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Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway
Conclusion: Our findings suggest that icariin treatment can alleviate the development of RA by reducing cell proliferation and inflammation in RA-FLS through the regulation of the GAREM1/MAPK signaling pathway. These results support the potential of icariin as a therapeutic agent for RA treatment. As icariin is safe and well-tolerated in previous studies, further research is warranted to explore its efficacy in clinical settings.PMID:37647355 | DOI:10.1080/08923973.2023.2253990 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 30, 2023 Category: Allergy & Immunology Authors: Zhiming Wu Qin Liu Zhengliu Cao Hui Li Yifen Zhou Peng Zhang Source Type: research

Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer
CONCLUSION: Compared to the Leptin-treated mDC and LPS-treated mDC vaccines, the Leptin/LPS-treated mDC vaccine was more effective in inhibiting BC development and boosting immune responses against tumor.PMID:37647347 | DOI:10.1080/08923973.2023.2253989 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 30, 2023 Category: Allergy & Immunology Authors: Pedram Basirjafar Raziyeh Zandvakili Javad Masoumi Nahid Zainodini Zahra Taghipour Hossein Khorramdelazad Soheila Yousefi Tayyebeh Tavakoli Mahboobeh Vatanparast Sepehr Safdel Mahsa Gheitasi Fatemeh Ayoobi Bahar Naseri Abdollah Jafarzadeh Source Type: research

Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway
Conclusion Our findings suggest that icariin treatment can alleviate development of RA by reducing cell proliferation and inflammation in RA-FLS through the regulation of the GAREM1/MAPK signaling pathway. These results support the potential of icariin as a therapeutic agent for RA treatment. As icariin has been shown to be safe and well-tolerated in previous studies, further research is warranted to explore its efficacy in clinical settings.PMID:37647355 | DOI:10.1080/08923973.2023.2253990 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 30, 2023 Category: Allergy & Immunology Authors: Zhiming Wu Qin Liu Zhengliu Cao Hui Li Yifen Zhou Peng Zhang Source Type: research

Effects of erucin on inflammatory mediators and antioxidant enzymes' expression in TNF- α-stimulated human oral epithelial cells
Conclusions: These results suggest that erucin may provide a new anti-inflammatory agent that can be used in the treatment of periodontitis.PMID:37624680 | DOI:10.1080/08923973.2023.2250551 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 25, 2023 Category: Allergy & Immunology Authors: Masahiro Shimoyama Yoshitaka Hosokawa Ikuko Hosokawa Kazumi Ozaki Keiichi Hosaka Source Type: research

The effects of erucin on inflammatory mediators and antioxidant enzymes expression in TNF- α-stimulated human oral epithelial cells
Immunopharmacol Immunotoxicol. 2023 Aug 25:1-15. doi: 10.1080/08923973.2023.2250551. Online ahead of print.ABSTRACTPeriodontitis is a chronic inflammatory disease induced by periodontal disease-causing bacteria. It has been shown that excessive immune response against bacteria is involved in periodontal tissue destruction including alveolar bone resorption. Erucin is a biologically active substance found in cruciferous plants such as arugula, and is classified as an isothiocyanate. No previous studies have attempted to use erucin in the treatment of periodontitis, and there are no papers that have examined the effects of e...
Source: Immunopharmacology and Immunotoxicology - August 25, 2023 Category: Allergy & Immunology Authors: Masahiro Shimoyama Yoshitaka Hosokawa Ikuko Hosokawa Kazumi Ozaki Keiichi Hosaka Source Type: research

Protective Effect of Pregabalin on Renal and Renal Endothelial Damage in Sepsis Induced by Lipopolysaccharide
Immunopharmacol Immunotoxicol. 2023 Aug 22:1-16. doi: 10.1080/08923973.2023.2250911. Online ahead of print.ABSTRACTWe investigated the protective effects of pregabalin (PRG) on kidney and renal endothelial damage in sepsis induced by Lipopolysaccharide (LPS). Rats randomly divided into three groups as control, LPS and LPS + PRG. Saline solution was administered 30 mg/kg orally and 5 mg/kg intraperitoneally (i.p.) to the control group. LPS was applied as 5 mg/kg, i.p. to the LPS group. In the LPS + PRG group, PRG at 30 mg/kg orally and one hour before LPS administration, one hour later 5 mg/kg i.p. LPS was applied. Rats wer...
Source: Immunopharmacology and Immunotoxicology - August 22, 2023 Category: Allergy & Immunology Authors: Dilek Çevik Nurhan G ümral Rahime Aslanko ç Özlem Özmen Arzu Yal çın O ğuzhan Kavrık Source Type: research

Ciclopirox mitigates inflammatory response in LPS-induced septic shock via inactivation of SORT1-mediated wnt/ β-Catenin signaling pathway
Conclusions: In sum, we found that CPX protected against LPS-induced septic shock by mitigating inflammation via SORT1-mediated Wnt/β-Catenin signaling pathway.PMID:37606515 | DOI:10.1080/08923973.2023.2231628 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 22, 2023 Category: Allergy & Immunology Authors: Liangliang Zhou Yingfeng He Yijun Deng Xinxin Li Wei Wang Jianjun Chen Source Type: research