Effects of large volume, isotonic nasal saline irrigation for acute rhinosinusitis: a randomized controlled study
ConclusionThe add-on isotonic nasal saline irrigation using a large volume, positive pressure device did not add benefits equally for all ARS patients. The benefits of irrigation on quality of life and nasal symptoms were only observed in the common cold patient subgroup. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 18, 2021 Category: Allergy & Immunology Authors: Wirach Chitsuthipakorn, Angsuthorn Thanaphiphatsatja, Peeravuit Doungbuppha, Saranath Lawpoolsri, Kachorn Seresirikachorn, Kornkiat Snidvongs Tags: ORIGINAL ARTICLE Source Type: research

Septum submucosal glands exhibit aberrant morphology and reduced mucin production in chronic rhinosinusitis
ConclusionHere, we describe a significant alteration in SMG structure and function in the adult CRS posterior septum suggesting reduced gland contribution to MCC. The SMGs of both the nose and sinuses may represent targets for future therapeutic approaches. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 6, 2021 Category: Allergy & Immunology Authors: Onyekachi Ezinna Nnabue, Steven D. Pletcher, Jose G. Gurrola, Andrew N. Goldberg, Kristiana M. Jordan, Sarah M. Knox, Alison J. May Tags: ORIGINAL ARTICLE Source Type: research

Botulinum toxin for chronic rhinitis: A systematic review and meta ‐analysis
ConclusionsBTX-A improved TNSS and QOL in patients with chronic rhinitis. These effects were demonstrated up to 24  weeks post treatment. BTX-A was safe, well tolerated, and may be considered in patients who are refractory to current standard-of-care therapies. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 6, 2021 Category: Allergy & Immunology Authors: Kencho Rinzin, Minh P. Hoang, Kachorn Seresirikachorn, Kornkiat Snidvongs Tags: ORIGINAL ARTICLE Source Type: research

HPV in the malignant transformation of sinonasal inverted papillomas: A meta ‐analysis
Conclusions: There appears to be a significant association between HPV infection and malignant transformation of IPs. While HPV testing is not currently the standard of care for IPs, these data suggest a link between the two and suggest further studies should be performed to identify a link between the virus and malignant transformation. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 6, 2021 Category: Allergy & Immunology Authors: Wesley H. Stepp, Zainab Farzal, Adam J. Kimple, Charles S. Ebert, Brent A. Senior, Adam M. Zanation, Brian D. Thorp Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Adjunctive techniques to dacryocystorhinostomy: an evidence ‐based review with recommendations
ConclusionRecommendations for adjunctive techniques to external and endoscopic DCR surgeries can be made based on the current literature. Higher ‐level studies are needed to better optimize perioperative approaches to DCR. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Michael Yim, Peter ‐John Wormald, Manon Doucet, Amarbir Gill, Todd Kingdom, Richard Orlandi, Alison Crum, Douglas Marx, Jeremiah Alt Tags: ORIGINAL ARTICLE Source Type: research

Inflammatory features and predictors for postsurgical outcomes in patients with nasal polyps stratified by local and systemic eosinophilia
ConclusionDifferent blood and tissue eosinophilia revealed distinct tissue inflammatory patterns in CRSwNP patients. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Li Pan, Bo Liao, Cui ‐Lian Guo, Jin‐Xin Liu, Heng Wang, Xiao‐Bo Long, Zheng Liu Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of the exhalation delivery system with fluticasone in patients who remain symptomatic on standard nasal steroid sprays
ConclusionEDS ‐FLU comparably improves symptoms, irrespective of whether patients are symptomatic while using conventional nasal steroids before treatment. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Brent A. Senior, Rodney J. Schlosser, John Bosso, Zachary M. Soler Tags: ORIGINAL ARTICLE Source Type: research

Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients
ConclusionCRS patients report bitter stimuli as less intense but sweet stimuli as more intense than do control subjects. We speculate that taste responses may reflect the competence of sinonasal innate immunity mediated by taste receptor function, and thus a taste test may have potential for clinical utility in CRS patients. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Cailu Lin, Alyssa M. Civantos, Monique Arnold, Elizabeth M. Stevens, Beverly J. Cowart, Lauren R. Colquitt, Corrine Mansfield, David W. Kennedy, Steven G. Brooks, Alan D. Workman, Mariel T. Blasetti, Michael A. Kohanski, Laurel Doghramji, Jen Tags: ORIGINAL ARTICLE Source Type: research

Solitary chemosensory cells are innervated by trigeminal nerve endings and autoregulated by cholinergic receptors
ConclusionSCCs are innervated by trigeminal nerve endings in healthy turbinate tissue but not in NPs. SCCs express ACh receptors as well as choline acetyltransferase and, in the setting of a type 2 inflammatory environment, denervated SCCs dramatically expand with nicotinic stimulation. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Jie Deng, Li Hui Tan, Michael A. Kohanski, David W. Kennedy, John V. Bosso, Nithin D. Adappa, James N. Palmer, Jianbo Shi, Noam A. Cohen Tags: ORIGINAL ARTICLE Source Type: research

Pepsin exposure in a non ‐acidic environment upregulates mucin 5AC (MUC5AC) expression via matrix metalloproteinase 9 (MMP9)/nuclear factor κB (NF‐κB) in human airway epithelial cells
ConclusionThese findings suggest that pepsin increased MUC5AC expression in non ‐acidic conditions via the activation of MMP9 and NF‐κB in human airway epithelial cells. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Yoon Seok Choi, Hyung Gyun Na, Chang Hoon Bae, Si ‐Youn Song, Yong‐Dae Kim Tags: ORIGINAL ARTICLE Source Type: research

Sinonasal and gastrointestinal bacterial composition and abundance are stable after 1 week of once ‐daily oral antibiotic treatment for chronic rhinosinusitis
ConclusionAntibiotic prescription for CRS should be further investigated because of preliminary evidence of poor sinonasal drug penetration, unproven efficacy, and the potential impact of dysbiosis in the sinuses and off ‐target sites. Further studies should consider distinguishing the presence of DNA from viable and nonviable bacteria. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 20, 2021 Category: Allergy & Immunology Authors: Joey Siu, Brett Wagner Mackenzie, Lilian Klingler, Kristi Biswas, Yi Wang, Cheung ‐Tak Hung, Soo Hee Jeong, Daniel Barnett, Malcolm Drummond Tingle, Richard George Douglas Tags: ORIGINAL ARTICLE Source Type: research

Psychometric properties of the brief version of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis
ConclusionThe 7 ‐item B‐QOD captures a structurally coherent and reliable single dimension, with minimal information loss and excellent external predictive utility when compared to the QOD‐NS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 17, 2021 Category: Allergy & Immunology Authors: Jose L. Mattos, Todd E. Bodner, Jess C. Mace, Rodney J. Schlosser, Daniel M. Beswick, Vijay R. Ramakrishnan, Jeremiah A. Alt, Spencer C. Payne, Timothy L. Smith, Zachary M. Soler Tags: ORIGINAL ARTICLE Source Type: research

Risk factors and characteristics associated with persistent smell loss in coronavirus disease 2019 (COVID ‐19) patients
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 17, 2021 Category: Allergy & Immunology Authors: Bita Shahrvini, Divya P. Prajapati, Mena Said, Jacklyn Liu, Shanmukha Srinivas, Samuel Jayaraj, Valerie J. Lund, Adam S. DeConde, Matt Lechner, Carol H. Yan Tags: CLINICAL LETTER Source Type: research

Virtual interprofessional chronic cough clinic: An efficient and appealing approach to a complex problem
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 17, 2021 Category: Allergy & Immunology Authors: Merin Kuruvilla, Jeanne Hatcher, Sandeep Shelly, Adviteeya Narasimhan Dixit, Amanda I. Gillespie, Keriann VanNostrand, Eri Saikawa, Anand Jain, Adam M. Klein Tags: CLINICAL LETTER Source Type: research