Hyperthermia promotes exosome secretion by regulating Rab7b while increasing drug sensitivity in adriamycin-resistant breast cancer
CONCLUSIONS: Our results demonstrated a novel function of hyperthermia in promoting exosome secretion in adriamycin-resistant breast cancer cells and revealed the effects of hyperthermia on tumor cell biology. These hyperthermia-triggered exosomes can carry antitumor genes to the residual tumor and tumor microenvironment, which may be more beneficial to the effects of hyperthermia. These results represent an exploration of the relationship between therapeutic strategies and exosome biology.PMID:35100921 | DOI:10.1080/02656736.2022.2029585 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 1, 2022 Category: Internal Medicine Authors: Di Xu Wen-Juan Tang Yi-Zhi Zhu Zhen Liu Kai Yang Ming-Xing Liang Xiu Chen Yang Wu Jin-Hai Tang Wei Zhang Source Type: research

A novel method of bedside hyperthermic intraperitoneal chemotherapy as adjuvant therapy for stage-III gastric cancer
CONCLUSION: HIPEC with cisplatin plus oral S-1 is a safe and effective adjuvant therapy for patients with advanced gastric cancer following D2 radical gastrectomy. Trial registration: This study was registered at ClinicalTrials.gov with the identifier (NCT number): NCT02396498.PMID:35100917 | DOI:10.1080/02656736.2022.2028018 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 1, 2022 Category: Internal Medicine Authors: Lili Liu Li Sun Ning Zhang Cheng-Gong Liao Haichuan Su Jie Min Yang Song Xue Yang Xiaofeng Huang Dongxu Chen Yu Chen Hong-Wei Zhang Helong Zhang Source Type: research

Hyperthermia promotes exosome secretion by regulating Rab7b while increasing drug sensitivity in adriamycin-resistant breast cancer
CONCLUSIONS: Our results demonstrated a novel function of hyperthermia in promoting exosome secretion in adriamycin-resistant breast cancer cells and revealed the effects of hyperthermia on tumor cell biology. These hyperthermia-triggered exosomes can carry antitumor genes to the residual tumor and tumor microenvironment, which may be more beneficial to the effects of hyperthermia. These results represent an exploration of the relationship between therapeutic strategies and exosome biology.PMID:35100921 | DOI:10.1080/02656736.2022.2029585 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 1, 2022 Category: Internal Medicine Authors: Di Xu Wen-Juan Tang Yi-Zhi Zhu Zhen Liu Kai Yang Ming-Xing Liang Xiu Chen Yang Wu Jin-Hai Tang Wei Zhang Source Type: research

High-intensity focused ultrasound treatment for symptomatic uterine fibroids: a systematic review and meta-analysis
CONCLUSIONS: Although HIFU has relatively high re-intervention rate, it may offer a higher pregnancy rate and shorter pregnancy interval with little influence on ovarian function, thus making it an attractive option for treating symptomatic fibroids in young women who wish to plan a pregnancy in the future.PMID:35094613 | DOI:10.1080/02656736.2022.2029956 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 31, 2022 Category: Internal Medicine Authors: Ling Yan Huimin Huang Jingwen Lin Ruimei Yu Source Type: research

Effects of deep heating modalities on the morphological and elastic properties of the non-insertional region of achilles tendon: a pilot study
CONCLUSION: this pilot study demonstrated larger effects on morphological and elastic properties of the non-insertional region of the Achilles tendon after diathermy than ultrasound therapy in normal tendons. Diathermy may be a useful deep heat modality for treating non-insertional Achilles tendinopathy.PMID:35094631 | DOI:10.1080/02656736.2022.2026497 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 31, 2022 Category: Internal Medicine Authors: Daniele Munari Anna Serina Arianna Leonardelli Davide Lanza Alberto Caramori Andrea Guerrini Modenese Angela Mirko Filippetti Nicola Smania Alessandro Picelli Source Type: research

High-intensity focused ultrasound treatment for symptomatic uterine fibroids: a systematic review and meta-analysis
CONCLUSIONS: Although HIFU has relatively high re-intervention rate, it may offer a higher pregnancy rate and shorter pregnancy interval with little influence on ovarian function, thus making it an attractive option for treating symptomatic fibroids in young women who wish to plan a pregnancy in the future.PMID:35094613 | DOI:10.1080/02656736.2022.2029956 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 31, 2022 Category: Internal Medicine Authors: Ling Yan Huimin Huang Jingwen Lin Ruimei Yu Source Type: research

Effects of deep heating modalities on the morphological and elastic properties of the non-insertional region of achilles tendon: a pilot study
CONCLUSION: this pilot study demonstrated larger effects on morphological and elastic properties of the non-insertional region of the Achilles tendon after diathermy than ultrasound therapy in normal tendons. Diathermy may be a useful deep heat modality for treating non-insertional Achilles tendinopathy.PMID:35094631 | DOI:10.1080/02656736.2022.2026497 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 31, 2022 Category: Internal Medicine Authors: Daniele Munari Anna Serina Arianna Leonardelli Davide Lanza Alberto Caramori Andrea Guerrini Modenese Angela Mirko Filippetti Nicola Smania Alessandro Picelli Source Type: research

Ultrasound-guided laser ablation of very large benign thyroid nodules: 4-year, retrospective follow-up in 24 patients
CONCLUSIONS: In this patient series, percutaneous, ultrasound-guided laser ablation of very large thyroid modules provided long-term benefits and the treatment was well tolerated.PMID:35078372 | DOI:10.1080/02656736.2022.2025923 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 26, 2022 Category: Internal Medicine Authors: Giovanni Gambelunghe Serenella Ristagno Elisa Stefanetti Nicola Avenia Pierpaolo De Feo Source Type: research

Long-term efficacy of microwave ablation in the treatment of subcapsular hepatocellular carcinomas of ≤3 cm in diameter: a multicenter, propensity score-matched study
CONCLUSION: There were no significant differences in DFS, OS, incidence of local tumor progression, and major complications between patients with subcapsular and non-subcapsular HCCs treated with MWA.PMID:35067144 | DOI:10.1080/02656736.2021.2023228 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 24, 2022 Category: Internal Medicine Authors: Jundong Yao Binbin Liu Xiaohui Wang Jie Yu Zhigang Cheng Zhiyu Han Fangyi Liu Rongqin Zheng Wen Cheng Qiang Wei Songyuan Yu Kai Li Peng Chen Yanchun Luo Xiaoling Yu Ping Liang Source Type: research

Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia
CONCLUSIONS: Hyperthermia decreased the levels of MAP3K TAK1, RAF1 and MEKK2, without reduction of the downstream components in the MAP3K-MAP2K-MAPK cascade, by a calpain-dependent degradation pathway or transcriptional regulation. TAK1, RAF1 and/or MEKK2 play crucial roles in cell proliferation and clonogenicity and are potential molecular targets for hyperthermia.PMID:35042442 | DOI:10.1080/02656736.2021.2024281 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 19, 2022 Category: Internal Medicine Authors: Atsushi Enomoto Takemichi Fukasawa Hiroshi Terunuma Keiichi Nakagawa Ayumi Yoshizaki Shinichi Sato Kiyoshi Miyagawa Source Type: research

Risk factors for the recurrence of early hepatocellular carcinoma treated by percutaneous radiofrequency ablation with a multiple-electrode switching system: a multicenter prospective study
CONCLUSIONS: The MESS-RFA is an effective method for local control of tumors in early HCC. Early HCC with multiple high-ALP tumors has a higher rate of recurrence, which mainly occurs in an IDR pattern. Early HCC with high AFP levels and a shorter initial recurrence interval resulted in a poorer prognosis. Thus, treatments such as liver transplantation or surgical resection may be a good strategy in those cases.CLINICALTRIALS.GOV ID: NCT02046356.PMID:35042449 | DOI:10.1080/02656736.2021.2024279 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 19, 2022 Category: Internal Medicine Authors: Yunhua Tan Xin Wang Kuansheng Ma Lin Zhang Jing Li Ping Chen Ben Zhang Source Type: research

Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia
CONCLUSIONS: Hyperthermia decreased the levels of MAP3K TAK1, RAF1 and MEKK2, without reduction of the downstream components in the MAP3K-MAP2K-MAPK cascade, by a calpain-dependent degradation pathway or transcriptional regulation. TAK1, RAF1 and/or MEKK2 play crucial roles in cell proliferation and clonogenicity and are potential molecular targets for hyperthermia.PMID:35042442 | DOI:10.1080/02656736.2021.2024281 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 19, 2022 Category: Internal Medicine Authors: Atsushi Enomoto Takemichi Fukasawa Hiroshi Terunuma Keiichi Nakagawa Ayumi Yoshizaki Shinichi Sato Kiyoshi Miyagawa Source Type: research

Risk factors for the recurrence of early hepatocellular carcinoma treated by percutaneous radiofrequency ablation with a multiple-electrode switching system: a multicenter prospective study
CONCLUSIONS: The MESS-RFA is an effective method for local control of tumors in early HCC. Early HCC with multiple high-ALP tumors has a higher rate of recurrence, which mainly occurs in an IDR pattern. Early HCC with high AFP levels and a shorter initial recurrence interval resulted in a poorer prognosis. Thus, treatments such as liver transplantation or surgical resection may be a good strategy in those cases.CLINICALTRIALS.GOV ID: NCT02046356.PMID:35042449 | DOI:10.1080/02656736.2021.2024279 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 19, 2022 Category: Internal Medicine Authors: Yunhua Tan Xin Wang Kuansheng Ma Lin Zhang Jing Li Ping Chen Ben Zhang Source Type: research