Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions
ConclusionsOur approach uses disease dynamic models and machine learning to support decision-making and resource investment, facilitating development of new malaria interventions. By evaluating the intervention capabilities in relation to the targeted health goal, our analysis allows prioritization of interventions and of their specifications from an early stage in development, and subsequent investments to be channeled cost-effectively towards impact maximization. This study highlights the role of mathematical models to support intervention development. Although we focus on five malaria interventions, the analysis is gene...
Source: Infectious Diseases of Poverty - June 4, 2022 Category: Infectious Diseases Source Type: research
Armigeres subalbatus is a potential vector for Zika virus but not dengue virus
ConclusionsZIKV but not DENV-2 can infectAr. subalbatus by blood meal and artificial urine, and the infected mosquitoes can transmit ZIKV to suckling mice by bite. From these findings, we can conclude that theAr. subalbatus isolated from Guangdong province, China, is a potential vector for ZIKV and should therefore be considered in vector control programs to prevent and control of Zika virus disease.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 4, 2022 Category: Infectious Diseases Source Type: research
Establish an allele-specific real-time PCR for Leishmania species identification
ConclusionsOur assay provides a rapid and accurate tool forLeishmania species identification which is applicable for species-adapted therapeutic schedule and patient management.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 2, 2022 Category: Infectious Diseases Source Type: research
Assessment of echinococcosis control in Tibet Autonomous Region, China
ConclusionBetween 2017 and 2019, the number of stray dogs and infection rate ofEchinococcus spp. in domestic dogs decreased significantly, indicating that dogs were effectively controlled as a source of infection in TAR and reflecting a significant decrease in the risk of echinococcosis transmission.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 26, 2022 Category: Infectious Diseases Source Type: research
Human pediculosis, a global public health problem
ConclusionsHuman pediculosis is a public health problem affecting millions of people worldwide, particularly in developing countries. More progress can be made if emphasis is placed on the use of emerging omics technologies to elucidate the mechanisms that underpin the physiological, ecological, and evolutionary aspects of lice.Graphic Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 26, 2022 Category: Infectious Diseases Source Type: research
Towards a global One Health index: a potential assessment tool for One Health performance
ConclusionsGOHI —subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promo ting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 22, 2022 Category: Infectious Diseases Source Type: research
Could China ’s journey of malaria elimination extend to Africa?
AbstractWorld Health Organization (WHO) certified China malaria-free on June 30, 2021, which brightens the goal of global malaria elimination efforts. China contributed its unique innovations to the global community: Artemisinin, discovered by Tu Youyou, has saved millions of lives globally; the “1-3-7” norm developed in 2012, has been adapted in the local contexts of countries in the Southeast Asia and Africa. How to the targets of Global Technical Strategy for Malaria (GTS) 2016−2030. By looking into the malaria control phase, towards elimination phase from 1960 to 2011 in sub-Sahar an Africa and China, we found th...
Source: Infectious Diseases of Poverty - May 16, 2022 Category: Infectious Diseases Source Type: research
COVID-19 vaccines in patients with decompensated cirrhosis: a retrospective cohort on safety data and risk factors associated with unvaccinated status
ConclusionsPatients with decompensated cirrhosis in eastern China are largely remained at unvaccinated status, particularly those with previous episodes of ACLF or hepatic encephalopathy and liver transplantation recipients. Vaccination against COVID-19 in this population is safe.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 16, 2022 Category: Infectious Diseases Source Type: research
Vector control in China, from malaria endemic to elimination and challenges ahead
ConclusionsThe tailored and adapted vector control strategies have played a critical role in China ’s malaria prevention, control, and elimination. Achievements and lessons learned on vector control from this progress would provide a practical reference in coping with the challenges and potential barriers other countries face in the global effort to eliminate malaria. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 13, 2022 Category: Infectious Diseases Source Type: research
Potential risk of colonization of Bulinus globosus in the mainland of China under climate change
ConclusionsAnnual regeneration ofB. globosus can be supported by the current climate conditions in the mainland of China, and a gradual expansion trend from south to north is shown in the study from 2015 to 2019. Thus, there is a potential risk of colonization ofB. globosus in the mainland of China under climate change.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 13, 2022 Category: Infectious Diseases Source Type: research
Immunogenicity and safety of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine: a systematic review
ConclusionsHeterologous ChAd/BNT schedule induced at least comparable immunogenicity compared with homologous BNT/BNT and better immunogenicity compared with homologous ChAd/ChAd vaccination. The synthetical evidence supported the general application of heterologous prime-boost vaccination using ChAd and BNT COVID-19 vaccines.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 13, 2022 Category: Infectious Diseases Source Type: research
Malaria from hyperendemicity to elimination along international borders in Yunnan, China during 2003 ‒2020: a case study
ConclusionsIn Yunnan malaria burden has successfully reduced by dynamically accurate stratification and comprehensive interventions; and then the region achieved elimination and prevented reintroduction of malaria transmission through intensive surveillance, rapid response and border collaboration. Other border areas should perform their own intervention trials to develop their own effective strategy.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 10, 2022 Category: Infectious Diseases Source Type: research
Uncovering the genetic diversity of Giardia intestinalis in isolates from outbreaks in New Zealand
ConclusionsThis study showed thatG. intestinalis infections in humans are frequently mixed, with multiple subtypes present in each host. Shared sequences among epidemiologically linked cases not identified through Sanger sequencing were detected. Considering the variation in symptoms observed in cases of giardiasis, and the potential link between symptoms and (sub-) assemblages, the frequency of mixed infections could have implications for our understanding of host –pathogen interactions.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 4, 2022 Category: Infectious Diseases Source Type: research
Using amino acid features to identify the pathogenicity of influenza B virus
ConclusionsThe optimized informative features had the best performance and were used to build a predictive model so as to identify the phenotype of influenza B virus with high pathogenicity and provide early risk warning for disease control.Graphical Abstract (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 4, 2022 Category: Infectious Diseases Source Type: research
Social insights on the implementation of One Health in zoonosis prevention and control: a scoping review
ConclusionsBased on reviewed literature, although there seems to be a lack of guidelines for assessing and visualizing the outcomes of OH implementation, which may limit the large-scale adoption of it, evidence on the contributions of implementing OH concepts on zoonosis prevention and control indicates long-term benefits to society, including a better integration of politics, stakeholders and academics to improve their cooperation, a potential to address economic issues caused by zoonosis, and a comprehensive consideration on social determinants of health during zoonosis prevention and control. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 3, 2022 Category: Infectious Diseases Source Type: research
