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Prediction of prognostic and immune therapy response in lung adenocarcinoma based on MHC-I-related genes
Immunopharmacol Immunotoxicol. 2023 Sep 20:1-15. doi: 10.1080/08923973.2023.2261146. Online ahead of print.ABSTRACTThe study investigated the prognostic and immune predictive potential of major histocompatibility complex class I (MHC-I) in lung adenocarcinoma (LUAD). With TCGA-LUAD and GEO datasets (GSE26939, GSE72094) as the training and validation sets, respectively, we identified 8 MHC-I-related genes and established a prognostic model via Cox regression analysis. The predictive capacity of the model was assessed in both sets using the receiver operating characteristic curve and Kaplan-Meier survival curves, with outcom...
Source: Immunopharmacology and Immunotoxicology - September 20, 2023 Category: Allergy & Immunology Authors: Hangdi Xu Yanjie Hu Xiuming Peng Enguo Chen Source Type: research