The Olink proteomics profile in nasal secretion of patients with allergic rhinitis
Key points Nasal secretions of allergic rhinitis patients were analyzed by Olink proteomics. Fifteen differentially expressed proteins (DEPs) were identified. The DEPs were significantly correlated with the total nasal symptom scores of patients with allergic rhinitis. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 22, 2023 Category: Allergy & Immunology Authors: Haotao Zeng, Jiangqi Liu, Lihua Mo, Minyao Li, Aifa Tang, Xianhai Zeng, Miao Zhao, Pingchang Yang Tags: RESEARCH NOTE Source Type: research

Letter to the editor regarding “Use of nonsteroidal anti‐inflammatory drugs and poor olfaction in women”
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 21, 2023 Category: Allergy & Immunology Authors: Xiao Cui, Sai Wang, Liyin Wang Tags: LETTER TO THE EDITOR Source Type: research

Factors that predict pursuing sinus surgery in the era of highly effective modulator therapy
ConclusionsWorse sinonasal symptom burden, lack of ETI treatment, sleep quality, depression, and nasal endoscopy scores were associated with electing ESS, while lung disease severity and sinus CT scores were not. ETI use was associated with lower odds of pursuing ESS independent of sinonasal symptom burden. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 20, 2023 Category: Allergy & Immunology Authors: Daniel M. Beswick, Ethan J. Han, Jess C. Mace, Karolin Markarian, Jeremiah A. Alt, Todd E. Bodner, Naweed I. Chowdhury, Patricia H. Eshaghian, Anne E. Getz, Peter H. Hwang, Ashoke Khanwalkar, Adam J. Kimple, Jivianne T. Lee, Douglas A. Li, M Tags: ORIGINAL ARTICLE Source Type: research

A cost ‐effective alternative for nasal corticosteroid saline irrigations
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 17, 2023 Category: Allergy & Immunology Authors: Do Yeon Cho, Jessica W. Grayson, Bradford A. Woodworth Tags: LETTER TO THE EDITOR Source Type: research

Combination of omalizumab with allergen immunotherapy versus immunotherapy alone for allergic diseases: A meta ‐analysis of randomized controlled trials
ConclusionOmalizumab + AIT can significantly enhance the efficacy and safety of AIT by increasing TMD and SU to allergens, while decreasing severe systemic AEs. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 16, 2023 Category: Allergy & Immunology Authors: Ying ‐Ying Zhang, Min Zhang, Jia‐Qi Zhang, Qiu‐Qi Li, Mei‐Ping Lu, Lei Cheng Tags: ORIGINAL ARTICLE Source Type: research

Endoscopic vidian and vidian ‐branch neurectomy for refractory allergic rhinitis: A systematic review
ConclusionEVN and vidian-branch neurectomy (including SVN and PNN) are effective treatments, but the former has a higher risk of complications. Additionally, vidian-branch neurectomy with FESS is beneficial for patients with mixed CRSwNP. SVN is a potential approach for patients with coexisting AR and asthma. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 16, 2023 Category: Allergy & Immunology Authors: Xun Niu, Yuzhang Chen, Tao Zhou, Hongjun Xiao Tags: REVIEW ARTICLE Source Type: research

Eustachian tube dysfunction symptoms after endonasal skull base surgery
Key points ETD symptoms are present in 16% patients with underlying skull base pathology. Preoperative ETD symptoms improve following surgical treatment of skull base pathology. ETD symptoms may worsen in patients with central, posterior, or malignant skull base pathology. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 12, 2023 Category: Allergy & Immunology Authors: David Grimm, Rachel Daum, Bruna R. Castro Silva, Christine K. Lee, Juan C. Fernandez ‐Miranda, Jayakar V. Nayak, Zara M. Patel, Peter H. Hwang, Michael T. Chang Tags: RESEARCH NOTE Source Type: research

Mutational landscape and predictors of survival in head and neck mucosal melanoma
Key PointsHead and neck mucosal melanomas have a diverse mutational landscape with low mutational burden.A molecular subset ( ∼13%) has ROS1 mutations, which is an actionable driver mutation.ROS1-mutated patients have improved overall survival likely due to high mutational burden. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 8, 2023 Category: Allergy & Immunology Authors: Brandon M. Lehrich, Arash Abiri, Theodore V. Nguyen, Benjamin F. Bitner, Charles C. L. Tong, Edward C. Kuan Tags: RESEARCH NOTE Source Type: research

Pro ‐inflammatory markers associated with COVID‐19‐related persistent olfactory dysfunction
ConclusionIFN pathway cytokines were found elevated in the olfactory microenvironment of COVID-19 persistent OD compared to those with no OD and no prior history of COVID-19 infection. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 7, 2023 Category: Allergy & Immunology Authors: Sophie S. Jang, Kwang S. Pak, Allyssa Strom, Leslie Gomez, Laura Kim, Taylor A. Doherty, Adam S. DeConde, Allen F. Ryan, Carol H. Yan Tags: ORIGINAL ARTICLE Source Type: research

Combined endoscopic sinus surgery and endonasal septal perforation repair: Symptom outcomes and perforation closure rates
KEYPOINTS Combined endoscopic sinus surgery and nasal septal perforation repair is technically feasible. NOSE-Perf is a recently developed patient-reported outcome measure for nasal septal perforation. The decision to perform combined ESS and NSP repair should be made on a case-by-case basis. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 6, 2023 Category: Allergy & Immunology Authors: Sabrina W. Leung, Tripti Brar, Stephen F. Bansberg, Michael J. Marino, Devyani Lal, Cullen Taylor, Amar Miglani Tags: CLINICAL LETTER Source Type: research

Lunar dust: A unique nasal irritant forgotten by history
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 3, 2023 Category: Allergy & Immunology Authors: Scott A Hardison, Brian D Thorp, Charles S Ebert Jr, Cristine N Klatt ‐Cromwell, Brent A Senior, Adam J Kimple Tags: LETTER TO THE EDITOR Source Type: research

International consensus statement on allergy and rhinology: Sinonasal tumors
ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - September 2, 2023 Category: Allergy & Immunology Authors: Edward C. Kuan, Eric W. Wang, Nithin D. Adappa, Daniel M. Beswick, Nyall R. London, Shirley Y. Su, Marilene B. Wang, Waleed M. Abuzeid, Borislav Alexiev, Jeremiah A. Alt, Paolo Antognoni, Michelle Alonso ‐Basanta, Pete S. Batra, Mihir Bhaya Tags: REVIEW ARTICLE Source Type: research

Impact of medical treatment for chronic rhinosinusitis on eustachian tube dysfunction
Key points CRS patients treated with medical management have improvement in ETD symptoms as reflected by lower ETDQ-7 scores However, appropriate CRS medical management may be limited in ability to significantly improve, or resolve, ETD (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - August 31, 2023 Category: Allergy & Immunology Authors: Sarah M. Adams, Armo Derbarsegian, Ahmad R. Sedaghat, Katie M. Phillips Tags: RESEARCH NOTE Source Type: research

Predictive factors for decreased baseline quality of life in patients with sinonasal malignancies
ConclusionsOur findings demonstrate a negative impact on baseline QOL in patients with SNMs and suggest sex-specific and symptom-related lower QOL scores, with minimal histopathology association. Anatomical tumor involvement may be more reflective of QOL than T-staging, as orbital and skull base erosion, PNI, and palate lesions are significantly associated with reduced baseline QOL. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - August 30, 2023 Category: Allergy & Immunology Authors: Cara M. Fleseriu, Daniel M. Beswick, Sabrina L. Maoz, Peter H. Hwang, Garret Choby, Edward C. Kuan, Erik P. Chan, Nithin D. Adappa, Mathew Geltzeiler, Anne E. Getz, Ian M. Humphries, Christopher H. Le, Waleed M. Abuzeid, Eugene H. Chang, Ari Tags: ORIGINAL ARTICLE Source Type: research

Dynamic changes of nasal tight junctions in patients with convalescent COVID ‐19 with allergic rhinitis
KEY POINTS Nasal tight junction module score correlates negatively to allergy module score in COVID-19. Omicron variant may slow-down tight junction restoration in patients with AR. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - August 26, 2023 Category: Allergy & Immunology Authors: Yating Liu, Zaichuan Wang, Limin Zhao, Xue Wang, Xinyi Li, Zhennan Qu, Yuan Zeng, Yingyue Liu, Liusiqi Hao, Mengzhe Yang, Yuling Zhang, Shujian Zhang, Qiqi Wang, Yan Li, Feng Lan, Luo Zhang Tags: RESEARCH NOTE Source Type: research