Intact Calibers of Retinal Vessels in Patients with Systemic Sclerosis.
CONCLUSION: The evidence that retinal microcirculation is spared in SSc suggests that fibroproliferative vasculopathy may depend on specific cellular or soluble factors not present in the retinal environment. PMID: 25641886 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Aissopou EK, Bournia VK, Protogerou AD, Panopoulos S, Papaioannou TG, Vlachoyiannopoulos PG, Matucci-Cerinic M, Sfikakis PP Tags: J Rheumatol Source Type: research

Urinary Albumin Excretion Is Increased in Patients with Rheumatoid Arthritis and Associated with Arterial Stiffness.
CONCLUSION: Urinary albumin excretion was higher in patients with RA than controls and correlated with increased arterial stiffness, higher VCAM-1, and lower IL-10 concentrations. PMID: 25641887 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Becetti K, Oeser A, Ormseth M, Solus JF, Raggi P, Stein CM, Chung CP Tags: J Rheumatol Source Type: research

Characterization of Cumulative Joint Damage Patterns in Patients with Rheumatoid Arthritis: A Clinical, Serological, and Gene Polymorphism Perspective.
Abstract OBJECTIVE: To characterize cumulative joint damage (CJD) patterns in rheumatoid arthritis (RA) and determine their associations with demographic/clinical features and HLA-DRB1 gene polymorphism. METHODS: Hand and foot radiographs were obtained from 404 patients with RA. CJD patterns were determined by 3 derivations from Sharp/van der Heijde scores, obtained by the mathematical division of scores for hands/feet (Sharp-h/f score), fingers/wrists (Sharp-f/w score), and erosion/space narrowing (Sharp-e/sn score), respectively. DNA and serum were obtained for deter- mination of HLA-DRB1 polymorphism, rheu...
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Alarcon RT, Fernandes AD, Laurindo IM, Bertolo MB, Pinheiro GD, Andrade LE Tags: J Rheumatol Source Type: research

Choosing Wisely: The Canadian Rheumatology Association's List of 5 Items Physicians and Patients Should Question.
CONCLUSION: The list of 5 items has identified starting points to promote discussion about practices that should be questioned to assist rheumatology healthcare providers in delivering high-quality care. PMID: 25641889 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Chow SL, Thorne JC, Bell MJ, Ferrari R, Bagheri Z, Boyd T, Colwill AM, Jung M, Frackowiak D, Hazlewood GS, Kuriya B, Tugwell P, on behalf of the Canadian Rheumatology Association Choosing Wisely Committee Tags: J Rheumatol Source Type: research

Leukemia and Myelodysplastic Syndrome in Granulomatosis with Polyangiitis: Subtypes, Clinical Characteristics, and Outcome.
CONCLUSION: The findings emphasize the longterm risk of leukemia and MDS in CYC-treated, severely ill patients with GPA. Cytopenia during the course of GPA may be a warning sign and warrants a liberal attitude toward bone marrow examination. PMID: 25641890 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Knight A, Hjorton K, Sundström C, Höglund M, Backlin C, Smedby KE, Askling J, Baecklund E Tags: J Rheumatol Source Type: research

Variants of the IFI16 Gene Affecting the Levels of Expression of mRNA Are Associated with Susceptibility to Behçet Disease.
CONCLUSION: Our findings suggest association of IFI16, a cytosolic sensor of dsDNA and mediator of the AIM2 inflammasome-dependent pathway, in susceptibility to BD. Differences genetically determined in the levels of this molecule could be the cause of this association. PMID: 25641891 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Ortiz-Fernández L, García-Lozano JR, Montes-Cano MA, Conde-Jaldón M, Ortego-Centeno N, García-Hernández FJ, Espinosa G, Graña-Gil G, Sánchez-Bursón J, Blanco R, Barnosi-Marín AC, Solans R, Fanlo P, Rodríguez-Carballeira M, Camps T, Castañeda S, Tags: J Rheumatol Source Type: research

Abatacept in the Treatment of Severe, Longstanding, and Refractory Uveitis Associated with Juvenile Idiopathic Arthritis.
CONCLUSION: A sustained response to ABA was uncommon in patients with severe and refractory uveitis. PMID: 25641892 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Tappeiner C, Miserocchi E, Bodaghi B, Kotaniemi K, Mackensen F, Gerloni V, Quartier P, Lutz T, Heiligenhaus A Tags: J Rheumatol Source Type: research

Assessment of Risks of Pulmonary Infection During 12 Months Following Immunosuppressive Treatment for Active Connective Tissue Diseases: A Large-scale Prospective Cohort Study.
iyasaka N, Harigai M, for the PREVENT Study Group Abstract OBJECTIVE: Pulmonary infections (PI) are leading causes of death in patients with connective tissue diseases (CTD). The PREVENT study (Pulmonary infections in patients receiving immunosuppressive treatment for CTD) assessed risk of PI in patients with active CTD in the contemporary era of advanced immunosuppressive therapy. METHODS: In patients who started corticosteroids (n = 763), conventional immunosuppressants or biologics for active CTD were enrolled. Clinical and laboratory data, usage of drugs, and occurrence of PI were collected for 12 months....
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Yamazaki H, Sakai R, Koike R, Miyazaki Y, Tanaka M, Nanki T, Watanabe K, Yasuda S, Kurita T, Kaneko Y, Tanaka Y, Nishioka Y, Takasaki Y, Nagasaka K, Nagasawa H, Tohma S, Dohi M, Sugihara T, Sugiyama H, Kawaguchi Y, Inase N, Ochi S, Hagiyama H, Kohsaka H, Tags: J Rheumatol Source Type: research

A Qualitative Investigation of the Barriers to Help-seeking Among Members of the Public Presented with Symptoms of New-onset Rheumatoid Arthritis.
CONCLUSION: To our knowledge, our study is the first to investigate barriers to and drivers of help-seeking in response to the onset of RA symptoms in individuals without a diagnosis of RA. It has revealed a number of additional factors (e.g., the importance of the location of the symptoms) besides those previously identified in retrospective studies of patients with RA. Together with the data from previous research, these findings will help inform future health interventions aimed at increasing knowledge of RA and encouraging help-seeking. PMID: 25641894 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Simons G, Mallen CD, Kumar K, Stack RJ, Raza K Tags: J Rheumatol Source Type: research

Imaging as an Outcome Measure in Gout Studies: Report from the OMERACT Gout Working Group.
CONCLUSION: The working group prioritized gaps in the data and identified a research agenda. PMID: 25641895 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Grainger R, Dalbeth N, Keen H, Durcan L, Edwards NL, Perez-Ruiz F, Diaz-Torne C, Singh JA, Khanna D, Simon LS, Taylor WJ Tags: J Rheumatol Source Type: research

Deliberative Dialogue on Developing Consensus on Measurement and Presentation of Patient Important Outcomes in Systematic Reviews: A Preconference Meeting at OMERACT 12.
Abstract Prior to the Outcome Measures in Rheumatology (OMERACT) 12 meeting in Budapest, Hungary, a workshop was held bringing together individuals from a number of international outcome measure organizations to assess how best to further develop consensus on how pain is conceptualized and measured in trials of musculoskeletal conditions, and how the trials should be reported in systematic reviews. PMID: 25641896 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Tugwell PS, Maxwell LJ, Beaton DE, Busse JW, Christensen R, Conaghan PG, Simon LS, Terwee C, Tovey D, Wells GA, Williamson P Tags: J Rheumatol Source Type: research

Disease Activity in Ankylosing Spondylitis and Associations to Markers of Vascular Pathology and Traditional Cardiovascular Disease Risk Factors: A Cross-sectional Study.
Abstract OBJECTIVE: To compare the risk of cardiovascular disease (CVD) in ankylosing spondylitis (AS) and population controls, and to examine the associations between disease activity and CVD risk. METHODS: A cross-sectional study was done of patients with AS grouped according to Ankylosing Spondylitis Disease Activity Score (ASDAS) into ASDAS-high and ASDAS-low. Markers of vascular pathology, impaired endothelial function [asymmetric dimethylarginine (ADMA)], and arterial stiffness [augmentation index (AIx) and pulse wave velocity (PWV)], and traditional CVD risk factors [blood pressure, lipids, body mass i...
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Berg IJ, van der Heijde D, Dagfinrud H, Seljeflot I, Olsen IC, Kvien TK, Semb AG, Provan SA Tags: J Rheumatol Source Type: research

Lumpers and splitters: ongoing issues in the classification of large vessel vasculitis.
PMID: 25641963 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Grayson PC Tags: J Rheumatol Source Type: research

The need for preclinical biomarkers in systemic autoimmune rheumatic diseases.
PMID: 25641964 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Landolt-Marticorena C Tags: J Rheumatol Source Type: research

Obstetric antiphospholipid syndrome: has the black swan swallowed a red herring?
PMID: 25641965 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Clark CA, Spitzer KA, Laskin CA Tags: J Rheumatol Source Type: research

Obstetric antiphospholipid syndrome: lobsters only? Or should we also look for selected red herrings?
PMID: 25641966 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Meroni PL, Chighizola CB, Gerosa M, Trespidi L, Acaia B Tags: J Rheumatol Source Type: research

Dual-energy Computed Tomography for the Evaluation of Calcinosis in Systemic Sclerosis.
PMID: 25641967 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Hsu V, Bramwit M, Schlesinger N Tags: J Rheumatol Source Type: research

A vertebral bite by an aneurysm.
PMID: 25641968 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Verhoeven F, Wendling D Tags: J Rheumatol Source Type: research

Tumoral calcinosis during the course of systemic sclerosis.
enu B PMID: 25641969 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Audemard A, Silva NM, Boutemy J, Maigné G, Bienvenu B Tags: J Rheumatol Source Type: research

Chemerin and cardiovascular risk in rheumatoid arthritis after interleukin 6 receptor blockade.
PMID: 25641970 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Makrilakis K, Fragiadaki K, Sfikakis PP, Kitas GD Tags: J Rheumatol Source Type: research

Dr. Dessein, et al reply.
PMID: 25641971 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Dessein PH, Tsang L, Norton GR, Solomon A Tags: J Rheumatol Source Type: research

Comment on "fibromyalgia and physical trauma: the concepts we invent".
Comment on "fibromyalgia and physical trauma: the concepts we invent". J Rheumatol. 2015 Feb;42(2):351 Authors: Mader R, Buskila D, Ehrenfeld M PMID: 25641972 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Mader R, Buskila D, Ehrenfeld M Tags: J Rheumatol Source Type: research

Dr. Wolfe replies.
PMID: 25641973 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - February 1, 2015 Category: Rheumatology Authors: Wolfe F Tags: J Rheumatol Source Type: research

Association Between Corrected QT Interval and Inflammatory Cytokines in Rheumatoid Arthritis.
Abstract OBJECTIVE: Corrected QT (QTc) interval predicts all-cause and cardiovascular mortality and may contribute to the increased mortality risk in rheumatoid arthritis (RA). Animal experiments have shown that proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin 1 (IL-1)] can prolong cardiomyocyte action potential. We sought to determine whether elevations in circulating inflammatory cytokines were independently associated with QTc prolongation in patients with RA. METHODS: One hundred twelve patients [median age 62 (interquartile range 17) yrs; 80 women (71%)] from a well-characte...
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Adlan AM, Panoulas VF, Smith JP, Fisher JP, Kitas GD Tags: J Rheumatol Source Type: research

Takayasu Arteritis-associated Pulmonary Hypertension.
CONCLUSION: Patients with TA are at increased risk for PH. Early screening of patients with TA with unexplained symptoms related to PH should be applied. PH-specific therapies or revascularization may be effective treatments in the early stages of patients with PA, PH, and severe pulmonary artery stenosis. PMID: 25593224 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Wang X, Dang A, Chen B, Lv N, Liu Q Tags: J Rheumatol Source Type: research

Assessment of Fatigue in Rheumatoid Arthritis: A Psychometric Comparison of Single-item, Multiitem, and Multidimensional Measures.
CONCLUSION: The different instruments appear to access a common underlying domain of fatigue severity, but differ considerably in their measurement precision along the continuum. The SF-36 vitality scale can be used to measure fatigue severity in samples with relatively mild fatigue. For samples expected to have higher levels of fatigue, the multidimensional BRAF-MDQ appears to be a better choice. The BRAF-NRS are not recommended if precise assessment is required, for instance in longitudinal settings. PMID: 25593225 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Oude Voshaar MA, Ten Klooster PM, Bode C, Vonkeman HE, Glas CA, Jansen T, van Albada-Kuipers I, van Riel PL, van de Laar MA Tags: J Rheumatol Source Type: research

Isolated Hematuria and Sterile Pyuria May Indicate Systemic Lupus Erythematosus Activity.
CONCLUSION: Although not proven, our results suggest that these manifestations were associated with SLE activity, either before or after the episode, and therefore may represent a phase of active disease. PMID: 25593226 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Ding JY, Ibañez D, Gladman DD, Urowitz MB Tags: J Rheumatol Source Type: research

Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis.
Abstract OBJECTIVE: Immunoglobulin free light chains (FLC) represent biomarkers of B cell activity in rheumatoid arthritis (RA) and are associated with all-cause mortality in the general population. Our objective was to evaluate the relationships of serum FLC to preclinical disease, RA characteristics, and mortality in RA compared to non-RA subjects. METHODS: A population-based study in Olmsted County, Minnesota, USA, was performed by crosslinking a large cohort in the general population having available serum FLC measurements with established RA incidence and prevalence cohorts. Serum κ, λ, and ...
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Deng X, Crowson CS, Rajkumar SV, Dispenzieri A, Larson DR, Therneau TM, Matteson EL, Kyle RA, Katzmann JA, Gabriel SE, Davis JM Tags: J Rheumatol Source Type: research

Neurocognitive Impairment in Corticosteroid-naive Patients with Active Systemic Lupus Erythematosus: A Prospective Study.
CONCLUSION: We conclude that reduced psychomotor speed is an SLE-specific pattern of NCI. Verbal-memory deficits that have been reported in patients with SLE were not evident among patients who were corticosteroid-naive. Our results indicate that impaired psychomotor speed may be added to the symptoms of early SLE. PMID: 25593228 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Nishimura K, Omori M, Katsumata Y, Sato E, Gono T, Kawaguchi Y, Harigai M, Mimura M, Yamanaka H, Ishigooka J Tags: J Rheumatol Source Type: research

High Degree of Nonadherence to Oral Disease-modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis.
CONCLUSION: We demonstrated low adherence, suggesting differences between doctors' records and patients' practice of antirheumatic drug therapy. PMID: 25593229 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Rauscher V, Englbrecht M, van der Heijde D, Schett G, Hueber AJ Tags: J Rheumatol Source Type: research

Rates of Serious Infections and Malignancies Among Patients with Rheumatoid Arthritis Receiving Either Tumor Necrosis Factor Inhibitor or Rituximab Therapy.
CONCLUSION: Our results provide some reassurance of the safety of biologic treatments in the treatment of RA. PMID: 25593230 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Aaltonen KJ, Joensuu JT, Virkki L, Sokka T, Aronen P, Relas H, Valleala H, Rantalaiho V, Pirilä L, Puolakka K, Uusitalo T, Blom M, Konttinen YT, Nordström D Tags: J Rheumatol Source Type: research

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive.
Abstract Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis remains poorly understood. OA is no longer considered a "wear and tear" condition but rather one driven by proteases where chronic low-grade inflammation may play a role in perpetuating proteolytic activity. While multiple factors are likely active in this process, recent evidence has implicated the innate immune system, the older or more primitive part of the body's immune defense mechanisms. The roles of some of the components of the innate immune system have been tested in OA models in vivo including the rol...
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Orlowsky EW, Kraus VB Tags: J Rheumatol Source Type: research

Anti-carbamylated Protein Antibodies Are Present Prior to Rheumatoid Arthritis and Are Associated with Its Future Diagnosis.
CONCLUSION: Adding anti-CarP-FCS to antibody combinations did not improve AUC. However, anti-CarP-FCS was associated with future onset of RA, and was present in prediagnosis serum in ~10% of RA cases negative for anti-CCP2 but positive for RF. PMID: 25593232 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Gan RW, Trouw LA, Shi J, Toes RE, Huizinga TW, Demoruelle MK, Kolfenbach JR, Zerbe GO, Deane KD, Edison JD, Gilliland WR, Norris JM, Holers VM Tags: J Rheumatol Source Type: research

Longterm (52-week) Results of a Phase III Randomized, Controlled Trial of Apremilast in Patients with Psoriatic Arthritis.
CONCLUSION: Continuous apremilast treatment resulted in sustained improvements in PsA for up to 52 weeks. Apremilast had an acceptable safety profile and was generally well tolerated. Clinical trial registration: NCT01172938. PMID: 25593233 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Kavanaugh A, Mease PJ, Gomez-Reino JJ, Adebajo AO, Wollenhaupt J, Gladman DD, Hochfeld M, Teng LL, Schett G, Lespessailles E, Hall S Tags: J Rheumatol Source Type: research

Objective Evaluation of Physical Functioning after Tumor Necrosis Factor Inhibitory Therapy in Patients with Ankylosing Spondylitis: A Selection of 3 Feasible Performance-based Tests.
CONCLUSION: The 3 selected tests are recommended for use in daily practice because they generate information comparable to the full set. They are reliable and feasible, and the combination of these tests showed improved physical functioning after TNFi therapy in 67% of the patients. Evaluation of physical functioning might be improved by adding these tests to other AS outcome measures. PMID: 25593234 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: van Weely SF, Dekker J, Steultjens MP, van Denderen JC, Nurmohamed MT, Dijkmans BA, van der Horst-Bruinsma IE Tags: J Rheumatol Source Type: research

Chronic Obstructive Pulmonary Disease Is Common in Never-smoking Patients with Primary Sjögren Syndrome.
CONCLUSION: COPD was a common finding in patients with pSS, even among never-smoking patients. An obstructive pattern was the predominant PFT finding in patients with pSS, although a superimposed restrictive lung disease could not be excluded. The results suggest that the disease per se is involved in the development of COPD in pSS. PMID: 25593235 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Nilsson AM, Diaz S, Theander E, Hesselstrand R, Piitulainen E, Ekberg O, Wollmer P, Mandl T Tags: J Rheumatol Source Type: research

Incidence of Malignancy and the Risk of Lymphoma in Japanese Patients with Rheumatoid Arthritis Compared to the General Population.
CONCLUSION: Patients with RA had no higher overall incidence of malignancies, but lymphoma was significantly more frequent than in the general population. PMID: 25593236 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Hashimoto A, Chiba N, Tsuno H, Komiya A, Furukawa H, Matsui T, Nishino J, Tohma S Tags: J Rheumatol Source Type: research

A Simplified Baseline Prediction Model for Joint Damage Progression in Rheumatoid Arthritis: A Step toward Personalized Medicine.
CONCLUSION: A simple prediction model for joint damage progression in early RA, by only counting the number of risk factors, has adequate performance. This facilitates the translation of the theoretical prognostic models to daily clinical practice. PMID: 25593237 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: de Punder YM, van Riel PL, Fransen J Tags: J Rheumatol Source Type: research

Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts.
Abstract OBJECTIVE: To investigate the effects of the endothelin 1 (ET-1) receptor antagonists (ETRA) macitentan, its active metabolite ACT-132577, and bosentan on myofibroblast activation and extracellular matrix production induced by ET-1 in cultured systemic sclerosis (SSc) and control skin fibroblasts. METHODS: Fibroblasts were obtained from skin biopsies of 6 patients with SSc and 5 healthy subjects. Some cultured cells were untreated or treated with macitentan, ACT-132577, or bosentan alone (10 μM). Other cultured cells were treated with ET-1 alone (100 nM) or with ETRA, and after 1 h, also with ET-1...
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Cutolo M, Montagna P, Brizzolara R, Smith V, Alessandri E, Villaggio B, Sulli A, Tavilla PP, Pizzorni C, Soldano S Tags: J Rheumatol Source Type: research

A Preliminary Study of Acoustic Radiation Force Impulse Quantification for the Assessment of Skin in Diffuse Cutaneous Systemic Sclerosis.
Abstract OBJECTIVE: To investigate skin elasticity using acoustic radiation force impulse (ARFI) quantification in systemic sclerosis (SSc), and compare the modified Rodnan skin score (mRSS) with measured shear wave velocity (SWV) and thickness of the skin. METHODS: Fifteen patients with diffuse cutaneous SSc (dcSSc) and 15 age-matched and sex-matched healthy controls were evaluated. The SWV and thickness of skin were measured at 17 sites corresponding to those assessed in the mRSS in each participant. The SWV measurements of skin were compared between patients with dcSSc and healthy controls. The correlation...
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Hou Y, Zhu QL, Liu H, Jiang YX, Wang L, Xu D, Li MT, Zeng XF, Zhang FC Tags: J Rheumatol Source Type: research

Quantitation of Circumferential Syndesmophyte Height along the Vertebral Rim in Ankylosing Spondylitis Using Computed Tomography.
Abstract OBJECTIVE: Using the 3-D imaging capability of computed tomography (CT), we developed an algorithm quantitating syndesmophyte height along the entire vertebral rim. We investigated its reliability and sensitivity to change, performed a 2-year longitudinal study, and compared it to CT measures of syndesmophyte volume. METHODS: We performed thoracolumbar spine CT scans on 33 patients at baseline, Year 1, and Year 2, and computed syndesmophyte height in 4 intervertebral disc spaces (IDS). Height was computed every 5° (72 angular sectors) along the vertebral rim. These 72 measures were summed to form...
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Tan S, Yao J, Flynn JA, Yao L, Ward MM Tags: J Rheumatol Source Type: research

Personalizing Treatment Targets in Rheumatoid Arthritis by Using a Simple Prediction Model.
CONCLUSION: Presence of anti-CCP, acute-phase response, and erosions at baseline can be used to set individual treatment targets in RA. In patients without these risk factors, a moderate DAS as a target is sufficient, while for patients with all 3 risk factors, a low DAS is not strict enough to limit the risk for joint damage. PMID: 25593241 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: de Punder YM, Jansen TL, van Ede AE, den Broeder AA, van Riel PL, Fransen J Tags: J Rheumatol Source Type: research

Safety and Efficacy of Rituximab in Childhood-onset Systemic Lupus Erythematosus and Other Rheumatic Diseases.
CONCLUSION: RTX can be safely administered to children and appears to contribute to decreased disease activity and steroid burden. PMID: 25593242 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Tambralli A, Beukelman T, Cron RQ, Stoll ML Tags: J Rheumatol Source Type: research

Variation in Rheumatoid Hand and Wrist Surgery among Medicare Beneficiaries: A Population-based Cohort Study.
CONCLUSION: Surgical reconstruction of rheumatoid hand deformities varies widely across the United States, driven by both regional availability of subspecialty care in rheumatology and individual patient factors. PMID: 25593243 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Zhong L, Chung KC, Baser O, Fox DA, Yuce H, Waljee JF Tags: J Rheumatol Source Type: research

Magnetic resonance imaging - key to understanding and monitoring disease progression in spondyloarthritis?
h;rensen IJ PMID: 25554801 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2015 Category: Rheumatology Authors: Østergaard M, Sørensen IJ Tags: J Rheumatol Source Type: research

Surfactant protein d family: potential for diagnosis or monitoring therapy in autoimmune diseases?
PMID: 25554802 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2015 Category: Rheumatology Authors: Fox RI, Fox C Tags: J Rheumatol Source Type: research

Progress in the evolution of systemic sclerosis classification criteria and recommendation for additional comparative specificity studies.
PMID: 25554803 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2015 Category: Rheumatology Authors: Masi AT, Medsger TA Tags: J Rheumatol Source Type: research

Systemic sclerosis classification: a rose by any other name would smell as sweet?
PMID: 25554804 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2015 Category: Rheumatology Authors: Pope JE Tags: J Rheumatol Source Type: research

Arthritis clinical trials at a crossroad.
PMID: 25554805 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2015 Category: Rheumatology Authors: Pope JE, Thorne JC, Haraoui BP, Karsh J, Keystone EC, Bennett L Tags: J Rheumatol Source Type: research

Delivering future clinical trials in rheumatology.
PMID: 25554806 [PubMed - in process] (Source: J Rheumatol)
Source: J Rheumatol - January 1, 2015 Category: Rheumatology Authors: Galloway JB, Scott DL Tags: J Rheumatol Source Type: research