Chitogel following endoscopic sinus surgery promotes a healthy microbiome and reduces postoperative infections
ConclusionChitogel significantly improved both the nasoendoscopic appearance of the sinuses and sinus ostial patency at 12 weeks postoperatively. Chitogel used following ESS helps restore an improved microbiome resulting in an increase in the relative abundance of commensalsCorynebacterium andCutibacterium (Propionibacterium). A significant decrease in postoperative infections was noted following use of Chitogel. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 8, 2022 Category: Allergy & Immunology Authors: Anna Megow, Yazeed Alsuliman, George Bouras, Martha Menberu, Erich Vyskocil, Sarah Vreugde, Peter ‐John Wormald Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term oncologic outcomes in esthesioneuroblastoma: An institutional experience of 143 patients
ConclusionsPatients with low Hyams grade and mKadish stage have favorable 5 year OS, PFS, and DMFS.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 7, 2022 Category: Allergy & Immunology Authors: Ryan A. McMillian, Jamie J. Van Gompel, Michael J. Link, Eric J. Moore, Daniel L. Price, Janalee L. Stokken, Kathryn M. Van Abel, Jamie O'Byrne, Caterina Giannini, Ashish Chintakuntlawar, Carlos D. Pinheiro Neto, Maria Peris Celda, Robert Foot Tags: ORIGINAL ARTICLE Source Type: research

Analysis of ceRNA crosstalk in eosinophilic chronic rhinosinusitis with nasal polyps
ConclusionsIn summary, the present study provided the first comprehensive assessment of the ceRNA crosstalk in eosinophilic CRSwNP. These findings will be of interest to the understanding of the potential pathophysiology of this disease.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 6, 2022 Category: Allergy & Immunology Authors: Ke Li, Fang ‐Fang Liu Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 4, 2022 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

International consensus statement on allergy and rhinology: Olfaction
ConclusionThis critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 4, 2022 Category: Allergy & Immunology Authors: Zara M. Patel, Eric H. Holbrook, Justin H. Turner, Nithin D. Adappa, Mark W. Albers, Aytug Altundag, Simone Appenzeller, Richard M. Costanzo, Ilona Croy, Greg E. Davis, Puya Dehgani ‐Mobaraki, Richard L. Doty, Valerie B. Duffy, Bradley J. G Tags: REVIEW ARTICLE Source Type: research

See many, do one, teach many more: Assessing quality and reliability of publicly available endoscopic videos in rhinology
ConclusionsEndoscopic videos are rapidly growing in prominence and remain an important part of surgical education, but overall are heterogeneous in quality and reliability, necessitating an effort to establish both video sharing regulations and objective standards of quality.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 3, 2022 Category: Allergy & Immunology Authors: Benjamin F. Bitner, Sanjita Gowda, Michelle E. Mark, Danielle C. Warner, Bobby A. Tajudeen, Edward C. Kuan Tags: ORIGINAL ARTICLE Source Type: research

CRS ‐PRO and SNOT 22 correlations with Type 2 inflammatory mediators in chronic rhinosinusitis
ConclusionThe CRS-PRO total score had significant correlation with type 2 biomarkers especially when assessed post-ESS and among CRSwNP patients.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 1, 2022 Category: Allergy & Immunology Authors: Samuel D. Racette, Alexander L. Schneider, Meera Ganesh, Julia H. Huang, David S. Lehmann, Caroline P. E. Price, Samuel G. Rodegherio, Abhita T. Reddy, Jacob G. Eide, David B. Conley, Kevin C. Welch, Robert C. Kern, Stephanie Shintani ‐Smith Tags: ORIGINAL ARTICLE Source Type: research

Use of intra ‐operative frontal sinus mometasone‐eluting stents decreased IL‐5 and IL‐13 in patients with chronic rhinosinusitis with nasal polyps
Conclusion: Although patients who received intra-operative frontal MES had significantly higher pre-ESS MM IL-13 and ECP, patients who received frontal MES had lower concentrations of IL-4 and IL-13 than those who did not at a median 8 months post-ESS. However, these changes did not correspond to significantly different measures of symptomatic or radiographic disease severity.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 1, 2022 Category: Allergy & Immunology Authors: Alexander L. Schneider, Samuel D. Racette, Anthony K. Kang, Abhita T. Reddy, Julia H. Huang, David S. Lehmann, Caroline P.E. Price, Jacob G. Eide, Samuel R. Rodeghiero, David B. Conley, Kevin C. Welch, Robert C. Kern, Stephanie Shintani ‐Smi Tags: ORIGINAL ARTICLE Source Type: research

Open and endoscopic surgery improve survival for squamous and nonsquamous cell nasopharyngeal carcinomas: An NCDB cohort study
ConclusionBoth endoscopic and open surgical approaches are associated with improved overall survival of patients with NPT. These findings highlight important oncologic validity as endoscopic and robotic platforms to the nasopharynx become more widely adopted. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 1, 2022 Category: Allergy & Immunology Authors: Andrey Finegersh, Mena Said, Adam Deconde, Peter H. Hwang, Floyd Christopher Holsinger, Ryan K. Orosco Tags: ORIGINAL ARTICLE Source Type: research

Reply to Leopold, et  al.’s “EDS‐FLU: An Important Step in Appropriate Medical Therapy for Chronic Rhinosinusitis with Nasal Polyps”
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 30, 2022 Category: Allergy & Immunology Authors: Richard Orlandi Tags: CORRESPONDENCE AND REPLY Source Type: research

EDS ‐FLU: An important step in appropriate medical therapy for chronic rhinosinusitis with nasal polyps
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 30, 2022 Category: Allergy & Immunology Authors: Donald A. Leopold, David Elkayam, Joseph K. Han, Daniel F. Soteres, John C. Messina, Jennifer L. Carothers, Harry J. Sacks, Ramy A. Mahmoud, Per G. Djupesland, Raj Sindwani Tags: CORRESPONDENCE AND REPLY Source Type: research

A comparison of central compartment atopic disease and lateral dominant nasal polyps
ConclusionsPolyps originating from the central compartment were related to asthma and allergic rhinitis in Taiwanese patients. A higher eosinophil count was suggested in both serum and local nasal tissue from patients with CCAD. FESS serves as an effective treatment for symptom relief in patients with CCAD.Level of EvidenceLevel 4.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 29, 2022 Category: Allergy & Immunology Authors: Liang ‐Chun Shih, Bing‐Han Hsieh, Jia‐Hung Ma, Shuang‐Shuang Huang, Yung‐An Tsou, Chia‐Der Lin, Kuang‐Hua Huang, Chih‐Jaan Tai Tags: ORIGINAL ARTICLE Source Type: research

Use of a novel Chinchilla skull base repair model to test a photo ‐initiated thiol‐ene biopolymer
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 28, 2022 Category: Allergy & Immunology Authors: Adam M. Terella, Peter Mariner, Carlyne D. Cool, Vijay R. Ramakrishnan Tags: RESEARCH NOTE Source Type: research

Vision loss caused by immunoglobulin G4 –related disease of the skull base complicated by a mucocele of the sphenoid sinus
DiscussionThis case illustrates that in therapy-resistant sino-orbital IgG4-RD, extensive surgery might be necessary at an earlier stage. It may even be the only option to prevent irreversible damage to the surrounding tissues. A multidisciplinary approach in the management of sino-orbital IgG4-RD is therefore warranted. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 28, 2022 Category: Allergy & Immunology Authors: Sanne E. Detiger, Dion Paridaens, Robert M. Verdijk, Jan A.M. Laar, Ruben Dammers, Dominiek A. Monserez, A. Paul Nagtegaal Tags: CLINICAL LETTER Source Type: research

Mental health burden of empty nose syndrome compared to chronic rhinosinusitis and chronic rhinitis
ConclusionsAs seen previously, ENS patients had diminished sinonasal quality of life and a higher prevalence of comorbid anxiety and depression, compared to CR and CRS. ENS patients were more likely to exceed thresholds for OCD and somatic symptom disorder compared to controls. Future studies are needed to assess the role of somatic symptom disorder in ENS to help optimize treatment for these complex patients.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 27, 2022 Category: Allergy & Immunology Authors: Meredith Lamb, Daniel R. Bacon, Abdullah Zeatoun, Princess Onourah, Brian D. Thorp, Jonathon Abramowitz, Charles S. Ebert, Adam J. Kimple, Brent A. Senior Tags: ORIGINAL ARTICLE Source Type: research