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Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 24, 2023 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Biological sex as a modulator in rhinologic anatomy, physiology and pathology: A scoping review
ConclusionsAlthough many sex-based differences exist in rhinology, further research is necessary to offer evidence-based treatment guidelines. Gonadal hormones should be studied as a therapeutic in rhinologic pathology as baseline physiologic differences exist such as those found in nasal mucosa receptor density.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 24, 2023 Category: Allergy & Immunology Authors: Shreya P. Ramkumar, Tripti Brar, Lisa Marks, Michael J. Marino, Devyani Lal Tags: REVIEW ARTICLE Source Type: research

Diagnosis, prognosticators, and management of acute invasive fungal rhinosinusitis: multidisciplinary consensus statement and Evidence ‐Based review with recommendations
ConclusionBased on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidisciplinary team via a combination of surgery (including resection whenever possible), antifungal therapy, and correcting sources of immunosuppression. Higher quality (i.e., prospective) studies are needed to better define the roles of each modality and determine diagnosis and treatment algorithms.This article is protected by copyright....
Source: International Forum of Allergy and Rhinology - January 22, 2023 Category: Allergy & Immunology Authors: Lauren T. Roland, Ian M. Humphreys, Christopher H. Le, Jennifer M. Babik, Christopher E. Bailey, Lilangi S. Ediriwickrema, Monica Fung, Joshua A. Lieberman, Kelly R. Magliocca, Hannah H. Nam, Neville W. Teo, Penelope C. Thomas, Blair A. Winega Tags: ORIGINAL ARTICLE Source Type: research

Incidence, risk factors and prognostic value of nodal involvement in sinonasal cancers
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 21, 2023 Category: Allergy & Immunology Authors: Alice Renou, Guillaume De Bonnecaze, Bastien Cabarrou, Emilien Chabrillac, S ébastien Vergez, Paul Mazerolle Tags: RESEARCH NOTE Source Type: research

Role of trigeminal sensation in patients without nasal obstruction: A pilot study
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 19, 2023 Category: Allergy & Immunology Authors: Frederick G. Durrant, Craig Salvador, Tiffany Chen, Nikita Chapurin, Rodney J. Schlosser Tags: RESEARCH NOTE Source Type: research

Methotrexate for recurrent chronic rhinosinusitis with nasal polyps: A randomized, controlled, phase 2 clinical trial
ConclusionLow-dose MTX was a safe and effective maintenance therapy for patients with recurrent postoperative CRSwNPs. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 19, 2023 Category: Allergy & Immunology Authors: Asli Cakir Cetin, Yesim Tuncok, Pembe Keskinoglu, Mualla Aylin Arici, Fatos Onen, Mustafa Cenk Ecevit Tags: ORIGINAL ARTICLE Source Type: research

Microbial metabolite succinate activates solitary chemosensory cells in the human sinonasal epithelium
ConclusionOverall, these findings demonstrate the need for further investigation into the activation of the sinonasal epithelium by succinate in the pathogenesis of CRS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 11, 2023 Category: Allergy & Immunology Authors: Elizabeth A. Sell, Li Hui Tan, Cailu Lin, John V. Bosso, James N. Palmer, Nithin D. Adappa, Robert J. Lee, Michael A. Kohanski, Danielle R. Reed, Noam A. Cohen Tags: ORIGINAL ARTICLE Source Type: research

Tranexamic acid does not significantly lower postoperative bleeding after endoscopic sinus and nasal surgery
Conclusion: While TXA has previously demonstrated efficacy to reduce intraoperative bleeding during sinonasal surgery, when postoperative bleeding is already minimal at baseline, TXA does not appear to reduce it significantly further.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 7, 2023 Category: Allergy & Immunology Authors: Ashoke Khanwalkar, Erik Chan, Pooya Roozdar, Dayoung Kim, Yifei Ma, Peter H. Hwang, Jayakar V. Nayak, Zara M. Patel Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 4, 2023 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Management Paradigms for Chronic Rhinosinusitis in Individuals with Asthma: An Evidence ‐Based Review with Recommendations
Conclusion: Evidence supports managing CRS in individuals with CRSwA in a stepwise fashion, starting with traditional non-biologic oral and topical medication, and escalating to second-line treatments, such as ESS and biologics. Optimal treatment of individuals who suffer from CRSwA often requires concurrent, directed management of asthma, as not all CRS interventions impact asthma status.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - December 30, 2022 Category: Allergy & Immunology Authors: Amarbir S. Gill, Jeremiah A. Alt, Kara Y. Detwiller, Nicholas R. Rowan, Stacey T. Gray, Peter W. Hellings, Shyam R. Joshi, Jivianne T. Lee, Zach M. Soler, Bruce K. Tan, Jennifer L. Taylor ‐Cousar, Sarah K. Wise, Tara J. Wu, Daniel M. Beswic Tags: REVIEW ARTICLE Source Type: research

Inotodiol suppresses allergic inflammation in allergic rhinitis mice
Conclusions: These results indicate inotodiol can help suppress allergic responses by immunomodulation activities.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - December 29, 2022 Category: Allergy & Immunology Authors: Jaein Chung, Mi ‐Ra Choi, Soo‐kyoung Park, Jae‐Yoon Kang, Eun Hee Chung, Jong‐Tae Park, Yong Min Kim Tags: ORIGINAL ARTICLE Source Type: research

Climate Change, The Environment, And Rhinologic Disease
This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - December 28, 2022 Category: Allergy & Immunology Authors: Jean Kim, Darryn W Waugh, Benjamin F Zaitchik, Amber Luong, Regan Bergmark, Kent Lam, Lauren Roland, Lauren Roland, Joshua Levy, Joshua Levy, Jivianne T Lee, Do ‐Yeon Cho, Murugappan Ramanathan, Fuad Baroody, Mas Takashima, Daniel O'Brien Tags: VIEWPOINT Source Type: research

Methotrexate for recurrent chronic rhinosinusitis with nasal polyps: A randomized controlled phase II clinical trial
ConclusionLow-dose MTX was a safe and effective maintenance therapy for patients with recurrent postoperative CRSwNP.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - December 28, 2022 Category: Allergy & Immunology Authors: Asli CAKIR CETIN, Yesim TUNCOK, Pembe KESKINOGLU, Mualla Aylin ARICI, Fatos ONEN, Mustafa Cenk ECEVIT Tags: ORIGINAL ARTICLE Source Type: research

Avoiding bias in artificial intelligence
This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - December 27, 2022 Category: Allergy & Immunology Authors: David A. Gudis, Edward D. McCoul, Michael J. Marino, Zara M. Patel Tags: VIEWPOINT Source Type: research

Microbial metabolite succinate activates solitary chemosensory cells (SCCs) in the human sinonasal epithelium
Conclusions: Overall, these findings demonstrate the need for further investigation into the activation of the sinonasal epithelium by succinate in the pathogenesis of CRS.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - December 25, 2022 Category: Allergy & Immunology Authors: Elizabeth A. Sell, Li Hui Tan, Cailu Lin, John V. Bosso, James N. Palmer, Nithin D. Adappa, Robert J. Lee, Michael A. Kohanski, Danielle R. Reed, Noam A. Cohen Tags: Original Article Source Type: research