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Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Immunopharmacol Immunotoxicol. 2024 Mar 13:1-41. doi: 10.1080/08923973.2024.2330641. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a significant global health concern with high mortality rates. Patients who undergo renal transplants and other major surgeries are at a heightened risk of developing AKI. Importantly, these patients primarily receive immunosuppressants to reduce excessive immune system activation. However, specific immunosuppressants have been associated with the progression of AKI. Some drugs, on the other hand, exert renoprotection. Presently, there is no consensus on which immunosuppressants fo...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-Cell Metabolism in Rheumatoid Arthritis: Focus on Mitochondrial and Lysosomal Dysfunction
Immunopharmacol Immunotoxicol. 2024 Mar 13:1-10. doi: 10.1080/08923973.2024.2330645. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by immune cell dysregulation, synovial hyperplasia, and progressive cartilage destruction. The loss of immunological self-tolerance against autoantigens is the crucial insult responsible for the pathogenesis of RA. These immune abnormalities are experienced many years before the onset of clinical arthritis. T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pa...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic Reprogramming of T Cell: A New Frontier for Pharmacotherapy of Rheumatoid Arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 13:1-32. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognised as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Isorhamnetin ameliorates cisplatin-induced acute kidney injury in mice by activating SLPI-mediated anti-inflammatory effect in macrophage
Conclusion: Isorhamnetin inhibits macrophage inflammation and protects kidney in AKI may be related to downregulating Mincle/Syk/NF-κB-maintained macrophage phenotype by activating SLPI.PMID:38466121 | DOI:10.1080/08923973.2024.2329621 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 11, 2024 Category: Allergy & Immunology Authors: Jia Jian Li Yu-Qing Han Rang-Yue Zhong Xia Xie Ke-Huan Yan Ying Wang Li Tan Rui-Zhi Source Type: research

Correction
Immunopharmacol Immunotoxicol. 2024 Feb 7:1-2. doi: 10.1080/08923973.2024.2314849. Online ahead of print.NO ABSTRACTPMID:38323597 | DOI:10.1080/08923973.2024.2314849 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 7, 2024 Category: Allergy & Immunology Source Type: research