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Vinpocetine mitigates methotrexate-induced duodenal intoxication by modulating NF- κB, JAK1/STAT-3, and RIPK1/RIPK3/MLKL signals
CONCLUSION: Therefore, VNP may represent a promising approach that can attenuate intestinal toxicity in patients receiving MTX.PMID:37493389 | DOI:10.1080/08923973.2023.2239491 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 26, 2023 Category: Allergy & Immunology Authors: Hanaa M Tashkandi Hanan S Althagafy Fatima A Jaber Turki Alamri Nouf S Al-Abbas Nehad A Shaer Steve Harakeh Emad H M Hassanein Source Type: research

Vinpocetine mitigates methotrexate-induced duodenal intoxication by modulating NF- κB, JAK1/STAT-3, and RIPK1/RIPK3/MLKL signals
Immunopharmacol Immunotoxicol. 2023 Jul 26:1-13. doi: 10.1080/08923973.2023.2239491. Online ahead of print.ABSTRACTMethotrexate (MTX) is an antimetabolite agent widely used to manage a variety of tumors and autoimmune diseases. Nonetheless, MTX-induced intestinal intoxication is a serious adverse effect limiting its clinical utility. Inflammation and oxidative stress are possible mechanisms for MTX-induced intestinal toxicity. Vinpocetine (VNP) is a derivative of the alkaloid vincamine with potent anti-inflammatory and antioxidant effects. The current study investigated the protective intestinal impact of VNP in attenuatin...
Source: Immunopharmacology and Immunotoxicology - July 26, 2023 Category: Allergy & Immunology Authors: Hanaa M Tashkandi Hanan S Althagafy Fatima A Jaber Turki Alamri Nouf S Al-Abbas Nehad A Shaer Steve Harakeh Emad H M Hassanein Source Type: research

Cancer-associated immune cells and their modulation by melatonin
Immunopharmacol Immunotoxicol. 2023 Jul 25:1-25. doi: 10.1080/08923973.2023.2239489. Online ahead of print.ABSTRACTRapidly growing evidence suggests that immune cells play a key role in tumor progression. Tumor cells are surrounded by a microenvironment composed of different cell populations including immune cells. The cross talk between tumor cells and the mentioned neighboring microenvironment is an important factor to take into account while designing tumor therapies. Despite significant advances in immunotherapy strategies, a relatively small proportion of patients have successfully responded to them. Therefore, the se...
Source: Immunopharmacology and Immunotoxicology - July 25, 2023 Category: Allergy & Immunology Authors: Shirin Hekmatirad Milad Moloudizargari Marjan Fallah Atena Rahimi Vahdat Poortahmasebi Mohammad Hossein Asghari Source Type: research

HIV protease inhibitor Saquinavir inhibits toll-like receptor 4 activation by targeting receptor dimerization
Immunopharmacol Immunotoxicol. 2023 Jul 24:1-10. doi: 10.1080/08923973.2023.2239488. Online ahead of print.ABSTRACTToll like receptor 4 (TLR4) is crucial in induction of innate immune response through recognition of invading pathogens or endogenous alarming molecules. Ligand-triggered dimerization of TLR4 is essential for the activation of NF-kB and IRF3 through MyD88- or TRIF-dependent pathways. Saquinavir (SQV), a FDA-approved HIV protease inhibitor, has been shown to attenuate the activation of NF-kB induced by HMGB1 by blocking TLR4-MyD88 association in proteasome-independent pathway. However, it remains unknown whethe...
Source: Immunopharmacology and Immunotoxicology - July 24, 2023 Category: Allergy & Immunology Authors: Kai Yao Zheng Wang Cheng Peng Yong Wang Bichen Xue Yulin Tang Zhichao Wang Hongbo Xu Source Type: research