Intramuscular corticosteroid injections should be an option under the policy level recommendation in the International Consensus Statement on Allergic Rhinitis
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - August 5, 2023 Category: Allergy & Immunology Authors: Sarah K. Wise, Fuad Baroody Tags: REPLY Source Type: research

Accessing the Eustachian Tube: Conventional nasal spray vs. exhalation delivery system and the impact of targeted endoscopic sinus surgery on topical distribution patterns
ConclusionsEDS is more effective than NS in topical delivery to the NP and ET orifices in cadavers. Targeted ESS may facilitate greater NP penetration by EDS compared to NS, with possible synergism after ESS for augmented delivery. These findings suggest a role for EDS delivery methods for ETD management and in CRS+ETD patients undergoing sinus surgery.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - August 3, 2023 Category: Allergy & Immunology Authors: Lucas G. Axiotakis, Daniel B. Spielman, David A. Gudis, Nathan Yang, Carol H. Yan, Zachary M. Soler, Joshua M. Levy, Nicholas R. Rowan, Alexandria L. Irace, Brandon J. Vilarello, Patricia T. Jacobson, Jonathan B. Overdevest Tags: ORIGINAL ARTICLE Source Type: research

Postnasal drip and chronic cough in patients with chronic rhinitis treated with temperature ‐controlled radiofrequency neurolysis
ConclusionPND and CC contribute to the symptomatology of chronic rhinitis and are significantly improved after TCRF neurolysis of the PNN. The inclusion of PND and CC symptoms in a chronic rhinitis assessment instrument could provide important additional information for the characterization of the disease state and outcomes after any therapeutic treatment. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - August 2, 2023 Category: Allergy & Immunology Authors: Daniel Gorelik, Jumah G. Ahmad, Samuel E. Razmi, Masayoshi Takashima, Yin Yiu, Apurva Thekdi, Murugappan Ramanathan, Aatin K. Dhanda, Michael T. Yim, Omar G. Ahmed Tags: ORIGINAL ARTICLE Source Type: research

The Impact of Nasal Packing on Skull Base Reconstruction and Quality ‐of‐Life Outcomes Following Endoscopic Skull Base Surgery
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 29, 2023 Category: Allergy & Immunology Authors: Arash Abiri, Theodore V. Nguyen, Ji Y. Li, David Shan, Timothy Hsu, Jonathan C. Pang, Khodayar Goshtasbi, Frank P. K. Hsu, Edward C. Kuan Tags: RESEARCH NOTE Source Type: research

Optimizing the timing of biologic and surgical therapy for patients with refractory chronic rhinosinusitis with nasal polyposis (CRSwNP)
ConclusionIn CRSwNP patients, combined ESS and biologic therapy results in a significant and sustained decrease in polyp burden compared to biologic therapy alone. Larger studies are warranted to further examine the impact of combined therapy.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 28, 2023 Category: Allergy & Immunology Authors: Emily Garvey, Bita Naimi, Alexander Duffy, Paavali Hannikainen, Chase Kahn, Douglas Farquhar, Marc Rosen, Mindy Rabinowitz, Elina Toskala, Gurston Nyquist Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 24, 2023 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Incidence of hypocortisolism with long ‐term budesonide irrigation for chronic rhinosinusitis
ConclusionProlonged use of BI alone is not likely to cause hypocortisolemia in the majority of patients. However, concomitant use of inhaled and oral steroids and male sex may be associated with hypocortisolemia. Surveillance of cortisol levels may be considered in vulnerable populations who use BI regularly, particularly in patients using other forms of corticosteroids with known systemic absorption. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 24, 2023 Category: Allergy & Immunology Authors: Bruna R. C. Silva, Matthew A. Tyler, Yifei Ma, Jane Wang, Jayakar V. Nayak, Zara M. Patel, Peter H. Hwang Tags: ORIGINAL ARTICLE Source Type: research

The Direct Impact of the COVID ‐19 Pandemic on Rhinology Practice
ConclusionsCOVID-19 significantly affected the number of patients seen, virtual visit encounters, nasal endoscopies, and imaging utilization. Further research is needed to determine if patient outcomes were impacted and if these changes in practice will persist.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 22, 2023 Category: Allergy & Immunology Authors: Sarah R. Sutton, April Taniguchi, Shaun A. Nguyen, Zachary M. Soler, Rodney J. Schlosser Tags: CLINICAL LETTER Source Type: research

Intramuscular corticosteroid injections should be an option under the policy level recommendation in the international consensus statement on allergic rhinitis
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 22, 2023 Category: Allergy & Immunology Authors: Jacob Alexander Ru, Ahmed Bayoumy Bayoumy Tags: LETTER TO THE EDITOR Source Type: research

“Intramuscular corticosteroid injections should be an option under the policy level recommendation in the International Consensus Statement on Allergic Rhinitis”
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 21, 2023 Category: Allergy & Immunology Authors: Sarah K. Wise, Fuad Baroody Tags: RESPONSE TO LETTER TO THE EDITOR Source Type: research

miR ‐200a‐3p regulates epithelial–mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway
ConclusionsmiR-200a-3p suppresses EMT and inflammation by regulating the expression of ZEB1 via the ERK/p38 pathway. Our study presents new ideas for protecting nasal epithelial cells from tissue remodeling and finding a possible target for disease. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 20, 2023 Category: Allergy & Immunology Authors: Yisha Wu, Kaiyue Sun, Yanyi Tu, Ping Li, Dingqian Hao, Peng Yu, Aiping Chen, Yuzhu Wan, Li Shi Tags: ORIGINAL ARTICLE Source Type: research

Real ‐world effectiveness of mepolizumab in severe asthma and chronic rhinosinusitis in the United States: impact of comorbidity and sinus surgery
ConclusionsConsistent with trial data, mepolizumab use in real-world practice shows benefits across comorbid patient cohorts with more a pronounced impact in those with severe asthma+comorbid CRS  + sinus surgery. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 20, 2023 Category: Allergy & Immunology Authors: Jared Silver, Arijita Deb, Fran çois Laliberté, Chi Gao, Neil Bhattacharyya Tags: ORIGINAL ARTICLE Source Type: research

Hydrocortisone metabolism by Staphylococcus: effects on anti ‐inflammatory and antimicrobial action
This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 20, 2023 Category: Allergy & Immunology Authors: Lisa Mary Cherian, Sha Liu, Karen Hon, Mahnaz Ramezanpour, Hua Hu, Shari Javadiyan, Irene Stafford, Peter ‐John Wormald, Alkis James Psaltis FRACS, Sarah Vreugde Tags: RESEARCH NOTE Source Type: research

Chronic rhinosinusitis with nasal polyps (CRSwNP) treated with omalizumab, dupilumab, or mepolizumab: A systematic review of the current knowledge towards an attempt to compare agents ’ efficacy
ConclusionsAlthough the present analysis showed a moderate supremacy of dupilumab, there is still no evidence-based answer to the question “which biologic agent is the most effective in CRS treatment?” Improved statistical methodology, head-to-head trials, and real-life studies could lead to more robust conclusions, establishing the real role of the specific biologic agents. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 19, 2023 Category: Allergy & Immunology Authors: Georgios X. Papacharalampous, Jannis Constantinidis, George Fotiadis, Nan Zhang, Claus Bachert, Michael Katotomichelakis Tags: REVIEW ARTICLE Source Type: research

Reply to Letter to the Editor regarding “The benefits and risks of non‐steroidal anti‐inflammatory drugs for postoperative analgesia in sinonasal surgery: A systematic review and meta‐analysis”
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 19, 2023 Category: Allergy & Immunology Authors: Daniel J. Lee, Connor T. A. Brenna, John M. Lee Tags: REPLY Source Type: research