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Decoding chronic rhinosinusitis: A metabolomics ‐based approach
ConclusionsMetabolomics helps to shed light on the complexity of CRS. The mentioned findings highlight the importance of specific metabolic pathways and markers in understanding the pathophysiology of CRS. Despite that, challenges and future directions in metabolomics research for CRS would be worth being further explored. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 12, 2024 Category: Allergy & Immunology Authors: Xinru Gong, Yijie Fu, Lei Zhou, Aiming Wei, Chongsheng Pan, Tianmin Zhu, Hui Li Tags: REVIEW ARTICLE Source Type: research

Patient perspectives on chronic rhinosinusitis in cystic fibrosis: Symptom prioritization in the era of highly effective modulator therapy
ConclusionsNasal congestion and post-nasal discharge were top priorities reported by PwCF  + CRS. Those electing surgery prioritized sleep and psychological symptoms, highlighting their importance in pre-operative discussions. Non-ETI users’ prioritization of sleep improvement may highlight their unique disease impact and therapeutic needs; however, additional investigation is requir ed. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 12, 2024 Category: Allergy & Immunology Authors: Christine M. Liu, Ethan J. Han, Jakob L. Fischer, Jess C. Mace, Jose L. Mattos, Karolin Markarian, Jeremiah A. Alt, Todd E. Bodner, Naweed I. Chowdhury, Patricia H. Eshaghian, Anne E. Getz, Peter H. Hwang, Ashoke Khanwalkar, Adam J. Kimple, Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 7, 2024 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Impact of dupilumab prescribing on utilization of medical and surgical therapies for chronic rhinosinusitis with nasal polyps
Key points Increased dupilumab utilization coincided with decreased ESS in patients with CRSwNP between 2019 and 2021. One potential confounder was the concurrent COVID-19 pandemic, which may have negatively impacted surgery utilization rates. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 1, 2024 Category: Allergy & Immunology Authors: Christopher M. Low, Allan R. Wang, Michael Yong, Jayakar Nayak, Zara Patel, Peter H. Hwang Tags: RESEARCH NOTE Source Type: research

Which intranasal corticosteroids can be used in patients on highly active antiretroviral therapy or pre ‐exposure prophylactic?
Key pointsAll intranasal corticosteroid spray formulations are safe to use in patients on pre-exposure prophylaxis.Beclomethasone nasal spray can be used safely with all HAART and PrEP regimens. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 1, 2024 Category: Allergy & Immunology Authors: Meghan Norris, Erin Lopez, Daniel Alicea Delgado, Brian Thorp, Christine Klatt ‐Cromwell, Brent Senior, Adam Kimple, Charles S. Ebert Jr. Tags: CLINICAL LETTER Source Type: research

Cognition and saccadic eye movement performance are impaired in chronic rhinosinusitis
ConclusionThis study is the first to utilize objective eye movement assessments in addition to researcher-administered cognitive testing in patients with CRS. These patients demonstrated a high prevalence of cognitive dysfunction, most notably within executive functioning and memory domains, with the degree of dysfunction correlating with the severity of CRS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 25, 2024 Category: Allergy & Immunology Authors: David J. Cvancara, Heather A. Wood, Mohamed Aboueisha, Thomas B. Marshall, Tzu ‐Cheg Kao, James O. Phillips, Ian M. Humphreys, Waleed M. Abuzeid, Ashton E. Lehmann, Yoshiko Kojima, Aria Jafari Tags: ORIGINAL ARTICLE Source Type: research

Tissue ‐specific early and late activated lymphocytes immunophenotype in chronic rhinosinusitis with nasal polyps
Key pointsT-cell activation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is enriched by late cytotoxic T cells.The proportion of early and intermediate activated cytotoxic T cells decreases in nasal polyps of patients with CRSwNP.Our results identify late activated cytotoxic T cells as potential biomarkers or therapeutic targets for patients with CRSwNP. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 25, 2024 Category: Allergy & Immunology Authors: Soledad L ópez‐Enríquez, Cristina Porras‐González, Ramón Moreno‐Luna, Francisca Palomares, José Luis Muñoz‐Bravo, Gonzalo Alba, Consuelo Santa‐María, Juan Maza‐Solano, Daniel Iván Martín‐Jiménez, Antonio Pérez‐Pérez, Tags: RESEARCH NOTE Source Type: research

ChatGPT ‐4 performance in rhinology: A clinical case series
Keypoints Chatbot Generative Pre-trained Transformer (ChatGPT)-4 indicated more than twice additional examinations than practitioners in the management of clinical cases in rhinology. The consistency between ChatGPT-4 and practitioner in the indication of additional examinations may significantly vary from one examination to another. The ChatGPT-4 proposed a plausible and correct primary diagnosis in 62.5% cases, while pertinent and necessary additional examinations and therapeutic regimen were indicated in 7.5% –30.0% and 7.5%–32.5% of cases, respectively. The stability of ChatGPT-4 responses is moderate-to-high. The ...
Source: International Forum of Allergy and Rhinology - January 25, 2024 Category: Allergy & Immunology Authors: Thomas Radulesco, Alberto Maria Saibene, Justin Michel, Luigi Angelo Vaira, J érôme R. Lechien Tags: RESEARCH NOTE Source Type: research

Nasoseptal flap with extended pedicle dissection based on the maxillary artery: Clinical series of 55 cases
Key points Nasoseptal flap with extended pedicle dissection is a low morbidity and high success rate flap. It is a flap that can be applied to reconstruct a wide range of ipsilateral skull base defects. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 25, 2024 Category: Allergy & Immunology Authors: Alessandro Vinciguerra, Mario Turri ‐Zanoni, Marco Ferrari, Davide Mattavelli, Giorgio Sileo, Vittorio Rampinelli, Vincenzo Abbate, Benjamin Verillaud, Alberto Schreiber, Paolo Battaglia, Maurizio Bignami, Piero Nicolai, Paolo Castelnuovo, Tags: RESEARCH NOTE Source Type: research

Frailty is an independent predictor of postoperative rescue medication use after endoscopic sinus surgery
ConclusionsModified frailty scores may be a useful clinical tool to predict the need for postoperative rescue medication use after ESS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 25, 2024 Category: Allergy & Immunology Authors: Kolin E. Rubel, Andrea Lopez, Rory J. Lubner, Diane L. Lee, Kristen Yancey, Rakesh K. Chandra, Naweed I. Chowdhury, Justin H. Turner Tags: ORIGINAL ARTICLE Source Type: research

Temperature ‐controlled radiofrequency ablation for the treatment of chronic rhinitis: Two‐year outcomes from a prospective multicenter trial
ConclusionTCRF ablation of the PNN is safe and resulted in a significant and sustained reduction in chronic rhinitis symptom burden through 2 years and a substantial reduction in concomitant medication burden. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 24, 2024 Category: Allergy & Immunology Authors: Masayoshi Takashima, J. Pablo Stolovitzky, Randall A. Ow, Stacey L. Silvers, Chad M. McDuffie, Marc Dean, Ahmad R. Sedaghat, Bobby A. Tajudeen Tags: ORIGINAL ARTICLE Source Type: research

Correlation between inflammatory biomarkers and disease control in chronic rhinosinusitis with nasal polyps
ConclusionsOur data suggest that asthma, NSAID-ERD, and IL-5 in nasal secretions/tissue may be helpful to identify more severe patients, as they are related to the risk of uncontrolled disease. Nonetheless, high levels of calprotectin and neutrophilia were also observed in uncontrolled patients, especially after multiple surgeries. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 24, 2024 Category: Allergy & Immunology Authors: Eugenio De Corso, Silvia Baroni, Stefano Settimi, Maria Elisabetta Onori, Tiziana di Cesare, Rodolfo Francesco Mastrapasqua, Francesca Sarlo, Daniele Penazzi, Giuseppe D'Agostino, Leandro Maria D'Auria, Gabriele De Maio, Anna Rita Fetoni, Jaco Tags: ORIGINAL ARTICLE Source Type: research

Microvessel barrier dysfunction in sinonasal inverted papilloma ‐associated squamous cell carcinoma and its manifestation in dynamic contrast‐enhanced MRI
ConclusionDCE-MRI can serve as a noninvasive biomarker of angiogenesis in the malignant transformation from SIP to IP-SCC. DCE-MRI may assist in the differentiation of malignancies and treatment selection. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 22, 2024 Category: Allergy & Immunology Authors: Mu Xian, Jiaqi Yu, Zheng Li, Yingshi Piao, Chegnshuo Wang, Junfang Xian, Luo Zhang Tags: ORIGINAL ARTICLE Source Type: research

Improved quality of life in patients with chronic rhinosinusitis with nasal polyps associated with expanded types of endoscopic sinus surgery: A 2 ‐year retrospective study
Key points Expanded types of functional endoscopic sinus surgery (FESS) significantly improve quality of life and reduce revision surgeries rates, supporting their early application for moderate-to-severe cases. Minimal clinically important difference may play as a crucial role in defining surgical treatment response (i.e., responder and super-responder conditions). Expanded FESS benefits patients with chronic rhinosinusitis with nasal polyps but more data are required to have a clearer understanding of its uses due to varied approaches and reported outcomes in the literature. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 17, 2024 Category: Allergy & Immunology Authors: Daniel I Martin ‐Jimenez, Ramon Moreno‐Luna, Amparo Callejon‐Leblic, Alfonso Del Cuvillo Bernal, Charles S. Ebert Jr, Juan M Maza‐Solano, Jaime Gonzalez‐Garcia, Serafin Sanchez‐Gomez Tags: RESEARCH NOTE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 16, 2024 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research