Systematic review of errors on beta ‐2 transferrin gel electrophoresis testing of rhinorrhea and otorrhea
ConclusionsMultiple potential or actual reasons for false or indeterminate results have been reported for B2-Tf GE testing of rhinorrhea and otorrhea. Future studies should explore reasons for B2-Tf testing errors and how these may affect clinical decision making. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 22, 2023 Category: Allergy & Immunology Authors: Jacob G. Eide, William Mason, Amrita Ray, John Carey, Bernard Cook, John R. Craig Tags: ORIGINAL ARTICLE Source Type: research

Response to Letter to the Editor: Nasal nitric oxide and chronic rhinosinusitis with nasal polyps: Is it a matter of inflammation or mechanical obstruction?
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 18, 2023 Category: Allergy & Immunology Authors: Vincent Wu, John M Lee Tags: REPLY Source Type: research

Nasal nitric oxide and chronic rhinosinusitis with nasal polyps: Is it a matter of inflammation or mechanical obstruction?
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 17, 2023 Category: Allergy & Immunology Authors: Pasquale Ambrosino, Andrea Motta, Mauro Maniscalco Tags: LETTER TO THE EDITOR Source Type: research

Elexacaftor –tezacaftor–ivacaftor decreases pseudomonas abundance in the sinonasal microbiome in cystic fibrosis
ConclusionsTreatment with ETI leads to a reduction inPseudomonas abundance within the sinonasal microbiome of individuals withPseudomonas at baseline. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 15, 2023 Category: Allergy & Immunology Authors: Anna C. Zemke, Yasmin Hilliam, Amanda L. Stapleton, Adam J. Kimple, Jennifer L. Goralski, Amber D. Shaffer, Joseph M. Pilewski, Brent A. Senior, Stella E. Lee, Vaughn S. Cooper Tags: ORIGINAL ARTICLE Source Type: research

Chinese adaptation and validation of the chronic rhinosinusitis ‐patient‐reported outcome: Assessment of health‐related quality‐of‐life
ConclusionsThe Chinese version of the CRS-PRO is a concise, reliable, and responsive instrument that can be utilized as a novel subjective evaluation tool for future clinical practice. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 13, 2023 Category: Allergy & Immunology Authors: Jiani Chen, Li Hu, Chen Zhang, Le Shi, Qianqian Zhang, Yumin Zhou, Fuying Cheng, Yingqi Gao, Houyong Li, Dehui Wang, Huan Wang, Xicai Sun Tags: ORIGINAL ARTICLE Source Type: research

Letter to the editor regarding “Long‐term treatment outcomes in refractory rhinitis medicamentosa managed with nasal surgery”
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 11, 2023 Category: Allergy & Immunology Authors: Xiao Cui, Sai Wang, Liyin Wang Tags: LETTER TO THE EDITOR Source Type: research

Response to letter to the editor regarding “Long‐term treatment outcomes in refractory rhinitis medicamnetosa managed with nasal surgery”
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 11, 2023 Category: Allergy & Immunology Authors: William Li, Richard John Harvey, Larry Kalish Tags: REPLY Source Type: research

Acoustic resonance therapy is safe and effective for the treatment of nasal congestion in rhinitis: A randomized sham ‐controlled trial
ConclusionART is a safe and effective non-pharmacologic alternative for the treatment of nasal congestion. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 9, 2023 Category: Allergy & Immunology Authors: Amber U. Luong, Michael Yong, Peter H. Hwang, Bryant Y. Lin, Paramesh Gopi, Vivek Mohan, Yifei Ma, Jacob Johnson, David M. Yen, Richard S. DeMera, Benjamin S. Bleier Tags: ORIGINAL ARTICLE Source Type: research

Predictors of persistent disease in biologic treated type 2 diffuse/eosinophilic chronic rhinosinusitis undergoing surgery
ConclusionLow tissue eosinophils and increased serum neutrophils while on biologics predict for poor response in the biological treatment of with CRSwNP. A serum neutrophil level of ≥5.75 × 109 cells/L predicts for poor response to current biologic therapy. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 8, 2023 Category: Allergy & Immunology Authors: Lu Hui Png, Larry Kalish, Raewyn G. Campbell, Kachorn Seresirikachorn, Tobias Albrecht, Nelufer Raji, Christine Choy, Janet Rimmer, Peter Earls, Raymond Sacks, Richard J. Harvey Tags: ORIGINAL ARTICLE Source Type: research

Histopathologic features of biologic therapy nonresponders in chronic rhinosinusitis with nasal polyposis
ConclusionHistopathologic analysis of biologic nonresponders demonstrates decreased eosinophilia and thickened basement membranes. These findings, particularly low tissue eosinophils, are consistent with a non-type 2 CRSwNP that may be recalcitrant to biologic therapies. Histopathologic analysis done in conjunction with FESS may aid clinicians in understanding response to biologic therapies in patients with CRSwNP who have persistent symptom burden necessitating FESS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 5, 2023 Category: Allergy & Immunology Authors: Ali M. Baird, Jamie Masliah, Peter Filip, Vidit Talati, Hannah J. Brown, Grant Owen, Sarah Khalife, Peter Papagiannopoulos, Paolo Gattuso, Pete S. Batra, Bobby A. Tajudeen Tags: ORIGINAL ARTICLE Source Type: research

Impact of dual electronic and conventional cigarette use on diagnosis and surgery for chronic rhinosinusitis: A multicenter study
Key points Dual EC/CC users had a significantly greater risk of CRS or FESS when compared to solo users. Dual EC/CC users did not have a significantly greater risk of polyposis when compared to solo users. This effect likely relates to bacterial, immune cell, genetic, and mucociliary alterations. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 4, 2023 Category: Allergy & Immunology Authors: Graham Pingree, Jonathan DeShazo, Theodore Schuman Tags: RESEARCH NOTE Source Type: research

Patient perspectives on recall period and response options in patient ‐reported outcome measures for chronic rhinosinusitis symptomatology: An international multi‐centered study
ConclusionFuture PROMs for CRS should consider assessment of symptoms over a 1-month period and use a four- or five-item Likert response scale to reflect global patient preferences. These findings also inform interpretation of current CRS PROMs. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - October 3, 2023 Category: Allergy & Immunology Authors: Ahmad R. Sedaghat, Armo Derbarsegian, Victor T. Yu, Ahmed Alsayed, Benjamin F. Bitner, Brian Yeom, David T. Liu, Sven Schneider, Sarah M. Adams, Firas A. Houssein, Zoe A. Walters, Siddhant Tripathi, Victoria L. Walker, Kyle W. Singerman, Jos Tags: ORIGINAL ARTICLE Source Type: research

Correspondence to the editor regarding “The association of gustatory dysfunction, olfactory dysfunction, and cognition in older adults”
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 28, 2023 Category: Allergy & Immunology Authors: Hyun Jin Min Tags: LETTER TO THE EDITOR Source Type: research

Letter to the editor regarding “Air pollution exposure is associated with rhinitis in older US adults via specific immune mechanisms”
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 27, 2023 Category: Allergy & Immunology Authors: Ling Tie, Guangjian Jiang Tags: LETTER TO THE EDITOR Source Type: research

Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases
ConclusionsOlder adults with OLD who experience olfactory decline face higher odds of developing frailty. Use of olfactory decline as a biomarker to identify frailty could allow earlier intervention and decrease adverse outcomes for high-risk older adults with OLD. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 26, 2023 Category: Allergy & Immunology Authors: Esther Wang, Kristen E. Wroblewski, Martha K. McClintock, Jayant M. Pinto, Leah J. Witt Tags: ORIGINAL ARTICLE Source Type: research