High infection rates for onchocerciasis and soil-transmitted helminthiasis in children under five not receiving preventive chemotherapy: a bottleneck to elimination
ConclusionsThis study reveals that children < 5 years of age are highly infected with STH and onchocerciasis, and could contribute to the spread of these diseases, perpetuating a vicious circle of transmission and hampering elimination efforts. These findings reveal the urgent need to provide (or scale) treatments (likely pediatric formulat ions) to these preschool-aged children, especially in areas of high transmission, to accelerate efforts to reach WHO 2030 target.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 28, 2022 Category: Infectious Diseases Source Type: research
Polymorphisms of potential drug resistant molecular markers in Plasmodium vivax from China –Myanmar border during 2008‒2017
ConclusionsMutations related with resistance to antifolate drugs are prevalent in this area, while their frequencies decrease significantly with time, suggestive of increased susceptibility ofP. vivax parasite to antifolate drugs. Resistance to chloroquine (CQ) is possibly emerging. However, since the molecular mechanisms underneath CQ resistance is yet to be better understood, close supervision of clinical drug efficiency and continuous function investigation is urgently needed to alarm drug resistance.Graphical abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 25, 2022 Category: Infectious Diseases Source Type: research
Viral haemorrhagic fevers and malaria co-infections among febrile patients seeking health care in Tanzania
ConclusionsCo-infections of VHF and malaria are prevalent in Tanzania and affect more the older than the younger population. Since the overlapping symptoms in co-infected individuals may challenge accurate diagnosis, adequate laboratory diagnosis should be emphasized in the management of febrile illnesses. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 25, 2022 Category: Infectious Diseases Source Type: research
Comparative study of the effect of solvents on the efficacy of neonicotinoid insecticides against malaria vector populations across Africa
ConclusionsThis study revealed a contrasted susceptibility pattern depending on the solvents with ethanol/acetone resulting to lower mortality, thus possibly overestimating resistance, whereas the MERO consistently showed a greater efficacy of neonicotinoids but it could prevent to detect early resistance development. Therefore, we recommend monitoring the susceptibility using both acetone alone and acetone + MERO (4 µg/ml for clothianidin) to capture the accurate resistance profile of the mosquito populations.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 25, 2022 Category: Infectious Diseases Source Type: research
Priorities of China ’s participation in global malaria elimination: the perspective of malaria endemic countries
ConclusionsChina could make full use of its own advantages in technique transfer, health system improvement, information system construction, and health human resource training and take an active part in global malaria elimination. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 20, 2022 Category: Infectious Diseases Source Type: research
Prompt and precise identification of various sources of infection in response to the prevention of malaria re-establishment in China
AbstractPrompt and precise diagnosis of patients is an essential component of malaria control and elimination strategies, it is even more vital for the prevention of malaria re-establishment in the post elimination phase. After eliminating malaria in China, the strategy for prevention of malaria re-establishment was updated in a timely manner from the elimination strategy focusing on each case/focus to the prevention of re-establishment focusing on timely identification of the source of infection. However, there are numerous challenges, such as the persistent large number of imported malaria cases, the long-term threat of ...
Source: Infectious Diseases of Poverty - April 18, 2022 Category: Infectious Diseases Source Type: research
Specific urban units identified in tuberculosis epidemic using a geographical detector in Guangzhou, China
ConclusionsThe spatial heterogeneity of the 2017 incidence of TB in the study area was considerably influenced by several socioeconomic and environmental factors and their pairwise interactions on a fine scale. We suggest that more attention should be paid to the units with pairwise interacting factors in Guangzhou. Our study provides helpful clues for local authorities implementing more effective intervention measures to reduce TB incidence in China ’s municipal areas, which are featured by both a high degree of urbanization and a high incidence of TB.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 15, 2022 Category: Infectious Diseases Source Type: research
Mapping the distributions of blood-sucking mites and mite-borne agents in China: a modeling study
ConclusionsEcological niches of major mite species and mite-borne pathogens are much more extensive than what have been observed, necessitating expansion of current filed surveillance.Graphic Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 9, 2022 Category: Infectious Diseases Source Type: research
Supporting tuberculosis program in active contact tracing: a case study from Pakistan
AbstractTuberculosis (TB) is on the rise in Pakistan and there could be multiple reasons including poverty, difficulty in access to TB treatment services, non-compliance with treatment, social stigma etc. According to the TB program managers, limited treatment and testing sites for tuberculosis and lack of trained human resources play a major role in compromising TB management. A major lacuna in the TB control program is the absence of active contact tracing strategy. This is essential for a disease where positive cases are known to be able to infect a further 10 ‒15 individuals in a year. Tackling tuberculosis in Pakist...
Source: Infectious Diseases of Poverty - April 9, 2022 Category: Infectious Diseases Source Type: research
Infection fatality rate and infection attack rate of COVID-19 in South American countries
ConclusionsThis study reveals possible reasons for the two waves of COVID-19 outbreaks in South America. We observed reductions in the transmission rate corresponding to each wave plausibly due to improvement in nonpharmaceutical interventions measures and human protective behavioral reaction to recent deaths. Thus, strategies coupling social distancing and vaccination could substantially suppress the mortality rate of COVID-19 in South America.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 6, 2022 Category: Infectious Diseases Source Type: research
Reaching the malaria elimination goal in Brazil: a spatial analysis and time-series study
ConclusionsIt is likely that Brazil will reduce the number of new malaria cases in the Brazilian Amazon in 2030 in relation to that in 2015. Herein forecast shows a reduction by 46% (74,754 in 2030 forecast/137,982 in 2015), but this reduction is yet far from the proposed reduction under the WHO GTS 2030 milestone (90%). Stable and unbeatable transmission in the Juru á River Valley, Manaus, and Lábrea still support endemic malaria in the Brazilian Amazon. Today’s cross-border malaria is impacting the state of Roraima unprecedently. If this situation is maintained, the malaria elimination goal (zero cases) may not be re...
Source: Infectious Diseases of Poverty - April 5, 2022 Category: Infectious Diseases Source Type: research
How to improve the COVID-19 health education strategy in impoverished regions: a pilot study
ConclusionsBy proposing and verifying the theoretical framework, this study put forward specific suggestions on how to improve COVID-19 health education strategies in impoverished regions viaimplementation methods,key groups andeffect evaluation, which also provided references about future public health emergencies for other impoverished regions of the world.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 29, 2022 Category: Infectious Diseases Source Type: research
Vaccination as an alternative to non-drug interventions to prevent local resurgence of COVID-19
ConclusionsAs vaccine coverage improves, the NPIs can be gradually relaxed. Until that threshold is reached, however, strict NPIs are still needed to control the epidemic. The more transmissible SARS-CoV-2 variant led to higher resurgence probability, which indicates the importance of accelerated vaccination and achieving the vaccine coverage earlier.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 26, 2022 Category: Infectious Diseases Source Type: research
Hybridization increases genetic diversity in Schistosoma haematobium populations infecting humans in Cameroon
ConclusionsHybrids betweenS. haematobium andS. bovis were identified in 11.3% of miracidia that hatched from eggs present in the urine of Cameroonian schoolchildren. The percentages of these hybrids are correlated with the genetic diversity of the parasite, indicating that hybridization increases genetic diversity in our sampling sites. Hybridization is therefore a major biological process that shapes the genetic diversity ofS. haematobium.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 26, 2022 Category: Infectious Diseases Source Type: research
Optimal resource allocation with spatiotemporal transmission discovery for effective disease control
ConclusionsComputationally characterizing spatiotemporal transmission patterns allows for the effective risk mapping and resource prioritization; such adaptive strategies are of critical importance in achieving timely outbreak control under insufficient capacity. The proposed method can help guide public-health responses not only to the Omicron outbreaks but also to the potential future outbreaks caused by other new variants. Moreover, the investigation conducted in Hong Kong, China provides useful suggestions on how to achieve effective disease control with insufficient capacity in other highly populated countries and reg...
Source: Infectious Diseases of Poverty - March 25, 2022 Category: Infectious Diseases Source Type: research
