Thermal ablation in the management of oligometastatic colorectal cancer
CONCLUSIONS: The routine incorporation of image-guided thermal ablation into the therapeutic armamentarium for the treatment of oligometastatic colorectal cancer can provide long survival and even cure.PMID:35477367 | DOI:10.1080/02656736.2021.1941311 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 28, 2022 Category: Internal Medicine Authors: Thierry De Baere Lambros Tselikas Alexandre Delpla Charles Roux Eloi Varin Adrian Kobe Steven Yevich Frederic Deschamps Source Type: research

A new thermal dose model based on Vogel-Tammann-Fulcher behaviour in thermal damage processes
Int J Hyperthermia. 2022;39(1):697-705. doi: 10.1080/02656736.2022.2065367.ABSTRACTThermal dose models are metrics that quantify the thermal effect on tissues based on the temperature and the time of exposure. These models are used to predict and control the outcome of hyperthermia (up to 45°C) treatments, and of thermal coagulation treatments at higher temperatures (>45°C). The validity and accuracy of the commonly used models (CEM43) are questionable when heating above the hyperthermia temperature range occurs, leading to an over-estimation of the accumulation of thermal damage. A new CEM43 dose model based on an Ar...
Source: International Journal of Hyperthermia - April 26, 2022 Category: Internal Medicine Authors: H T I Assi M G Arsenault W M Whelan J C Kumaradas Source Type: research

Irreversible electroporation for colorectal cancer liver metastasis: a review
Int J Hyperthermia. 2022;39(1):682-687. doi: 10.1080/02656736.2021.2008025.ABSTRACTIrreversible electroporation (IRE) ablation is gaining popularity over the last decade as a nonthermal alternative to thermal ablation technologies such as radiofrequency ablation (RFA) and Microwave ablation (MWA). This review serves as a practical guide for applying IRE to colorectal cancer liver metastases (CRLM) for interventional radiologists, oncologists, surgeons, and anesthesiologists. It covers patient selection, procedural technique, anesthesia, imaging, and outcomes.PMID:35469520 | DOI:10.1080/02656736.2021.2008025 (Source: Intern...
Source: International Journal of Hyperthermia - April 26, 2022 Category: Internal Medicine Authors: Yilun Koethe Nicole Wilson Govindarajan Narayanan Source Type: research

The role of neoadjuvant conventional transarterial chemoembolization with radiofrequency ablation in the treatment of recurrent hepatocellular carcinoma after initial hepatectomy with microvascular invasion
CONCLUSIONS: Neoadjuvant cTACE could effectively reduce re-recurrence after RFA, and improve the long-term survivals for patients with solitary small recurrent HCC whose primary tumor was MVI-positive. Key pointsFor recurrent hepatocellular carcinoma (HCC) patients whose primary tumor was positive for microvascular invasion, neoadjuvant conventional transarterial chemoembolization (cTACE) with radiofrequency ablation (RFA) achieved better efficacy.Multivariable analyses showed that the interval of recurrence from initial treatment > 1 year and RFA alone were independent prognostic factors of overall survival and recurre...
Source: International Journal of Hyperthermia - April 26, 2022 Category: Internal Medicine Authors: Zhenwei Peng Xiaoxue Wu Jiaping Li Hui Pang Yaojun Zhang Manxia Lin Zaiguo Wang Han Xiao Bin Li Minshan Chen Shiting Feng Ming Kuang Shuling Chen Source Type: research

A new thermal dose model based on Vogel-Tammann-Fulcher behaviour in thermal damage processes
Int J Hyperthermia. 2022;39(1):697-705. doi: 10.1080/02656736.2022.2065367.ABSTRACTThermal dose models are metrics that quantify the thermal effect on tissues based on the temperature and the time of exposure. These models are used to predict and control the outcome of hyperthermia (up to 45°C) treatments, and of thermal coagulation treatments at higher temperatures (>45°C). The validity and accuracy of the commonly used models (CEM43) are questionable when heating above the hyperthermia temperature range occurs, leading to an over-estimation of the accumulation of thermal damage. A new CEM43 dose model based on an Ar...
Source: International Journal of Hyperthermia - April 26, 2022 Category: Internal Medicine Authors: H T I Assi M G Arsenault W M Whelan J C Kumaradas Source Type: research

Irreversible electroporation for colorectal cancer liver metastasis: a review
Int J Hyperthermia. 2022;39(1):682-687. doi: 10.1080/02656736.2021.2008025.ABSTRACTIrreversible electroporation (IRE) ablation is gaining popularity over the last decade as a nonthermal alternative to thermal ablation technologies such as radiofrequency ablation (RFA) and Microwave ablation (MWA). This review serves as a practical guide for applying IRE to colorectal cancer liver metastases (CRLM) for interventional radiologists, oncologists, surgeons, and anesthesiologists. It covers patient selection, procedural technique, anesthesia, imaging, and outcomes.PMID:35469520 | DOI:10.1080/02656736.2021.2008025 (Source: Intern...
Source: International Journal of Hyperthermia - April 26, 2022 Category: Internal Medicine Authors: Yilun Koethe Nicole Wilson Govindarajan Narayanan Source Type: research

The role of neoadjuvant conventional transarterial chemoembolization with radiofrequency ablation in the treatment of recurrent hepatocellular carcinoma after initial hepatectomy with microvascular invasion
CONCLUSIONS: Neoadjuvant cTACE could effectively reduce re-recurrence after RFA, and improve the long-term survivals for patients with solitary small recurrent HCC whose primary tumor was MVI-positive. Key pointsFor recurrent hepatocellular carcinoma (HCC) patients whose primary tumor was positive for microvascular invasion, neoadjuvant conventional transarterial chemoembolization (cTACE) with radiofrequency ablation (RFA) achieved better efficacy.Multivariable analyses showed that the interval of recurrence from initial treatment > 1 year and RFA alone were independent prognostic factors of overall survival and recurre...
Source: International Journal of Hyperthermia - April 26, 2022 Category: Internal Medicine Authors: Zhenwei Peng Xiaoxue Wu Jiaping Li Hui Pang Yaojun Zhang Manxia Lin Zaiguo Wang Han Xiao Bin Li Minshan Chen Shiting Feng Ming Kuang Shuling Chen Source Type: research

Ablation for oligometastatic colorectal carcinoma in extrahepatic, extrapulmonary sites
Int J Hyperthermia. 2022;39(1):633-638. doi: 10.1080/02656736.2021.1952318.ABSTRACTTreatment of metastatic colorectal carcinoma has evolved in the era of increasingly effective systemic therapies. Increasing survival rates provide opportunities for repeated focal therapies to be directed at limited metastatic disease. Surgical resection and other ablative therapies to eliminate oligometastases in the most common sites, namely liver and lung, have been proven to prolong survival. As such, patients develop additional sites of metastasis in the course of their disease, including adrenal, peritoneal, nodal, and skeletal metast...
Source: International Journal of Hyperthermia - April 25, 2022 Category: Internal Medicine Authors: Scott M Thompson Brian T Welch A Nick Kurup Source Type: research

Volumetric analyses of ablation dimensions in microwave ablation for colorectal liver metastases
CONCLUSIONS: This study confirmed that factors beyond the applied ablation energy might affect volumetric ablation dimensions, resulting in poor predictability. Further clinical trials including tissue sampling are needed to relate physical tissue properties to ablation expansion.PMID:35465802 | DOI:10.1080/02656736.2021.1965224 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 25, 2022 Category: Internal Medicine Authors: Iwan Paolucci Simeon J S Ruiter Jacob Freedman Daniel Candinas Koert P de Jong Stefan Weber Pascale Tinguely Source Type: research

Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment
Int J Hyperthermia. 2022;39(1):649-663. doi: 10.1080/02656736.2021.1970245.ABSTRACTImage-guided percutaneous ablation techniques represent an attractive local therapy for the treatment of colorectal liver metastases (CLM) given its low risk of severe complications, which allows for early initiation of adjuvant therapies and spare functional liver parenchyma, allowing repeated treatments at the time of recurrence. However, ablation does not consistently achieve similar oncological outcomes to surgery, with the latter being currently considered the first-line local treatment modality in international guidelines. Recent appli...
Source: International Journal of Hyperthermia - April 25, 2022 Category: Internal Medicine Authors: Yuan-Mao Lin Reto Bale Kristy K Brock Bruno C Odisio Source Type: research

Shaping the future of microwave tumor ablation: a new direction in precision and control of device performance
Int J Hyperthermia. 2022;39(1):664-674. doi: 10.1080/02656736.2021.1991012.ABSTRACTMicrowave ablation (MWA) is becoming an increasingly important minimally invasive treatment option for localized tumors in many organ systems due to recent advancements in microwave technology that have conferred many advantages over other tumor ablation modalities. Despite these improvements in technology and development of applicators for site-specific tumor applications, the vast majority of commercially available MWA applicators are generally designed to create large-volume, symmetric, ellipsoid or spherically-shaped treatment zones and ...
Source: International Journal of Hyperthermia - April 25, 2022 Category: Internal Medicine Authors: Austin Pfannenstiel Jason Iannuccilli Francois H Cornelis Damian E Dupuy Warren L Beard Punit Prakash Source Type: research

Yttrium-90 for colorectal liver metastasis - the promising role of radiation segmentectomy as an alternative local cure
Int J Hyperthermia. 2022;39(1):620-626. doi: 10.1080/02656736.2021.1933215.ABSTRACTThe majority of patients with metastatic colorectal cancer (CRC) to the liver are not amenable to curative-intent surgery or thermal ablation; there is a need for alternative locoregional therapies to control oligometastatic liver disease. Sequential lobar Yttrium-90 (Y90) radioembolization has demonstrated favorable results in the salvage setting for CRC patients with liver only or liver-dominant metastatic disease, but the role of Y90 in earlier-stage disease has not shown to be as promising. Recently, radiation segmentectomy, the super se...
Source: International Journal of Hyperthermia - April 25, 2022 Category: Internal Medicine Authors: Pouya Entezari Ahmed Gabr Riad Salem Robert J Lewandowski Source Type: research

Molecular imaging in management of colorectal metastases by the interventional oncologist
Int J Hyperthermia. 2022;39(1):675-681. doi: 10.1080/02656736.2021.1998657.ABSTRACTInterventional oncologists provide several effective treatment options for patients with metastatic colorectal cancer (mCRC), including embolization and ablation-based techniques. Molecular imaging methods such as positron emission tomography (PET) can play an important role in managing mCRC patients. In this review, we aim to highlight the role of molecular imaging in mCRC management by interventional oncologists including: initial staging and pretreatment planning; predicting molecular subtypes, prognosis, and treatment outcomes; intraproc...
Source: International Journal of Hyperthermia - April 25, 2022 Category: Internal Medicine Authors: Stephen Hunt Alireza Zandifar Abass Alavi Source Type: research

Thromboelastography maximum amplitude as an early predictor of disseminated intravascular coagulation in patients with heatstroke
CONCLUSIONS: MA < 45.4 mm in patients with heatstroke may predict elevated risk of DIC. HighlightsPatients with heatstroke-induced disseminated intravascular coagulation (DIC) has high mortality.A retrospective, single-center study was performed to investigate the ability of thromboelastography (TEG) to predict DIC associated with heatstroke.The maximum amplitude (MA) value of TEG decreased significantly with the increase of DIC score.MA < 45.4 mm was firstly demonstrated to an independent predictor of heatstroke-induced DIC.PMID:35465816 | DOI:10.1080/02656736.2022.2066206 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 25, 2022 Category: Internal Medicine Authors: Longping He Qingwei Lin Lincui Zhong Qingbo Zeng Jingchun Song Source Type: research