bracaglia C, Passarelli C, De Benedetti F Tags: J Rheumatol Source Type: research

Predictors of Achieving Remission among Patients with Psoriatic Arthritis Initiating a Tumor Necrosis Factor Inhibitor.
Abstract OBJECTIVE: To examine predictors of remission among patients with psoriatic arthritis (PsA) initiating a tumor necrosis factor (TNF) inhibitor. METHODS: Patients with PsA enrolled in the Corrona Registry between 2005 and 2013 were followed from initiation of a TNF inhibitor (TNFi; etanercept, adalimumab, infliximab, certolizumab, or golimumab) to the visit closest to 12 months. Additional inclusion criteria included 3 tender or 3 swollen joints. Outcomes of interest were Clinical Disease Activity Index (CDAI) ≤ 2.8 (remission), low disease activity (LDA; CDAI ≤ 10), change in the modified Healt...
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Ogdie A, Palmer JL, Greenberg J, Curtis JR, Harrold LR, Solomon DH, Kavanaugh A, Kremer JM, Mease PJ Tags: J Rheumatol Source Type: research

Position Statement: A Pragmatic Approach for Medical Cannabis and Patients with Rheumatic Diseases.
CONCLUSION: Despite lack of evidence for use of medical cannabis in rheumatology patients, we acknowledge the need to provide empathetic and pragmatic guidance for patient care. This position statement aims to facilitate the dialogue between patients and healthcare professionals in a mutually respectful manner to ensure harm reduction for patients and society. PMID: 30647183 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Fitzcharles MA, Zahedi Niaki O, Hauser W, Hazlewood G, the Canadian Rheumatology Association Tags: J Rheumatol Source Type: research

Epidemiologic Profile of Erectile Dysfunction in Patients with Systemic Lupus Erythematosus: The Latin American Landscape.
CONCLUSION: Regardless of comorbidities, treatment (excluding steroids), and type of disease activity, patients with SLE have a high prevalence of ED, especially considering that most patients are young. Recent corticosteroid use and persistent lymphopenia, which could be related to endothelial dysfunction, are risk factors for this complication in men with SLE. PMID: 30647184 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Merayo-Chalico J, Barrera-Vargas A, Morales-Padilla S, Reyna-De la Garza R, Vázquez-Rodríguez R, Campos-Guzmán J, Alcocer-Varela J, Sotomayor M, Abud-Mendoza C, Martínez-Martínez M, Colunga-Pedraza I, Uriarte-Hernández C, Acosta-Hernández R, Fajard Tags: J Rheumatol Source Type: research

The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis.
CONCLUSION: The updated core domain set for hip and/or knee OA has been agreed upon. Work will commence to determine which outcome measurement instrument should be recommended to cover each core domain. PMID: 30647185 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Smith TO, Hawker GA, Hunter DJ, March LM, Boers M, Shea BJ, Christensen R, Guillemin F, Terwee CB, Williamson PR, Dodd S, Roos EM, Loeser RF, Schnitzer TJ, Kloppenburg M, Neogi T, Ladel CH, Kalsi G, Kaiser U, Buttel TW, Ashford AE, Mobasheri A, Arden NK, Tags: J Rheumatol Source Type: research

Association Between Psoriasis with Arthritis and Hearing Impairment in US Adults: Data from the National Health and Nutrition Examination Survey.
CONCLUSION: PsA is independently associated with a significantly increased risk of HI, which partially mediates an association with worsened psychiatric outcomes. PMID: 30647186 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Semenov YR, Hsiang EY, Huang A, Herbosa CM, Hui X, Kwatra SG, Cohen B, Anadkat MJ Tags: J Rheumatol Source Type: research

The Third Biennial 2018 OMERACT First-time Participant Program: A Qualitative and Quantitative Study.
CONCLUSION: The expanded new participant training program is valued by attendees. PMID: 30647187 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Sloan VS, Grosskleg S, Wells G, Singh JA Tags: J Rheumatol Source Type: research

Association of Smoking and Obesity on the Risk of Developing Primary Sj ögren Syndrome: A Population-based Cohort Study.
CONCLUSION: In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association. PMID: 30647188 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Servioli L, Maciel G, Nannini C, Crowson CS, Matteson EL, Cornec D, Berti A Tags: J Rheumatol Source Type: research

Opioid Use in Patients with Ankylosing Spondylitis is Common in the United States: Outcomes of a Retrospective Cohort Study.
CONCLUSION: AS patients receive opioids with concerning frequency. The infrequent prescription of recommended therapies to these patients reflects a need to optimize treatment further through education of patients and healthcare professionals alike. PMID: 30647189 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Sloan VS, Sheahan A, Stark JL, Suruki RY Tags: J Rheumatol Source Type: research

Use of Magnetic Resonance Imaging to Support Dose Selection in a Phase II Trial of Baricitinib Combined with Conventional Synthetic Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis.
CONCLUSION: Using MRI findings in this subgroup of patients suggest suppression of synovitis, osteitis, and combined inflammation by baricitinib 4- and 8-mg, which corroborate previously demonstrated clinical efficacy of baricitinib and increase confidence that baricitinib 4-mg could positively effect reduction of the radiographic progression in Phase III studies. PMID: 30647190 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Peterfy C, DiCarlo J, Emery P, Genovese MC, Keystone EC, Taylor PC, Schlichting DE, Beattie SD, Luchi M, Macias W Tags: J Rheumatol Source Type: research

The OMERACT Emerging Leaders program: The good, the bad and the future.
CONCLUSION: The ELP has the potential to provide targeted training for early career researchers to develop relevant skills for future leadership roles within OMERACT. PMID: 30647191 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Flurey CA, Tugwell PS, Black RJ, Halls S, Page MJ, Robson JC, Sahbudin I, Siddle HJ, Sinnathurai P, Stok KS, Richards B Tags: J Rheumatol Source Type: research

Use of Anakinra in Hospitalized Patients with Crystal-associated Arthritis.
CONCLUSION: This is the largest observational study of anakinra use in the inpatient setting for the acute treatment of crystal-associated arthritis. We observed a rapid response to anakinra, with 75% of episodes significantly improving or completely resolving within four days of the first dose. Our data also support the use of this biologic agent in individuals with infections, as well as perioperative individuals and immunosuppressed transplant recipients. PMID: 30647192 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2019 Category: Rheumatology Authors: Liew JW, Gardner GC Tags: J Rheumatol Source Type: research

Too Little of a Good Thing: Hydroxychloroquine in Pregnancy.
PMID: 30600233 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2019 Category: Rheumatology Authors: Bermas BL Tags: J Rheumatol Source Type: research