Optimal resource allocation with spatiotemporal transmission discovery for effective disease control
ConclusionsComputationally characterizing spatiotemporal transmission patterns allows for the effective risk mapping and resource prioritization; such adaptive strategies are of critical importance in achieving timely outbreak control under insufficient capacity. The proposed method can help guide public-health responses not only to the Omicron outbreaks but also to the potential future outbreaks caused by other new variants. Moreover, the investigation conducted in Hong Kong, China provides useful suggestions on how to achieve effective disease control with insufficient capacity in other highly populated countries and reg...
Source: Infectious Diseases of Poverty - March 25, 2022 Category: Infectious Diseases Source Type: research
Intra-urban variation in tuberculosis and community socioeconomic deprivation in Lisbon metropolitan area: a Bayesian approach
ConclusionsWe demonstrated significant heterogeneity in the spatial distribution of both non-MDR-TB and MDR-TB at the parish level and we found that socioeconomically disadvantaged parishes are disproportionally affected by both non-MDR-TB and MDR-TB. Our findings suggest that the emergence of MDR-TB and transmission are specific from each location and often different from the non-MDR-TB settings. We identified priority areas for intervention for a more efficient plan of control and prevention of non-MDR-TB and MDR-TB.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 24, 2022 Category: Infectious Diseases Source Type: research
Establishment and evaluation of an overlap extension polymerase chain reaction technique for rapid and efficient detection of drug-resistance in Mycobacterium tuberculosis
ConclusionsIn present study, a novel SOE PCR diagnostic method was successfully developed for the accurate detection ofM. tuberculosis drug resistance. Our results using this method have a high consistency with that of traditional phenotypic DST or GeneXpert MTB/RIF, and SOE PCR testing in clinical isolates can also be conducted rapidly and simultaneously for detection of drug resistance to RFP, EMB, and INH.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 24, 2022 Category: Infectious Diseases Source Type: research
Cost-effectiveness analysis on COVID-19 surveillance strategy of large-scale sports competition
ConclusionsHigh-frequency NATs such as bidaily, daily, and twice a day were cost-effective. NAT daily for CRP with strengthening close-contact control could be prioritized in defense against COVID-19 at large-scale sports competitions. This study could assist policymakers by assessing the cost-effectiveness of NAT scenarios and provide the host country with an optimal COVID-19 surveillance strategy.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 18, 2022 Category: Infectious Diseases Source Type: research
Non-traumatic coma in young children in Benin: are viral and bacterial infections gaining ground on cerebral malaria?
ConclusionsInfections were found in all children who died, and cerebral malaria was by far the most common cause of non-traumatic coma. Missed opportunities to receive early effective antimalarial treatment were common. Other central nervous system infections must be considered in their management. Some factors that proved to be protective against early death were unexpected. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 14, 2022 Category: Infectious Diseases Source Type: research
Possibility of COVID-19 eradication with evolution of a new omicron variant
AbstractCOVID-19 has been a global health concern since 2019 until date. Global concerted efforts to combat this pandemic has resulted in a number of vaccines distributed across the globe. Although the presence of these vaccines produced quick interventions, dynamic mutation in the causal virus and the continuous evolution of new stains that defy available vaccines has given rise to pertinent questions. The most recent emergence of a new COVID-19 virus variant (omicron), the rapid spread and overwhelming rate of morbidity and mortality has reopened these questions for debate. This commentary summarizes major view on these ...
Source: Infectious Diseases of Poverty - March 14, 2022 Category: Infectious Diseases Source Type: research
High prevalence of soil-transmitted helminth infections in Myanmar schoolchildren
ConclusionsDespite bi-annual deworming of schoolchildren in the fourth-grade and below, STH prevalence remains stubbornly high. These results informed the expansion of the Myanmar National STH control programme to include all school-aged children by the Ministry of Health and Sports in 2017, however further expansion to the whole community should be considered along with improving sanitation and hygiene measures. This would be augmented by rigorous monitoring and evaluation, including national prevalence surveys. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 10, 2022 Category: Infectious Diseases Source Type: research
Drug research and development opportunities in low- and middle-income countries: accelerating traditional medicine through systematic utilization and comprehensive synergy
ConclusionTraditional medicines inspires drug discoveries in LMICs, while a comprehensive and efficient R&D system could accelerate its R&D process and save investment. The discovery of artemisinin in China gave a reliable pattern to promote sustainable development of traditional medicines and a good example to realize R&D of traditional medicine under low-resource settings. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 7, 2022 Category: Infectious Diseases Source Type: research
HIV incidence and risk factors among transgender women and cisgender men who have sex with men in two cities of China: a prospective cohort study
ConclusionsCompared to cis-MSM, transgender women were at higher risk of HIV acquisition, highlighting an urgent need of tailored prevention. Future HIV program should consider to include them to ensure that this population in China are not left behind.Graphical abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 7, 2022 Category: Infectious Diseases Source Type: research
A direct, sensitive and high-throughput genus and species-specific molecular assay for large-scale malaria screening
ConclusionsmCLIP-PCR provides a sensitive and high-throughput approach to large-scale infectious disease screening with low cost and labor, making it a valuable tool for malaria elimination in endemic region.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 7, 2022 Category: Infectious Diseases Source Type: research
Condolence letter for Dr Mwelecele Ntuli Malecela (1963 –2022)
(Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 7, 2022 Category: Infectious Diseases Source Type: research
Epidemiological characteristics of imported respiratory infectious diseases in China, 2014 ‒2018
ConclusionsOur study documented importation of RIDs into China from 142 countries. Inbound travel poses a significant risks bringing important RIDs to China. It is urgent to strengthen surveillance at customs of inbound travelers and establish an intelligent surveillance and early warning system to prevent importation of RIDs to China for preventing further spread within China.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 4, 2022 Category: Infectious Diseases Source Type: research
Spatio-temporal analysis of leprosy risks in a municipality in the state of Mato Grosso-Brazilian Amazon: results from the leprosy post-exposure prophylaxis program in Brazil
ConclusionsThe disease distribution was partly explained by poverty indicators. LPEP influences the spatial dynamic of the disease and results highlighted the relevance of systematic contact surveillance for leprosy elimination.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - February 22, 2022 Category: Infectious Diseases Source Type: research
Improving the surveillance and response system to achieve and maintain malaria elimination: a retrospective analysis in Jiangsu Province, China
ConclusionsJiangsu Province has maintained its malaria-free status since 2012. The continuous improvement of a surveillance and response system plays an important role in the early detection and rapid response of potential malaria-related outbreaks in Jiangsu, China, and has important lessons for other malaria eliminating settings. Remaining vigilant in the detection of imported malaria cases and maintaining an active surveillance and response system is critical to sustain the success of malaria elimination.Graphic Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - February 21, 2022 Category: Infectious Diseases Source Type: research
Comparing different machine learning techniques for predicting COVID-19 severity
ConclusionsOur results indicated that RF could be a useful predictive tool to identify patients with severe COVID-19, which may facilitate effective care and further optimize resources.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - February 17, 2022 Category: Infectious Diseases Source Type: research
