International Forum of Allergy and Rhinology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dupilumab prevents nasal epithelial function alteration by IL ‐4 in vitro: Evidence for its efficacy
ConclusionDupilumab, in vitro, restored epithelial integrity by counteracting the effect of IL-4 on the epithelial barrier (increased epithelial permeability, decreased ciliary beating efficiency, and decreased wound repair rate). (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 12, 2024 Category: Allergy & Immunology Authors: Maxime Fieux, Florent Carsuzaa, Yvan Bellanger, Sophie Bartier, Virginie Fournier, Jean Claude Lecron, Matthieu Bainaud, Bruno Louis, St éphane Tringali, Xavier Dufour, André Coste, Laure Favot, Emilie Bequignon Tags: ORIGINAL ARTICLE Source Type: research

The Inflation Reduction Act: Implications for Medicare spending and access to biologic therapies for chronic rhinosinusitis with nasal polyposis and asthma
Key Points In 2021, Medicare spending on biologics was $926  million in Part B (FFS) and $1.3 billion in Part D (FFS/MA). Between 2017 and 2021, annual Medicare spending on biologics increased by approximately 200%. Between 2023 and 2025, Medicare Part D OOP costs for biologics will decrease by an estimated 50%–60%. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 11, 2024 Category: Allergy & Immunology Authors: Vinay K. Rathi, Zachary M. Soler, Rodney J. Schlosser, Alan D. Workman, Nikita Chapurin, Nicholas R. Rowan, Stacie B. Dusetzina Tags: RESEARCH NOTE Source Type: research

Combined balloon Eustachian tuboplasty/endoscopic sinus surgery for patients with chronic rhinosinusitis and Eustachian tube dysfunction
ConclusionCombined BET/ESS could decrease otologic symptoms and improve Eustachian tube function. BET may be an appropriate adjunctive procedure for treating chronic rhinosinusitis with obstructive ETD. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 11, 2024 Category: Allergy & Immunology Authors: Cheng ‐Yu Hsieh, Wei‐Chieh Lin, Chung‐Ching Lin, Yi‐Fan Chou Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 11, 2024 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Medication utilization for patients with chronic rhinosinusitis with nasal polyposis and asthma in 12 months pre ‐ and post‐dupilumab initiation
This study examines the impact of dupilumab on medication use for chronic rhinosinusitis with nasal polyposis (CRSwNP) and asthma patients. Patients on dupilumab had a reduction in oral/inhaled/topical steroids, antibiotics, and leukotriene receptor antagonists (LTRAs). The reduction in medication use had no impact on total polyp or SNOT-22 scores. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 27, 2024 Category: Allergy & Immunology Authors: Emily Garvey, Bita Naimi, Alexander Duffy, Chase Kahn, Douglas Farquhar, Marc Rosen, Mindy Rabinowitz, Damaris Pena Evertz, Jessica Most, Elina Toskala, Gurston G. Nyquist Tags: CLINICAL LETTER Source Type: research

The effect of PM2.5 on acute sinusitis: A population ‐based study
Key Points PM2.5 exposure is a risk factor for the development of acute sinusitis. PM2.5 exposure affects acute sinusitis in a dose response fashion. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 24, 2024 Category: Allergy & Immunology Authors: David Grimm, Z. Jason Qian, Michael Yong, Peter H. Hwang Tags: RESEARCH NOTE Source Type: research

SNOT ‐22 subdomain outcomes following treatment for sinonasal malignancy: A prospective, multicenter study
ConclusionsSinonasal QOL improvements associated with treatment of SNM are driven by rhinologic, extra-nasal, psychological, and sleep subdomains. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 20, 2024 Category: Allergy & Immunology Authors: David R. Grimm, Daniel M. Beswick, Sabrina L. Maoz, Eric W. Wang, Garret W. Choby, Edward C. Kuan, Erik P. Chan, Nithin D. Adappa, Mathew Geltzeiler, Anne E. Getz, Ian M. Humphreys, Christopher H. Le, Waleed M. Abuzeid, Eugene H. Chang, Aria Tags: ORIGINAL ARTICLE Source Type: research

Severe epistaxis after posterior nasal nerve ablation requiring surgical intervention: A multi ‐center case series
Key PointsSevere epistaxis occurs in 2% of PNN ablation cases, independent of method or device type.Major epistaxis requiring intervention after PNN ablation can occur on average 20 days post-procedure. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 19, 2024 Category: Allergy & Immunology Authors: Najm S. Khan, Yuki Yoshiyasu, Brian S. Wang, Antoine Khoudari, Dean M. Clerico, Jackson M. King, Toby O. Steele, Aatin K. Dhanda, Masayoshi Takashima, Omar G. Ahmed Tags: CLINICAL LETTER Source Type: research

Health care disparities and chronic rhinosinusitis: Does neighborhood disadvantage impact outcomes in sinonasal disease?
ConclusionsGeographic socioeconomic deprivation was associated with worse baseline disease severity and history of prior surgical intervention. However, ADI did not correlate with improvement in disease-specific outcomes. The impact of socioeconomic deprivation on outcomes in CRS requires further investigation. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 18, 2024 Category: Allergy & Immunology Authors: Amarbir S. Gill, Benton Tullis, Jess C. Mace, Conner Massey, Vivek C. Pandrangi, Jorge A. Gutierrez, Vijay R. Ramakrishnan, Daniel M. Beswick, Zachary M. Soler, Timothy L. Smith, Jeremiah A. Alt Tags: ORIGINAL ARTICLE Source Type: research

Severe unilateral refractory epistaxis arising from the septal branch of the anterior ethmoid artery
Key PointsThe septal branch of the anterior ethmoid artery (sbAEA) is an underrecognized source of severe refractory epistaxis.Herein, we describe the presentation, predisposing factors, treatment strategies, and outcomes of a series of patients with this condition. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 15, 2024 Category: Allergy & Immunology Authors: Theodore V. Nguyen, Benjamin F. Bitner, Ellen M. Hong, Jonathan C. Pang, Leo Li Tang Meller, Cecilia Nguyen, Edward C. Kuan Tags: CLINICAL LETTER Source Type: research

Comparison between upper and lower airway microbiome profiles in chronic rhinosinusitis patients
ConclusionThe sinus and bronchial bacterial microbiomes differ in important ways. Our study suggests that migration of bacteria from the sinus into the lower airways is unlikely in patients with CRS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 12, 2024 Category: Allergy & Immunology Authors: Juan Carlos Hernaiz ‐Leonardo, Changwan Ryu, Athenea Pascual, Judy Fan, Maria Caray, Rogério Pezato, Julia Yang, Don Sin, Andrew Thamboo Tags: ORIGINAL ARTICLE Source Type: research

Ensuring the appropriate use of biologics: A call for specialty evaluation
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 12, 2024 Category: Allergy & Immunology Authors: Aurelia Monk, Brian D. Thorp, Brent A. Senior, Adam J. Kimple, Cristine Klatt ‐Cromwell, Charles S. Ebert Jr. Tags: CLINICAL LETTER Source Type: research

Assessment of social vulnerability impact in care and prognosis of sinonasal cancers in the United States
Key PointsSocial determinants of health interactively influence sinonasal cancer care and prognosis.Housing-transportation and socioeconomic status showed the largest associations with disparities.The social vulnerability index can reveal the social determinants of sinonasal cancers. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 12, 2024 Category: Allergy & Immunology Authors: Achilles A. Kanaris, David J. Fei ‐Zhang, Lily B. Fletcher, Stephanie S. Smith, Urjeet A. Patel, Jill N. D'Souza, Daniel C. Chelius, Anthony M. Sheyn, Jeffrey C. Rastatter Tags: RESEARCH NOTE Source Type: research

Decoding chronic rhinosinusitis: A metabolomics ‐based approach
ConclusionsMetabolomics helps to shed light on the complexity of CRS. The mentioned findings highlight the importance of specific metabolic pathways and markers in understanding the pathophysiology of CRS. Despite that, challenges and future directions in metabolomics research for CRS would be worth being further explored. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 12, 2024 Category: Allergy & Immunology Authors: Xinru Gong, Yijie Fu, Lei Zhou, Aiming Wei, Chongsheng Pan, Tianmin Zhu, Hui Li Tags: REVIEW ARTICLE Source Type: research

Patient perspectives on chronic rhinosinusitis in cystic fibrosis: Symptom prioritization in the era of highly effective modulator therapy
ConclusionsNasal congestion and post-nasal discharge were top priorities reported by PwCF  + CRS. Those electing surgery prioritized sleep and psychological symptoms, highlighting their importance in pre-operative discussions. Non-ETI users’ prioritization of sleep improvement may highlight their unique disease impact and therapeutic needs; however, additional investigation is requir ed. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 12, 2024 Category: Allergy & Immunology Authors: Christine M. Liu, Ethan J. Han, Jakob L. Fischer, Jess C. Mace, Jose L. Mattos, Karolin Markarian, Jeremiah A. Alt, Todd E. Bodner, Naweed I. Chowdhury, Patricia H. Eshaghian, Anne E. Getz, Peter H. Hwang, Ashoke Khanwalkar, Adam J. Kimple, Tags: ORIGINAL ARTICLE Source Type: research