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Clinical translation of abdominal histotripsy: a review of preclinical studies in large animal models
Int J Hyperthermia. 2023;40(1):2272065. doi: 10.1080/02656736.2023.2272065. Epub 2023 Oct 24.ABSTRACTHistotripsy is an emerging noninvasive, non-thermal, and non-ionizing focused ultrasound (US) therapy that can be used to destroy targeted tissue. Histotripsy has evolved from early laboratory prototypes to clinical systems which have been comprehensively evaluated in the preclinical environment to ensure safe translation to human use. This review summarizes the observations and results from preclinical histotripsy studies in the liver, kidney, and pancreas. Key findings from these studies include the ability to make a clin...
Source: International Journal of Hyperthermia - October 24, 2023 Category: Internal Medicine Authors: Katrina L Falk Paul F Laeseke Meridith A Kisting Annie M Zlevor Emily A Knott Amanda R Smolock Charles Bradley Eli Vlaisavljevich Fred T Lee Timothy J Ziemlewicz Source Type: research

HYPER: pre-clinical device for spatially-confined magnetic particle hyperthermia
Int J Hyperthermia. 2023;40(1):2272067. doi: 10.1080/02656736.2023.2272067. Epub 2023 Oct 24.ABSTRACTPURPOSE: Magnetic particle hyperthermia is an approved cancer treatment that harnesses thermal energy generated by magnetic nanoparticles when they are exposed to an alternating magnetic field (AMF). Thermal stress is either directly cytotoxic or increases the susceptibility of cancer cells to standard therapies, such as radiation. As with other thermal therapies, the challenge with nanoparticle hyperthermia is controlling energy delivery. Here, we describe the design and implementation of a prototype pre-clinical device, c...
Source: International Journal of Hyperthermia - October 24, 2023 Category: Internal Medicine Authors: Hayden Carlton Matthias Weber Maximilian Peters Nageshwar Arepally Yash Sharad Lad Anshul Jaswal Robert Ivkov Anilchandra Attaluri Patrick Goodwill Source Type: research

Research progress of hyperthermia in tumor therapy by influencing metabolic reprogramming of tumor cells
Int J Hyperthermia. 2023;40(1):2270654. doi: 10.1080/02656736.2023.2270654. Epub 2023 Oct 23.ABSTRACTCellular metabolic reprogramming is an important feature of malignant tumors. Metabolic reprogramming causes changes in the levels or types of specific metabolites inside and outside the cell, which affects tumorigenesis and progression by influencing gene expression, the cellular state, and the tumor microenvironment. During tumorigenesis, a series of changes in the glucose metabolism, fatty acid metabolism, amino acid metabolism, and cholesterol metabolism of tumor cells occur, which are involved in the process of cellula...
Source: International Journal of Hyperthermia - October 23, 2023 Category: Internal Medicine Authors: Yuchuan Yang Linkuan Huangfu Huizhen Li Daoke Yang Source Type: research

Synchronous percutaneous core-needle biopsy and microwave ablation for stage I non-small cell lung cancer in patients with Idiopathic pulmonary fibrosis: initial experience
CONCLUSIONS: According to the results of the current study, CT-guided synchronous percutaneous CNB and MWA appears to be a safe and effective for stage I NSCLC in patients with IPF and providing an alternative therapeutic option for local control of pulmonary malignancy in high-risk patients.PMID:37848399 | DOI:10.1080/02656736.2023.2270793 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 17, 2023 Category: Internal Medicine Authors: Bin Li Zhixin Bie Yuanming Li Runqi Guo Chengen Wang Xiaoguang Li Source Type: research

Publications on ultrasound-guided thermal ablation for thyroid nodules from 2000 to 2022: a bibliometric analysis
CONCLUSION: This bibliometric study conducts a comprehensive analysis of publications on thermal ablation for thyroid nodules, which aids investigators in discovering potential research directions.PMID:37848401 | DOI:10.1080/02656736.2023.2268874 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 17, 2023 Category: Internal Medicine Authors: Jiajia Tang Liangkai Wang Zhe Sun Xinyi Liu Huilin Li Jiaojiao Ma Xuehua Xi Bo Zhang Source Type: research

Clinical outcomes of radiofrequency ablation for solitary T1aN0M0 versus T1bN0M0 papillary thyroid carcinoma: a propensity-matched cohort study
CONCLUSIONS: The presence of T1b did not influence the patients' prognoses following RFA for T1N0M0 PTC. After appropriate patient selection and adequate preoperative assessment, RFA has the potential to serve as an effective therapy for individuals with T1a and T1b PTC.PMID:37848402 | DOI:10.1080/02656736.2023.2257908 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 17, 2023 Category: Internal Medicine Authors: Mengying Tong Linchun Wang Ziru Gai Yalin Zhu Ying Che Source Type: research